Showing posts with label Big Pharma. Show all posts
Showing posts with label Big Pharma. Show all posts

Wednesday, April 05, 2023

SSRI Antidepressants Cause Mass Shootings

amidwesterndoctor |  Much like the vaccine industry, the psychiatric industry will always try to absolve their dangerous medications of responsibility and will aggressively gaslight their victims. Despite these criticisms,there are three facts can be consistently found throughout the literature on akathisia homicides which Gøtzsche argues irrefutably implicate psychiatric medications as the cause of violent homicides:

• These violent events occur in people of all ages, who by all objective and subjective measures were completely normal before the act and where no precipitating factors besides the psychiatric medication could be identified.
• The events were preceded by clear symptoms of akathisia.
• The violent offenders returned to their normal personality when they came off the antidepressant.

Numerous cases where this has happened are summarized within this article from the Palm Beach Post. In most of those cases, a common trend of these spontaneous acts of violence emerges: the act of violence was immediately preceded by a significant change in the psychiatric medications used by the individual. In one case, shortly before committing one of these murders, one of the perpetrators also wrote on a blog that, while taking Prozac, he felt as if he was observing himself "from above." 

Individuals with a mutation in the gene that metabolizes psychiatric drugs are much more vulnerable to developing excessive levels of these drugs and triggering severe symptoms such as akathisia and psychosis. There is a good case to be made that individuals with this gene are responsible for many of the horrific acts of iatrogenic (medically induced) violence that occur, however to my knowledge, this is never considered when psychiatric medications are prescribed. Gøtzsche summarized a peer-reviewed forensic investigation of 10 cases where this happened (all but one of these involved an SSRI or an SNRI):

Note: This original version of this article (which has been revised and updated) was published a year ago, but sadly is just as pertinent now as it was then. Each time one of these shootings happen, I watch people get up in arms over what needs to be done to stop murdering our children, but at the same time this, the elephant in the room, the clear and irrefutable evidence linking psychiatric medications to homicidal violence is never discussed (which I believe is due their sales making approximately 40 billion dollars a year).

Many of the stories in here are quite heart wrenching, and I humbly request that you make the effort to bear witness to these tragic events.

Prior to the Covid vaccinations, psychiatric medications were the mass-prescribed medication that had the worst risk-to-benefit ratio on the market. In addition to rarely providing benefits to patients, there is a wide range of severe complications that commonly result from psychiatric medications. Likewise, I and many colleagues believe the widespread adoption of psychotropic drugs has distorted the cognition of the demographic of the country which frequently utilizes them (which to some extent stratifies by political orientation) and has created a wide range of detrimental shifts in our society. 

Selective serotonin reuptake inhibitors (SSRIs) have a similar primary mechanism of action to cocaine. SSRIs block the reuptake of Serotonin, SNRIs, also commonly prescribed block the reuptake of Serotonin and Norepinephrine (henceforth “SSRI refers to both SSRI and SNRI), and Cocaine blocks the reuptake of Serotonin, Norepinephrine, and Dopamine. SSRIs (and SNRIs) were originally used as anti-depressants, then gradually had their use marketed into other areas and along the way have amassed a massive body count.

Once the first SSRI entered the market in 1988, Prozac quickly distinguished itself as a particularly dangerous medication and after nine years, the FDA received 39,000 adverse event reports for Prozac, a number far greater than for any other drug. This included hundreds of suicides, atrocious violent crimes, hostility and aggression, psychosis, confusion, distorted thinking, convulsions, amnesia, and sexual dysfunction (long-term or permanent sexual dysfunction is one of the most commonly reported side effects from anti-depressants, which is ironic given that the medication is supposed to make you less, not more depressed). 

SSRI homicides are common, and a website exists that has compiled thousands upon thousands of documented occurrences. As far as I know (there are most likely a few exceptions), in all cases where a mass school shooting has happened, and it was possible to know the medical history of the shooter, the shooter was taking a psychiatric medication that was known for causing these behavioral changes. After each mass shooting, memes illustrating this topic typically circulate online, and the recent events in Texas [this article was written shortly after the shooting last year] are no exception. I found one of these and made an updates version of it (the one I originally used contained some inaccuracies)

Oftentimes, “SSRIs cause mass shootings” is treated as just another crazy conspiracy theory. However, much in the same way the claim “COVID Vaccines are NOT safe and effective” is typically written off as a conspiracy theory, if you go past these labels and dig into the actual data, an abundantly clear and highly concerning picture emerges.

There are many serious issues with psychiatric medications. For brevity, this article will exclusively focus on their tendency to cause horrific violent crimes. This was known long before they entered the market by both the drug companies and the FDA. While there is a large amount of evidence for this correlation, it is the one topic that is never up for debate when a mass shooting occurs. I have a lot of flexibility to discuss highly controversial topics with my colleagues, but this topic is met with so much hostility that I can never bring it up. It is, for this reason, I am immensely grateful to have an anonymous forum I can use.

 

How Big Pharma And The FDA Buried The Dangers Of SSRI Antidepressants

pierrekory |   One of the pharmaceutical executives directly involved in obtaining the approval for the original SSRI antidepressant, Prozac, developed a great deal of guilt for what he was complicit in once a large number of SSRI-linked deaths occurred. John Virapen, along with Peter Rost are the only pharmaceutical executives I know of who have become whistleblowers and shared the intimate details of how these companies actually operate. Although the events Virapen alleged seem hard to believe, other whistleblowers have also made similar observations to Virapen (the accounts of the Pfizer whistleblowers can be found in this article and this article).

John Virapen chronicled the events in which he was complicit in “Side Effects: Death—Confessions of a Pharma Insider.” These included outrageous acts of bribery to get his drugs approved, and photographing physicians with prostitutes provided by Eli Lilly so that they could be blackmailed into serving Eli Lilly. For those interested, this is a brief talk that Virapen gave about his experiences. I greatly appreciate the fact he used candid language rather than euphemisms like almost everyone else does:

At the start of the saga, Lilly was in dire financial straits and the company’s survival hinged on the approval of Prozac. Prozac had initially been proposed as a treatment for weight loss (as this side effect of Prozac had been observed in treatment subjects), but Lilly subsequently concluded it would be easier to get approval for treating depression and then get a post-marketing approval for the treatment of weight loss.

As Prozac took off, it became clear that depression was a much better market, and the obesity aspect was forgotten. Lilly then used a common industry tactic and worked tirelessly to expand the definition of depression so that everyone could become eligible for the drug and aggressively marketed this need for happiness to the public, before long, transforming depression from a rare to a common condition. For those wishing to learn more, Peter Gøtzsche has extensively documented how this fraud transpired and both this brief documentary and this article show how depression became popularized in Japan so that treatments for it could be sold.

Unfortunately, while the marketing machine had no difficulties creating a demand for Prozac, the initial data made it abundantly clear that the first SSRI, Prozac, was dangerous and ineffective. Lilly settled on the strategy of obtaining regulatory approval in Sweden, and using this approval as a precedent to obtain approval in other countries. Virapen was assigned to this task and told by his superiors that if he failed, his career was over. Virapen, unfortunately, discovered that whenever he provided Lilly’s clinical trial data to experts, they had trouble believing he was actually seeking regulatory approval, as Prozac’s trial data was just that bad. 

Sweden (following their regulatory procedures) elected to allow an outside independent expert to make the final determination on whether Prozac should be approved or not. The identity of this expert witness was concealed, but Virapen was able to determine that it was Anders Forsman, a forensic psychiatrist and member of the legal council on the Swedish National Board of Health. After meeting with Virapen, Forsman proposed an untraceable bribe. Then, upon receiving payment, wrote a glowing letter in support of Prozac, fully reversing his position on Prozac (he had ridiculed it two weeks before) and guided Virapen through re-writing the trial to conceal the 5 attempted (4 of which were successful) SSRI suicides in Lilly’s trial. 

Forsman’s expert opinion resulted in Prozac being partially approved and formally priced for reinbursement in Sweden, which was used as a precedent to market it around the world at that same lucrative price. Virapen noted that during this time, German drug regulators who had clearly and unambiguously stated that Prozac was “totally unsuitable for the treatment of depression” suddenly reversed their position, leading Virapen to suspect that similar under-the-table activity must have occurred in Germany. David Healey, a doctor and director of the North Wales School of psychological medicine, likewise concluded that the German approval was due to “unorthodox lobbying methods exercised on independent members of the regulatory authorities.”

Not long after saving Eli Lilly, Virapen was fired. Virapen believes he was fired because he was a man of color in an otherwise Caucasian company (he was told this by his supervisor). Gøtzsche, a leading expert in pharmaceutical research fraud and meta-analyses, on the other hand, attributed this to typical organized crime tactics where Lilly sought to conceal their illegal activity by firing Virapen and his two assistants to bribe Forsman (because immediately afterwards, none of them were permitted to access their offices, and thus could not obtain any of the files that proved that this bribery occurred). Fortunately, as happened with Peter Rost, this unjust firing eventually motivated Virapen to become an invaluable whistleblower.

Heavily Abused Legal Drugs Adderall And Xanax Blocked By "Secret Limits"

Word on the street, and what I've witnessed with my very own lying eyes, information technology CHUDS and medical students alike have been crying like little bishes about the market failure to keep them supplied with their longtime legal drugs of dependency.

Bloomberg  |  Patients diagnosed with conditions like anxiety and sleep disorders have become caught in the crosshairs of America’s opioid crisis, as secret policies mandated by a national opioid settlement have turned filling legitimate prescriptions into a major headache.

In July, limits went into effect that flag and sometimes block pharmacies’ orders of controlled substances such as Adderall and Xanax when they exceed a certain threshold. The requirement stems from a 2021 settlement with the US’s three largest drug distributors — AmerisourceBergen Corp., Cardinal Health Inc. and McKesson Corp. But pharmacists said it curtails their ability to fill prescriptions for many different types of controlled substances — not just opioids.

Independent pharmacists said the rules force them come up with creative workarounds. Sometimes, they must send patients on frustrating journeys to find pharmacies that haven’t yet exceeded their caps in order to buy prescribed medicines.

“I understand the intention of this policy is to have control of controlled substances so they don’t get abused, but it’s not working,” said Richard Glotzer, an independent pharmacist in Millwood, New York. “There’s no reason I should be cut off from ordering these products to dispense to my legitimate patients that need it.”

It's unclear how the thresholds are impacting major chain pharmacies. CVS Health Corp. didn’t provide comment. A spokesperson for Walgreens Boots Alliance Inc. said its pharmacists “work to resolve any specific issues when possible, in coordination with our distributors.” 

The Drug Enforcement Administration regulates the manufacturing, distribution and sale of controlled substances, which can be dangerous when used improperly. Drugmakers and wholesalers were always supposed to keep an eye out for suspicious purchases and have long had systems to catch, report and halt these orders. The prescription opioid crisis, enabled by irresponsible drug company marketing and prescribing, led to a slew of lawsuits and tighter regulations on many parts of the health system, including monitoring of suspicious orders. One major settlement required the three largest distributors to set thresholds on orders of controlled substances starting last July.

The “suspicious order” terminology is a bit of a misnomer, pharmacists said. The orders themselves aren't suspicious, it's just that the pharmacy has exceeded its limit for a specific drug over a certain time period. Any order that puts the pharmacy over its limit can be stopped. As a result, patients with legitimate prescriptions get caught up in the dragnet.

Adding to the confusion, the limits themselves are secret. Drug wholesalers are barred by the settlement agreement from telling pharmacists what the thresholds are, how they’re determined or when the pharmacy is getting close to hitting them.

Wednesday, July 27, 2022

What "A Midwestern Doctor" Had To Say About Carlson's Broadside On The Medical Industrial Complex

I was in the doctors lounge this evening with two other docs.

Tucker came on. A 20 minute monologue about Big Pharma and the corruption Thereof. I simply could not believe what I was seeing.

He took 20 minutes and decimated opiates, SSRIs, COVID vaccines, Fauci, Birx, and the Biogen Alzheimer’s drug.

If you want an idea what I am barraged with daily even by the MSNBC crowd, look no further. I hear these same issues from patients all day long.

Tucker clearly has his problems but he also clearly has balls of steel. The execs at Fox with Big Pharma providing about half their revenue must clearly know the gig is up or they would not be allowing this on TV.

People are getting more enraged by the day. It is clips like this that make me certain the day of reckoning is coming soon.

Both the other docs in the lounge tonight, MSNBC watchers, agreed with me that there is not a thing in this monologue to be quibbled about.

Since the mid 2000s, right when Tom Cruise did his SSRI interview with Lauer – Tucker played part of it – the original Lilly Pfizer papers have been a standard the world over on how data is manipulated and how relative risk is abused. I have used them as examples of inappropriate data manipulation in classes for more than a decade. Most physicians with a questioning mind have known these drugs were a problem for years. And this is the first time I have ever heard this discussed on national TV in my life.

The Birx clip he features “I knew they were not going to be effective stopping the spread of the virus” was played today in a conference. Immediately followed by the Fauci, Walensky, Biden, and Maddow clips detailing that the vaxxes were a dead end, that you would never catch it, etc.

The ID fellow presenter, whose hospital and clinics are now being overrun with vaxxed and boosted COVID patients, after the above clips were played, in a dull monotone said, “One needs to ask WHAT exactly did these people know and more importantly WHEN did they know it?”

I could scarcely believe it. That kind of talk would have garnered intense guffaws and probably a trip to the chairman’s office just a few weeks ago. Now silent resignation.

The Fauci clip where he is asked about menstrual problems and states “we are going to study it….”. An epidemiologist commented “Seriously, you forced this upon millions of young women, and ONLY now we are going to study it? Did anyone have a hint this was a problem before the mandates? Knowing Pfizer’s history, my gut tells me they knew all too well.”

And yet another zinger from a retired ID professor – “If they knowingly released a non-sterilizing vaccine into an acute coronavirus pandemic and forced millions to take it, that may be the greatest act of medical malpractice in the history of this whole world.”

I am slowly seeing the return of “science” in my profession. Tough questions are being asked. Finally.

What do I feel tonight ….. the sun is shining, the scales are falling out of the eyes…and we are on the Road to Damascus. This may take quite a bit longer than you would expect, but I am fairly sure this is going to get really interesting

Tucker Carlson Wandered Off The Reservation And Put Big Pharma On Blast

nationalreview |  I approach science news cautiously. I was blessed to have, in my own college-level science class, a professor who enjoyed showing us examples of how labs and the scientific press conspired together to keep federal and private funding going on research they viewed as important.

But I’m sort of astonished that in the last month or so the medical field seems to be abandoning the regnant theories of depression and Alzheimer’s.

The first is the publication in Molecular Psychology of a paper reviewing and ultimately dismissing the serotonin theory of depression. The conclusion is stunning:

Our comprehensive review of the major strands of research on serotonin shows there is no convincing evidence that depression is associated with, or caused by, lower serotonin concentrations or activity. Most studies found no evidence of reduced serotonin activity in people with depression compared to people without, and methods to reduce serotonin availability using tryptophan depletion do not consistently lower mood in volunteers. High quality, well-powered genetic studies effectively exclude an association between genotypes related to the serotonin system and depression, including a proposed interaction with stress. Weak evidence from some studies of serotonin 5-HT1A receptors and levels of SERT points towards a possible association between increased serotonin activity and depression. However, these results are likely to be influenced by prior use of antidepressants and its effects on the serotonin system [30, 31]. The effects of tryptophan depletion in some cross-over studies involving people with depression may also be mediated by antidepressants, although these are not consistently found [63].

The chemical imbalance theory of depression is still put forward by professionals [17], and the serotonin theory, in particular, has formed the basis of a considerable research effort over the last few decades [14]. The general public widely believes that depression has been convincingly demonstrated to be the result of serotonin or other chemical abnormalities [15, 16], and this belief shapes how people understand their moods, leading to a pessimistic outlook on the outcome of depression and negative expectancies about the possibility of self-regulation of mood [64,65,66]. The idea that depression is the result of a chemical imbalance also influences decisions about whether to take or continue antidepressant medication and may discourage people from discontinuing treatment, potentially leading to lifelong dependence on these drugs [67, 68].

This follows on another study in PLOS ONE saying that treatment of depression with SSRIs does not improve quality of life.

An astonishing percentage of Americans have been prescribed SSRIs and are on them for long-term use. A survey in 2015–18 showed that 13 percent of Americans over age 18 took anti-depressant drugs in any given month. Millions of people, even very young people, are on SSRIs for depression.

 

Tuesday, December 14, 2021

Pfizer Bets On Bowel Disease

cnbc  | Pfizer said on Monday it would buy drug developer Arena Pharmaceuticals for $6.7 billion in cash, to add a promising treatment candidate that targets diseases affecting the stomach and intestine.

The $100 per share offer is double the last closing price of Arena’s shares, which surged 92% to $95.90 in premarket trading.

This is the latest deal Pfizer has struck this year to expand its treatment pipeline. The company last month acquired immuno-oncology company Trillium Therapeutics for about $2.22 billion to strengthen its arsenal of blood cancer therapies.

Arena is developing several treatments for gastroenterology, dermatology and cardiology. Its lead candidate, etrasimod, is being tested in a late-stage study in ulcerative colitis, as well as a mid-to-late stage study in Crohn’s disease, both types of inflammatory bowel diseases that cause ulcers in the digestive tract.

Pfizer is also developing a treatment for ulcerative colitis, a chronic and inflammatory bowel disease that affects 3 million people in the United States. The candidate is currently in a mid-stage study, which is expected to be completed by the end of next year.

“The proposed acquisition of Arena complements our capabilities and expertise in inflammation and immunology,” Pfizer executive Mike Gladstone said, adding the company plans to accelerate the clinical development of etrasimod.

″(Arena) was our top pick for 2022, so Christmas came a bit early... We would not expect another bidder to come in at this point,” said Wells Fargo analyst Derek Archila.

Archila said he expects positive data from the late-stage trial based on etrasimod’s performance in an earlier study. He estimated peak sales of $2.5 billion, assuming the treatment is approved and is found to be more effective than Bristol Myers Squibb’s currently-approved Zeposia.

The deal is expected to close in the first half of 2022.  Fist tap Big Don.

 

Friday, July 30, 2021

Why Is The FDA Attacking A Safe Effective Drug While Approving Hot Garbage?

 WSJ  |  The Food and Drug Administration claims to follow the science. So why is it attacking ivermectin, a medication it certified in 1996?

Earlier this year the agency put out a special warning that “you should not use ivermectin to treat or prevent COVID-19.” The FDA’s statement included words and phrases such as “serious harm,” “hospitalized,” “dangerous,” “very dangerous,” “seizures,” “coma and even death” and “highly toxic.” Any reader would think the FDA was warning against poison pills. In fact, the drug is FDA-approved as a safe and effective antiparasitic.

Ivermectin was developed and marketed by Merck & Co. while one of us (Mr. Hooper) worked there years ago. William C. Campbell and Satoshi Omura won the 2015 Nobel Prize for Physiology or Medicine for discovering and developing avermectin, which Mr. Campbell and associates modified to create ivermectin. 

Ivermectin is on the World Health Organization’s List of Essential Medicines. Merck has donated four billion doses to prevent river blindness and other diseases in Africa and other places where parasites are common. A group of 10 doctors who call themselves the Front Line Covid-19 Critical Care Alliance have said ivermectin is “one of the safest, low-cost, and widely available drugs in the history of medicine."

Ivermectin fights 21 viruses, including SARS-CoV-2, the cause of Covid-19. A single dose reduced the viral load of SARS-CoV-2 in cells by 99.8% in 24 hours and 99.98% in 48 hours, according to a June 2020 study published in the journal Antiviral Research.

Some 70 clinical trials are evaluating the use of ivermectin for treating Covid-19. The statistically significant evidence suggests that it is safe and works for both treating and preventing the disease. 

In 115 patients with Covid-19 who received a single dose of ivermectin, none developed pneumonia or cardiovascular complications, while 11.4% of those in the control group did. Fewer ivermectin patients developed respiratory distress (2.6% vs. 15.8%); fewer required oxygen (9.6% vs. 45.9%); fewer required antibiotics (15.7% vs. 60.2%); and fewer entered intensive care (0.1% vs. 8.3%). Ivermectin-treated patients tested negative faster, in four days instead of 15, and stayed in the hospital nine days on average instead of 15. Ivermectin patients experienced 13.3% mortality compared with 24.5% in the control group.

Moreover, the drug can help prevent Covid-19. One 2020 article in Biochemical and Biophysical Research Communications looked at what happened after the drug was given to family members of confirmed Covid-19 patients. Less than 8% became infected, versus 58.4% of those untreated.

 

Crackdowns On Pro-Palestinian Protest And Gaza Ethnic Cleansing

nakedcapitalism  |   Many US papers are giving front-page, above the fold treatment to university administrators going wild and calling in...