Monday, January 19, 2015
you know some of this already exists given how far along those paperclip nazis were 60 years ago...,
By CNu at January 19, 2015 0 comments
Labels: Great Filters , macrobiology , Possibilities
policy-makers know that climate disaster is inevitable
By CNu at January 19, 2015 0 comments
Labels: Great Filters , macrobiology , What Now?
Saturday, January 17, 2015
the great acceleration
“Radioactive isotopes from this detonation were emitted to the atmosphere and spread worldwide entering the sedimentary record to provide a unique signal of the start of the Great Acceleration, a signal that is unequivocally attributable to human activities,” the paper reports. The research explores the underlying drivers of the Great Acceleration: predominantly globalisation.
By CNu at January 17, 2015 0 comments
Labels: Great Filters , What Now?
Thursday, October 30, 2014
elon musk's fears not completely crazy?
By CNu at October 30, 2014 0 comments
Labels: count zero , egregores , Great Filters
Wednesday, October 15, 2014
how depressed does the ebola make you?
LiverTox Introduction
Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. Imipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
Background
Imipramine (im ip' ra meen) is a dibenzazepine derived tricyclic antidepressant which acts by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters. Imipramine is indicated for therapy of depression and was approved for this indication in the United States in 1959; it is still widely used, with more than 1 million prescriptions being filled yearly. Imipramine is also used for childhood enuresis. Imipramine is available in generic forms and under the brand names of Tofranil in 10, 25, and 50 mg tablets and as capsules of 75, 100, 125 and 150 mg for nighttime dosing. The typical recommended dose for depression in adults is 75 to 100 mg daily in divided doses, increasing gradually to a maximum of 200 mg daily. Imipramine can also be given as a single nighttime dose. The recommended dose in children (ages 6 years or above) is 25 to 75 mg daily 1 hour before bedtime. Common side effects include dizziness, headache, drowsiness, restlessness, confusion, gastrointestinal upset, increased appetite, weight gain, blurred vision, dry mouth and urinary retention.
By Dale Asberry at October 15, 2014 7 comments
Labels: Great Filters
at least the ebola is quick...
Wikipedia Niemann–Pick type C has a wide clinical spectrum. Affected individuals may have enlargement of the spleen (splenomegaly) and liver (hepatomegaly), or enlarged spleen/liver combined (hepatosplenomegaly), but this finding may be absent in later onset cases. Prolonged jaundice or elevated bilirubin can present at birth. In some cases, however, enlargement of the spleen and/or liver does not occur for months or years – or not at all. Enlargement of the spleen and/or liver frequently becomes less apparent with time, in contrast to the progression of other lysosomal storage diseases such as Niemann–Pick disease, Types A and B or Gaucher disease. Organ enlargement does not usually cause major complications.
By Dale Asberry at October 15, 2014 0 comments
Labels: Great Filters
who might have natural immunity to the ebola?
National Center for Biotechnology Information Infections by the Ebola (EboV) and Marburg (MarV) filoviruses cause a rapidly fatal hemorrhagic fever in humans for which no approved antivirals are available1. Filovirus entry is mediated by the viral spike glycoprotein (GP), which attaches viral particles to the cell surface, delivers them to endosomes, and catalyzes fusion between viral and endosomal membranes2. Additional host factors in the endosomal compartment are likely required for viral membrane fusion. However, despite considerable efforts, these critical host factors have defied molecular identification3,4,5. Here we describe a genome-wide haploid genetic screen in human cells to identify host factors required for EboV entry. Our screen uncovered 67 mutations disrupting all six members of the HOPS multisubunit tethering complex, which is involved in fusion of endosomes to lysosomes6, and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter protein Niemann-Pick C1 (NPC1)7. Cells defective for the HOPS complex or NPC1 function, including primary fibroblasts derived from human Niemann-Pick type C1 disease patients, are resistant to infection by EboV and MarV, but remain fully susceptible to a suite of unrelated viruses. We show that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment requires the NPC1 protein, independent of its known function in cholesterol transport. Our findings uncover unique features of the entry pathway used by filoviruses and suggest potential antiviral strategies to combat these deadly agents
By Dale Asberry at October 15, 2014 0 comments
Labels: Great Filters
Tuesday, October 14, 2014
Ebola's progression in Africa
Datasciencecentral Having found a dataset on Ebola cases, thought of checking it out quickly what the statistics really look like.
By Dale Asberry at October 14, 2014 12 comments
Labels: Great Filters
Monday, October 13, 2014
something strange happens to civilizations, strange in a bad way...,
By CNu at October 13, 2014 15 comments
Labels: Great Filters , What Now?
why dispersal may be our only option...,
By CNu at October 13, 2014 0 comments
Labels: Great Filters , weather report
Friday, September 19, 2014
humanzee essentials: what it do...,
By CNu at September 19, 2014 22 comments
Labels: ethology , Great Filters , monkey see - monkey do , status-seeking
Thursday, August 28, 2014
a little on the history and consequences of not wanting for others what you want for yourself...,
But over the last three decades, the enclosure debate has been swept up in a broader discourse on the nature of common property of any kind. The overgrazing of English common land has been held up as the archetypal example of the "tragedy of the commons" — the fatal deficiency that a neoliberal intelligentsia holds to be inherent in all forms of common property. Attitudes towards enclosures in the past were always ideologically charged, but now any stance taken towards them betrays a parallel approach to the crucial issues of our time: the management of global commons and the conflict between the global and the local, between development and diversity.
By CNu at August 28, 2014 0 comments
Labels: Great Filters , Peak Capitalism , Rule of Law , What Now?
Monday, July 21, 2014
the final century of civilization?
By CNu at July 21, 2014 0 comments
Labels: Great Filters , weather report
Sunday, July 20, 2014
superintelligence
By CNu at July 20, 2014 6 comments
Labels: cultural darwinism , Great Filters , What Now?
Thursday, July 03, 2014
my red beards gestalt: divine right of a jewish state, bet not be no caliphate...,
By CNu at July 03, 2014 4 comments
Labels: Great Filters , the wattles
Wednesday, July 02, 2014
too good to stay in the comments: capitalism is a system by which the past DEVOURS the future
By CNu at July 02, 2014 3 comments
Labels: as above-so below , cull-tech , Great Filters
capitalist industrial civilization = M.A.D
By CNu at July 02, 2014 0 comments
Labels: Great Filters
Wednesday, June 11, 2014
matthew 26:34 - cowards always deny truth...,
By CNu at June 11, 2014 0 comments
Labels: as above-so below , Great Filters
Saturday, May 10, 2014
congress learns an EMP could kill 90% of americans...,
An EMP is caused by the detonation of a high-altitude nuclear bomb which sends a massive surge that fries anything electrical. It destroys anything with a microchip, the entire electric grid, and all vehicles built after the mid-1980s.
McCaul opened the hearing entitled, "Electromagnetic Pulse (EMP): Threat to Critical Infrastructure," saying an EMP would be far more catastrophic than even ground-level nuclear bombs. (watch video below)
"Some would say it’s low probability, but the damage that could be caused in the event of an EMP attack, both by the sun, a solar event, or a man-made attack, would be catastrophic," said McCaul. "We talk a lot about a nuclear bomb in Manhattan, and cybersecurity threat to the power grid in the Northeast, and all of these things would actually probably pale in comparison to the devastation that an EMP attack could perpetrate on Americans."
By CNu at May 10, 2014 24 comments
Labels: cull-tech , Great Filters , What IT DO Shawty...
Wednesday, May 07, 2014
confusing the right to be heard with the right to be taken seriously
…really shocked by the sheer authoritarianism of those who would have excluded from the debate the point of view of people who were climate change deniers.
By CNu at May 07, 2014 0 comments
Labels: Great Filters , helplessness , magical thinking , weather report
AIPAC Powered By Weak, Shameful, American Ejaculations
All filthy weird pathetic things belongs to the Z I O N N I I S S T S it’s in their blood pic.twitter.com/YKFjNmOyrQ — Syed M Khurram Zahoor...
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theatlantic | The Ku Klux Klan, Ronald Reagan, and, for most of its history, the NRA all worked to control guns. The Founding Fathers...
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Video - John Marco Allegro in an interview with Van Kooten & De Bie. TSMATC | Describing the growth of the mushroom ( boletos), P...
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Farmer Scrub | We've just completed one full year of weighing and recording everything we harvest from the yard. I've uploaded a s...