international bioterrorism tabletop exercise

Interpol | In September 2009, senior law enforcement officials, health care professionals and experts from international organizations joined their forces to confront a chilling crisis – the plague had just been unleashed on their countries by unknown evildoers.

A fictional scenario with a serious aim

Fortunately, this terrifying situation was a scenario under control, and the civilian authorities were all participants in a Tabletop Exercise on Preventing Bioterrorism hosted by INTERPOL. This exercise simulated a global bioterrorism attack and its aftermath. Participants in the Black Death scenario were faced with a fictional, intentional plague attack involving countries from their region, with the exercise designed to assist them in identifying critical co-operation and co-ordination issues which could hinder a quick and successful response to such an attack in real life.

The idea behind this exercise, the third in a series organized by INTERPOL, has been described by the Organization's Secretary General, Ronald K. Noble, as “helping focus our joint understanding of the role and responsibility of each of us – police, health care professionals, experts – in response to a bioterrorism incident, as well as identifying possible gaps or redundancies so that we can draw lessons from them.”

Inter-agency co-operation in Central and Eastern Europe

Organized by the INTERPOL Bioterrorism Unit, this third edition of the event took place from 29-30 September in Warsaw, Poland. Participants in the workshop numbered 27 from six Central and Eastern European countries (Belarus, Czech Republic, Finland, Poland, Slovakia, Ukraine), as well as 15 participants from international organizations such as Europol, the UN Office for Disarmament Affairs (UNODA), the World Health Organization (WHO), the European Centre for Disease Control, the European Commission (Directorate General for Health and Consumer Affairs and Directorate General for Justice, Freedom and Security), the Organization for Security and Co-operation in Europe and the Commonwealth of Independent States (CIS).

u.s. to donate 1/10th of its H1N1 vaccine to ukraine

Kyiv Post | "In an effort to stop the global spread of pandemic 2009 H1N1 influenza virus, the United States is planning to donate 10 percent of US domestic H1N1 vaccine supply, as it becomes available, to a WHO-led H1N1 vaccine initiative. The US donation to WHO, equivalent to 25 million doses of vaccine, would be valued commercially at approximately $10 million," the embassy said in a statement.

As part of the first phase of this initiative, Ukraine is scheduled to receive 930, 000 doses of H1N1 vaccine in early December, the embassy said.

"Planning to complement this donation with a broad range of interventions to support the safe delivery and deployment of the vaccines, the US government will be working closely with the government of Ukraine in the days ahead to identify needs and agree on a package of immunization-related commodity and technical support that can be implemented rapidly to support H1N1 immunization," the statement reads.

Besides, the US government is prepared to make available immunization ancillary materials such as syringes, needles, and vaccine safety disposal boxes, to provide technical support for immunization planning as well as for logistics and assistance to transport the vaccine, to train vaccinators and other professionals, and to prepare communications materials in support of the immunization campaign.

yushchenko team unveils sinister plans for declaring state of emergency

Zik | Speaking live on the popular 5th TV Kanal Nov. 6, the secretary of the national security and defense council, NSDC, Rayisa Bohatyryova, said the number of flue victims is so large it may be necessary to declare the state of emergence to effectively deal with the outbreak. [According to the health ministry, as of Nov. 5, there were 13 cases of the swine flue by a London lab. The number of Ukrainian who died from all kinds of flue and cold stands at about 100, or fewer than in 2008 – Ed.].

The constitution gives enough legal ground for Yushchenko to declare the emergency, Bohatyryova claimed.

As the country’s politicians cannot join their forced to combat the flue epidemic, the state of emergency may help to do this, Bohatyryova continued. All the causes of why Ukraine found itself amid the flue hurricane must be investigated and perpetrators be brought to account. But the punishment can come later. Not it is important to help the population and not to sow panic, the official summed up.

Another Yushchenko insider, his deputy chief of staff Ihor Popov believes the uncontrolled swine flue epidemic is a good enough reason for putting off the presidential election till May 30, Popov writes in his article “Elections lead to swine scenario” published by the Ukrayinska Pravda.

The flue outbreak has radically changed the course of presidential campaigning in Ukraine. It affected campaign priorities, played havoc with campaign plans, leading candidates’ teams to revise spin tactics to hype their candidates, Popov said.

In his opinion, the outbreak in Ukraine was quite timely, as without all the hubbub and rhetoric about the flue the ratings of presidential candidates would not have changed even by Feb. 7. It is the full-sized epidemic, when all Ukrainians are involved with their emotions and panic, that can affect the voting results, the official claimed.

Popov ruled out the purposeful nature of the outbreak. “Experts proved that the epidemic is here and it will take more than a week to deal with it. Unfortunately, we missed the start of the epidemic, as we did the financial crisis,” Popov noted.

Popov then listed benefits from the state of emergency, saying it will allow to control the distribution of drugs with the help of interior troops, enforce the ban on mass rallies, ensure implementation of decisions by the NSDC and minimize declarations by politicians regarding the flue handling. Also, the vertical chain of staffs set up as a result of declaring the state of emergency will curb red-tape and competition of ministries.

withheld ukraine sequences raise pandemic concerns

Recombinomics | Right now we know that many clinical specimens and viruses have been sent to one of the WHO collaborating centres for further study. We don't know the results of those studies, and it will probably take a couple of days for the full analysis of those viruses to be available. But in the meantime, what we do not have is any evidence of viruses there or anywhere else as showing any big mutations. I raise this point because I have seen in some media reports that there are reports that WHO or other groups are saying that there are mutations and I want to point out that these are rumours and factually, untrue.

The above comments from Keiji Kukuda offer some general comments on the Ukrainian H1N1 sequences at Mill Hill in London. He specifically says WHO doesn't see any "big" mutations in the samples being sequenced, which would refer to reassortment or Tamiflu resistance. However, the changes seen in Ukraine do not require "big" mutations. Small mutations, such as SNP can have profound effects for a virus like pandemic H1N1.

That virus normally circulates in swine, and has recently jumped to humans. It already has many characteristics with the 1918 pandemic strain. Both are swine H1N1 that jumped to humans. Such species jumpers can increase efficiencies with small changes. One good example is position 627 in the PB2 gene. That position comes in two forms. When there is glutamic acid (E) at that position, the PB2 enzyme copies the viral genetic material most efficiently at 41 C, the body temperature of a bird. However, if that position has a lysine (K), the enzyme is most active at 33 C, the temperature of a human nose in the winter. The swine H1N1 has an E, which may be why it goes well in lung, which is 37 C and closer to the optimal replication temperature of 41C. However, a single change that produced the most efficient replication at 37C would lead to even higher levels in the lungs, which could lead to frequent cytokine storms, like those in 1918, instead of the less frequent level seen in Ukraine.

However, the rapid spread of H1N1 in Ukraine (see map), coupled with the high frequency of hemorrhagic pneumonia raise concerns that a small change is leading to a more virulent virus. Similarly, the rapid spread of the virus could also be affected by a small change in another gene, such as HA, which controls entry of the virus to cells and influences tissue tropism.

Mill Hill has acknowledged that they have at least 15 H1N1 positive samples from Ukraine, which would identify a Ukranian specific change. The delay in the announcement of sequence results raises concerns that such changes have been detected, and such changes are undergoing further analysis.

The number of cases in Ukraine continues to expand. The number of patients with H1N1 symptoms is now approaching 1 million. Cases have been increasing at almost 200,000 per day, so it is likely that tomorrow's report will have over 1 million cases. This rapid spread increases concern that the 15 sequences at Mill Hill contain one or more of these small changes, which has led to a delay in the announcement of sequence results.

More detail on the sequences at Mill Hill is overdue. The rapid spread of H1N1 in Ukraine demands rapid sequence results. Continued delay will only increase concerns.

national h1n1 epidemic declared in bulgaria

Recombinomics | The Health Ministry made the decision based on the grounds that the number of people with swine flu has reached 210 per 10 000.

Thus, all schools in Bulgaria will be in a swine flu break all of next week (9-14 November). The Health Ministry recommends limiting the number and scope of public events.

The above comments describe the declaration of a national swine flu epidemic in Bulgaria. Earlier this week an epidemic level of H1N1 had been reported in a select number of Oblasts and municipalities (see map). However, this level was subsequently reported for the entire country, so an epidemic was declared.

Although the number of fatalities reported this far are markedly below the levels reported for Ukraine, the rapid spread of H1N1 in Bulgaria raises concerns that there will be a dramatic increases in cases and deaths in the area. Spikes in deaths have already been reported in Turkey and Italy, although none have approached the numbers reported in Ukraine, where influenza/ARI cases are approaching 1 million, and will likely surpass that number in the next report.

The explosion of cases in Ukraine raise concerns that the H1N1 virus has subtly changed, with associated increase in cases and deaths.

Sequence data on these recent fatalities in Bulgaria and neighboring countries would be useful.

reported cases in ukraine double in two days

Recombinomics | Update: The numbers from the latest update from Ukraine (see map) continue to alarm. More than half of the Oblasts and cities listed exceed the epidemic threshold, including Kiev and Kiev Oblast, raising concerns that the increase in case numbers will accelerate. Moreover, hospitalization of 39,603 raises concerns that the number of deaths will also accelerate, since 11% of hospitalized cases in California died.

478,456 Influenza/ARI

24,003 Hospitalized

60 Ventilators

81 Deaths

The above numbers are from the latest update from Ukraine. The number of infected patients has almost doubled to just under ½ million, compared to the report two days ago (see map). Hospitalized patients also have spiked higher, to 24K from 15K. ICU cases are not listed, but 60 on ventilators are. However, most (37) of those on ventilators are Chernivisti Oblast, but Lviv, which has the most fatalities and cases, has none, suggesting the data is incomplete or there are significant shortages of ventilators. The number of dead has risen to 81, but media reports describe additional fatalities, include those in the Kiev Oblast.

The explosion of cases again raises concerns that the number of fatalities is significantly higher than the 81 listed. Media reports have described an equal number of pneumonia fatalities which were not considered flu related. The basis of these exclusions remains unclear. Similarly, anecdotal reports suggest the number of fatalities is markedly higher than the 81 in the table.

The rapid rise in reported infections, hospitalizations, and deaths in the past few days raise concerns that the virus is transmitting very efficiently. Spikes in cases have been reported throughout the northern hemisphere, but the spike in fatalities and the frequency in hemorrhagic cases in Ukraine have raised concerns.

Earlier media reports suggest that an update by WHO might be issued today and include preliminary analysis of samples sent to Mill Hill in London.

Daily updates on the rapidly evolving situation in Ukraine, including sequence analysis, would be useful.

sista dr. teresa forcades drops knowledge on the flu

unidentified flue outbreak in western ukraine

Zik | Western Ukraine was hit by a severe epidemic of unidentified influenza, tentatively diagnosed by doctors as viral pneumonia. The number of dead has climbed dramatically. Doctors advise Western Ukrainians to stay at home and use preventive medication. The first pedestrians wearing face masks have been seen on Lviv streetsTwo of the dead patients were in the 22-35 age group, with 2 others over 60. He diagnosed the disease as viral pneumonia.

“We have sent the analyses to Kyiv. We don’t believe it’s the swine flue. Neither do we know what kind of pneumonia it is,
Borysevych stressed. Viral tests can last from one to two weeks. They are complicated and not done in Lviv. The course of the disease was very quick. The symptoms included very high temperature and short-wind cough.

The disease started as an ordinary chill with headache and temperature. The symptoms lasted for a week before patient condition began to aggravate.

Zakarpattya Oblast
A man has died from the swine flue in Volovets. He has recently returned from Saint Petersburg, Russia, suffering from a cold. He was rushed to the hospital when pneumonia symptoms were found by doctors. Another local who came from Moscow became sick and went to see his doctor in time. Now he is recovering safely.

Ivano-Frankivsk Oblast
All the six dead young people had symptoms of severe hemmorhagic pneumonia. The disease starts slowly, with temperature rising to 37.2 – 37.3 degrees, slight cough and pain in joints. Nasal catarrh developed at the end of the second or third day. Autopsy revealed that the lungs were soaked with blood, the oblast chief specialist said.

Chernivtsi Oblast
The number of persons with common flue in Chernivtsi has grown from 2,623 to 4,053. According to the local medical authorities, the city has been hit by an unknown type of the flue. The tests to identify the virus will be ready only in 2 weeks, doctors say.

nanoparticles hazardous to dna

The Scientist | Nanoparticles can damage DNA even in cells that are not directly exposed to them, according to an in vitro study published online today (November 5) in Nature Nanotechnology -- raising further questions about the safety of nanomaterials used in clinical therapies.

"DNA damage due to nanoparticles has been described for many types of nanoparticles, but that's done in a primary or direct sense," said Andre Nel, chief of NanoMedicine at the University of California, Los Angeles, who was not involved in the study. "Indirect DNA damage to hazardous nanoparticles is not something that I have seen described before."

Scientists are using nanotechnology to develop delivery systems for drugs and imaging agents, but some studies have suggested these particles may be toxic. Researchers have linked inhalation of nanoparticles or nanotubes to cardoirespiratory disease, for example. Additionally, nanoparticle debris from implants, such as cobalt-chromium (CoCr) alloy particles which can be released from metal-on-metal orthopedic joint replacements, are known to damage human cells in culture.

clusters of hemorrhagic H1N1 pneumonia in ukraine

Recombinomics | All the six dead young people had symptoms of severe hemmorhagic pneumonia. The disease starts slowly, with temperature rising to 37.2 - 37.3 degrees, slight cough and pain in joints. Nasal catarrh developed at the end of the second or third day. Autopsy revealed that the lungs were soaked with blood, the oblast chief specialist said.

The above comments are from an early story describing cases in Ukraine. The clustering of hemorrhagic cases raised concerns. The concern was increased by anecdotal reports citing a high frequency of such cases in Lviv (see map). The recent WHO announcement that they were initially focusing of severe acute respiratory illness in Lviv also increased concerns.

Hemorrhagic pneumonia was also observed in the 1918 pandemic and was thought to be linked to cytokine storm. Consequently, those with robust immune systems (previously health young adults) disproportionately died, which has also been seen in the current outbreak (Mexico, US, and worldwide). However, the cases in Ukraine appear to be clustered, raising concerns that the virus has changed.

However, the change may be minor, since the current H1N1 has produced the above symptoms in earlier cases. More severe cases may be linked to a higher viral load, which could be linked to minor genetic changes, or simply due to concentration of virus in schools. In the US the spread of the virus has been linked to school openings, which lead to an explosion of cases and subsequent student deaths. However, now there are increases in fatalities in teachers and administrators, increasing concerns worldwide.

In Ukraine, weather changes and heating issues may have led to a surge in cases, and increased concentrations of virus could have produced conditions favoring high viral loads and increased cytokine storms.

the strange case of joseph moshe

HuffPo | A man suspected of making threats against the White House was pulled from his car Thursday after an hours-long standoff in the parking lot of the Federal Building in West Los Angeles.

The man had refused to leave his red Volkswagen Beetle and withstood four rounds of chemical agents tossed inside the car after police broke a rear window. About an hour later, officers shot out the drivers window with a bean bag gun and pulled him out.

Secret Service spokesman Ed Donovan identified the suspect as Joseph Moshe, 56, of Los Angeles. Moshe is suspected of calling a police dispatch number Wednesday and making threatening statements about the White House, Donovan said.

(but that's not the interesting part)

The interesting part is in the comments below the article about this arrest;

Project Camelot and Bill Deagle reported another side of this story involving Joseph Moshe, a biological­-scientist with a dual citizenship in Israel and mussad traning in biological warfare, hence his ability to withstand the tear gas attack. Moshe phoned Dr. Tru Ott's radio show and said that he had evidence that the vaccine company Baxter was making a bioweapon that would cause a plague when the vaccine was released.

The day after Moshe phoned the radio show, a swat team surrounded his Volkswagen Beetle near the Federal building near the Israeli consulate which was apparently Moshes destination. The mainstream media spun a story that Moshe had threatened the White House with a bomb, that there were outstanding warrants against him and that he was depressed. No mention of that Moshe was a biological­-scientist or the information he provided on Dr. True Otts radio show about the vaccine company Baxter.

NBC LA reported on Aug 17 that Moshe was in jail but Dr. Deagle says that Moshe has been sent to Israel.

The would-be bomber, Joseph Moshe, called into the Dr True Ott Show on Republic Broadcasting and said he was a microbiologist who wanted to hand over evidence to a States Attorney regarding tainted H1N1 vaccines being produced by Baxter pharmaceutical. He claimed that that Baxter’s lab in the Ukraine was in fact preparing a bioweapon disguised as a vaccine. He maintained that the vaccine contained both adjuvants designed to weaken the immune system, and replicated RNA from the virus responsible for the 1918 global pandemic. That’s it. He made no threat against Obama, nor said anything about bombs or any attack. The following day he was hauled out of his red VW beetle by a SWAT team and arrested. He was immediately extradited to Israel, where he has dual-citizenship, and hasn’t been heard from since. All this talk portraying him as being a right-wing nutcase is disinformation designed to keep his disturbing comments from alarming the public.

Read the extended commentary that accompanies this youtube video of the arrest of Moshe.

policy and technology - conflict or synergy?

UCTV | A highlight of this year's Energy Summit was the Town-Hall Meeting where audience members engaged in a dialogue with energy experts Randy Komisar, Arun Majumdar and Michael McQuade who touched mainly on consumer behavior, energy investment strategies, future energy outlook, and broadly on social responsibility of energy efficiency.

technology, politics, and the economics of reduced energy consumption

UCTV | Lynn Scarlett, former Deputy Secretary of the Interior, argues that investing in nature's capital is a smart twenty-first century energy policy. Arun Majumdar, Lawrence Berkeley Lab, explores how regulation and technology can work together to improve energy consumption. He also looks at some of the new technologies that may become large-scale solutions.

science for energy efficient production and use

UCTV | Raymond Orbach, former Under Secretary for Science, United States Department of Energy, argues that the three major energy challenges in the US are energy security, environmental sustainability, and economic impact and that a unique opportunity has emerged to change the world using a new ability to alter materials at the atomic scale like never before possible.

suncatcher

in the muck

The Scientist | Duckweed first appeared in satellite images of Venezuela in 2004 as a mysterious swirl of green on the surface of Lake Marcaibo, doubling in size with each passing day. Marcaibo is one of South America’s largest bodies of water, but with brackish water and few nutrients, it had never harbored this rapid-growing aquatic plant. Local scientists speculated that heavy rains washed sewage and nutrients into the lake along with duckweed colonies from neighboring ponds. By June, they estimated that the world’s smallest flowering plant covered 18 percent of the lake’s surface before it began receding.

The invasion could have been an ecological disaster, but for Rutgers geneticist Randall Kerstetter, it was a sign of hope. In the taxonomic showdown over the ideal organism for producing biofuel, Kerstetter is putting his mental energy into duckweed. “Duckweed is the fastest growing plant,” he says. “If you’re interested in biofuels, you’re interested in biomass.”

tiny tubers

The Scientist | When Ros Gleadow opened the airlock to the greenhouse at The Australian National University, she stepped into the atmosphere of the future. The air was thick with carbon dioxide—700 parts per million, to be precise—which matches the concentration predicted 90 years from now. While evaluating the responses of crops to the altered atmosphere in the summer of 2008, she found that the cotton, sorghum, soybean and cassava plants she’d planted 9 months earlier grew higher, a little woodier, and with more stems and smaller leaves than normal—all of which she’d expected. But when she dug the cassavas out of their pots, the tubers, which usually grow as large as yams, looked like stunted fingers.

Her cassavas of the future had produced 80 percent less food. “It came completely unexpectedly because plants normally grow bigger under higher CO2,” says Gleadow, a plant physiologist at Monash University in Melbourne. Her immediate thought went to the millions of people living in the tropics, where cassava is the third largest source of dietary carbohydrates. “If the yield decreases, there’s going to be a lot of hungry people.”

That wasn’t the only problem. The cassava plants themselves had become poisonous. Like 60 percent of all our staple crops, cassava produces chemicals called cyanogenic glycosides to deter grazing animals, which, when chewed, release cyanide gas. In small quantities, the cyanide tastes like bitter cherries, enough to ward off animals. But the high-CO2 cassavas produced three times the cyanide of today’s plant. (The poison largely shows up in the leaves, which most people avoid, although some in African countries eat the leaves as a protein supplement.) Gleadow hypothesizes that her cassavas may have poisoned themselves, meaning the extra cyanide shrank the tubers (Plant Biology, published online August 6, 2009).

Until recently, modelers saw CO2’s effect on plant life as the silver lining of climate change. They thought increases in the gas would act as fertilizer, making crops grow bigger and more lush. After all, CO2 is one of the main components of photosynthesis. In the late 1980s, experimenters projected as much as 30 percent increases by 2050 in yield for staples like wheat and soy. But recent experiments under open-air conditions showed half that rate of growth (Science, 312: 1918–21, 2006).

buffett buys bnsf...,

Washington Post | The biggest name in investing is making what he calls an "all-in wager" on the U.S. economy - $34 billion to own a railroad that hauls everything from corn to cars across the country.

The acquisition of Burlington Northern Santa Fe, the nation's second-largest railroad, would be the biggest ever for Warren Buffett's Berkshire Hathaway investment company.

It's a natural fit for the Oracle of Omaha, a city with a special place in railroad history. It was the starting point for the westward push of the transcontinental railroad. Today, Omaha is the headquarters of Union Pacific, and BNSF trains rumble through every day.

In a statement, Buffett, whose investing decisions are carefully scrutinized by the world of finance, voiced confidence in the railroad industry.

"Most important of all, however, it's an all-in wager on the economic future of the United States. I love these bets," he said Tuesday.

inside lsd - tonight

National Geographic | LSDs inventor Albert Hofmann called it "medicine for the soul." The Beatles wrote songs about it. Secret military mind control experiments exploited its hallucinogenic powers. Outlawed in 1966, LSD became a street drug and developed a reputation as the dangerous toy of the counterculture, capable of inspiring either moments of genius, or a descent into madness. Now science is taking a fresh look at LSD, including the first human trials in over 35 years. Using enhanced brain imaging, non-hallucinogenic versions of the drug and information from an underground network of test subjects who suffer from an agonizing condition for which there is no cure, researchers are finding that this "trippy" drug could become the pharmaceutical of the future. Can it enhance our brain power, expand our creativity and cure disease? To find out, Explorer puts LSD under the microscope.

foxes and chicken coops

HuffPo | There have been a few financial insiders who've raised an eyebrow over Storch's hire. Zero Hedge pointed to a big flaw in Storch's background "...at least the SEC could have hired someone with actual market/broker experience. Based on his record, Mr. Storch is not even a licensed (Series 7/63) broker."

The Atlantic points to some real concerns about his level of experience: "I'm not sure what's scarier, that this guy worked at an investment bank that many believe has questionable ethics and too cozy a Washington connection, or that he's just 29. His 'great deal of background' must be those seven long years since college ended."

For those who've lamented the various links between Goldman Sachs and the financial regulatory system, this certainly isn't good news.

Bloomberg reports that the Securities Exchange Commission has named Adam Storch, a former Goldman exec, as its enforcement division's first chief operating officer. Storch is actually just 29 years old and previously worked in Goldman's business intelligence unit.

Here's Bloomberg:

"The COO, who started Oct. 13, has "a great deal of background" in technology and managing processes and the pace of work, Robert Khuzami, head of enforcement, said yesterday in Washington. Storch, who worked since 2004 in a unit at Goldman Sachs that reviewed contracts and transactions for signs of fraud, will be charged with making the unit more efficient. Storch, reached by telephone at the SEC, declined to comment."

According to what appears to be his LinkedIn profile, Storch spent his undergraduate years at the State University Of New York At Buffalo, and earned an MBA from New York University's Stern School Of Business. Other experience -- besides Goldman -- includes working as a Senior Analyst at Deloitte and Touche.

smooth criminals

Neurological Correlates | New journal volume on “Biosocial Criminality” and two reports selected: One, because psychopaths use murder more as an instrumentality than as an expression of emotion, they don’t tell anyone about their crimes, and, moreover, therefore, are brought up on lesser offenses and get out earlier (my interpretation). Two, psychopaths can see vulnerability in others by the way they walk. Fist tap Dale.

militarism and extremism

teach your teachers well....,

NYTimes | ARNE DUNCAN, the secretary of education, recently called for sweeping changes to the way we select and train teachers. He’s right. If we really want good schools, we need to create a critical mass of great teachers. And if we want smart, passionate people to become these great educators, we have to attract them with excellent programs and train them properly in the substance and practice of teaching.

Our best universities have, paradoxically, typically looked down their noses at education, as if it were intellectually inferior. The result is that the strongest students are often in colleges that have no interest in education, while the most inspiring professors aren’t working with students who want to teach. This means that comparatively weaker students in less intellectually rigorous programs are the ones preparing to become teachers.

So the first step is to get the best colleges to throw themselves into the fray. If education was a good enough topic for Plato, John Dewey and William James, it should be good enough for 21st-century college professors.

These new teacher programs should be selective, requiring a 3.5 undergraduate grade point average and an intensive application process. But they should also be free of charge, and admission should include a stipend for the first three years of teaching in a public school.

schools are where stimulus saved jobs

NYTimes | The best symbol of the $787 billion federal stimulus program turns out not to be a construction worker in a hard hat, but rather a classroom teacher saved from a layoff.

On Friday, the Obama administration released the most detailed information yet on the jobs created by the stimulus. Of the 640,239 jobs recipients claimed to have created or saved so far, officials said, more than half — 325,000 — were in education. Most were teachers’ jobs that states said were saved when stimulus money averted a need for layoffs.

Although the stimulus was initially sold in large part as a public works program, only about 80,000 of the jobs that were claimed Friday were in construction.

Of course, counting jobs that were saved can be a squishier proposition than counting jobs that were created. Teachers have been laid off in some areas — and budget officials say that there would have been more layoffs without the stimulus money — but it is difficult to say with certainty how many teachers would have been laid off without that money.

Indiana, for example, reported saving or creating 13,232 education jobs with its stimulus money, but Cris Johnston, the director of the government efficiency division of the state budget office, said that it was difficult to say whether the state would have actually lost those jobs without the money.

homelessness rises, redefining living conditions for schoolchildren

Chicago Tribune | Maria Maior's son is a football-playing, skateboard-riding, Xbox-loving kid whose home reveals all the trappings of domesticity: a cushy sofa, big-screen TV, a framed poster of Brian Urlacher -- one of the 12-year-old's favorite football players. On most evenings, two big dogs curl up on the carpeting.

The scene could be lifted from any suburban subdivision -- except that it's located not in a den, but in a storage unit.

The boy moved into the 10-foot-by-25-foot bunker about two months ago with his mom and her fiance, after a long run of bad luck and the loss of both of their jobs. His mother didn't not want his name used for this article. "As long as I have my parents, I'm fine with this," Maior's son said of the accommodations. "It's really not that bad."

School district officials said the boy is one of a record number of area students living in motels, campgrounds, shelters, cars and, yes, storage facilities.

According to recently released data, McHenry County's homeless enrollment increased by 125 percent from the 2007-08 school year to the 2008-09 school year -- the biggest hike in the six-county metropolitan area. Schools in Kane (85 percent), Will (61 percent), DuPage (53 percent), Lake (44 percent) and suburban Cook (24 percent) counties also posted their largest increases, reflecting the surge in foreclosures and unemployment. Early reports indicate that the trend has continued this fall, with numbers spiraling even higher

appeasement not.....,

NYTimes | I continued to be conflicted — believing that when it comes to salutes (and one or two other matters), presidents deserved to be cut some slack, but also feeling a little uneasy about the whole thing.

My ambivalence came to an end last week, when I saw a videotape of the president’s midnight trip to Dover Air Force Base in Delaware, where he had participated, very early that morning, in the “dignified transfer” of 15 Army soldiers and three Drug Enforcement Administration agents killed that week in Afghanistan. Mr. Obama stood ramrod straight and saluted as six soldiers carried the coffin bearing the body of Sgt. Dale Griffin of Indiana off a C-17 transport aircraft and into a waiting van. His salute, it struck me, was impeccable in every way.

warsocialism's full spectrum redux...,

Seems like it may be time to do a memory refresh on the institutional expanse and behemoth totality of what Pres. Obama and SecDef Gates are wrestling with. It took me longer than I thought it would to find instances of the Joint Vision 2020 Report and its predecessor Joint Vision 2010. Though getting a sweeping strategic interpretation of what these doctrinal realignments portend was fairly easy to do.

commander in chief bidnis....,

Fist tap Submariner

in congress, a call to review internal cybersecurity policies

Washington Post | House leaders on Friday called for an "immediate and comprehensive assessment" of congressional cybersecurity policies, a day after an embarrassing data breach that led to the disclosure of details of confidential ethics investigations.

Speaker Nancy Pelosi (D-Calif.) and Minority Leader John A. Boehner (R-Ohio) said they had asked the chief administrative officer of the House to report back to them on the policies and procedures for handling sensitive data as a result of the breach. The inadvertent disclosure of a House ethics committee document, obtained by The Washington Post, summarized the status of investigations into lawmakers' activities on subjects such as influence peddling and defense lobbying.

"We are working diligently to provide the highest level of data security for the House in order to ensure that the operations of House offices are secure from unauthorized access," Pelosi and Boehner said in a statement.

The breach angered lawmakers who were the subject of the previously undisclosed investigations, and it raised questions about the security of other sensitive documents.

cracking the whip...,

Washington Post | House ethics investigators have been scrutinizing the activities of more than 30 lawmakers and several aides in inquiries about issues including defense lobbying and corporate influence peddling, according to a confidential House ethics committee report prepared in July.

7 on defense panel scrutinized

Sanchez sisters eyed by House ethics panel for alleged collusion

Rep. Shuler's land swap deal eyed by ethics committee

The report appears to have been inadvertently placed on a publicly accessible computer network, and it was provided to The Washington Post by a source not connected to the congressional investigations. The committee said Thursday night that the document was released by a low-level staffer.

The ethics committee is one of the most secretive panels in Congress, and its members and staff members sign oaths not to disclose any activities related to its past or present investigations. Watchdog groups have accused the committee of not actively pursuing inquiries; the newly disclosed document indicates the panel is conducting far more investigations than it had revealed.

Shortly after 6 p.m. Thursday, the committee chairman, Zoe Lofgren (D-Calif.), interrupted a series of House votes to alert lawmakers about the breach. She cautioned that some of the panel's activities are preliminary and not a conclusive sign of inappropriate behavior.

the big don bottleneck...,

once again on the upswing...,

Washington Post | A worldwide upsurge in a crime that officials say could stop trains, flood basements and darken homes has come to the Washington area, where this week's examples include the theft of a bus shelter roof.

The crime involves stealing copper, whether pipes, fittings or wiring. Authorities said the incidence of the thefts often rises with copper's price per pound, which has rebounded sharply in the past year to nearly $3.

In Fairfax City three major copper thefts were reported this week. On Thursday, police were told that a thief had filched the copper roof of a bus shelter at Jermantown Road and Carol Street. The same day, they said, "a large quantity" of wire was reported stolen from a Dominion Virginia Power storage yard in the 11100 block of Fairfax Boulevard. A similar theft was reported at the utility's substation in the 10500 block of Main Street.

In June 2008, with copper prices close to $4 per pound, theft soared around the world, and the consequences rippled through daily life.

As prices fell to about $1.30 in late December, pilferage appeared to decline. Now, in accounts from Australia to Atlanta and Canada to Cape Town, South Africa, officials say copper thieves appear increasingly active.

the victory of the commons

Yesmagazine | The biggest roadblock standing in the way of many people’s recognition of the importance of the commons came tumbling down when Indiana University professor Elinor Ostrom won the Nobel Prize for Economics.

Over many decades, Ostrom has documented how various communities manage common resources – grazing lands, forests, irrigation waters, fisheries— equitably and sustainably over the long term. The Nobel Committee’s recognition of her work effectively debunks popular theories about the Tragedy of the Commons, which hold that private property is the only effective method to prevent finite resources from being ruined or depleted.

Awarding the world’s most prestigious economics prize to a scholar who champions cooperative behavior greatly boosts the legitimacy of the commons as a framework for solving our social and environmental problems. Ostrom’s work also challenges the current economic orthodoxy that there are few, if any, alternatives to privatization and markets in generating wealth and human well being.

The Tragedy of the Commons refers to a scenario in which commonly held land is inevitably degraded because everyone in a community is allowed to graze livestock there. This parable was popularized by wildlife biologist Garrett Hardin in the late 1960s, and was embraced as a principle by the emerging environmental movement. But Ostrom’s research refutes this abstract concept with the real life experience from places like Nepal, Kenya and Guatemala.

“When local users of a forest have a long-term perspective, they are more likely to monitor each other’s use of the land, developing rules for behavior,” she cites as an example. “It is an area that standard market theory does not touch.”

Garrett Hardin himself later revised his own view, noting that what he described was actually the Tragedy of the Unmanaged Commons. Columbia University economist Joseph Stiglitz, also a Nobel winner, commented, “Conservatives used the Tragedy of the Commons to argue for property rights, and that efficiency was achieved as people were thrown off the commons…What Ostrom has demonstrated is the existence of social control mechanisms that regulate the use of the commons without having to resort to property rights.”

culture of "we" buffers genetic tendency toward depression

Physorg | A genetic tendency to depression is much less likely to be realized in a culture centered on collectivistic rather than individualistic values, according to a new Northwestern University study.

In other words, a genetic vulnerability to depression is much more likely to be realized in a Western culture than an East Asian culture that is more about we than me-me-me.

The study coming out of the growing field of cultural neuroscience takes a global look at mental health across social groups and nations.

Depression, research overwhelmingly shows, results from genes, environment and the interplay between the two. One of the most profound ways that people across cultural groups differ markedly, cultural psychology demonstrates, is in how they think of themselves.

"People from highly individualistic cultures like the United States and Western Europe are more likely to value uniqueness over harmony, expression over agreement, and to define themselves as unique or different from the group," said Joan Chiao, the lead author of the study and assistant professor of psychology in the Weinberg College of Arts and Sciences at Northwestern.

In contrast, people from collectivist cultures are more likely to value social harmony over individuality. "Relative to people in an individualistic culture, they are more likely to endorse behaviors that increase group cohesion and interdependence," Chiao said.

Collectivist cultures may give individuals who are genetically susceptible to depression a tacit or explicit expectation of social support. "Such support seems to buffer vulnerable individuals from the environmental risks or stressors that serve as triggers to depressive episodes," Chiao said.

The study by Chiao and Northwestern graduate student Katherine Blizinsky, "Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene," will be published online in the journal Proceedings of the Royal Society B: Biological Sciences.

The study compared genetic frequency information and cultural value data across 29 countries (major European countries as well as South Africa, Eastern Europe, South Asia, East Asia and South America). The serotonin transporter gene (STG) that the researchers studied has two variants - a short allele and a long allele. In Western populations, the short allele leads to a phenotype of major depressive episodes when people who carry it experience multiple life stressors.

long-term anti-depressant drug use

Science Daily | A dramatic rise in antidepressant prescriptions issued by GPs has been caused by a year on year increase in the number of people taking antidepressant drugs on a long-term basis, according to researchers from the University of Southampton.

In a paper, published in the printed edition of British Medical Journal (BMJ), scientists found that despite a drop in the number of new patients diagnosed with depression over 11 years, the number of prescriptions doubled.

"We estimate that more than 2 million people are now taking antidepressants long-term over several years, in particular women aged between 18 and 30," comments Tony Kendrick, a professor in Primary Medical Care of the University's School of Medicine, who led the study.

The number of prescriptions issued per patient rose from 2.8 in 1993 to 5.6 in 2004.

Prescription Pricing Authority data shows that more than 30 million prescriptions for SSRIs (selective serotonin reuptake inhibitors) such as Prozac and Seroxat, are now issued per year, twice as many as the early 1990s. Researchers at the University of Southampton found 90 per cent of people diagnosed with depression are now taking SSRIs either continuously or as repeated courses over several years.

skewering warsocialist stupidity

the case for legalization

AlterNet | By any objective standard, marijuana prohibition is an abject failure.

Nationwide, U.S. law enforcement have arrested over 20 million American citizens for marijuana offenses since 1965, yet today marijuana is more prevalent than ever before, adolescents have easier access to marijuana than ever before, the drug is more potent than ever before, and there is more violence associated with the illegal marijuana trade than ever before.

Over 100 million Americans nationally have used marijuana despite prohibition, and 1 in 10 -- according to current government survey data -- use it regularly.

The criminal prohibition of marijuana has not dissuaded anyone from using marijuana or reduced its availability; however, the strict enforcement of this policy has adversely impacted the lives and careers of millions of people who simply elected to use a substance to relax that is objectively safer than alcohol.

NORML believes that the state of California ought to amend criminal prohibition and replace it with a system of legalization, taxation, regulation and education.

cali gwan legalize it....,

NYTimes | These are heady times for advocates of legalized marijuana in California — and only in small part because of the newly relaxed approach of the federal government toward medical marijuana.

State lawmakers are holding a hearing on Wednesday on the effects of a bill that would legalize, tax and regulate the drug — in what would be the first such law in the United States. Tax officials estimate the legislation could bring the struggling state about $1.4 billion a year, and though the bill’s fate in the Legislature is uncertain, Gov. Arnold Schwarzenegger, a Republican, has indicated he would be open to a “robust debate” on the issue.

California voters are also taking up legalization. Three separate initiatives are being circulated for signatures to appear on the ballot next year, all of which would permit adults to possess marijuana for personal use and allow local governments to tax it. Even opponents of legalization suggest that an initiative is likely to qualify for a statewide vote.

“All of us in the movement have had the feeling that we’ve been running into the wind for years,” said James P. Gray, a retired judge in Orange County who has been outspoken in support of legalization. “Now we sense we are running with the wind.”

spitting into the food superpower wind...,

NYTimes | The “cautiously optimistic” authors of the United Nations food report believe that humanity will somehow be able to produce more food while still honoring the value of other species by protecting their habitat. And it’s true that this is not a zero-sum game. A 70 percent increase in food production doesn’t necessarily mean a 70 percent reduction in habitat.

But the Food and Agriculture Organization also warns that agricultural acreage will have to grow by some 297 million acres, a little less than three times the size of California. Add to this the ongoing rate of habitat destruction — including deforestation, often for fuel but usually for producing more food — and other threats like the growing production of biofuels, and it is hard to argue that there isn’t a profound conflict between what our species will need to survive by 2050 and the needs of nearly every other species on this planet.

The question isn’t whether we can feed 9.1 billion people in 2050 — they must be fed — or whether we can find the energy they will surely need. The question is whether we can find a way to make food and energy production sustainable in the broadest possible sense — and whether we can act on the principle that our interest includes that of every other species on the planet.

insight for IQ fetishists..,

Nature | An anatomical signature for literacy.

Language is a uniquely human ability that evolved at some point in the roughly 6,000,000 years since human and chimpanzee lines diverged1, 2. Even in the most linguistically impoverished environments, children naturally develop sophisticated language systems3. In contrast, reading is a learnt skill that does not develop without intensive tuition and practice. Learning to read is likely to involve ontogenic structural brain changes4, 5, 6, but these are nearly impossible to isolate in children owing to concurrent biological, environmental and social maturational changes. In Colombia, guerrillas are re-integrating into mainstream society and learning to read for the first time as adults. This presents a unique opportunity to investigate how literacy changes the brain, without the maturational complications present in children. Here we compare structural brain scans from those who learnt to read as adults (late-literates) with those from a carefully matched set of illiterates. Late-literates had more white matter in the splenium of the corpus callosum and more grey matter in bilateral angular, dorsal occipital, middle temporal, left supramarginal and superior temporal gyri. The importance of these brain regions for skilled reading was investigated in early literates, who learnt to read as children. We found anatomical connections linking the left and right angular and dorsal occipital gyri through the area of the corpus callosum where white matter was higher in late-literates than in illiterates; that reading, relative to object naming, increased the interhemispheric functional connectivity between the left and right angular gyri; and that activation in the left angular gyrus exerts top-down modulation on information flow from the left dorsal occipital gyrus to the left supramarginal gyrus. These findings demonstrate how the regions identified in late-literates interact during reading, relative to object naming, in early literates.

genomics richard stallman?

The Scientist | In the future, Hubbard says that gene-prediction programs need to get good enough that they can find genes without the aid of experimental data or comparative genome analyses to guide them. “Because that’s cheating,” he says. “For example, an RNA polymerase does not go and look at the mouse genome when it’s working out whether to transcribe a particular stretch of human sequence. But that’s what many of our algorithms do now.” Instead, he says that annotation programs should take an RNA polymerase–eye-view of the sequence, modeling the biology closely enough to accurately locate and assess the activity of genes. As we move into an era of personal genomics, such an approach will be necessary for predicting the effect that a certain SNP variant might have on gene function. He and his team have had some early success, producing a transcription start-site predictor that nails about half the genes in a genome sequence with very few false positives.

Hubbard also spends quite a bit of time working on issues of open access and the economics of innovation. “Governments are spending all this money for research and then not maximizing its value because they’re not investing enough in making sure people can access and reuse that data,” says Hubbard, who has discussed these issues at meetings of the Organisation for Economic Cooperation and Development (OECD) and the World Health Organization. Much of this work he does in his spare time. “Other people go fishing,” laughs Birney. “Tim likes to reform international patent law and go to UN conferences to discuss how open-access agreements should be arranged to maximize the way science gets translated into meaningful outcomes.”

Those outcomes, of course, include potential improvements in the diagnosis and treatment of disease, which makes the issue more urgent and more fraught. “If you look at the health implications of all the work being done in genomics, the opportunities are tremendous and the obstacles are staggering—and a lot of those are political,” says Haussler. “I just have the ultimate respect for Tim, as he’s willing to move through those political hurdles and try to get things to happen.”

“In a way, Tim’s contribution to the scientific endeavor is a very interesting one and rather different from most scientists,” says EBI director Janet Thornton. “Although he’s had a hand in producing many of the big genome publications, his unique input lies in his broad perspective, his sense of fairness, and his openness to new ideas. His diplomatic efforts have really been fundamental in making these large-scale, collaborative genomics projects work—and in making the data available so that the science can be put to good use for biology and medicine around the world.”

“A lot of things can be done by one person with a computer,” adds Flicek. “If the Internet age taught us anything, it’s taught us that.”

national institute of food and agriculture

The Scientist | Historically short-shrifted by federal funding bodies, academic agricultural research was recently promised redemption: a federal funding agency of its very own that will award competitive grants in a fashion similar to the National Institutes of Health (NIH). But will the new agency, the National Institute of Food and Agriculture (NIFA), be able to put public-sector agricultural science on an equal footing with biomedical research?

NIFA, to be administrated by the US Department of Agriculture (USDA), was modeled after the government's other large science funding agencies -- the National Science Foundation (NSF), the Department of Energy, and especially the NIH. Its mission is to fund research addressing several pressing issues ranging from increasing sustainable food production to bioenergy, food safety, and global climate change while encouraging a renaissance in agricultural research at universities across the country.

Unlike university-based biomedical research, however, which in general has enjoyed robust funding in the recent past, academic agricultural research has withered under a USDA that has traditionally meted out small, non-competitive grants to land grant universities, often at the behest of US legislators trying to direct funds to their home districts or states. The result is an intellectual landscape where much of the knowledge surrounding plant science and agriculture resides not in universities but in industry, locked behind the walls of large agribusinesses.

"We're starting at a different point with NIFA than the one at which we find ourselves at NIH," said Keith Yamamoto, a University of California, San Francisco, molecular biologist who serves as an advisor to the NIH and led the agency's recent efforts to revamp its peer-review process. "The current tilt in the fundamental knowledge about plants, their growth, and development is on the industry side and I would say that it's precisely because of the lack of resources on the public side," he told The Scientist. "It's the basic, fundamental information that needs to be in the realm of the public sector."

The disparity between private and public agriculture research becomes apparent when one considers data from the US Patent and Trademark Office (USPTO). Lists of recent patent holders in technology classes related to biomedicine -- surgery, drugs, prosthesis, etc. -- are replete with universities, which typically hold patents generated by publicly-funded research. Agricultural patents from 2004-2008, however, are overwhelmingly held by large agribusinesses such as Monsanto, DuPont, and Syngenta. In the USPTO's "Multicellular Living Organisms and Unmodified Parts Thereof and Related Processes" technology class (which includes genetically modified organisms), six companies -- Pioneer Hi-Bred International, Monsanto Technology, Stine Seed Farm, DuPont, Syngenta, and Mertec -- were awarded a total of 255 patents in 2008, while the Regents of the University of California system, which held the most patents in that technology class out of any university or university system last year, was awarded only six. Other technology classes relating to agriculture, such as "Plant Protecting and Regulating Compositions" and "Planting," have been devoid of university-held patents over the past 4-5 years.

That balance must be corrected, experts say, and NIFA may be key. "What's been missing so long in USDA is the forcing of competitive research ideas," said Martin Apple, president of the Council of Scientific Society Presidents who has been involved with the formation of NIFA since Congress created it in the Food, Conservation, and Energy Act of 2008. "The ace in the hole at NIFA is peer-reviewed research."

a molecule of motivation

NYTimes | If you’ve ever had a problem with rodents and woken up to find that mice had chewed their way through the Cheerios, the Famous Amos, three packages of Ramen noodles, and even that carton of baker’s yeast you had bought in a fit of “Ladies of the Canyon” wistfulness, you will appreciate just how freakish is the strain of laboratory mouse that lacks all motivation to eat.

The mouse is physically capable of eating. It still likes the taste of food. Put a kibble in its mouth, and it will chew and swallow, all the while wriggling its nose in apparent rodent satisfaction.

Yet left on its own, the mouse will not rouse itself for dinner. The mere thought of walking across the cage and lifting food pellets from the bowl fills it with overwhelming apathy. What is the point, really, of all this ingesting and excreting? Why bother? Days pass, the mouse doesn’t eat, it hardly moves, and within a couple of weeks, it has starved itself to death.

Behind the rodent’s fatal case of ennui is a severe deficit of dopamine, one of the essential signaling molecules in the brain. Dopamine has lately become quite fashionable, today’s “it” neurotransmitter, just as serotonin was “it” in the Prozac-laced ’90s.

People talk of getting their “dopamine rush” from chocolate, music, the stock market, the BlackBerry buzz on the thigh — anything that imparts a small, pleasurable thrill. Familiar agents of vice like cocaine, methamphetamine, alcohol and nicotine are known to stimulate the brain’s dopamine circuits, as do increasingly popular stimulants like Adderall and Ritalin.

In the communal imagination, dopamine is about rewards, and feeling good, and wanting to feel good again, and if you don’t watch out, you’ll be hooked, a slave to the pleasure lines cruising through your brain. Hey, why do you think they call it dopamine?

Yet as new research on dopamine-deficient mice and other studies reveal, the image of dopamine as our little Bacchus in the brain is misleading, just as was the previous caricature of serotonin as a neural happy face.

yikes...,