Localism in the 2020's

libertyblitzkrieg |  Contrary to popular opinion, I think a loss of faith in Washington D.C. and its institutions is entirely rational and healthy. Maintaining faith in something due to tradition or the fumes of hope won’t lead to anything productive, rather, it’s preferable to honestly assess the reality of whatever situation you’re in and reorient your worldview and priorities accordingly.

Whether the issue relates to above the law criminal bankers, a Federal Reserve which systematically funnels free money to the already wealthy and powerful, the societal dominance of free speech and privacy-despising tech giant monopolies, or the national security state’s undeclared forever wars for empire, there’s no good reason to maintain any faith in the federal government and the oligarchs/special interests who control it.

Philosophically speaking, I’ve come to conclude the only way to truly have self-government where community life reflects the desires and needs of the people who live there is by concentrating decision making at the local level. I’ve become increasingly interested in the general idea of localism not just because I agree with it in theory, but because it seems more and more people will begin to gravitate toward this perspective and life strategy out of necessity and frustration.

Rather than groveling to Washington D.C., grassroots movements should focus more on the local level where community can be built and things can get done to reflect the desires of the people living there. The entire notion of a one-size fits all approach to virtually all aspects of life dictated via laws passed by corrupt egomaniacs in the swamp is certifiably deranged.

Bidens Corrupt AF!!!

NYPost |  Political figures have long used their families to route power and benefits for their own self-enrichment. In my new book, “Profiles in Corruption: Abuse of Power by America’s Progressive Elite,” one particular politician — Joe Biden — emerges as the king of the sweetheart deal, with no less than five family members benefiting from his largesse, favorable access and powerful position for commercial gain. In Biden’s case, these deals include foreign partners and, in some cases, even U.S. taxpayer dollars.

The Biden family’s apparent self-enrichment involves no less than five family members: Joe’s son Hunter, son-in-law Howard, brothers James and Frank, and sister Valerie.

When this subject came up in 2019, Biden declared, “I never talked with my son or my brother or anyone else — even distant family — about their business interests. Period.”

As we will see, this is far from the case…

 oe Biden’s younger brother, James, has been an integral part of the family political machine from the earliest days when he served as finance chair of Joe’s 1972 Senate campaign, and the two have remained quite close. After Joe joined the U.S. Senate, he would bring his brother James along on congressional delegation trips to places like Ireland, Rome and Africa.

When Joe became vice president, James was a welcomed guest at the White House, securing invitations to such important functions as a state dinner in 2011 and the visit of Pope Francis in 2015. Sometimes, James’ White House visits dovetailed with his overseas business dealings, and his commercial opportunities flourished during his brother’s tenure as vice president.

The Virginia Gun Rights Conflict

alt-market |  In my article 'Trump Impeachment And The Civil War Scenario', I warned that conservatives and leftists are being pushed to the brink of a shooting war using various methods of social manipulation and 4^th Gen warfare, and that this conflict, if dictated by gatekeepers of the false Left/Right paradigm, would only benefit establishment elites in the long run. Internal division among the public is designed to keep us at each other's throats while losing focus on the real enemies.

Hard line democrats and the social justice cult are merely a symptom of the disease, they are not the source of the disease. However, I also acknowledge that the rift between conservatives and the political left has become so extreme that reconciliation is almost impossible. War might be unavoidable, and the globalists love it. If they can pretend like they had nothing to do with creating tensions, and if conservatives are so blinded by anger against Democrats that they refuse to admit that some of their own political leaders (including Trump) have been co-opted, the elites win.

The danger in any civil war is that BOTH sides end up being manipulated and controlled, and that the situation is maneuvered towards an outcome that only serves the interests of a select few.

Virginia may be a test bed, a trial run for a nationwide conflagration, and if it does hit a point where state officials compel a violent response from the citizenry, then it is important that liberty advocates remain vigilant and steer clear of incompetent or controlled leaders. It is also important that they remember there is a much larger agenda at play here; the Democrats may be useful idiots fueling that agenda, but most of them are oblivious to their role. Our fight is not with the Democrats, our fight is with the globalists that influence them; the same globalists that are trying to influence us.

First and foremost we have to address the propaganda, because all wars begin first in the public consciousness.  The current situation in Virginia remains a battle of political rhetoric and “fluid” interpretations of the law. Here are the arguments I've seen from the political left so far on the issue of 2^nd Amendment Sanctuaries:

AOC Still Cute, But This Plump, Pasty, Gun-Grabbing Ginger Here...., Really?

dcist |  A planned gun rally in Richmond, Va. on Monday has prompted Governor Ralph Northam to declare a state of emergency in the commonwealth’s capital, citing “credible intelligence” that many of the demonstrators “may be armed, and have as their purpose not peaceful assembly but violence, rioting, and insurrection.” Northam instituted a temporary ban on firearms on State Capitol grounds in anticipation of the demonstration.

But he’s not the only Virginia politician fearful that the protests slated for Martin Luther King, Jr. Day in Richmond could result in a dangerous clash like the fatal Charlottesville Unite the Right rally in 2017.

Facing a series of death threats, Manassas Delegate Lee Carter says he will spend Monday at a safe house instead of the state house, as first reported by Gen.

The threats against Carter—a Democratic Socialist first elected in 2017—also show how an echo chamber of conspiracy theories that begin as social media posts get laundered into mainstream outlets like the Wall Street Journal, and can ultimately lead to real-world peril.

Monday’s rally is a tradition for the Virginia Citizens Defense League, a pro-gun group that lobbies each year in Richmond on Martin Luther King Jr. Day while bearing arms. But this year, a large number of armed militia groups have pledged to join the rally. Northam tweeted that “intelligence suggests militia groups and hate groups, some from out of state, plan to come to the Capitol to disrupt our democratic process with acts of violence.”

At least some of the people who say they’re coming have described it as a “boogaloo,” a word used by the far-right to describe a violent civil war, according to the Daily Beast. This morning, the Federal Bureau of Investigation arrested three suspected members of a neo-Nazi hate group who were considering going to Virginia’s capital for the rally and had more than 1,500 rounds of rifle ammunition, per prosecutors, the New York Times reported.

As these protesters get ready to descend on Richmond, Carter is planning to be at an undisclosed location amid concerns over his safety.

“People were threatening to murder me and murder my family over something I’m not even doing,” Carter tells DCist from Richmond on Wednesday evening. “These threats are more hateful and more numerous than anything I’ve seen before. I mean, I’m the only socialist elected to a legislature in the south, so I do occasionally get waves of death threats—about every two three months it’ll happen—but this one is far larger and far more serious than anything I’ve seen before by orders of magnitude.” Carter has reported the threats to the Virginia Capitol Police.

Could a Hypothetical Cult Operate Without an ACTUAL Public Accountant?

pogo |  KPMG had been performing disastrously on inspections conducted by the Public Company Accounting Oversight Board (PCAOB), and it was under pressure to improve. In the annual inspections, the oversight board scrutinizes a sample of the audits that major accounting firms perform on companies listed on U.S. stock markets. Advance word of which audits the PCAOB planned to inspect would give KPMG an edge.

On Sweet’s first day at the firm, over lunch at a posh Mediterranean restaurant, KPMG brass pumped him for information on the PCAOB’s inspection plans. His second day on the job, in a tête-à-tête in an executive conference room, as Sweet recalled, his boss’s boss referred to the uneasiness Sweet had shown divulging such information and told him he needed to remember where his paycheck came from. His fourth day on the job, while Sweet and his new boss, Thomas Whittle, walked back to the office from lunch at a Chinese restaurant, Sweet told Whittle that he knew which audits the oversight board planned to inspect that year—and that he had taken PCAOB documents with him.

That evening, “Thomas Whittle came by my office where I was sitting and he leaned against the door and asked me to give him the list,” Sweet testified.

Brian Sweet was part of a pipeline that funneled confidential information from KPMG’s prime regulator to KPMG.

The conspiracy took Washington’s notorious revolving door to a criminal extreme. According to the Justice Department, KPMG partners hired PCAOB employees, pumped them for inside information on the oversight board’s plans, and then exploited it to cheat on inspections. Meanwhile, PCAOB employees angled for jobs at KPMG and divulged regulatory secrets to the audit firm.

The case has led to a series of convictions and guilty pleas—and a $50 million administrative fine against KPMG. It also laid bare inner workings of the revolving door in detail seldom seen.

Beyond the conduct labeled as criminal, in little-noticed testimony the case revealed a series of side contacts between senior KPMG partners and top officials of the PCAOB—one, or in some cases two, members of its five-member governing board. The low-profile meetings at locations such as the Capital Hilton, which is steps from the PCAOB’s Washington headquarters, gave KPMG leaders a preview of questioning they would later face at periodic meetings with the full board.

But all of that is just part of a larger picture: The supposedly independent regulator is inextricably tied to the industry it oversees, a Project On Government Oversight (POGO) investigation found.

Q-Anon and "The Cult" Strike Me As Distractions...,

americanthinker |  If you’re unfamiliar with Q or only know it through the media’s attacks, I’d like to provide a brief introduction to this extraordinary phenomenon. I’ve followed Q since the first drop, and I’ve grown increasingly impressed by the accuracy, breadth and depth of Q’s messages. Q followers were prepared long in advance for the easing of hostilities with North Korea, the deflation of the mullahs of Iran, and the discovery of Ukraine as a hotbed of corruption for American politicians. They knew a great deal about Jeffrey Epstein’s activities before the public did and anticipate even more shocking revelations to come. As Q likes to say, “Future proves past.” As Q’s predictions come true, they lend retroactive credibility to the entire enterprise.

Q’s followers believe that Q is a military intelligence operation, the first of its kind, whose goal is to provide the public with secret information. Many Q followers think the Q team was founded by Admiral Michael Rogers, the former Director of the National Security Agency and former Commander of US Cyber Command.  Some suspect that Dan Scavino, White House Director of Social Media, is part of the team, because the high quality of Q’s writing has the luster of a communications expert.

Q is a new weapon in the game of information warfare, bypassing a hostile media and corrupt government to communicate directly with the public. Think of Q as a companion to Trump’s twitter. Whereas Trump communicates bluntly and directly, Q is cryptic, sly and subtle, offering only clues that beg for context and connection.

Here’s the way it works: Q posts messages (also known as “drops” or “crumbs”) on an anonymous online forum, which are discussed, analyzed, and critiqued by the board’s inhabitants. (The forum has changed a few times after massive online attacks.) Hundreds of social media accounts then spread Q’s latest posting to worldwide followers who share their research, analysis, and interpretations of Q’s latest information.

Human Supremacy Alert : Urgently Repeating Myself for Slow Cats...,

PNAS |  Most technologies are made from steel, concrete, chemicals, and plastics, which degrade over time and can produce harmful ecological and health side effects. It would thus be useful to build technologies using self-renewing and biocompatible materials, of which the ideal candidates are living systems themselves. Thus, we here present a method that designs completely biological machines from the ground up: computers automatically design new machines in simulation, and the best designs are then built by combining together different biological tissues. This suggests others may use this approach to design a variety of living machines to safely deliver drugs inside the human body, help with environmental remediation, or further broaden our understanding of the diverse forms and functions life may adopt.  

ABSTRACT

Living systems are more robust, diverse, complex, and supportive of human life than any technology yet created. However, our ability to create novel lifeforms is currently limited to varying existing organisms or bioengineering organoids in vitro. Here we show a scalable pipeline for creating functional novel lifeforms: AI methods automatically design diverse candidate lifeforms in silico to perform some desired function, and transferable designs are then created using a cell-based construction toolkit to realize living systems with the predicted behaviors. Although some steps in this pipeline still require manual intervention, complete automation in future would pave the way to designing and deploying unique, bespoke living systems for a wide range of functions.

Most modern technologies are constructed from synthetic rather than living materials because the former have proved easier to design, manufacture, and maintain; living systems exhibit robustness of structure and function and thus tend to resist adopting the new behaviors imposed on them. However, if living systems could be continuously and rapidly designed ab initio and deployed to serve novel functions, their innate ability to resist entropy might enable them to far surpass the useful lifetimes of our strongest yet static technologies. As examples of this resistance, embryonic development and regeneration reveal remarkable plasticity, enabling cells or whole organ systems to self-organize adaptive functionality despite drastic deformation (1, 2). Exploiting the computational capacity of cells to function in novel configurations suggests the possibility of creating synthetic morphology that achieves complex novel anatomies via the benefits of both emergence and guided self-assembly (3).

Currently, there are several methods underway to design and build bespoke living systems. Single-cell organisms have been modified by refactored genomes, but such methods are not yet scalable to rational control of multicellular shape or behavior (4). Synthetic organoids can be made by exposing cells to specific culture conditions but very limited control is available over their structure (and thus function) because the outcome is largely emergent and not under the experimenter’s control (5). Conversely, bioengineering efforts with 3D scaffolds provide improved control (6⇓–8), but the inability to predict behavioral impacts of arbitrary biological construction has restricted assembly to biological machines that resemble existing organisms, rather than discovering novel forms through automatic design.

Meanwhile, advances in computational search and 3D printing have yielded scalable methods for designing and training machines in silico (9, 10) and then manufacturing physical instances of them (11⇓–13). Most of these approaches employ an evolutionary search method (14) that, unlike learning methods, enables the design of the machine’s physical structure along with its behavior. These evolutionary design methods continually generate diverse solutions to a given problem, which proves useful as some designs can be instantiated physically better than others. Moreover, they are agnostic to the kind of artifact being designed and the function it should provide: the same evolutionary algorithm can be reconfigured to design drugs (15), autonomous machines (11, 13), metamaterials (16), or architecture (17).

Here, we demonstrate a scalable approach for designing living systems in silico using an evolutionary algorithm, and we show how the evolved designs can be rapidly manufactured using a cell-based construction toolkit. The approach is organized as a linear pipeline that takes as input a description of the biological building blocks to be used and the desired behavior the manufactured system should exhibit (Fig. 1). The pipeline continuously outputs performant living systems that embody that behavior in different ways. The resulting living systems are novel aggregates of cells that yield novel functions: above the cellular level, they bear little resemblance to existing organs or organisms.

EVERY Machine is Vulnerable to Unadvertised Behaviors (I Don't Play Guitar, I Play Electricity)

lareviewofbooks |  The past two decades have brought two interrelated and disturbing developments in the technopolitics of US militarism. The first is the fallacious claim for precision and accuracy in the United States’s counterterrorism program, particularly for targeted assassinations. The second is growing investment in the further automation of these same operations, as exemplified by US Department of Defense Algorithmic Warfare Cross-Functional Team, more commonly known as Project Maven.

Artificial intelligence is now widely assumed to be something, some thing, of great power and inevitability. Much of my work is devoted to trying to demystify the signifier of AI, which is actually a cover term for a range of technologies and techniques of data processing and analysis, based on the adjustment of relevant parameters according to either internally or externally generated feedback

Some take AI developers’ admission that so-called “deep-learning” algorithms are beyond human understanding to mean that there are now forms of intelligence superior to the human. But an alternative explanation is that these algorithms are in fact elaborations of pattern analysis that are not based on significance (or learning) in the human sense, but rather on computationally detectable correlations that, however meaningless, eventually produce results that are again legible to humans. From training data to the assessment of results, it is humans who inform the input and evaluate the output of the algorithmic system’s operations.

When we hear calls for greater military investments in AI, we should remember that the United States is the overwhelmingly dominant global military power. The US “defense” budget, now over $700 billion, exceeds that of the next eight most heavily armed countries in the world combined (including both China and Russia). The US maintains nearly 800 military bases around the world, in seventy countries. And yet a discourse of US vulnerability continues, not only in the form of the so-called war on terror, but also more recently in the form of a new arms race among the US, China and Russia, focused on artificial intelligence.

The problem for which algorithmic warfare is the imagined solution was described in the early 19th century by Prussian military theorist Carl von Clausewitz, and subsequently became known as the “fog of war.” That phrase gained wider popular recognition as the title of director Errol Morris’s 2003 documentary about the life and times of former US Defense Secretary Robert McNamara. In the film, McNamara reflects on the chaos of US operations in Vietnam. The chaos made one thing clear: reliance on uniforms that signal the difference between “us” and “them” marked the limits of the logics of modern warfighting, as well as of efforts to limit war’s injuries.

Was the Real Cause of Physics Winter 1990 Immigration Reform?

iai |  In the foundations of physics, we have not seen progress since the mid 1970s when the standard model of particle physics was completed. Ever since then, the theories we use to describe observations have remained unchanged. Sure, some aspects of these theories have only been experimentally confirmed later. The last to-be-confirmed particle was the Higgs-boson, predicted in the 1960s, measured in 2012. But all shortcomings of these theories – the lacking quantization of gravity, dark matter, the quantum measurement problem, and more – have been known for more than 80 years. And they are as unsolved today as they were then.

The major cause of this stagnation is that physics has changed, but physicists have not changed their methods. As physics has progressed, the foundations have become increasingly harder to probe by experiment. Technological advances have not kept size and expenses manageable. This is why, in physics today, we have collaborations of thousands of people operating machines that cost billions of dollars.

With fewer experiments, serendipitous discoveries become increasingly unlikely. And lacking those discoveries, the technological progress that would be needed to keep experiments economically viable never materializes. It’s a vicious cycle: Costly experiments result in lack of progress. Lack of progress increases the costs of further experiment. This cycle must eventually lead into a dead end when experiments become simply too expensive to remain affordable. A $40 billion particle collider is such a dead end.

The only way to avoid being sucked into this vicious cycle is to choose carefully which hypothesis to put to the test. But physicists still operate by the “just look” idea like this was the 19th century. They do not think about which hypotheses are promising because their education has not taught them to do so. Such self-reflection would require knowledge of the philosophy and sociology of science, and those are subjects physicists merely make dismissive jokes about. They believe they are too intelligent to have to think about what they are doing.

The consequence has been that experiments in the foundations of physics past the 1970s have only confirmed the already existing theories. None found evidence of anything beyond what we already know.

But theoretical physicists did not learn the lesson and still ignore the philosophy and sociology of science. I encounter this dismissive behavior personally pretty much every time I try to explain to a cosmologist or particle physicists that we need smarter ways to share information and make decisions in large, like-minded communities. If they react at all, they are insulted if I point out that social reinforcement – aka group-think – befalls us all, unless we actively take measures to prevent it.

Do We REALLY Have a Long Way to Go and a Short Time to Get There?

bbc |  At the start of the 2010s, one of the world leaders in AI, DeepMind, often referred to something called AGI, or "artificial general intelligence" being developed at some point in the future. 

Machines that possess AGI - widely thought of as the holy grail in AI - would be just as smart as humans across the board, it promised. 

DeepMind's lofty AGI ambitions caught the attention of Google, who paid around £400m for the London-based AI lab in 2014 when it had the following mission statement splashed across its website: "Solve intelligence, and then use that to solve everything else."

Several others started to talk about AGI becoming a reality, including Elon Musk's $1bn AI lab, OpenAI, and academics like MIT professor Max Tegmark. 

In 2014, Nick Bostrom, a philosopher at Oxford University, went one step further with his book Superintelligence. It predicts a world where machines are firmly in control.

But those conversations were taken less and less seriously as the decade went on. At the end of 2019, the smartest computers could still only excel at a "narrow" selection of tasks. 

Gary Marcus, an AI researcher at New York University, said: "By the end of the decade there was a growing realisation that current techniques can only carry us so far."

He thinks the industry needs some "real innovation" to go further.

"There is a general feeling of plateau," said Verena Rieser, a professor in conversational AI at Edinburgh's Herriot Watt University. 

One AI researcher who wishes to remain anonymous said we're entering a period where we are especially sceptical about AGI. 

"The public perception of AI is increasingly dark: the public believes AI is a sinister technology," they said. 

For its part, DeepMind has a more optimistic view of AI's potential, suggesting that as yet "we're only just scratching the surface of what might be possible".

"As the community solves and discovers more, further challenging problems open up," explained Koray Kavukcuoglu, its vice president of research.

"This is why AI is a long-term scientific research journey.

"We believe AI will be one of the most powerful enabling technologies ever created - a single invention that could unlock solutions to thousands of problems. The next decade will see renewed efforts to generalise the capabilities of AI systems to help achieve that potential - both building on methods that have already been successful and researching how to build general-purpose AI that can tackle a wide range of tasks."

Human Supremacy - A New Political Axis of Man's Possible Development?

jacobin |  Populism involves the exclusion of elements from society not considered a part of the “people,” usually cultural “others” and the ambiguously defined “elites” or “anti-nationals.” A nationalist populist discourse, as in the Indian case, differentiates between who belongs to the nation and who does not. Hindutva’s “people” is imagined as a religious and ethno-cultural Hindu community which excludes Muslims and liberal elites.

In addition to delimiting the authentic “people,” this form of populism typically relies on a leader who claims to be the sole representative of the people and the embodiment and authority of the popular will. Modi is a paradigmatic example of such a leader.

At an event hosted by the Indian diaspora in Houston, the “Howdy Modi?” rally, Modi’s answer to the rhetorical question was revealing: “Modi is nothing by himself. I am only a common man working on the orders of 1.3 billion people. So, when you ask, ‘Howdy Modi?’ I can only answer, ‘everything in Bharat is good.’” Despite the pretensions of humility, Modi understands the populist logic well: to ask the question how is Modi is precisely to ask how is the nation.

Additionally, this form of populism is a political style which involves a whole repertoire of staged, mediatized performances by the leader that are transmitted to wider audiences through media. Part of the performative rhetoric of such populist leaders centers around some kind of a pervasive crisis or threat. With Modi and the BJP, there is ever present specter of “Urban-Naxals,” “terrorists,” “anti-nationals,” “Tukde-Tukde Gang,” and “Khan Market Gang,” all of whom are portrayed as trying to undermine the integrity of the nation, and in effect polluting the purity of the people.

These Are Novel Living Machines

telegraph | The world’s first living robots have been built using stem cells from frog embryos, in a strange machine-animal hybrid that scientists say is an ‘entirely new life-form.’

Dubbed ‘xenobots’ because they are constructed of biological material taken from the Xenopus laevis frog, the little bots are the first to be constructed from living cells.

Researchers are hopeful they could be programmed to move through arteries scraping away plaque, or swim through oceans removing toxic microplastic.

And because they are alive, they can replicate and repair themselves if damaged or torn.

“These are novel living machines,” said Dr Joshua Bongard, a computer scientist and robotics expert at the University of Vermont, who co-led the new research.

“They're neither a traditional robot nor a known species of animal. It's a new class of artifact: a living, programmable organism.”

Living organisms have often been manipulated by humans in the past, right down to their DNA code, but this is the first time that biological machines have been built completely from scratch.

Scientists first used the Deep Green supercomputer cluster at the University of Vermont to create an algorithm that assembled a few hundred virtual skin and heart cells into a myriad forms and body shapes, for specific tasks.

Based on the blueprints, a team of biologists from Tufts University, Massachusetts, then assembled the cells into living bots, just one millimetre wide. 

Stakes is High - So the DNC Lies, and Lies, and Lies....,

CNN |  The stakes were high when Bernie Sanders and Elizabeth Warren met at Warren's apartment in Washington, DC, one evening in December 2018. The longtime friends knew that they could soon be running against each other for president. 

The two agreed that if they ultimately faced each other as presidential candidates, they should remain civil and avoid attacking one another, so as not to hurt the progressive movement. They also discussed how to best take on President Donald Trump, and Warren laid out two main reasons she believed she would be a strong candidate: She could make a robust argument about the economy and earn broad support from female voters.

 

Sanders responded that he did not believe a woman could win.

 

The description of that meeting is based on the accounts of four people: two people Warren spoke with directly soon after the encounter, and two people familiar with the meeting. 

 

That evening, Sanders expressed frustration at what he saw as a growing focus among Democrats on identity politics, according to one of the people familiar with the conversation. Warren told Sanders she disagreed with his assessment that a woman could not win, three of the four sources said.

Sanders denied the characterization of the meeting in a statement to CNN. 

 

"It is ludicrous to believe that at the same meeting where Elizabeth Warren told me she was going to run for president, I would tell her that a woman couldn't win," Sanders said. "It's sad that, three weeks before the Iowa caucus and a year after that private conversation, staff who weren't in the room are lying about what happened. What I did say that night was that Donald Trump is a sexist, a racist and a liar who would weaponize whatever he could. Do I believe a woman can win in 2020? Of course! After all, Hillary Clinton beat Donald Trump by 3 million votes in 2016."

 

Warren's communications director Kristen Orthman declined to comment.

DNC Pissing Its Granny Pannies Over Truth and Popularity of the Bern...,

thehill |  Democrats who believe Sen. Bernie Sanders (I-Vt.) had a negative influence on the 2016 general election against President Trump are increasingly expressing worries he’ll hurt the party again in 2020. 

The Democrats complaining about Sanders, some of whom have histories with former Secretary of State Hillary Clinton’s presidential campaign, argue the rhetoric being employed by the Vermont senator in some cases goes too far in damaging his rivals. 

They say it will make it harder for the party to unify around a nominee, and they’re particularly worried that supporters of Sanders won’t back any nominee who isn’t their favored candidate.

“He needs to stop,” said one Democratic strategist, who is not affiliated with any of the presidential campaigns. “It's not helpful and it actually hurts the party. It’s like he didn't learn his lesson the last time. It’s incredibly short-sighted and terrible.”

This strategist pointed to the senator’s recent remarks in a Los Angeles Times editorial board meeting where he said that Trump would eat former Vice President Joe Biden’s lunch if he is the nominee. 

“Joe Biden is a personal friend of mine, so I’m not here to, you know, to attack him, but my God, if you are, if you’re a Donald Trump and got Biden having voted for the war in Iraq, Biden having voted for these terrible, in my view, trade agreements, Biden having voted for the bankruptcy bill. Trump will eat his lunch,” Sanders told the Times.

Biden isn't the only rival Democrat taking fire from Sanders, and it's not just those who worked on the Clinton campaign who are complaining about him....

... Sanders is rising in polls and increasingly is seen as a real contender in the Iowa caucuses and New Hampshire primary — and for the general election. A new poll released Friday found Sanders with 20 percent support and Warren in second with 17 percent, just ahead of former South Bend, Ind., Mayor Pete Buttigieg (D) with 16 percent and Biden with 15 percent.

Some of the Democratic angst about his rhetoric seems linked to the idea that he could actually win. 

Lottery Underway for One Hundred Doses of the Most Expensivist...,

thescientist |  SMA occurs from having two copies of a mutated version of the survival motor neuron 1 (SMN1) gene, which is responsible for the proteins that maintain neurons related to muscle movement. Without proper signals from the brain to move, muscles begin to atrophy and cause a host of related problems, such as decreased mobility and an inability to swallow. Many patients die by age two, and applicants for the lottery must be under two years old. The drug, given intravenously, provides the brain with a functional copy of SMN1 through a viral vector.

Pharmaceutical giant Novartis has begun accepting applications for a lottery-based program to give away 100 doses of a gene therapy for spinal muscular atrophy, a sometimes-deadly muscle-wasting disease that affects about 1 in 10,000 births. The initiative will provide access to children with SMA living in countries where the intervention, Zolgensma, has not yet been approved. But there are far more than 100 patients who could be eligible.

The company has cited production limitations as the reason for high treatment costs and limited doses for the lottery. An independent bioethics committee worked with Novartis to develop the terms of the lottery.

“It’s a difficult situation,” Ricardo Batista, the father of an infant with SMA who lives in Canada, tells The Globe And Mail. “It’s a lottery where we’re leaving children’s lives up to chance. I don’t think it’s a game that any of us want to play.”

Biologics Global Market Opportunities And Strategies To 2021

Shortly before I went on "hiatus" last year, I posted about the Nobel given for "directed evolution" and what I casually referred to as "Mubabs" - you know - all those newfangled biologic medicines that have become pervasive mainstays of broadcast and print advertising. I thought it was amusing just how many oddly named mubabs there were and began collecting the oddly named drugs and what they were prescribed for summer before last.

reportlinker  |  The biologics industry comprises companies manufacturing biological products that are derived from genetically modified proteins and human genes.Biologics products include a wide range of recombinant therapeutic proteins, vaccines, and monoclonal antibodies.

These products are isolated from natural sources such as human, animal, and microorganisms by biotechnological methods and other cutting-edge technologies.

Executive Summary
The global biologics market was worth $221 billion in 2017 and is essentially segmented into monoclonal antibodies, therapeutic proteins and vaccines. Biologics are very large complex molecules manufactured in a living system such as microorganisms, animal cells or plant cells. They are produced using the recombinant DNA technology and are composed of sugars, proteins, nucleic acids or a combination of these substances. In 2017, 12 biologics were approved in the USA, 10 in European Union and 7 in Japan. There are over 1000 biologics under development which will drive the biologics market in the future. Cancer is the therapeutic area with maximum number of biologics under development and Alzheimer’s has the least number.

Of the total biologics market across the globe, Monoclonal antibodies (mAbs) accounted for a share of 43% in 2017 and was worth $94 billion. North America had the highest share in 2017 at $39.2 billion followed by Western Europe with a market value of $26.4 billion. Asia-Pacific was the third largest market with a share of 12% and a market value of $11.4 billion. mAbs are biological drugs that recognize and bind to a specific antigen that causes various chronic health conditions such as arthritis, cancer, multiple sclerosis. mAbs can be further segmented based on the presence of different amounts of murine (mouse or rat origin) sequences in the variable region. The segments consist of murine mAbs, chimeric mAbs, human and humanized mAbs. Of these, humanized mAbs accounted for 43% share in the monoclonal antibody market with a market value of $37.6 billion followed by human mAbs and chimeric mAbs at $32.9 billion and $18.8 billion respectively. Murine mAbs accounted only for 5% of the total mAbs market and was worth $4.7 billion in 2017.

Therapeutic proteins or recombinant proteins are engineered in the laboratory and works by targeting therapeutic process which compensates for the deficiency of an essential protein. Therapeutic proteins include cytokines, peptide hormones and enzymes. The market for therapeutic protein was worth $80 billion in 2017 accounting for a share of 36% of the global biologics market. North American market for therapeutic proteins was worth $33 billion in 2017 followed by Western Europe at $17.3 billion. The market in Asia Pacific was worth $11.3 billion and the markets in South America, Eastern Europe, Middle East and Africa accounted only for 4%, 6%, 9% and 4% respectively. Based on the segmentation of therapeutic proteins into cytokines, peptide hormones and enzymes, peptide hormones accounted for 45% of the market followed by cytokines at 18% and enzymes at 10% share. Other blood factors also had a share of around 27% in the total therapeutic proteins market globally.

Eric Weinstein Explains The Replacement Negroe Program

ineteconomics |  Upcoming labor market shortages will devastate Science and Engineering.

This was a mantra heard through much of the 1980s.  And yet, the predicted “seller’s market” for talent never materialized as unemployment rates actually spiked for newly minted PhDs in technical fields. In fact, most US economists seemed to think that the very idea of labor market shortages hardly made sense in a market economy since wages could simply rise to attract more entrants.

In the late nineties, in the course of research into immigration, I became convinced that our US high skilled immigration policy simply did not add up intellectually. As I studied the situation, it became increasingly clear that the groups purporting to speak for US scientists in Washington DC (e.g. NSF, NAS, AAU, GUIRR) actually viewed themselves as advocates for employers in a labor dispute with working scientists and were focused on undermining scientists’ economic bargaining power through labor market intervention and manipulation. 

Increasingly the research seemed to show that interventions by government, universities and industry in the US labor market for scientists, especially after the University system stopped growing organically in the early 1970s were exceedingly problematic. By 1998, it was becoming obvious that the real problems of high skilled immigration were actually rather well understood by an entire class of policy actors who were not forthcoming about the levers of policy they were using to influence policy. The NSF/NAS/GUIRR complex appeared to be feigning incompetence by issuing labor market studies that blatantly ignored wages and market dynamics and instead focused on demographics alone. 

During the late 1990s I became convinced that in order to orchestrate lower wages for scientists, there would have to have been a competent economic study done to guide the curious policy choices that had resulted in the flooded market for STEM PhDs. For this theory to be correct, the private economic study would have had to have been done studying both supply and demand so that the demand piece could later be removed, resulting in the bizarre ‘supply only’ demographic studies released to the public. Through a bit of economic detective work, I began a painstaking search of the literature and discovered just such a study immediately preceded the release of the foolish demography studies that provided the public justification for the Immigration Act of 1990. This needle was located in the haystack of documents the NSF was forced to turn over when the House investigated the NSF for faking alarms about a shortfall. 

The title of this study was “The Pipeline For Scientific and Technical Personnel: Past Lessons Applied to Future Changes of Interest to Policy-Makers and Human Resource Specialists.” The study was undated and carried no author’s name. Eventually I gathered my courage to call up the National Science Foundation and demand to speak to the study’s author. After some hemming and hawing, I was put through to a voice belonging to a man I had never heard of named Myles Boylan. In our conversation, it became clear that it was produced in 1986, as predicted, immediately before the infamous and now disgraced demographic shortfall studies. 

The author turned out, again as predicted, not to be a demographer, but a highly competent Ph.D. in economics who was fully aware of the functioning of the wage mechanism. But, as the study makes clear, the problem being solved was not a problem of talent but one of price: scientific employers had become alarmed that they would have to pay competitive market wages to US Ph.D.s with other options. The study’s aim was not to locate talent but to weaken its ability to bargain with employers by using foreign labor to undermine the ability to negotiate for new Ph.D.s 

That study was a key link in a chain of evidence leading to an entirely different view of the real origins of the Immigration Act of 1990s and the H1-B visa classification. In this alternative account, American industry and Big Science convinced official Washington to put in place a series of policies that had little to do with any demographic concerns. Their aims instead were to keep American scientific employers from having to pay the full US market price of high skilled labor. They hoped to keep the US research system staffed with employees classified as “trainees,” “students,” and “post-docs” for the benefit of employers. The result would be to render the US scientific workforce more docile and pliable to authority and senior researchers by attempting to ensure this labor market sector is always flooded largely by employer-friendly visa holders who lack full rights to respond to wage signals in the US labor market.

We Wuz BadMuhhukkahs Till We Got Hoodwinked, Bamboozled, Raped, and Pillaged Like Little Bishes..,.,

Full Paper

NAP |  The academic research community in the United States is heading toward an era of unparalleled discovery, productivity, and excitement. In fields as diverse as computing and materials science, high-energy physics and psychology, cosmology and the neurosciences, university-based research will open new worlds of knowledge and make possible innovations not yet imagined. The research enterprise holds great promise for advancing social, health, and economic goals into the next century.

The academic research community in the United States is heading toward an era of unparalleled discovery, productivity, and excitement. In fields as diverse as computing and materials science, high-energy physics and psychology, cosmology and the neurosciences, university-based research will open new worlds of knowledge and make possible innovations not yet imagined.

This hopeful vision for the U.S. academic research enterprise motivated the working group's deliberations and analyses. To achieve this vision, the enterprise must be guided wisely by current and future generations of investigators, university administrators, the sponsors of research, and the broader public. The working group's strong and positive presentation of this vision assumes that such guidance will prevail.

Dynamic change is a central component of this vision. The research enterprise of the future will be unlike the one of today. Significant opportunities and challenges can be expected in the decades ahead.

A GLOBAL RESEARCH SYSTEM

International research cooperation will become a pervasive feature of the U.S. academic research enterprise in the next century. Multinational research arrangements will be essential for studying such phenomena as large-scale environmental effects and the most demanding experimental problems in the physical and biological sciences. The research communities of both industrialized and developing countries will rely more and more on cooperative ventures to address these and other research problems. Just as foreign-based companies now support research in U.S. universities, in the future more governments and industries are likely to support the research activities of other nations.

Over the next few decades, the number of nations with highly effective research systems will grow. Their university, government, and industry laboratories will collaborate in novel, imaginative, and effective ways. Global competition in science and technology will require that the United States pay close attention to the research activities of other countries, especially those targeting economic growth as their primary research goal. This will be particularly true for the Western European and Pacific Rim countries, which have become fierce competitors in the knowledge-intensive global marketplace. Several of the newly democratized nations of Eastern

International research cooperation will become a pervasive feature of the U.S. academic research enterprise in the next century.

Epstein a Construct: One of His Functions - Funding Blue-Sky Science

Weinstein holding out on an Epstein podcast because of a creepy threatening dinner at which he was told not to put out what he thinks and knows?

Weinstein meets Epstein before Florida charges. Goes to Epstein's house where Epstein plainly signals that he's recording guests, Epstein meets Weinstein in a dining room where Epstein desecrates the flag,  Weinstein is not judgemental about consenting adults, though he believe Epstein is Humbert Humbert not living up to the requirements of his construct role.

Science people continued talking to Epstein after charges because he funded cowboy science disagreeable to the "woke" crowd. Science people knew that it wasn't Epstein funding them, but that it was "something else" funding them through the Epstein construct.  The Govt. stepped away from blue sky science in 1986 under Reagan.

The Govt underfunds science. So when the "rich guy" comes into the room, it matters. The NSF National Academy of Science under Eric Block and the Government and University Research Round Table conspired to destroy the bargaining power of scientists as laborers by implementing a replacement negroe program for science. The Reagan Govt. realized it could import scientists from China, Taiwan, South Korea and India. 

H1-B's and the 1990 Immigration Reform Act took China from 0-60 in half a second and launched our current great power nemesis. The Vannevar Bush Endless Frontier Agreement was abandoned in favor of importing cheap, foreign STEM workers. Asymmetric access to the labor market is fundamental right of citizenship argues Weinstein, and this fundamental right was stripped pursuant to capital interests in removing the privileged labor value of American STEM workers and replacing them with cheap, foreign STEM workers at a 100-1 ratio.

Vulture capitalism metastatically destroyed American fundamental science! Sam Harris makes some weak and trifling "free market" mouth noises, but realizes he's up against an informational rock and a hard place in Weinstein. Then the discussion veers back to creepy-assed Epstein and the holes he was filling....,

MIT and Jeffrey Epstein

MIT |  On January 10, 2020, the Executive Committee of the MIT Corporation, the Institute’s governing board, released the results of Goodwin Procter’s fact-finding regarding interactions between Jeffrey Epstein and the Institute. In September 2019, at the request of President L. Rafael Reif and the Executive Committee, MIT's General Counsel retained the firm to design and conduct the fact-finding process.

• View Goodwin Procter’s report
• View the Executive Committee's statement
• View President Reif's letter to the community
• View the MIT News article
• View frequently asked questions