Tuesday, August 12, 2014

voices from within: gut microbes and the central nervous system

springer |  Recent advances in research have greatly increased our understanding of the importance of the gut microbiota. Bacterial colonization of the intestine is critical to the normal development of many aspects of physiology such as the immune and endocrine systems. It is emerging that the influence of the gut microbiota also extends to modulation of host neural development. Furthermore, the overall balance in composition of the microbiota, together with the influence of pivotal species that induce specific responses, can modulate adult neural function, peripherally and centrally. Effects of commensal gut bacteria in adult animals include protection from the central effects of infection and inflammation as well as modulation of normal behavioral responses. There is now robust evidence that gut bacteria influence the enteric nervous system, an effect that may contribute to afferent signaling to the brain. The vagus nerve has also emerged as an important means of communicating signals from gut bacteria to the CNS. Further understanding of the mechanisms underlying microbiome–gut–brain communication will provide us with new insight into the symbiotic relationship between gut microbiota and their mammalian hosts and help us identify the potential for microbial-based therapeutic strategies to aid in the treatment of mood disorders.


BigDonOne said...

"gut bacteria in adult animals include .... modulation of normal behavioral responses. "

Today's behavior-is-genetic PRR item -- http://blogs.kqed.org/science/2014/08/11/some-of-us-may-have-a-genetic-predisposition-to-disliking-exercise/

Excerpt: -- "...story starts a few years ago when scientists noticed that some rats loved to run around on their wheel all night while others liked doing that a whole lot less. These scientists then took the most enthusiastic exercisers and put them together so they would breed. They did the same thing with the least enthusiastic rats. They repeated this for each group for ten generations. In the end, the researchers found that a huge gap had developed between these two groups in terms of their desire to exercise...."

Link includes the shocking photo below. Perhaps certain dietary choices unleash the gut microbes that stimulate behavioral genetic tendencies....??

As they say, 'What it do Shawty...'

Vic78 said...

Take two or three of the non exercising rats out of their cages and let them stay in your house for a few days.