nature | A laboratory in Wuhan is on the cusp of being cleared to work with the
world’s most dangerous pathogens. The move is part of a plan to build
between five and seven biosafety level-4 (BSL-4) labs across the Chinese
mainland by 2025, and has generated much excitement, as well as some
concerns.
Some scientists outside China worry about pathogens escaping, and the
addition of a biological dimension to geopolitical tensions between
China and other nations. But Chinese microbiologists are celebrating
their entrance to the elite cadre empowered to wrestle with the world’s
greatest biological threats.
“It will offer
more opportunities for Chinese researchers, and our contribution on the
BSL‑4-level pathogens will benefit the world,” says George Gao, director
of the Chinese Academy of Sciences Key Laboratory of Pathogenic
Microbiology and Immunology in Beijing. There are already two BSL-4 labs
in Taiwan, but the National Bio-safety Laboratory, Wuhan, would be the
first on the Chinese mainland.
The lab was
certified as meeting the standards and criteria of BSL-4 by the China
National Accreditation Service for Conformity Assessment (CNAS) in
January. The CNAS examined the lab’s infrastructure, equipment and
management, says a CNAS representative, paving the way for the Ministry
of Health to give its approval. A representative from the ministry says
it will move slowly and cautiously; if the assessment goes smoothly, it
could approve the laboratory by the end of June.
BSL-4
is the highest level of biocontainment: its criteria include filtering
air and treating water and waste before they leave the laboratory, and
stipulating that researchers change clothes and shower before and after
using lab facilities. Such labs are often controversial. The first BSL-4
lab in Japan was built in 1981, but operated with lower-risk pathogens
until 2015, when safety concerns were finally overcome.
The expansion of BSL-4-lab networks in the United States and Europe
over the past 15 years — with more than a dozen now in operation or
under construction in each region — also met with resistance, including
questions about the need for so many facilities.
The Wuhan lab cost 300 million yuan (US$44 million), and to allay safety
concerns it was built far above the flood plain and with the capacity
to withstand a magnitude-7 earthquake, although the area has no history
of strong earthquakes. It will focus on the control of emerging
diseases, store purified viruses and act as a World Health Organization
‘reference laboratory’ linked to similar labs around the world. “It will
be a key node in the global biosafety-lab network,” says lab director
Yuan Zhiming.
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