Wednesday, October 15, 2014

how depressed does the ebola make you?



LiverTox Introduction

Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression.  Imipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.


Background

Imipramine (im ip' ra meen) is a dibenzazepine derived tricyclic antidepressant which acts by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters.  Imipramine is indicated for therapy of depression and was approved for this indication in the United States in 1959; it is still widely used, with more than 1 million prescriptions being filled yearly.  Imipramine is also used for childhood enuresis.  Imipramine is available in generic forms and under the brand names of Tofranil in 10, 25, and 50 mg tablets and as capsules of 75, 100, 125 and 150 mg for nighttime dosing.  The typical recommended dose for depression in adults is 75 to 100 mg daily in divided doses, increasing gradually to a maximum of 200 mg daily.  Imipramine can also be given as a single nighttime dose.  The recommended dose in children (ages 6 years or above) is 25 to 75 mg daily 1 hour before bedtime.  Common side effects include dizziness, headache, drowsiness, restlessness, confusion, gastrointestinal upset, increased appetite, weight gain, blurred vision, dry mouth and urinary retention.

7 comments:

makheru bradley said...

Another contact-tracing epic fail: Sana Syed, a spokeswoman for the city of Dallas, said she didn’t know why the caregiver was allowed to fly.

Oct. 15 (Bloomberg) -- The second health-care worker diagnosed with Ebola in Texas flew from Cleveland to Dallas hours before she reported her symptoms, U.S. officials said today. The caregiver caught the deadly virus while treating patient Thomas Eric Duncan at Texas Health Presbyterian Hospital in Dallas earlier this month. She flew to Dallas on Frontier Airlines flight 1143 the night of Oct. 13, according to an e-mailed statement by the U.S. Centers for Disease Control and Prevention. She then reported symptoms the next morning.

“Because of the proximity in time between the evening flight and first report of illness the following morning, CDC is reaching out to passengers,” the agency said. The plane had 132 passengers, the CDC said.

The flight was the last of the day for the aircraft, which returned to service the next day after receiving “a thorough cleaning per our normal procedures,” Frontier Airlines said in a statement. It has since been taken out of service. The health worker originally traveled to Cleveland from Dallas on Frontier flight 1142 on Oct. 10, the airline said. The CDC didn’t say that it was contacting people on that flight. Ebola is only contagious while a person is symptomatic. Thomas Frieden, director of the CDC, said while the health worker was self-monitoring for potential symptoms after caring for Duncan, “because at that point she was in a group of individuals known to have exposure to Ebola, she should not have traveled on a commercial airline.” Frieden said the new patient didn’t have a fever, nausea or vomiting on the plane from Cleveland to Dallas, suggesting “that the risk to any around that individual would have been extremely low.”

BigDonOne said...

..."...findings uncover unique features of the entry pathway used by filoviruses and suggest potential antiviral strategies to combat these deadly agents..."

By the time folks really get the message, it's going to be too late, if it isn't already --->http://www.theblaze.com/stories/2014/10/15/viewers-quickly-noticed-something-that-makes-no-sense-in-raw-video-of-officials-loading-dallas-ebola-patient-onto-plane/

Dale Asberry said...

Help me here Don... what does the linked article have to do with the quote you referenced?

CNu said...

The guy in the shirt sleeves must think himself naturally immune? (I was wondering about this one myself, honestly. Is this a lapse of protocol, boo-boo the fool, a natural immune, or like one of the time travelers from a 1930's photograph holding what appears to be a cell phone?)

It's anomalous as hell....,

BigDonOne said...

Illiteracy Item (definition) -- Antiviral Strategy: any defense that prevents a virus from doing it to you (drugs, masks, moon-suits)

Uglyblackjohn said...

The guy probably had Triclosan-based Invisible Armour sanitizer slathered all over him. The stuff can last for up to four hours and was used to prevent the spread of MRSA. (The long term effect of using the product might not be worth it though.)

CNu said...

I bet Alex Jones sells that on his daily broadcast, along with the little pouch to keep TPTB from tracking your cell phone?