Tuesday, May 11, 2021

Gain Of Function Program For Covid-21: Build Back Better!

Over the weekend I watched a very interesting discussion between Dutch virologist, Geest Vanden Bossche and Bret Weinstein. Vanden Bossche made exactly this point about using vaccinations in the middle of an epidemic – he points out that - this is the first time a major vaccination program has taken place while a pandemic is at its peak.

He particularly emphasized that ‘two shot’ vaccinations have a longer immunological ramp up time, giving the virus more time to evolve. The mRNA therapeutic program is nothing other than an active gain of function experiment on the virus at a global scale.

The real worries here are the following:

First, the breakthrough (mRNA therapeutic breach) cases are asymptomatic/mild now, but they will not be mild later in the year, as antibodies for the synthetic spike protein decline in those who received these shots.

Second, and most important, from the evolutionary perspective of the virus, its evolutionary “goal” is not just to survive, but to make as many copies of itself as possible. Milder cases tend to have less of the virus (yes, there are completely asymptomatic superspreaders that generate a huge amount of virus in their upper respiratory tracts, but in general, if Covid-21 can get past the upper respiratory tract and cause real damage, that means a lot more copies of the virus.) Clearly the evolutionary pressure is there for Covid-21 to evolve in that direction.

Whatever can escape the antibodies generated by the mRNA synthetic spike protein and lead to more replication will be selected for. That will mean a much more contagious and virulent virus (Covid-21_ just from that.) So far, immune escape has evolved hand in hand with stronger affinity for the ACE2 receptor, which directly translates into higher contagiousness and also elevated virulence as well. The likely mutations to come next have been identified in vitro (to be noted, in vitro evolution had already correctly identified the ones that characterize the current variants, so it has a good track record so far).

In vitro has also identified ways for it to get deadlier through a different mechanism – that is - shutting down innate immunity by inhibiting the interferon response. This second mutation is a key strategy that these viruses have evolved in their battle with bats’ immune systems.  There is some evidence that Covid-19 is actually not all that good at this compared to, for example, the first SARS virus from 2003. I suspect that this was a major reason why SARS-1 was much more lethal.

Can the mRNA therapeutic regimen select for a reversion back to that state, i.e. it goes in the direction of countering the immune system as a whole by becoming better at overcoming the innate arm of the immune system. When the adaptive arm of Covid-19 has been strengthened by mRNA therapeutics, the evolutionary potential for a much more contagious and lethal Covid-21 may become evident?

I don’t have an answer, but I sure hope that it does not.

The mRNA therapeutic approach runs the risk of breeding something much more contagious and deadly Covid-21. And because it may well happen in stages, there is also the risk of it becoming gradually normalized, just as the current level of death has become normalized.  I remember learning about gain of function research reading Annie Jacobson's Operation Paperclip. So it's not as if potential outcomes aren't well understood.

So not only do we have lying officials that did everything possible to help the spread of an aerosol pathogen, now those same officials are running a playbook for creating more virulent strains taking us from Covid-19 to Covid-21. Meanwhile, we're drowned in and overwhelmed by dueling narratives Outside of what you read here, there's scant information to be gotten about gain of function mutations and the rate of infection of those whose mRNA therapeutic injections have been breached.

"Trust the science" pretenders like the frightening Dr. Kavita (force the injections) Patel are pretending that shots will get the virus under control - and they won’t. mRNA therapeutic jabs won't even get degenerating public health care systems under control. So, not only does this grand Covid-21 gain of function experiment have the potential to be even more deadly, nary any of the deep seated issues with any of the impacted health care systems have been fixed.