No Time Or Place Or Space For Thee - But Eternity's For Meeee...,

euronews  |  What if you could live forever? It's a question long pondered by fictional supervillains and Silicon Valley billionaires alike.

Now researchers in Japan say they may have taken a step toward boosting human longevity with successful trials of a vaccine against the cells that contribute to the ageing process.

In laboratory trials, a drug targeting a protein contained in senescent cells - those which have naturally stopped reproducing themselves - slowed the progression of frailty in older mice, the researchers from Tokyo's Juntendo University said.

The vaccine also successfully targeted the senescent cells in fatty tissue and blood vessels, suggesting it could have a positive impact on other medical conditions linked to ageing.

"We can expect that (the vaccine) will be applied to the treatment of arterial stiffening, diabetes and other ageing-related diseases," Juntendo professor Toru Minamino told Japan's Jiji news agency.

What is cellular senescence?

Cells become senescent when they stop duplicating themselves, often in response to naturally-occurring damage to their DNA. Cellular senescence is thought to contribute to the ageing process itself, as well as ageing-related diseases like Alzheimer's and some cancers.

"Senescent cells secrete a series of factors that disrupt the function of the tissue," Dr Salvador Macip, head of the University of Leicester's Mechanisms of Cancer and Ageing Lab, told Euronews Next.

"They 'call' cells from the immune system, in theory to be cleared by them (but that eventually fails) and create a chronic low level inflammation, mixed with fibrosis," Macip said.

Macip was part of an international team of academics from universities in the UK, Spain, Nigeria and Saudi Arabia that published research on another method of tackling senescent cells in October this year.

"The biological process of ageing is very complex, therefore it is unlikely that one single strategy will completely stop it or reverse it. However, there are probably many ways to slow it down, and clearing senescent cells seems to be one of the easiest and potentially more effective," he said.