frontiersin | Dopamine is an inhibitory neurotransmitter involved in the pathology of
schizophrenia. The revised dopamine hypothesis states that dopamine
abnormalities in the mesolimbic and prefrontal brain regions exist in
schizophrenia. However, recent research has indicated that glutamate,
GABA, acetylcholine, and serotonin alterations are also involved in the
pathology of schizophrenia. This review provides an in-depth analysis of
dopamine in animal models of schizophrenia and also focuses on dopamine
and cognition. Furthermore, this review provides not only an overview
of dopamine receptors and the antipsychotic effects of treatments
targeting them but also an outline of dopamine and its interaction with
other neurochemical models of schizophrenia. The roles of dopamine in
the evolution of the human brain and human mental abilities, which are
affected in schizophrenia patients, are also discussed.
