Brave New World

genomemag |  Imagine if doctors could correct a cataract, for instance, not by using a scalpel or laser to perform surgery, but rather by sending off miniature surgical tools to reach right in and fix the diseased gene that was responsible. It might surprise you to learn that scientists have already shown that this sort of thing is doable today — not in humans perhaps, but in much tinier and fuzzier mice in the lab. The procedure doesn’t work perfectly every time (which partly explains why no one has tried it in a person just yet), but when it does, the animals grow healthy and disease-free.

Scientists in China successfully cured 24 mice of their eye condition, which was produced by a single, mutant copy of one gene. That demonstration, reported in the scientific literature two years ago, was billed as the first to show that it’s possible to correct a genetic disease using a genome editing tool, which scientists call CRISPR-Cas9. Although in mice, the findings offered the first proof of principle that scientists and doctors might one day have sufficient skill and precision to edit single-gene disorders out of human genomes in much the same way.

Jinsong Li, one of the leaders of the study from the Chinese Academy of Sciences, said then that he believes it is “absolutely possible to use CRISPR to cure genetic disease in the near future.” As further evidence in support of Li’s conclusion, his paper came out alongside another by researchers in the Netherlands. They had used CRISPR to correct a gene that causes cystic fibrosis in adult stem cells derived from patients with the single-gene disorder.

pan-troglodytic deuterostems are not the endpoint of terrestrial evolution...,

theatlantic |  “Most educated people are aware that we are the outcome of nearly 4 billion years of Darwinian selection, but many tend to think that humans are somehow the culmination. Our sun, however, is less than halfway through its lifespan. It will not be humans who watch the sun’s demise, 6 billion years from now. Any creatures that then exist will be as different from us as we are from bacteria or amoebae.”

Among the several questions that jostled for the uppermost in my mind was this: Where is the fiction that can rise to the level of this stupefying reality? (Only one novelist, Julian Barnes, was sufficiently struck to include Rees’s passage in a book, but that was in his extended nonfiction memoir about death, Nothing to Be Frightened Of.) I quite soon came to realize that there was indeed a writer who could have heard or read those words with equanimity, even satisfaction, and that this was J. G. Ballard. For him, the possibility of any mutation or metamorphosis was to be taken for granted, if not indeed welcomed, as was the contingency that, dead sun or no dead sun, the terrestrial globe could very readily be imagined after we’re gone.

As one who has always disliked and distrusted so-called science fiction (the votaries of this cult disagreeing pointlessly about whether to refer to it as “SF” or “sci-fi”), I was prepared to be unimpressed even after Kingsley Amis praised Ballard as “the most imaginative of H. G. Wells’s successors.” The natural universe is far too complex and frightening and impressive on its own to require the puerile add-ons of space aliens and super-weapons: the interplanetary genre made even C. S. Lewis write more falsely than he normally did. Hearing me drone on in this vein about 30 years ago, Amis fils (who contributes a highly lucid introduction to this collection) wordlessly handed me The Drowned World, The Day of Forever, and, for a shift in pace and rhythm, Crash. Any one of these would have done the trick.

For all that, Ballard is arguably best-known to a wide audience because of his relatively “straight” novel, Empire of the Sun, and the resulting movie by Steven Spielberg. Some of his devotees were depressed by the literalness of the subject matter, which is a quasi-autobiographical account of being 13 years old and an inmate in a Japanese internment camp in Shanghai. It’s not possible to read that book, however, and fail to see the germinal effect that experience had on Ballard the man. To see a once-thriving city reduced to beggary and emptiness, to live one day at a time in point of food and medicine, to see an old European order brutally and efficiently overturned, to notice the utterly casual way in which human life can be snuffed out, and to see war machines wheeling and diving in the overcast sky: such an education! Don’t forget, either, that young Ballard was ecstatic at the news of the atomic obliteration of Hiroshima and Nagasaki, an emotion that makes him practically unique among postwar literati. Included in this collection is a very strong 1977 story, “The Dead Time,” a sort of curtain-raiser to Empire—Ballard’s own preferred name for his book—in which a young man released from Japanese captivity drives a truckload of cadavers across a stricken landscape and ends up feeding a scrap of his own torn flesh to a ravenous child.

Miracles of Life (a book with a slightly but not entirely misleading title) will soon enough discern that he built on his wartime Shanghai traumas in three related ways. As a teenager in post-war England he came across first Freud, and second the surrealists. He describes the two encounters as devastating in that they taught him what he already knew: religion is abject nonsense, human beings positively enjoy inflicting cruelty, and our species is prone to, and can coexist with, the most grotesque absurdities.

the transhuman jump will not be wearable or reversible...,

MIT |  Sturdy, wearable skins that transform hostile environments into friendlier ones are among the projects developed by Media Lab’s Mediated Matter group, headed by Associate Professor Neri Oxman PhD ’10.

Oxman, who earned her PhD in design computation, leads her Mediated Matter group through explorations of “Nature-inspired Design and Design-inspired Nature” using the tools of computational design, digital fabrication, materials science, and synthetic biology. Many projects rely on advanced 3D printing technologies.

Four artifacts that represent this intersection of 3D printing and synthetic biology were unveiled in Germany last fall in an exhibit of Wanderers: An Astrobiological Exploration, a collaboration with German designers Christoph Bader and Dominik Kolb.

The wearables, printed with Stratasys multi-material 3D printing technology, are designed to create the necessities of human life in space environments. Capillaries are expected to hold synthetically engineered microorganisms that could produce oxygen, light, food, and biofuels. Mediated Matter members led by Will Patrick and Sunanda Sharma are working on embedding living matter in the form of engineered bacteria inside the 3D structures.

“The future of wearables lies in designing augmented extensions to our own bodies, that will blur the boundary between the environment and ourselves,”

the open conspiracy

physorg |  With memories of World War I still very much on his mind, in 1935 HG Wells wrote The Open Conspiracy, which advanced a new approach to the perennial problems of human aggression, national conflict and political inertia.

This conspiracy, as envisaged by Wells, would be a revolutionary movement that reflected the new spirit of the times. "Never before" he stated in the opening paragraph, "have the conditions of life changed so swiftly and enormously as they have changed for mankind in the last fifty years."

Reading Wells today one might be forgiven for experiencing a sense of déjà vu. The changes he identified were, as are those we face today, largely the result of technological and scientific advances. The telegraph and increased communication had shrunk the world, just as the internet and digitisation has done so for us today. Yet while science forged ahead, politics and morality lagged behind. The Open Conspiracy filled the ideas vacuum left by the failures of parliamentary democracy and socialism.

Conspiracy in the open

Wells suggested that, unlike conspiracies of old, this would be a visible conspiracy grown from below rather than led from above by an elite. His conspirators were "the most sane and energetic people" – anti-militarist in orientation, actively subversive of government and traditional institutions that perpetuated the folly of tradition. They would be drawn from different disciplines: banking, finance, and the sciences – and dedicated to spreading scientific knowledge worldwide.

Wells described his conspirators as awakening from an illusion, made possible by the almost instant exchange of information and a new method of organisation that would map the activities of the whole community. At the centre of the Open Conspiracy was "the brain of the modern community, a great encyclopedic organisation, kept constantly up-to-date and giving approximate estimates and directions for all the material activities of mankind" – which rather sounds like a view of "big data" as seen from the 1930s

struggley looking the wrong way for the "infinitely great and "incorporeal" intelligence"...,

NYTimes |  Bloggers have noticed the religious symbols in the movie. There are those 12 apostles, and there’s a Noah’s ark. There is a fallen angel named Dr. Mann who turns satanic in an inverse Garden of Eden. The space project is named Lazarus. The heroine saves the world at age 33. There’s an infinitely greater and incorporeal intelligence offering merciful salvation.

But this isn’t an explicitly religious movie. “Interstellar” is important because amid all the culture wars between science and faith and science and the humanities, the movie illustrates the real symbiosis between these realms.

More, it shows how modern science is influencing culture. People have always bent their worldviews around the latest scientific advances. After Newton, philosophers conceived a clockwork universe. Individuals were seen as cogs in a big machine and could be slotted into vast bureaucratic systems.

But in the era of quantum entanglement and relativity, everything looks emergent and interconnected. Life looks less like a machine and more like endlessly complex patterns of waves and particles. Vast social engineering projects look less promising, because of the complexity, but webs of loving and meaningful relationships can do amazing good.

As the poet Christian Wiman wrote in his masterpiece, “My Bright Abyss,” “If quantum entanglement is true, if related particles react in similar or opposite ways even when separated by tremendous distances, then it is obvious that the whole world is alive and communicating in ways we do not fully understand. And we are part of that life, part of that communication. ...”

I suspect “Interstellar” will leave many people with a radical openness to strange truth just below and above the realm of the everyday. That makes it something of a cultural event.

just for fun...,

What is FPV?

FPV is short for First Person View. Using specially designed FPV cameras and head sets, it’s possible to virtually put yourself in the cockpit of almost any RC model. Instead of just watching, you can go along for the ride!

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what you need to experience FPV

PLATFORM

An FPV platform can be any RC vehicle you fly or drive. All you need is enough room to mount an FPV camera system.

TRANSMITTER

You will need an RC transmitter to fly or drive the platform that carries your FPV camera.

CAMERA

The camera captures the first person view from the platform and sends the images via video transmitter to your headset.

HEADSET

The headset lets you see what the camera on the platform sees. It’s like sitting in the cockpit or behind the wheel.

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Spektrum Innovation Makes FPV Simple

Used to be, if you wanted to experience FPV RC, you had to piece together a system yourself. Once you did, you then had to figure out how to make everything work together. Spektrum FPV systems eliminate all the guesswork by giving you everything you need in one box. Camera, head set, batteries, charger – it’s all there, all compatible and can be ready to go in minutes.

Every component in a Spektrum FPV system is available separately too. If you want to add FPV capabilities to another model, all you have to do is buy the same camera that came with your system. Spektrum FPV cameras also come pre-installed on select Bind-N-Fly® aircraft and will work with the head set from any Spektrum system.

It doesn’t matter if you’re new to the FPV scene or a seasoned pro. Spektrum technology will allow you to have more fun with fewer hassles than ever before. Fist tap Arnach.

misinterpretation of spurious effects mixed with mathematical errors or species singularity?

register |  NASA has tested an "impossible" electric space drive that uses no propellant, and found it works even when it is designed not to – sparking immediate skepticism of the technology.

The system is designed to use microwave energy reflected along a specially designed chamber to produce thrust. The idea first appeared as the Emdrive by British inventor Roger Shawyer in 2001, who designed a motor that he showed could produce power in this way. But critics scoffed, saying it would violate the laws of momentum.

The EmDrive, we're told, generates thrust by using the properties of radiation pressure. An electromagnetic wave has a small amount of momentum which, when it hits a reflector, can translate that into thrust, Shawyer found, and this apparently can be used to power flight in the near-frictionless environment of space.

The idea languished, but a decade later the Chinese Academy of Sciences published a paper saying that it too had built an EmDrive-like which, when fed 2.5kW, generated 720mN of thrust – a tiny amount, admittedly.

But this got the attention of NASA boffins, who in 2013 commissioned a series of tests on the drive and got some surprising results.

In an eight-day trial held by US engineering firm Cannae, researchers found that by using a reflective chamber similar to that proposed by Shawyer, the team was able to use solely electrical input to generate 30 to 50 micro-Newtons of thrust. Again, incredibly tiny, enough to move a grain of sand, but apparently significant.

"Test results indicate that the RF resonant cavity thruster design, which is unique as an electric propulsion device, is producing a force that is not attributable to any classical electromagnetic phenomenon and therefore is potentially demonstrating an interaction with the quantum vacuum virtual plasma," the team reported in a paper to the 50th Joint Propulsion Conference in Cleveland, Ohio, at the end of July.

the first religion devoted to evolution

io9 |  Huxley's genteel progressivism seems at odds with the popular image of eugenics. While many eugenics enthusiasts were racists on the the far right of the political spectrum, Huxley was part of a "reform eugenics" movement which was popular among British socialists like H.G. Wells and George Bernard Shaw.

For these reform eugenicists, social equality was a necessary prerequisite for identifying genetic inequality. And that's where Huxley's notion of evolutionary humanism came in. He wrote that evolutionary humanism elevated this mission to a religious quest:

The lineaments of the new religion ... will arise to serve the needs of the coming era... Instead of worshipping supernatural rulers, it will sanctify the higher manifestations of human nature, in art and love, in intellectual comprehension and aspiring adoration, and will emphasize the fuller realization of life's possibilities as a sacred trust.

The key to achieving these aims was to educate the public, enabling them to think in evolutionary terms. In Huxley's mind, a widespread acceptance of an evolutionary worldview represented the process of evolution "reaching self-consciousness [and] becoming aware of itself."

In order to make sense of evolutionary humanism as a religion, however, you also have to understand Huxley's somewhat idiosyncratic approach to evolution itself. Biologists generally define evolution in terms of allele frequencies, mutations, selection, and drift. For Huxley, this was just a small part of a much broader picture. He radically expanded the concept so that all directional change was evolution. In Huxley's view, "the whole sum of reality is, in a perfectly legitimate sense, evolution." It was also, for Huxley, inherently progressive. Evolution necessarily moved towards "higher," or more complex, states of being.

Huxley broke this universal process of evolution down into three stages: cosmic, biological, and psychosocial. Cosmic evolution was the slow development of complex structures through physical and chemical processes; the formation of stars and production of heavier elements, the gradual formation of planets, and the emergence of simple organic chemistry. Biological evolution was more or less what we think of by the word "evolution" today, although Huxley believed that most biological progress ended roughly five million years ago, and that only minor improvements, especially among early hominids, had occurred since. Progress was the whole point of evolution, but had only just gotten started in the last, psychosocial stage.

the secret life of julian assange

Video - Elric

CNN | In a 2007 blog post on IQ.org, he wrote:

"The whole universe or the structure that perceives it is a worthy opponent, but try as I may I can not escape the sound of suffering. Perhaps as an old man I will take great comfort in pottering around in a lab and gently talking to students in the summer evening and will accept suffering with insouciance. But not now; men in their prime, if they have convictions are tasked to act on them."

IQ.org is believed to be a blog created by Assange and is registered under the name "JA" by the same U.S. domain company as WikiLeaks. Its Australian postal address is also the same as a submissions address for WikiLeaks.

Among myriad topics addressed in the blog, Assange discusses mathematics versus philosophy, the death of author Kurt Vonnegut, censorship in Iran and the corporation as a nation state.

Driven by the conviction of an activist and the curiosity of a journalist, Assange founded WikiLeaks in 2006. He slept little and sometimes forgot to eat. He hired staff and enlisted the help of volunteers.

Always, he protected his sources, never discussing where information came from.

"People should understand that WikiLeaks has proven to be arguably the most trustworthy new source that exists, because we publish primary source material and analysis based on that primary source material," Assange told CNN. "Other organizations, with some exceptions, simply are not trustworthy."

The Web site skyrocketed to notoriety in July when it published 90,000 secret documents about the war in Afghanistan. It was considered the largest intelligence leak in U.S. history.

WikiLeaks followed in October with classified documents about the Iraq war. And then this week, it began posting 250,000 cables revealing a trove of secret diplomatic information.

Some praised WikiLeaks as a beacon of free speech. But others, including outraged Pentagon and White House officials, consider it irresponsible and want WikiLeaks silenced for what they call irreparable damage to global security.

Assange, the elusive public face of WikiLeaks, catapulted to celebrity status.

The image of the lean, lanky, leather jacket-clad figure with the pale skin and mop of white hair was splashed on television screens and websites. Everyone wanted to know how the editor in chief of WikiLeaks had pulled it off.

Time magazine has nominated him for its Person of the Year, calling him a "new kind of whistle-blower ... for the digital age."

there it is BAMM!!!!!

The Journal Science Interviews J. Craig Venter About the first "Synthetic Cell"

artificial life breakthrough

BBCNews | Scientists in the US have succeeded in developing the first synthetic living cell.

The researchers constructed a bacterium's "genetic software" and transplanted it into a host cell.

The resulting microbe then looked and behaved like the species "dictated" by the synthetic DNA.

The advance, published in Science, has been hailed as a scientific landmark, but critics say there are dangers posed by synthetic organisms.

The researchers hope eventually to design bacterial cells that will produce medicines and fuels and even absorb greenhouse gases.

Craig Venter defends the synthetic living cell

The team was led by Dr Craig Venter of the J Craig Venter Institute (JCVI) in Maryland and California.

He and his colleagues had previously made a synthetic bacterial genome, and transplanted the genome of one bacterium into another.

Now, the scientists have put both methods together, to create what they call a "synthetic cell", although only its genome is truly synthetic.

Dr Venter likened the advance to making new software for the cell. Fist tap Nana.