Thursday, November 25, 2021

Does The Spike Protein Epigenetically Silence Endothelial SIRT6?

wmcresearch  |  One may view the actions of the spike protein by reversing a well-worn saying:

“If you give a man a fish, you feed him for a day. If you teach a man to fish, you feed him for a lifetime.”

The Spike prefers:

“If you stop a cell from repairing itself, it just dies. If you teach the host to stop repairing itself, you rob it of its lifetime.”

On May 31st of this year, researchers in Israel discovered the Fountain of Youth. They observed that SIRT6 controls the rate of healthy aging. If you increase this, the mice live for an average of THIRTY PERCENT LONGER. So, imagine 130 being the new 100. SIXTY being the new THIRTY! LITERALLY!

An interesting observation was also made by the team: “If we can determine how to activate it in humans, we will be able to prolong life, and this could have enormous health and economic implications."

Enormous implications, indeed. Clearly there are those who certainly DO NOT want Seven Billion people living an extra thirty years…

So, what happens if you REMOVE SIRT6? You guessed it. Very, very bad things happen. Especially death.

Without SIRT6 your body is unable to repair the DNA damage that we experience every day, and which is ENORMOUSLY increased in states of disease, particularly so in the case of SARS-CoV-2.

THE ENDOTHELIAL SENESCENCE CONNECTION

It has been established that endothelial cells become senescent when transfected with the Spike Protein. They have not determined WHY it happens, just that it DOES HAPPEN and the effects it has. I now know why it happens. The Spike Protein is epigenetically silencing SIRT6.

What does SIRT6 do, in addition to controlling DNA repair?

DNA Repair, Gene Expression, Telomeric Maintenance, Mitosis and Meiosis, Stem Cell Pluripotency and Differentiation (how cells obtain their specific functionality), Metablic Diseases (Diabetes, for example), Cancer, Immune Regulation, Stress Response, Senescence and Aging.

Everything COVID and Long COVID.

It has already been hypothesized that Sirtuins are implicated in COVID. In a paper on COVID and related Sepsis it was determined that Metformin may improve metabolic derangements, improve mitochondrial function, and decrease cytokine production. NAD+ boosters such as resveratrol, a naturally occurring polyphenol, found in red grapes and blueberries, activate Sirtuin activity and attenuate the NF-ĸB activity, improve endothelial function, and decrease microvascular inflammation.

SIRT1 is also implicated in COVID: COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity

But, what are the possible long term implications? Organisms that are deprived of their natural SIRT6 have very, very short lifespans. Mice, for example, die within four weeks without SIRT6.

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