Physical Basis for Morphogenesis: On Growth and Form

nature |  Still in print, On Growth and Form was more than a decade in the planning. Thompson would regularly tell colleagues and students — he taught at what is now the University of Dundee, hence the local media interest — about his big idea before he wrote it all down. In part, he was reacting against one of the biggest ideas in scientific history. Thompson used his book to argue that Charles Darwin’s natural selection was not the only major influence on the origin and development of species and their unique forms: “In general no organic forms exist save such as are in conformity with physical and mathematical laws.”

Biological response to physical forces remains a live topic for research. In a research paper, for example, researchers report how physical stresses generated at defects in the structures of epithelial cell layers cause excess cells to be extruded.

In a separate online publication (K. Kawaguchi et al. Nature http://dx.doi.org/10.1038/nature22321; 2017), other scientists show that topological defects have a role in cell dynamics, as a result of the balance of forces. In high-density cultures of neural progenitor cells, the direction in which cells travel around defects affects whether cells become more densely packed (leading to pile-ups) or spread out (leading to a cellular fast-lane where travel speeds up).

A Technology Feature investigates in depth the innovative methods developed to detect and measure forces generated by cells and proteins. Such techniques help researchers to understand how force is translated into biological function.

Thompson’s influence also flourishes in other active areas of interdisciplinary research. A research paper offers a mathematical explanation for the colour changes that appear in the scales of ocellated lizards (Timon lepidus) during development (also featured on this week’s cover). It suggests that the patterns are generated by a system called a hexagonal cellular automaton, and that such a discrete system can emerge from the continuous reaction-diffusion framework developed by mathematician Alan Turing to explain the distinctive patterning on animals, such as spots and stripes. (Some of the research findings are explored in detail in the News and Views section.) To complete the link to Thompson, Turing cited On Growth and Form in his original work on reaction-diffusion theory in living systems.

Finally, we have also prepared an online collection of research and comment from Nature and the Nature research journals in support of the centenary, some of which we have made freely available to view for one month.