Experiences Leave Behind Epigenetic Traces in Our Genetic Material

phys.org |  An ideological dispute is taking place in biology. And it's about a big topic that's central to everything: heredity. In his epoch-making book On the Origin of Species of 1859, Darwin wrote of the reigning ignorance about how differences between individuals come about. It was only with 'modern evolutionary synthesis' in the 1940s that people became convinced that heredity functions through genetics – in other words, that the characteristics of living creatures are passed on to the next generations through their genetic substance, DNA.

This perspective was helpful in providing a focus for research in the ensuing decades, which brought about extraordinary discoveries. As a result, many aspects of the form and function of living creatures can now be explained. But already in the 1950s, different observations called into question the seemingly exclusive control of the genes. For example, maize kernels can have different colours even if their DNA sequence is identical.

Plants remember aridity

Further investigations brought to light the fact that when individuals with identical genetic material have a different outward appearance, this can be traced back to different degrees of activity on the part of the genes. Whether a particular section of DNA is active or not – i.e., whether it is read – depends to a decisive degree on how densely packed the DNA is.

This packing density is influenced by several so-called epigenetic mechanisms. They form a complex machinery that can affix or detach tiny chemical attachments to the DNA. Here, the rule applies that the tighter packed the DNA, the more difficult it is to read – and this means that a particular gene will be more inactive.

Living creatures can adjust to a volatile environment by steering their epigenetic mechanisms. In this manner, for example, the epigenetic machinery can ensure that plants can deal better with a hot or arid climate if it at some point they already had to live through a similar situation. So in this sense, the epigenetic markings in the genetic material form a kind of 'stress memory' of the plants. This much is today a matter of consensus among biologists.

Doubts on heredity over generations

Several studies, however, suggest that the descendants of stressed plants are also better prepared against the dangers already faced by their ancestors. "However, these studies are a matter of controversial debate," says Ueli Grossniklaus, the director of the Department of Plant and Microbial Biology at the University of Zurich. Like many other epigeneticists who are involved in deciphering these mechanisms, he believes that, "since the evidence is patchy, we can't yet say to what degree acquired characteristics can be transmitted in stable form over several generations." So it still remains to be proven whether epigenetics actually brings organisms long-lasting advantages and thus plays a role in evolution. It's an attractive idea, thinks Grossniklaus, but it's still to be demonstrated.

It's not just in plants that results on the heredity of epigenetic markings are causing a stir – the same is true in mice. In order to investigate the possible long-term effects of severe childhood trauma, for example, the research group led by Isabelle Mansuy, a professor of neuro-epigenetics at the University of Zurich and ETH Zurich, has been taking mouse offspring away from their mothers for three hours each day, just a few days after being born.