nature | These jokers created some super-covid from the worst strains of existing covid variants. (Gain of Function Research) It’s virological and immunological <s>dual use bioweapons</s> research. Hope none gets out of the NYC lab where they created it over a year ago.
They then tested antibodies created from a natural Covid-19
infection - and - antibodies created by someone with an mRNA vaccine against
this “gain of function” super strain of Covid-19. The super Covid was
resistant to both types of antibodies. However, antibodies
from someone who both was infected and recovered from a Covid-19
infection AND received an mRNA vaccination defeated the super strain of
Covid-19.
The number and variability of the neutralizing epitopes targeted by
polyclonal antibodies in SARS-CoV-2 convalescent and vaccinated
individuals are key determinants of neutralization breadth and the
genetic barrier to viral escape1–4. Using HIV-1 pseudotypes and plasma-selection experiments with vesicular stomatitis virus/SARS-CoV-2 chimeras5,
we show that multiple neutralizing epitopes, within and outside the
receptor binding domain (RBD), are variably targeted by human polyclonal
antibodies. Antibody targets coincide with spike sequences that are
enriched for diversity in natural SARS-CoV-2 populations. By combining
plasma-selected spike substitutions, we generated synthetic ‘polymutant’
spike protein pseudotypes that resisted polyclonal antibody
neutralization to a similar degree as circulating variants of concern
(VOC). By aggregating VOC-associated and antibody-selected spike
substitutions into a single polymutant spike protein, we show that 20
naturally occurring mutations in SARS-CoV-2 spike are sufficient to
generate pseudotypes with near-complete resistance to the polyclonal
neutralizing antibodies generated by convalescents or mRNA vaccine
recipients. Strikingly, however, plasma from individuals who had been
infected and subsequently received mRNA vaccination, neutralized
pseudotypes bearing this highly resistant SARS-CoV-2 polymutant spike,
or diverse sarbecovirus spike proteins. Thus, optimally elicited human
polyclonal antibodies against SARS-CoV-2 should be resilient to
substantial future SARS-CoV-2 variation and may confer protection
against potential future sarbecovirus pandemics.
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