technologyreview | Imagine, a few weeks or months from now, having a covid-19 test kit
sent to your home. It’s small and portable, but pretty easy to figure
out. You prick your finger as in a blood sugar test for diabetics, wait
maybe 15 minutes, and bam—you now know whether or not you’re immune to
coronavirus.
If you are, you can request government-issued
documentation that says so. This is your “immunity passport.” You are
now free to leave your home, go back to work, and take part in all
facets of normal life—many of which are in the process of being booted
back up by “immunes” like yourself.
Pretty enticing, right? Some countries are taking the idea seriously. German researchers want to send out hundreds of thousands of tests to
citizens over the next few weeks to see who is immune to covid-19 and
who is not, and certify people as being healthy enough to return to
society. The UK, which has stockpiled over 17.5 million home antibody
testing kits, has raised the prospect of doing something similar,
although this has come under major scrutiny from scientists who
have raised concerns that the test may not be accurate enough to be
useful. As the pressure builds from a public that has been cooped up for
weeks, more countries are looking for a way out of strict social
distancing measures that doesn’t require waiting 12 to 18 months for a
vaccine (if one even comes).
There are some serious problems with trying to use the tests to
determine immunity status. For example, we still know very little about
what human immunity to the disease looks like, how long it lasts, whether an immune response prevents reinfection,
and whether you might still be contagious even after symptoms have
dissipated and you’ve developed IgG antibodies. Immune responses vary
greatly between patients, and we still don’t know why. Genetics could
play a role.
“We’ve only known about this virus for four
months,” says Donald Thea, a professor of global health at Boston
University. “There’s a real paucity of data out there.”
SARS-CoV-1, the virus that causes SARS and whose genome is about 76% similar to that of SARS-CoV-2, seems to elicit an immunity that lasts up to three years.
Other coronaviruses that cause the common cold seem to elicit a far
shorter immunity, although the data on that is limited—perhaps, says
Thea, because there has been far less urgency to study them in such
detail. It’s too early to tell right now where SARS-CoV-2 will fall in
that time range
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