Thursday, October 16, 2014
but I bet they got some clipboards though....,
By CNu at October 16, 2014 3 comments
Labels: hardscrabble , horror , hustle-hard
i want me one of these anti-ebola clipboards!!!
By CNu at October 16, 2014 0 comments
Labels: Ass Clownery
DIYbio
Radar O'Reilly Whither thou goest, synthetic biology? First, let’s put aside the dystopian scenarios of nasty modified viruses escaping from the fermentor Junior has jury-rigged in his bedroom lab. Designing virulent microbes is well beyond the expertise and budgets of homegrown biocoders.
By Dale Asberry at October 16, 2014 0 comments
Labels: as above-so below , culture of competence
Wednesday, October 15, 2014
how depressed does the ebola make you?
LiverTox Introduction
Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. Imipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
Background
Imipramine (im ip' ra meen) is a dibenzazepine derived tricyclic antidepressant which acts by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters. Imipramine is indicated for therapy of depression and was approved for this indication in the United States in 1959; it is still widely used, with more than 1 million prescriptions being filled yearly. Imipramine is also used for childhood enuresis. Imipramine is available in generic forms and under the brand names of Tofranil in 10, 25, and 50 mg tablets and as capsules of 75, 100, 125 and 150 mg for nighttime dosing. The typical recommended dose for depression in adults is 75 to 100 mg daily in divided doses, increasing gradually to a maximum of 200 mg daily. Imipramine can also be given as a single nighttime dose. The recommended dose in children (ages 6 years or above) is 25 to 75 mg daily 1 hour before bedtime. Common side effects include dizziness, headache, drowsiness, restlessness, confusion, gastrointestinal upset, increased appetite, weight gain, blurred vision, dry mouth and urinary retention.
By Dale Asberry at October 15, 2014 7 comments
Labels: Great Filters
at least the ebola is quick...
Wikipedia Niemann–Pick type C has a wide clinical spectrum. Affected individuals may have enlargement of the spleen (splenomegaly) and liver (hepatomegaly), or enlarged spleen/liver combined (hepatosplenomegaly), but this finding may be absent in later onset cases. Prolonged jaundice or elevated bilirubin can present at birth. In some cases, however, enlargement of the spleen and/or liver does not occur for months or years – or not at all. Enlargement of the spleen and/or liver frequently becomes less apparent with time, in contrast to the progression of other lysosomal storage diseases such as Niemann–Pick disease, Types A and B or Gaucher disease. Organ enlargement does not usually cause major complications.
By Dale Asberry at October 15, 2014 0 comments
Labels: Great Filters
who might have natural immunity to the ebola?
National Center for Biotechnology Information Infections by the Ebola (EboV) and Marburg (MarV) filoviruses cause a rapidly fatal hemorrhagic fever in humans for which no approved antivirals are available1. Filovirus entry is mediated by the viral spike glycoprotein (GP), which attaches viral particles to the cell surface, delivers them to endosomes, and catalyzes fusion between viral and endosomal membranes2. Additional host factors in the endosomal compartment are likely required for viral membrane fusion. However, despite considerable efforts, these critical host factors have defied molecular identification3,4,5. Here we describe a genome-wide haploid genetic screen in human cells to identify host factors required for EboV entry. Our screen uncovered 67 mutations disrupting all six members of the HOPS multisubunit tethering complex, which is involved in fusion of endosomes to lysosomes6, and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter protein Niemann-Pick C1 (NPC1)7. Cells defective for the HOPS complex or NPC1 function, including primary fibroblasts derived from human Niemann-Pick type C1 disease patients, are resistant to infection by EboV and MarV, but remain fully susceptible to a suite of unrelated viruses. We show that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment requires the NPC1 protein, independent of its known function in cholesterol transport. Our findings uncover unique features of the entry pathway used by filoviruses and suggest potential antiviral strategies to combat these deadly agents
By Dale Asberry at October 15, 2014 0 comments
Labels: Great Filters
those thirteen year old incident response plans may fool a lazy auditor, but they won't fool ebola
Read more here: http://www.mcclatchydc.com/2014/10/14/243412_dallas-nurses-describe-ebola-hospital.html?&rh=1#storylink=cpy
By CNu at October 15, 2014 1 comments
Labels: The Hardline , the medical-industrial complex , truth
second texas nurse has ebola...,
By CNu at October 15, 2014 0 comments
Labels: doesn't end well , reality casualties
Tuesday, October 14, 2014
exponential increase and widening geographic footprint...,
By CNu at October 14, 2014 3 comments
Labels: doesn't end well , weather report
Ebola's progression in Africa
Datasciencecentral Having found a dataset on Ebola cases, thought of checking it out quickly what the statistics really look like.
By Dale Asberry at October 14, 2014 12 comments
Labels: Great Filters
lucy in the sky with diamonds....,
By CNu at October 14, 2014 0 comments
Labels: microcosmos , Possibilities
Monday, October 13, 2014
something strange happens to civilizations, strange in a bad way...,
By CNu at October 13, 2014 15 comments
Labels: Great Filters , What Now?
why dispersal may be our only option...,
By CNu at October 13, 2014 0 comments
Labels: Great Filters , weather report
Sunday, October 12, 2014
species final exams: dmitri orlov offers a prudent and scalable ebola mitigation strategy
Beyond that, there are the basic mechanics of handling the pandemic. The current strategy treats it as a medical problem, best handled by doctors and nurses working in hospitals and clinics. This strategy only works for as long as the epidemic can be said to be under control; once it can be said to be out of control, the surviving doctors and nurses (medics are usually the first to be exposed—and to die) would be well advised to specifically refuse to handle Ebola patients.
In absence of any curative or preventive therapies, Ebola patients need shelter, hydration, hygiene, palliative care and, if and when they die, sanitary disposal of the remains. The goal is to do what is possible to give patients a chance to recover more or less on their own. To this end, it is very important to do all the things necessary to make sure that people are dying just from Ebola, and not from exposure, dehydration, or from any of the opportunistic diseases that thrive in disrupted circumstances, such as cholera and typhus. Sanitation is the most important aspect of the entire operation.
These services need not be provided by trained medics. The main two requirements for such service are: 1. psychological immunity to scenes of horrific suffering and death; and 2. immunity to Ebola. The first of these requirements comes down to natural talent; some have it, some don't. The second requirement is being provided free of charge by the Ebola virus itself, in cooperation with the survivors' immune systems.
English lacks a good word to describe this type of specialist, but we don't have to reach far to find one: the Russian word for it is “sanitar.” A popular Russian saying goes “wolves are sanitars of the forest” because they take care of disposing of the sick, the weak and the lame, thus giving those that survive a better chance. A sanitar need not be medically trained, but some training is needed: in diagnosis, palliative care, sanitation procedures and corpse disposal.
A third requirement is one that applies to the sanitation service as a whole: the number of sanitars has to scale with the rate of infection. Since the number of those infected is increasing exponentially, the number of sanitars assigned to serve them has to be able to increase exponentially as well. It seems outlandish to think that sufficient numbers of people will spontaneously volunteer for the job, and this means that they have to be press-ganged into service. And a super-obvious way to do just that is to simply never discharge Ebola survivors: once you are in, you are in until the pandemic is over, or until you die, whichever comes first. If you recover, you are given a bit of training, and then you go to work.
If you don't like the mitigation strategy I am proposing, please feel free to propose your own. Keep in mind, however, that what you propose has to automatically scale with the increase in the rate of infection, which is exponential. Sure, you can propose setting a public health budget, but then it has to double every couple of weeks—and keep doubling until the number of patients is in the billions.
By CNu at October 12, 2014 1 comments
Labels: as above-so below , visitors? , What Now?
Saturday, October 11, 2014
elforsk ain't hesitate to interrogate (it gets cold in sweden and putin ackin a fool)...,
By CNu at October 11, 2014 2 comments
Labels: hustle-hard , scientific morality , What IT DO Shawty...
h8ters cain't wait to h8te...,
Yet another version of the E-Cat2 has been tested. This time the tests have been performed in Lugano3.
By CNu at October 11, 2014 0 comments
Labels: Possibilities , scientific mystery
nothing would please me more than for the boy to face the future close to home...,
Collections in this community
- Posters (18th International Conference on Condensed Matter Nuclear Science) [40]
- Presentations (18th International Conference on Condensed Matter Nuclear Science) ) [44]
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Recent Submissions
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Veneziano, Diego (University of Missouri, 2013-07)
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18th International Conference on Condensed Matter; International Conference on Condensed Matter Nuclear Science (18th : 2013 : Columbia, Mo.) (University of Missouri, 2013-07)
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Hubler, Graham K. (University of Missouri, 2013-07)
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Hubler, Graham K. (University of Missouri, 2013-07)
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Pfeifer, Peter (University of Missouri, 2013-07)
By CNu at October 11, 2014 0 comments
Labels: Possibilities , scientific mystery , What Now?
Friday, October 10, 2014
last night my son shifted his focus from chemical and petroleum engineering to physical chemistry and nuclear engineering...,
By CNu at October 10, 2014 12 comments
Labels: Possibilities
low energy nuclear reactions coming into view?
By CNu at October 10, 2014 2 comments
Labels: as above-so below , evolution , institutional deconstruction , Possibilities
straight loving the way this cat thinks yo!
By CNu at October 10, 2014 0 comments
Labels: banksterism
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