Showing posts with label Controlavirus. Show all posts
Showing posts with label Controlavirus. Show all posts

Sunday, December 19, 2021

Making Up Shit: When mRNA Gets Broken Through - They Now Call It "Super Immunity"

Forbes |  A breakthrough Covid-19 coronavirus infection may not be “super” to have. But can it actually give you what’s being called “super immunity” on social media? In other words, can a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after being fully vaccinated against Covid-19 bring you even greater protection? Well, a research letter just published in JAMA offered a small window into this “super” possibility.

If you search for “super immunity” on social media you will find plenty of posts such as the following:

You’ll also find mention of the study described by the JAMA research letter. For example, Monica Gandhi MD, MPH, a Professor of Medicine at the University of California, San Francisco (UCSF) and HIV researcher, used the terms “hybrid immunity” and “super immunity” when tweeting about the study:

She called it “hybrid immunity,” because the potentially boosted immune protection may come from a combination of vaccination and then subsequent infection. Gandhi also referenced another study described in a pre-print uploaded to MedRxiv that drew blood from 35 vaccinated individuals in Provincetown, Massachusetts, 14 of whom had had subsequent breakthrough infections. This pre-print described how the blood of the breakthrough infection group had 28-fold higher levels of binding antibodies and 34-fold higher levels of neutralizing antibodies against the SARS-CoV-2 Delta variant than the blood of the rest. This study also looked at another measure of immune protection, how the individual’s T cells responded to the virus, a measure that I described previously for Forbes. Those with breakthrough infections had a 4.4-fold higher Spike protein-specific CD8+ T cell responses against the Delta variant than the rest of the study participants. Take all the results from this pre-print with a Ugg boot full of salt though. Anyone with a laptop, an Internet connection, and opposable thumbs can upload a pre-print. It is not the same as a peer-reviewed study published in a reputable scientific journal.

Friday, October 22, 2021

Throw An Aspirin In With Your Vitamins D, C, Zinc, And Ivermectin

jpost  | Over-the-counter aspirin could protect the lungs of COVID-19 patients and minimize the need for mechanical ventilation, according to new research at the George Washington University.

The team investigated more than 400 COVID patients from hospitals across the United States who take aspirin unrelated to their COVID disease, and found that the treatment reduced the risk of several parameters by almost half: reaching mechanical ventilation by 44%, ICU admissions by 43%, and overall in-hospital mortality by 47%.
 
“As we learned about the connection between blood clots and COVID-19, we knew that aspirin – used to prevent stroke and heart attack – could be important for COVID-19 patients,” said Dr. Jonathan Chow of the study team. “Our research found an association between low-dose aspirin and decreased severity of COVID-19 and death.”
 
Low-dose aspirin is a common treatment for anyone suffering from blood clotting issues or in danger of stroke, including most people who had a heart attack or a myocardial infarction. Although affecting the respiratory system, the coronavirus has been associated with small blood vessel clotting, causing tiny blockages in the pulmonary blood system, leading to ARDS - acute respiratory distress syndrome.
 
Israeli researchers reached similar results in a preliminary trial at the Barzilai Medical Center in March. In addition to its effect on blood clots, they found that aspirin carried immunological benefits and that the group taking it was 29% less likely to become infected with the virus in the first place.
“Aspirin is low cost, easily accessible and millions are already using it to treat their health conditions,” said Chow. “Finding this association is a huge win for those looking to reduce risk from some of the most devastating effects of COVID-19.”

Tuesday, October 05, 2021

NIH/NIAID Blatantly Lying - Pretending It Just Now Figured Out Aerosol Transmission

NYTimes | Newer variants of the coronavirus like Alpha and Delta are highly contagious, infecting far more people than the original virus. Two new studies offer a possible explanation: The virus is evolving to spread more efficiently through air.

The realization that the coronavirus is airborne indoors transformed efforts to contain the pandemic last year, igniting fiery debates about masks, social distancing and ventilation in public spaces.

Most researchers now agree that the coronavirus is mostly transmitted through large droplets that quickly sink to the floor and through much smaller ones, called aerosols, that can float over longer distances indoors and settle directly into the lungs, where the virus is most harmful.

The new studies don’t fundamentally change that view. But the findings signal the need for better masks in some situations, and indicate that the virus is changing in ways that make it more formidable.

“This is not an Armageddon scenario,” said Vincent Munster, a virologist at the National Institute of Allergy and Infectious Diseases, who led one of the new studies. “It is like a modification of the virus to more efficient transmission, which is something I think we all kind of expected, and we now see it happening in real time.”

Dr. Munster’s team showed that small aerosols traveled much longer distances than larger droplets and the Alpha variant was much more likely to cause new infections via aerosol transmission. The second study found that people infected with Alpha exhaled about 43 times more virus into tiny aerosols than those infected with older variants.

The studies compared the Alpha variant with the original virus or other older variants. But the results may also explain why the Delta variant is so contagious — and why it displaced all other versions of the virus.

“It really indicates that the virus is evolving to become more efficient at transmitting through the air,” said Linsey Marr, an expert in airborne viruses at Virginia Tech who was not involved in either study. “I wouldn’t be surprised if, with Delta, that factor were even higher.”

Sunday, September 05, 2021

Why Hasn't This Research Been Converted Into A Prophylactic Nasal Spray?

yale |  Exposure to the rhinovirus, the most frequent cause of the common cold, can protect against infection by the virus which causes COVID-19, Yale researchers have found.

In a new study, the researchers found that the common respiratory virus jump-starts the activity of interferon-stimulated genes, early-response molecules in the immune system which can halt replication of the SARS-CoV-2 virus within airway tissues infected with the cold. 

Triggering these defenses early in the course of COVID-19 infection holds promise to prevent or treat the infection, said Ellen Foxman, assistant professor of laboratory medicine and immunobiology at the Yale School of Medicine and senior author of the study. One way to do this is by treating patients with interferons, an immune system protein which is also available as a drug.

But it all depends upon the timing,” Foxman said.

The results were published June 15 in the Journal of Experimental Medicine.

Previous work showed that at the later stages of COVID-19, high interferon levels correlate with worse disease and may fuel overactive immune responses. But recent genetic studies show that interferon-stimulated genes can also be protective in cases of COVID-19 infection.

Foxman’s lab wanted to study this defense system early in the course of COVID-19 infection.

Since earlier studies by Foxman’s lab showed that common cold viruses may protect against influenza, they decided to study whether rhinoviruses would have the same beneficial impact against the COVID-19 virus. For the study, her team infected lab-grown human airway tissue with SARS-CoV-2 and found that for the first three days, viral load in the tissue doubled about every six hours. However, replication of the COVID-19 virus was completely stopped in tissue which had been exposed to rhinovirus. If antiviral defenses were blocked, the SARS-CoV-2 could replicate in airway tissue previously exposed to rhinovirus.

The same defenses slowed down SARS-CoV-2 infection even without rhinovirus, but only if the infectious dose was low, suggesting that the viral load at the time of exposure makes a difference in whether the body can effectively fight the infection.

Friday, September 03, 2021

Back In The Day, There Was A Yahoo Group About Viral Parasols And Their Effect On The Weather..,

NYTimes |  Since the pandemic began, Covid has often followed a regular — if mysterious — cycle. In one country after another, the number of new cases has often surged for roughly two months before starting to fall. The Delta variant, despite its intense contagiousness, has followed this pattern.

After Delta took hold last winter in India, caseloads there rose sharply for slightly more than two months before plummeting at a nearly identical rate. In Britain, caseloads rose for almost exactly two months before peaking in July. In Indonesia, Thailand, France, Spain and several other countries, the Delta surge also lasted somewhere between 1.5 and 2.5 months.

And in the U.S. states where Delta first caused caseloads to rise, the cycle already appears to be on its downside. Case numbers in Arkansas, Florida, Louisiana, Mississippi and Missouri peaked in early or mid-August and have since been falling

We have asked experts about these two-month cycles, and they acknowledged that they could not explain it. “We still are really in the cave ages in terms of understanding how viruses emerge, how they spread, how they start and stop, why they do what they do,” Michael Osterholm, an epidemiologist at the University of Minnesota, said.

But two broad categories of explanation seem plausible, the experts say.

One involves the virus itself. Rather than spreading until it has reached every last person, perhaps it spreads in waves that happen to follow a similar timeline. How so? Some people may be especially susceptible to a variant like Delta, and once many of them have been exposed to it, the virus starts to recede — until a new variant causes the cycle to begin again (or until a population approaches herd immunity).

The second plausible explanation involves human behavior. People don’t circulate randomly through the world. They live in social clusters, Jennifer Nuzzo, a Johns Hopkins epidemiologist, points out. Perhaps the virus needs about two months to circulate through a typically sized cluster, infecting the most susceptible — and a new wave starts when people break out of their clusters, such as during a holiday. Alternately, people may follow cycles of taking more and then fewer Covid precautions, depending on their level of concern.

Whatever the reasons, the two-month cycle predated Delta. It has repeated itself several times in the U.S., including both last year and early this year, with the Alpha variant, which was centered in the upper Midwest

 

Thursday, August 26, 2021

Now Is The Time To Use Ivermectin

yomiuri shimbun  |  During the Tokyo Olympics, Delta strains originating in India raged and the number of infected people continues to increase. Why is Japan not trying to use ivermectin, which has few reports of side effects and has been reported to be effective in clinical trials in other countries? On August 5, we had an urgent interview with Mr. Ozaki, chairman of the Tokyo Metropolitan Medical Association, who had been proposing effective uses of ivermectin from early on.

The peak of infection spread that is not yet visible

――It seems that the explosive spread of infection, which is also called the 5th wave, is still rising. The number of people waiting at home and receiving medical treatment is increasing rapidly. How is the Tokyo Metropolitan Medical Association responding?

 "When the number of people waiting at home and receiving medical treatment increased sharply in the third wave of January, this was no good, and the Tokyo Metropolitan Medical Association and the Tokyo Metropolitan Medical Association worked together to build a system with the goal of 24-hour support. We have been able to handle up to 37 of the 47 district medical associations. However, the current situation where more than 1000 home caregivers are piled up every day is beyond the limit. , Vaccination, medical examination, home visit, etc. are not available. Now, the health center is coordinating hospitalization. There is also a hospitalization coordinating center in Tokyo, but there is a system that can quickly accept and treat suddenly changed corona patients. I haven't gotten to the point of being established. "

Many clinical trial results are "effective for prevention and treatment"

--If you read the papers on clinical trials of ivermectin that have been published around the world, there are many examples that are effective for both prevention and treatment.

 "I am aware that there are many papers that ivermectin is effective in the prevention and treatment of corona, mainly in Central and South America and Asia. There is no effective therapeutic drug, although it is necessary to deal with patients who develop it one after another. The vaccine is not in time. At such an imminent time, there is a paper that ivermectin is effective for corona, so it is a natural response for clinicians to try using it. Doctor-led clinical practice That's why many test papers came out. "

--Usually, pharmaceutical companies conduct large-scale clinical trials to see the effects, but ivermectin has been selected by the World Health Organization (WHO) as a silver bullet for tropical diseases such as onchocerciasis (river blindness) and lymphatic filariasis. It is a drug approved by countries around the world more than 20 years ago. If it is effective for the new corona, it is not applicable, but it is unavoidable that we decided to use it in a pandemic.

 "That's right. The medical field of a pandemic is a battlefield. It's the same as a field hospital. Patients are brought in and their condition deteriorates one after another and they die. So I can understand the feelings of the doctor who clings to this and administers it. "

 "The other day, a research group at the All India Institute of Medical Sciences / AIIMS, which sets guidelines for the treatment of corona infections in India, has published a paper investigating the preventive effects of ivermectin. According to the report, about 3,900 medical workers (staff and students) were given 0.3 mg / kg of ivermectin twice at 3-day intervals, only once, and then. As a result of conducting clinical trials divided into three groups of those who did not, it is said that those who received ivermectin twice reduced the new corona infection by 83%. It was the first time in the world to publish a paper. It's a class research group, so it's very reliable. "

 

How Did India Abruptly Stop Being Ground Zero Of The Coronapocalypse?

Why is no one interested in India anymore with respect to the Coronapocalypse? Can a couple of weeks really make such an incredible difference? The contrast from July to August is really stark. When the news was bad you couldn't turn to a news outlet that wasn’t reporting about the continuous megadeath in India. Now, not nary a peep...,

Speaks volumes how reporting is being used to gin up fear beyond what is suggested by the "science". Since the Indian coronapocalypse has fallen off the official narrative radar, I went over to the Times of India to have a look. They have a “Covid Tracker” that says that there were 382 deaths on Aug 22 related to Covid-21. New Cases are down 30%, to 25,320.

Now if you do the math, India has ~1.4 billion people. These Covid-21 figures don't even amount to rounding errors. Given that Ivermectin is in the Indian Covid-21 treatment protocol - AS ACROSS PARTS OF THE AFRICAN CONTINENT - maybe the 1.4 billion horse-paste eating Indian animals are getting some type of prophylactic and curative benefit from their veterinary medicine?

This site is another good place to watch and keep track of the numbers. I follow Uttar Pradesh. Their deaths from Covid today (with a population above 500 million) were …. zero, niente, rien, zed. aka none. 

Of course there were likely a few, but I challenge anyone to prove that India’s numbers are as through the roof as the U.S. There are no funeral pyres burning, floating bodies in the Ganges, hospitals overflowing, shortages of O2 canisters, etc.

Ivermectin use? High.

Vaccination rate? Still in the single digits.

Florida? Under reporting did you say? 

Texas? Pediatric wards packed. 

Oregon? Sending children to hospital in Seattle due to lack of beds?

India? Passez moi l’ ivermectin stp dégolas!

The Human Use Of Ivermectin

nih.gov |  Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis.)

Today, ivermectin is being increasingly used worldwide to combat other diseases in humans, such as Strongyloidiasis (which infects some 35 million each year), scabies (which causes 300 million cases annually), Pediculosis, Gnathostomiasis and Myiasis—and new and promising properties and uses for ivermectin and other avermectin derivatives are continuing to be found.) These include activity against another neglected tropical disease, Leishmaniasis.,) Of perhaps even greater significance is the evidence that the use of ivermectin has both direct and indirect beneficial impact on improving community health. Studies of long-term treatment with ivermectin to control Onchocerciasis have shown that use of the drug is additionally associated with significant reduction in the prevalence of infection with any soil-transmitted helminth parasites (including Ascaris, Trichuris and hookworm), most or all of which are deemed to be major causes of the morbidity arising from poor childhood nutrition and growth.) It is also known that the prevalence of head lice is markedly reduced in children taking ivermectin tablets) and that scabies is markedly reduced in populations taking the drug regularly.) Above all, ivermectin has proved to be a medicine of choice for the world’s rural poor. In many underprivileged communities throughout the tropics, intestinal worms and parasitic skin diseases are extremely common and associated with significant morbidity. They usually co-exist, with many individuals infected with both ecto- and endoparasites.,) Mass treatment of poly-parasitized populations is deemed to be the best means of control and ivermectin is the ideal drug for such interventions. A recent study in Brazil, using locally produced ivermectin, looked at the impact on internal helminthes and parasitic skin diseases. The researchers concluded that “mass treatment with ivermectin was an effective and safe means of reducing the prevalence of most of the parasitic diseases prevalent in a poor community in North-East Brazil. The effects of treatment lasted for a prolonged period of time”. This study also represented the first published report of human medical intervention using ivermectin that had not been produced by the hitherto traditional manufacturer, Merck & Co. Inc., the patent on the drug expiring in 1997.)

In reality, the renewed interest in fighting tropical diseases, including the involvement of the pharmaceutical industry, which has become increasingly evident over the past three decades, and which has saved lives and improved the welfare of billions of people, notably the poor and disadvantaged in the topics, can be traced back to the 1987 introduction of ivermectin for use in humans. According to a recent report, International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) data show that the global pharmaceutical industry provided over $9.2 billion in health interventions (medicines and equipment) between 2000–2007 alone, benefitting 1.75 billion people worldwide.) The hitherto unprecedented donation of ivermectin in 1987 can rightly be seen to be the origin of this philanthropic outpouring.

Since the inception of the Mectizan Donation Programme, Merck has donated well over 2.5 billion Mectizan® tablets for Onchocerciasis treatment, with in excess of 700 million treatments authorised. Currently, some 80–90 million people are taking the drug annually through MDA in Africa, Latin America and Yemen. A further 300 million total treatments have been approved for lymphatic filariasis, with around 90 million treatments being administered annually (Fig. (Fig.8 ).8 ). At present 33 countries are receiving ivermectin for Onchocerciasis and 15 for Lymphatic filariasis. Consequently, around US$4 billion worth of ivermectin tablets have been donated to date. In 2010, Ecuador became the second country in the Americas to halt River Blindness transmission. It is hoped that transmission of the disease in the Western hemisphere will be stopped by 2012—a goal that will have been achieved thanks to twice-yearly MDA with ivermectin. Lymphatic filariasis is targeted for global elimination by 2020, and, if all goes well, Onchocerciasis may well be eliminated from Africa soon thereafter.

The Story Of Ivermectin

isglobal  |   What do penicillin, aspirin and ivermectin have in common? Apart from the fact that they rhyme, all three belong to a very select group of drugs that can claim to have had the “greatest beneficial impact on the health and well-being of humanity”.

They have at least two other things in common: all three were found in nature and all three led to a Nobel prize. Aspirin is derived from salicin, a compound found in a variety of plants such as willow trees. Its use was first mentioned by Hippocrates in 400 BC, but was isolated only in 1829 as salicylic acid and synthesised some years later as acetylsalicylic acid. The discovery of the mechanisms underlying aspirin’s effects gave Sir John Vane the Nobel prize in 1982. Penicillin was isolated from mold that grew by accident on a Petri dish in Alexander Fleming’s laboratory. Its discovery changed the course of medicine, and earned Fleming the Nobel prize in 1945, which he shared with Howard Florey and Ernst Chain.

And this brings us to ivermectin- not likely a drug you will have in your first-aid kit, like aspirin or penicillin, but definitely a drug that has improved the lives of millions of people since its discovery in 1975.

The story of how ivermectin was discovered is quite incredible. In the late 1960s, Satoshi Ōmura, a microbiologist at Tokyo’s Kitasako Institute, was hunting for new antibacterial compounds and started to collect thousands of soil samples from around Japan. He cultured bacteria from the samples, screened the cultures for medicinal potential, and sent them 10,000 km away to Merck Research Labs in New Jersey, where his collaborator, William Campbell, tested their effect against parasitic worms affecting livestock and other animals. One culture, derived from a soil sample collected near a golf course southwest of Tokyo, was remarkably effective against worms. The bacterium in the culture was a new species, and was baptised Streptomyces avermictilis. The active component, named avermectin, was chemically modified to increase its activity and its safety. The new compound, called ivermectin, was commercialised as a product for animal health in 1981 and soon became a top-selling veterinary drug in the world. Remarkably, despite decades of searching, S. avermictilis remains the only source of avermectin ever found.

Thursday, July 29, 2021

The Natural Immune Response To SARS-Cov2 Is Forever...,

Nature |  Generating immunity against the SARS-CoV-2 coronavirus is of the utmost importance for bringing the COVID-19 pandemic under control, protecting vulnerable individuals from severe disease and limiting viral spread. Our immune systems protect against SARS-CoV-2 either through a sophisticated reaction to infection or in response to vaccination. A key question is, how long does this immunity last? Writing in Nature, Turner et al.1 and Wang et al.2 characterize human immune responses to SARS-CoV-2 infection over the course of a year.

There is ongoing discussion about which aspects of the immune response to SARS-CoV-2 provide hallmarks of immunity (in other words, correlates of immunological protection). However, there is probably a consensus that the two main pillars of an antiviral response are immune cells called cytotoxic T cells, which can selectively eliminate infected cells, and neutralizing antibodies, a type of antibody that prevents a virus from infecting cells, and that is secreted by immune cells called plasma cells. A third pillar of an effective immune response would be the generation of T helper cells, which are specific for the virus and coordinate the immune reaction. Crucially, these latter cells are required for generating immunological memory — in particular, for orchestrating the emergence of long-lived plasma cells3, which continue to secrete antiviral antibodies even when the virus has gone.

Immunological memory is not a long-lasting version of the immediate immune reaction to a particular virus; rather, it is a distinct aspect of the immune system. In the memory phase of an immune response, B and T cells that are specific for a virus are maintained in a state of dormancy, but are poised to spring into action if they encounter the virus again or a vaccine that represents it. These memory B and T cells arise from cells activated in the initial immune reaction. The cells undergo changes to their chromosomal DNA, termed epigenetic modifications, that enable them to react rapidly to subsequent signs of infection and drive responses geared to eliminating the disease-causing agent4. B cells have a dual role in immunity: they produce antibodies that can recognize viral proteins, and they can present parts of these proteins to specific T cells or develop into plasma cells that secrete antibodies in large quantities. About 25 years ago5, it became evident that plasma cells can become memory cells themselves, and can secrete antibodies for long-lasting protection. Memory plasma cells can be maintained for decades, if not a lifetime, in the bone marrow6.

The presence in the bone marrow of long-lived, antibody-secreting memory plasma cells is probably the best available predictor of long-lasting immunity. For SARS-CoV-2, most studies so far have analysed the acute phase of the immune response, which spans a few months after infection, and have monitored T cells, B cells and secreted antibodies7. It has remained unclear whether the response generates long-lived memory plasma cells that secrete antibodies against SARS-CoV-2.

Turner and colleagues took up the challenge of identifying antibody-secreting memory plasma cells in the bone marrow of people who have recovered from COVID-19 (called convalescent individuals). Memory plasma cells are rare, and those specific for a particular disease-causing agent will obviously be extremely scarce. Nevertheless, Turner and colleagues detected memory plasma cells that secreted antibodies specific for the spike protein encoded by SARS-CoV-2 in 15 of 19 individuals, approximately 7 months after infection. Notably, when the authors obtained samples 4 months later (11 months after SARS-CoV-2 infection), the number of such plasma cells had remained stable in all but one of the individuals analysed. Those plasma cells did not proliferate, which classifies them as bona fide memory plasma cells. Their numbers equalled those of memory plasma cells found in the individuals after vaccination against tetanus or diphtheria, and which provide long-term immunity to those diseases.

When Turner et al. tracked the concentrations of antibodies against SARS-CoV-2 in the individuals’ blood serum for up to one year, they observed a biphasic pattern (Fig. 1). In the acute immune response around the time of initial infection, antibody concentrations were high. They subsequently declined, as expected, because most of the plasma cells of an acute immune response are short-lived. After a few months, the antibody concentrations levelled off and remained more or less constant at roughly 10–20% of the maximum concentration observed. This is consistent with the expectation that 10–20% of the plasma cells in an acute immune reaction become memory plasma cells5, and is a clear indication of a shift from antibody production by short-lived plasma cells to antibody production by memory plasma cells. This is not unexpected, given that immune memory to many viruses and vaccines is stable over decades, if not for a lifetime8.

 

 

 

Saturday, June 05, 2021

The Fight To Uncover The Origin Of Covid-19

vanityfair |  Since December 1, 2019, the SARS-CoV-2 virus that causes COVID-19 has infected more than 170 million people around the world and killed more than 3.5 million. To this day, we don’t know how or why this novel coronavirus suddenly appeared in the human population. Answering that question is more than an academic pursuit: Without knowing where it came from, we can’t be sure we’re taking the right steps to prevent a recurrence.

And yet, in the wake of the Lancet statement and under the cloud of Donald Trump’s toxic racism, which contributed to an alarming wave of anti-Asian violence in the U.S., one possible answer to this all-important question remained largely off-limits until the spring of 2021.

Behind closed doors, however, national security and public health experts and officials across a range of departments in the executive branch were locked in high-stakes battles over what could and couldn’t be investigated and made public.

A months long Vanity Fair investigation, interviews with more than 40 people, and a review of hundreds of pages of U.S. government documents, including internal memos, meeting minutes, and email correspondence, found that conflicts of interest, stemming in part from large government grants supporting controversial virology research, hampered the U.S. investigation into COVID-19’s origin at every step. In one State Department meeting, officials seeking to demand transparency from the Chinese government say they were explicitly told by colleagues not to explore the Wuhan Institute of Virology’s gain-of-function research, because it would bring unwelcome attention to U.S. government funding of it.

In an internal memo obtained by Vanity Fair, Thomas DiNanno, former acting assistant secretary of the State Department’s Bureau of Arms Control, Verification, and Compliance, wrote that staff from two bureaus, his own and the Bureau of International Security and Nonproliferation, “warned” leaders within his bureau “not to pursue an investigation into the origin of COVID-19” because it would “‘open a can of worms’ if it continued.”

There are reasons to doubt the lab-leak hypothesis. There is a long, well-documented history of natural spillovers leading to outbreaks, even when the initial and intermediate host animals have remained a mystery for months and years, and some expert virologists say the supposed oddities of the SARS-CoV-2 sequence have been found in nature.

But for most of the past year, the lab-leak scenario was treated not simply as unlikely or even inaccurate but as morally out-of-bounds. In late March, former Centers for Disease Control director Robert Redfield received death threats from fellow scientists after telling CNN that he believed COVID-19 had originated in a lab. “I was threatened and ostracized because I proposed another hypothesis,” Redfield told Vanity Fair. “I expected it from politicians. I didn’t expect it from science.”

With President Trump out of office, it should be possible to reject his xenophobic agenda and still ask why, in all places in the world, did the outbreak begin in the city with a laboratory housing one of the world’s most extensive collection of bat viruses, doing some of the most aggressive research?

Saturday, May 29, 2021

David Asher "To Say Covid Came Out Of A Zoonotic Situation, It's Ridiculous"

Foxnews |  A government probe last year into the origins of the coronavirus found practically no evidence COVID-19 originated from nature, former State Department official David Asher told Fox News on Thursday.

"We were finding that despite the claims of our scientific community, including the National Institutes of Health and Dr. Fauci's NIAID organization, there was almost no evidence that supported a natural, zoonotic evolution or source of COVID-19," he told "America Reports."

The probe was led out of the State Department’s arms control and verification (AVC) bureau and initially launched at the request of former Trump Secretary of State Mike Pompeo before ending this year.

Asher, the lead contractor on the subject, said the team investigated the two chief hypotheses for the virus' origins, the other being the lab-leak theory that has gained credence after widespread media dismissal over the past year.

"The data disproportionately stacked up as we investigated that it was coming out of a lab or some supernatural source," he said.

Asher has a history of investigative work tracking money for the AQ Khan network, North Korea's nuclear program, and top Al Qaeda leaders, but has fallen under scrutiny from former State Department officials.

Asher was critical Thursday of former Assistant Secretary of State Chris Ford, who expressed reservations about the investigation's findings and cautioned against the lab theory. Ford told Fox News that the AVC probe had been kept secret from him and bypassed department and intelligence community biological experts, although adding the lab origin theory was "very possible."

The Wuhan Institute of Virology has become a central focus of investigators looking into the virus' origins, in part due to its known research on bat coronaviruses.

"That was the epicenter of synthetic biology in the People's Republic of China, and they were up to some very hairy stuff with synthetic biology and so-called gain-of-function techniques," Asher said, later saying the odds of natural origin were extremely long.

Thursday, May 27, 2021

Covid Lab Origin Went From "Awful Racist Theory" To Highly Plausible In the Mainstream Media Overnight

China Big Mad Its Biden Investments Not Shielding It From Scrutiny...,

china-embassy | Lately, some people have played the old trick of political hype on the origin tracing of COVID-19 in the world. Smear campaign and blame shifting are making a comeback, and the conspiracy theory of "lab leak" is resurfacing.

Since the outbreak of COVID-19 last year, some political forces have been fixated on political manipulation and blame game, while ignoring their people's urgent need to fight the pandemic and the international demand for cooperation on this front, which has caused a tragic loss of many lives. The lesson from last year is still fresh in our memory. While the pandemic is still causing great damage in today's world and the international community is expecting greater coordination among countries, some people are turning to their old playbook. We cannot but wonder, have they already put that bitter lesson behind them, so soon? Or do they want to see a replay of tragedies? With such irresponsible behaviors, how can they face up to their own people? How can they face up to the international community? And how can they face up to human conscience?

On the origin tracing of COVID-19, we have been calling for international cooperation on the basis of respecting facts and science, with a view to better coping with unexpected epidemics in the future. To politicize origin tracing, a matter of science, will not only make it hard to find the origin of the virus, but give free rein to the "political virus" and seriously hamper international cooperation on the pandemic. Out of a sense of responsibility towards the health of mankind, we support a comprehensive study of all early cases of COVID-19 found worldwide and a thorough investigation into some secretive bases and biological laboratories all over the world. Such study and investigation shall be full, transparent and evidence-based, and shall get to the bottom to make everything clear.

Friday, May 07, 2021

The Bulletin Of The Atomic Scientists DESTROYS Any Further Doubt About Covid's Origin

This is School For You!!!

Accept No MuthaPhukkin Substitutes...,

thebulletin |  Why would anyone want to create a novel virus capable of causing a pandemic? Ever since virologists gained the tools for manipulating a virus’s genes, they have argued they could get ahead of a potential pandemic by exploring how close a given animal virus might be to making the jump to humans. And that justified lab experiments in enhancing the ability of dangerous animal viruses to infect people, virologists asserted.

With this rationale, they have recreated the 1918 flu virus, shown how the almost extinct polio virus can be synthesized from its published DNA sequence, and introduced a smallpox gene into a related virus.

These enhancements of viral capabilities are known blandly as gain-of-function experiments. With coronaviruses, there was particular interest in the spike proteins, which jut out all around the spherical surface of the virus and pretty much determine which species of animal it will target. In 2000 Dutch researchers, for instance, earned the gratitude of rodents everywhere by genetically engineering the spike protein of a mouse coronavirus so that it would attack only cats.

Virologists started studying bat coronaviruses in earnest after these turned out to be the source of both the SARS1 and MERS epidemics. In particular, researchers wanted to understand what changes needed to occur in a bat virus’s spike proteins before it could infect people.

Researchers at the Wuhan Institute of Virology, led by China’s leading expert on bat viruses, Shi Zheng-li or “Bat Lady,” mounted frequent expeditions to the bat-infested caves of Yunnan in southern China and collected around a hundred different bat coronaviruses.

Shi then teamed up with Ralph S. Baric, an eminent coronavirus researcher at the University of North Carolina. Their work focused on enhancing the ability of bat viruses to attack humans so as to “examine the emergence potential (that is, the potential to infect humans) of circulating bat CoVs [coronaviruses].” In pursuit of this aim, in November 2015 they created a novel virus by taking the backbone of the SARS1 virus and replacing its spike protein with one from a bat virus (known as SHC014-CoV). This manufactured virus was able to infect the cells of the human airway, at least when tested against a lab culture of such cells.

The SHC014-CoV/SARS1 virus is known as a chimera because its genome contains genetic material from two strains of virus. If the SARS2 virus were to have been cooked up in Shi’s lab, then its direct prototype would have been the SHC014-CoV/SARS1 chimera, the potential danger of which concerned many observers and prompted intense discussion.

“If the virus escaped, nobody could predict the trajectory,” said Simon Wain-Hobson, a virologist at the Pasteur Institute in Paris.

Baric and Shi referred to the obvious risks in their paper but argued they should be weighed against the benefit of foreshadowing future spillovers. Scientific review panels, they wrote, “may deem similar studies building chimeric viruses based on circulating strains too risky to pursue.” Given various restrictions being placed on gain-of function (GOF) research, matters had arrived in their view at “a crossroads of GOF research concerns; the potential to prepare for and mitigate future outbreaks must be weighed against the risk of creating more dangerous pathogens. In developing policies moving forward, it is important to consider the value of the data generated by these studies and whether these types of chimeric virus studies warrant further investigation versus the inherent risks involved.”

That statement was made in 2015. From the hindsight of 2021, one can say that the value of gain-of-function studies in preventing the SARS2 epidemic was zero. The risk was catastrophic, if indeed the SARS2 virus was generated in a gain-of-function experiment.

Thursday, April 08, 2021

Related To Montagnier's Concern About mRNA? Extrachromosomal DNA Drives Tumor Malignancy

thescientist |   Despite being treated with drugs designed to target this gene, the patients were not getting better, and when we interrogated the genomes of their cancers after the tumors were surgically removed following treatment, we saw that they had changed. The tumors had dramatically reduced the number of copies of the targeted epidermal growth factor receptor (EGFR) gene, presumably giving them an advantage to escape the drugs, and they had evolved these genetic differences at a rate that seemed to make no sense—within just one to two weeks. 

Normally, we think of cancers evolving over many cell divisions, as the cells carrying genetic changes that provide a fitness advantage—such as an ability to resist a particular treatment—will be more likely to survive and divide. Here, we were noticing a change in the copy number of the gene within just a few generations. There was no way that we could explain how the tumors were altering their DNA so quickly. 

Even stranger, we could take any cell from the tumor, and whether it had high or undetectable protein levels of EGFR, it would give rise to a new tumor when cultured in the lab or implanted into a mouse. Each of these new tumors would then display the full spectrum of cells found in the original tumor, varied in their EGFR copy number. This makes no sense according to what we know about classical genetics. We would have expected that tumors arising from a cell with low levels of EGFR would give rise to a tumor with low EGFR levels, whereas a tumor arising from a cell with high levels of EGFR would give rise to a tumor with high EGFR levels. 

When we removed the treatment with the EGFR inhibitor from cultured tumor cells, EGFR copy number quickly rebounded, but again, not on chromosomes. When we saw this, we realized that ecDNA might explain why some cancers can become resistant to treatment so quickly, allowing tumors to evolve at a rate that far exceeds anything that could be accounted for by classical genetics. We published our results in Science in 2014, but they were not immediately accepted by the community. Although we had only studied one tumor type, glioblastoma, we began to wonder whether this might be the tip of the iceberg. 

Without realizing it, this study led us, and now others, to a series of discoveries that have changed the way that researchers view cancer in general, revealing frightening ways that tumors can evolve. We have learned that ecDNA is central to the behavior of some of the most aggressive forms of cancer, enabling remarkably elevated levels of oncogene transcription, creating new gene regulatory interactions, and providing a powerful mechanism for rapid change that can drive very high oncogene copy numbers or allow cancer cells to resist treatment. Fist tap Woodensplinter

Thursday, April 01, 2021

The Wholesale Discrediting Of The American Medical Industrial Complex

nakedcapitalism |  Of so many tragedies to come out of the COVID-19 pandemic, one of the saddest to me – and probably the one with the longest-reverberating consequences – has been its wholesale discrediting of our health science institutions.

Here we are, over a year into this pandemic, and we cannot get a straight answer on whether or not this relatively cheap and safe drug (ivermectin) saves human lives from COVID-19 or not. Worse, we can’t even seem to properly investigate it. All questions bring hysterics, or hardly-believable obfuscation, or (informed?) outrage, no matter what authority we turn to. The fallout in my own life from watching all this unfold has been… dramatic.

I don’t trust what the CDC says. I don’t trust what the WHO says. I don’t trust what the FDA says. I don’t trust Pfizer and the rest of the pharmaceutical companies any farther than I can throw them. I look with suspicion on my own scientist acquaintances, wondering if they are really following the data, or if they are clinging to a chosen worldview that science in America still works, oh god it still works, oh god it hasn’t been completely discredited, no it cannot be, my life work must have meant something, it must still work, it must still work….??

None of this means that ivermectin works–or for that matter, that it doesn’t work. It means that I have realized, slowly and then all-of-a-sudden, that I cannot know. Nor can any other layperson. We are alone, our economy is collapsing in slow-motion, and our lives are at stake. Or so we think! If we doubt so much, how much more should we really be doubting? I believe, for what it’s worth, that COVID-19 is real and that these experimental vaccines probably won’t kill us. At least… not that many of us.

But I wonder now, in my darker moments, whether the claim of those who don’t believe such things that refusing the vaccination is a “Darwin’s test – pass it and survive” have grokked something that was beyond me, in my previous worldview. How could it have come to this…? And if I am feeling like this, how must people with less scientific background (I attended a science magnet school) be feeling about it all??

Will my children be safe from measles, etc in the years to come? I have vaccinated them with the whole slate, and feel fine about that choice, but will the fallout from this debacle mean the end of herd immunity in America, as trust in the ‘health experts’ collapses into dust? How can we get it back, then – at gunpoint? With all that would imply… is it even worth such a high price…?

Tuesday, March 16, 2021

Virus Variants Developed In Those With Compromised Immune Systems

NYTimes |  Growing evidence suggests that people with cancer and other conditions that challenge their immune systems may be incubators of mutant viruses.

The version of the coronavirus that surfaced in Britain late last year was shocking for many reasons. It came just as vaccines had offered a glimpse of the end of the pandemic, threatening to dash those hopes. It was far more contagious than earlier variants, leading to a swift increase in hospitalizations. And perhaps most surprising to scientists: It had amassed a large constellation of mutations seemingly overnight.

A coronavirus typically gains mutations on a slow-but-steady pace of about two per month. But this variant, called B.1.1.7, had acquired 23 mutations that were not on the virus first identified in China. And 17 of those had developed all at once, sometime after it diverged from its most recent ancestor.

Experts said there’s only one good hypothesis for how this happened: At some point the virus must have infected someone with a weak immune system, allowing it to adapt and evolve for months inside the person’s body before being transmitted to others. “It appears to be the most likely explanation,” said Dr. Ravindra Gupta, a virologist at the University of Cambridge.

If true, the idea has implications for vaccination programs, particularly in countries that have not yet begun to immunize their populations. People with compromised immune systems — such as cancer patients — should be among the first to be vaccinated, said Dr. Adam Lauring, a virologist and infectious disease physician at the University of Michigan. The faster that group is protected, the lower the risk that their bodies turn into incubators for the world’s next supercharged mutant.

 

As Far As Covid Goes - States Without Lockdowns Fared No Worse Than States With Draconian Lockdowns

AP  |  Nearly a year after California Gov. Gavin Newsom ordered the nation’s first statewide shutdown because of the coronavirus, masks remain mandated, indoor dining and other activities are significantly limited, and Disneyland remains closed.

By contrast, Florida has no statewide restrictions. Republican Gov. Ron DeSantis has prohibited municipalities from fining people who refuse to wear masks. And Disney World has been open since July.

Despite their differing approaches, California and Florida have experienced almost identical outcomes in COVID-19 case rates.

How have two states that took such divergent tacks arrived at similar points?

“This is going to be an important question that we have to ask ourselves: What public health measures actually were the most impactful, and which ones had negligible effect or backfired by driving behavior underground?” said Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security.

Though research has found that mask mandates and limits on group activities such as indoor dining can help slow the spread of the coronavirus, states with greater government-imposed restrictions have not always fared better than those without them.

California and Florida both have a COVID-19 case rate of around 8,900 per 100,000 residents since the pandemic began, according to the federal Centers for Disease Control and Prevention. And both rank in the middle among states for COVID-19 death rates — Florida was 27th as of Friday; California was 28th.

Connecticut and South Dakota are another example. Both rank among the 10 worst states for COVID-19 death rates. Yet Connecticut Gov. Ned Lamont, a Democrat, imposed numerous statewide restrictions over the past year after an early surge in deaths, while South Dakota Gov. Kristi Noem, a Republican, issued no mandates as virus deaths soared in the fall.

While Lamont ordered quarantines for certain out-of-state visitors, Noem launched a $5 million tourism advertising campaign and welcomed people to a massive motorcycle rally, which some health experts said spread the coronavirus throughout the Midwest.

Both contend their approach is the best.

“Even in a pandemic, public health policy needs to take into account people’s economic and social well-being,” Noem said during a recent conservative convention.

 

Sunday, March 14, 2021

Marvelous Marvin Hagler Killed By mRNA Jab (But Not According To Google Or MSM)

worldboxingnews |  Former middleweight rival Thomas Hearns has claimed Marvin Hagler’s death at the age of 66 was linked to the coronavirus vaccine he received recently. 

Hearns, known as ‘The Hitman’ during his career, took to social media to report that Hagler was ‘fighting for his life in the ICU’ on Saturday. The ex-boxer also added that Hagler was there due to the ‘after-effects of the vaccine.’ 

In a sad final statement, Hearns said he believed ‘he’ll be just fine, but we could use the positive energy and Prayer for his full recovery.’ Sadly, that didn’t happen, and Hagler passed away a short time later. 

Hearns’ revelation will be a massive blow to the continued roll-out of the vaccination program. Reports in Europe of the AstraZeneca/Oxford vaccine causing blood clots in three patients already dealt a debilitating thud as countries have paused using the UK-based jab. Social media conspiracy theories have gone into overdrive, and there will be some work to be done to assure those taking the vaccine that it’s safe.

What Is France To Do With The Thousands Of Soldiers Expelled From Africa?

SCF  |    Russian President Vladimir Putin was spot-on this week in his observation about why France’s Emmanuel Macron is strutting around ...