Augustus Owsley Stanley - RIP

Video - Owsley Stanley expounding on cycles.

Third Age | Owsley Stanley, a 1960s counterculture icon who worked with The Grateful Dead and was a prolific LSD producer, died in a car crash in Australia, his family said Monday. "Bear" was 76.

Lyrics sung by The Grateful Dead, Jimi Hendrix and Frank Zappa reference Stanley and his brushes with the law, underlining his influence.

Stanley produced an estimated pound (half a kilogram) of pure LSD, or roughly 5 million "trips" of normal potency of the hallucinogenic drug, after enrolling in 1963 at the University of California at Berkeley and becoming involved in the drug scene that underpinned the hippie movement, according to the BookRags.com website.

He was an accomplished sound engineer who worked for the psychedelic rock band The Grateful Dead.

Sam Cutler, a firm friend of Stanley since 1970 when Cutler became the band's tour manager, described him as was "a wonderful man and a great teacher."
Owsley StanleyOwsley Stanley
Click to Enlarge

"His death is a grievous loss to his family and the tens of thousands of people from the '60s on who were influenced by his work with The Grateful Dead," Cutler said. Stanley, who had adopted Australia as his home country, was the son of a U.S. government attorney and his namesake grandfather, Augustus Owsley Stanley, was a Kentucky governor and U.S. senator.

Stanley was driving a car that swerved off a highway and down an embankment before hitting trees near the town of Mareeba in Queensland state Saturday. His wife was treated for minor injuries from the crash.

A family statement Monday described Stanley as "our beloved patriarch."

He is survived by his wife, Sheila, four children, eight grandchildren and two great-grandchildren, the statement said.

Video - Media Project rendering of White Rabbit.

obama does not get it...,

aljazeera | From Tunisia to Egypt to Bahrain, and in many places in between, protesters have been calling for free and accountable governments. Decades of bitter experience have shown them that unrepresentative governments are often willing to accept - or at the very least are unable to resist - subordination to Western, and particularly American, political and economic diktats.

The 1979 peace treaty between Israel and Egypt, for example, was not signed by a democratic Arab government but was reached in spite of the strong opposition – that persists until today – within the Arab world’s largest country. Likewise, it is unlikely that the 1978 Camp David Accords would have been signed if it were up to the Egyptian people who, undeterred by the alliance of consecutive Egyptian governments with Washington and their close ties to Tel Aviv, continued to resist all attempts to impose normalised relations with Israel.

Over the years, the Egyptian people have repeatedly shown – through demonstrations, their media and even their cinema – that they oppose US policies in the region and Israeli aggression towards the Palestinians.

But now some American analysts, officials and former officials are seeking to rewrite history - and possibly to convince themselves in the process - by claiming that popular animosity towards Israel was simply a product of the Mubarak regime’s efforts to deflect attention from its own vices.

Jackson Diehl, a Washington Post columnist, has even blamed the former Egyptian regime for deliberately keeping the peace with Israel cold and for sometimes challenging the US. "Imagine an Egypt that consistently opposes the West in international forums while relentlessly campaigning against Israel. A government that seeds its media with vile anti-Semitism, locks relations with Israel in a cold freeze and makes a habit of publicly rejecting "interference" in its affairs by the United States. A regime that allows Hamas to import tonnes of munitions and Iranian rockets into the Gaza Strip," Diehl wrote of the Mubarak regime in an article published on February 14.

Diehl seems to think that a democratic Egypt will be friendlier to the US and Israel than what he deemed to be an insufficiently cooperative dictatorship. The same idea has been presented by Condoleezza Rice, the former US secretary of state, who argued that Mubarak’s fear of the "Arab street" prevented him from fully endorsing US policies towards the Israeli-Palestinian conflict.

But what Rice and others seem not to realise – despite the fact that their statements implicitly acknowledge it – is that Mubarak’s supposed shortcomings reflected his realisation that he could go no further in his support of US policies without provoking popular anger.

Arab regimes have always sought to appease the opposition by paying lip service to the Palestinian cause, because they understand the place it holds in the Arab psyche. And while the revolutions have revealed that this tactic is no longer sufficient to keep the forces of opposition at bay, it is wrong to assume that the new Arab mood is somehow consistent with a friendlier posture towards a country that continues to occupy Palestinian land and to dispossess Palestinian people.

Defining democracy
This kind of misreading of the situation derives not from facts but from an Orientalist attitude that has long dominated American thinking and large sections of the American media.

the right to economic development in the arab world

RWER | At this juncture in Arab history, there is an opportunity to be grasped. Unless there is a successful transition from the political to the social revolution in the Arab world, the sacrifice made by the Arab working classes will be betrayed. The following is a proposal to expose some of the previous aspects of development and economic performance in the Arab world with the aim to infuse the development debate with the idea of development as a human right. It need not be said, the present struggle is a struggle for rights. The idea of rights empowers people; it gives them a sense of self-affirmation. The language of rights establishes a framework for the allocation of resources. Without the rights rhetoric we will end up with a totally uncaring market system that will not solve our problems.

In the Arab world, economic policies are concentrated in the competence of the state. It is the efficiency and practicality of public policies that should be accountable and come under independent public scrutiny. The role of economic policy and, more specifically, fiscal and monetary policy is to find the appropriate regime that mediates disparate developments and puts interest back in the national and regional economies. Under the right to development rubric, economic growth should meet basic needs and not be a trickle down arrangement. Also, the Arab world is a world that is so interlocked with the global economy, such that, it would not be possible to lock in resources for development without international cooperation. The international community, comprising countries and institutions at the international level, has the responsibility to create a global environment conducive for development.

By virtue of their acceptance and commitment to the legal instruments, the members of the international community have the obligation to support effectively the efforts of Arab States that set for themselves the goal of realizing human rights, including the right to development, through trade, investment, financial assistance and technology transfer. Without this rudimentary cornerstone of an economic strategy designed to reduce poverty and unemployment, it is unlikely that any economic program of action can meet the basics of human rights, compensate working people for their suffering under the combined assault of neoliberalism and Arab autocracy and, generally, to secure the right to development.

atlantis found?

Video - NBC affiliate talks to Richard Freund about his search for the lost city of Atlantis.

Reuters | A U.S.-led research team may have finally located the lost city of Atlantis, the legendary metropolis believed swamped by a tsunami thousands of years ago in mud flats in southern Spain.

"This is the power of tsunamis," head researcher Richard Freund told Reuters.

"It is just so hard to understand that it can wipe out 60 miles inland, and that's pretty much what we're talking about," said Freund, a University of Hartford, Connecticut, professor who lead an international team searching for the true site of Atlantis.

To solve the age-old mystery, the team used a satellite photo of a suspected submerged city to find the site just north of Cadiz, Spain. There, buried in the vast marshlands of the Dona Ana Park, they believe that they pinpointed the ancient, multi-ringed dominion known as Atlantis.

The team of archeologists and geologists in 2009 and 2010 used a combination of deep-ground radar, digital mapping, and underwater technology to survey the site.

Freund's discovery in central Spain of a strange series of "memorial cities," built in Atlantis' image by its refugees after the city's likely destruction by a tsunami, gave researchers added proof and confidence, he said.

Atlantis residents who did not perish in the tsunami fled inland and built new cities there, he added.

The team's findings will be unveiled on Sunday in "Finding Atlantis," a new National Geographic Channel special.

crowley just lost his hope for audacity too...,

Video - Crowley was willing to question the actions of military, why isn't Obama?

FoxNews | State Department spokesman P.J. Crowley is out of a job after criticizing the Pentagon last week for its detention of a private accused of feeding hundreds of thousands of documents to WikiLeaks.http://www.blogger.com/img/blank.gif

Crowley resigned Sunday after also recently angering the White House for comments that he made during the height of the Egyptian crisis that forced President Hosni Mubarak to step down.

Secretary of State Hillary Clinton issued a statement saying, "It is with regret that I have accepted the resignation of Philip J. Crowley as assistant secretary of state for public affairs. P.J. has served our nation with distinction for more than three decades, in uniform and as a civilian. His service to country is motivated by a deep devotion to public policy and public diplomacy, and I wish him the very best."

Crowley also issued a statement acknowledging his remarks about Manning.

"The unauthorized disclosure of classified information is a serious crime under U.S. law. My recent comments regarding the conditions of the pre-trial detention of Private First Class Bradley Manning were intended to highlight the broader, even strategic impact of discreet actions undertaken by national security agencies every day and their impact on our global standing and leadership.

"The exercise of power in today's challenging times and relentless media environment must be prudent and consistent with our laws and values. Given the impact of my remarks, for which I take full responsibility, I have submitted my resignation," he said.

Last week, Crowley attended an MIT event on social networking, Twitter and the Arab revolution and reportedly was asked by a guest in the audience about WikiLeaks and the "torturing" of a prisoner in a military brig.

According to blogger Phillipa Thomas, Crowley replied without pause that what's being done to Manning by military officials "is ridiculous and counterproductive and stupid."

impeccable culture

LATimes | She was elderly and alone, injured and in pain. When the massive earthquake struck, a heavy bookshelf toppled onto Hiroko Yamashita, pinning her down and shattering her ankle.

When paramedics finally reached her, agonizing hours later, Yamashita did what she said any "normal" person would do, her son-in-law recounted later: She apologized to them for the inconvenience, and asked if there weren't others they should be attending to first.

The worst earthquake in Japan's recorded history left a trail of blazing buildings, inundated coastal communities, wrecked roadways and potentially unstable nuclear power plants. But it barely made a dent in the implacably Japanese trait of exhibiting concern for others even in the worst of circumstances.

The Japanese language is full of ritual apologies, uttered so often as to become almost meaningless: I am about to make a nuisance of myself — please excuse me! Some of this is a matter of mere formality. But at a time of crisis, such politesse can be the glue that holds the country together.

Even though Friday's magnitude 8.9 quake was shocking and discombobulating, few would imagine burdening a stranger with their anxieties.

japan earthquake shifted earth on its axis

LATimes | Friday's magnitude 8.9 earthquake in Japan shifted Earth on its axis and shortened the length of a day by a hair. In the future, scientists said, it will provide an unusually precise view of how Earth is deformed during massive earthquakes at sites where one plate is sliding under another, including the U.S. Pacific Northwest.

The unusually rich detail comes from an extensive network of sensors that were placed at sites across Japan after that country's Kobe earthquake of 1995, a magnitude 6.8 quake that killed more than 6,000 people because its epicenter was near a major city.

"The Japanese have the best seismic information in the world," said Lucy Jones, chief scientist for the Multi-Hazards project at the U.S. Geological Survey, at a Saturday news conference at Caltech in Pasadena. "This is overwhelmingly the best-recorded great earthquake ever."

why socialism?

Video - Part 1 of Albert Einstein's Why Socialism?

Video - Part 2 of Albert Einstein's Why Socialism? (The Money Shot)

Monthly Review | I have now reached the point where I may indicate briefly what to me constitutes the essence of the crisis of our time. It concerns the relationship of the individual to society. The individual has become more conscious than ever of his dependence upon society. But he does not experience this dependence as a positive asset, as an organic tie, as a protective force, but rather as a threat to his natural rights, or even to his economic existence. Moreover, his position in society is such that the egotistical drives of his make-up are constantly being accentuated, while his social drives, which are by nature weaker, progressively deteriorate. All human beings, whatever their position in society, are suffering from this process of deterioration. Unknowingly prisoners of their own egotism, they feel insecure, lonely, and deprived of the naive, simple, and unsophisticated enjoyment of life. Man can find meaning in life, short and perilous as it is, only through devoting himself to society.

The economic anarchy of capitalist society as it exists today is, in my opinion, the real source of the evil. We see before us a huge community of producers the members of which are unceasingly striving to deprive each other of the fruits of their collective labor—not by force, but on the whole in faithful compliance with legally established rules. In this respect, it is important to realize that the means of production—that is to say, the entire productive capacity that is needed for producing consumer goods as well as additional capital goods—may legally be, and for the most part are, the private property of individuals. Fist tap Chauncy DeVega.

probably pray a lot, meditate....,

Video - America is over if it experiences a big one.

avoiding water wars

PakObserver | The US Senate report released the other day warned that the Indus Water Treaty may fail to avert water wars between India and Pakistan, acknowledging that dams India is building in occupied Kashmir will limit supply of water to Pakistan at crucial moments. “This report highlights how water security is vital in achieving our foreign policy and national security goals and provides recommendations to foster regional cooperation and long-term stability,” said Senator John Kerry, chairman of the US Senate Foreign Relations Committee, while releasing the report. India is constructing 33 dams that are at various stages of completions, and cumulative effect of storing water would limit the supply to Pakistan at crucial moments in the growing season, the report added. Currently, the most controversial dam project is the proposed 330-megawatt dam on the Kishenganga River, a tributary of the Indus. The US Senate Foreign Relations Committee should have come out with the solution to the problem instead of giving an impression that Indus Water Treaty has become redundant. In fact, it is the responsibility of the international community to urge India to honour its commitment under the treaty. And this is the only way to avoid war.

With the climate change and as a consequence shrinking water availability across the Middle East, Asia and sub-Saharan Africa, violent conflict between states is increasingly likely. This matter was on the agenda of annul World Water Week forum in Stockholm held in 2006, but it could not answer the question raised in the meeting whether we are heading for an era of “hydrological warfare” in which rivers, lakes and aquifers become national security assets to be fought over, or controlled through proxy armies and client states? Or can water act as a force for peace and cooperation? It has been estimated by the experts that by 2025, more than two billion people are expected to live in countries that find it difficult or impossible to mobilize the water resources needed to meet the needs of agriculture, industry and households. Population growth, urbanization and the rapid development of manufacturing industries are relentlessly increasing demand for finite water resources. Symptoms of the resulting water stress are increasingly visible. In northern China, rivers now run dry in their lower reaches for much of the year. In parts of Pakistan and India, groundwater levels are falling so rapidly that from 10 percent to 20 percent of agricultural production is under threat.

In the past, there have been wars between the countries over religions, usurpation of territories and control of resources including oil, but in view of acute shortages of water in Africa, Middle East, Asia and elsewhere, the future wars could be fought over water.

china's big dam problem

change gone come...,

Video - No more Fannie or Freddie propping up homeownership.

RT | It’s not just the US middle class that’s going to feel it. Foreign countries all over the world hold billions upon billions of US home mortgages in their portfolios. Doing away with Fannie and Freddie could amount to massive losses for these investors, and for US clout. Especially when you consider economists said shoring up foreign investment was a major reason for Fannie and Freddie’s bailout in the first place.But America appears unable to afford another option in the face of such massive failure.

“I believe the banks were making bad loans,” Sontra said from her experience. “I think it was just greed.”

“Fannie and Freddie got out of control took ridiculous amounts of risks which didn’t properly disclose to regulators or investors who were slammed by misadventure,” explained Wolff.

A misadventure coming at the cost of the American Dream that so many Americans and that the world, bought into.

Author and journalist David DeGraw said both Freddie Mac and Fannie Mae brought the system down through flawed policies, but they did not do it alone.

“Let’s talk about unwinding the people who caused this problem; Bank of America, Goldman Sachs, JP Moran, how come were not talking about winding them down?” asked DeGraw. “These are fraudulent institutions that exploded the housing market.”

He argued Wall Street is a “mafia racket” of legalized political bribery controlling the US legislature.

“The criminals have taken over. They are obviously above the law,” DeGraw comments. “These are the people that have to have their assets frozen and we can recoup the money that way. One tenth of the US population has robbed everyone blind.”

Americans simply are unaware of the magnitude how much money and wealth has been stolen by such a small version of the population, if the people knew, Egypt style revolt would sweep across the US, he argued.

breadbasket running dry?

naturalnews | It's the largest underground freshwater supply in the world, stretching from South Dakota all the way to Texas. It's underneath most of Nebraska's farmlands, and it provides crucial water resources for farming in Colorado, Kansas, Oklahoma and even New Mexico. It's called the Ogallala Aquifer, and it is being pumped dry.

Without the Ogallala Aquifer, America's heartland food production collapses. No water means no irrigation for the corn, wheat, alfalfa and other crops grown across these states to feed people and animals. And each year, the Ogallala Aquifer drops another few inches as it is literally being sucked dry by the tens of thousands of agricultural wells that tap into it across the heartland of America.

This problem with all this is that the Ogallala Aquifer isn't being recharged in any significant way from rainfall or rivers. This is so-called "fossil water" because once you use it, it's gone. And it's disappearing now faster than ever.

The end of cheap food in America?
It's a sobering thought, really: That "America's breadbasket" is on a collision course with the inevitable. A large percentage of the food produced in the United States is, of course, grown on farmlands irrigated from the Ogallala. For hundreds of years, it has been a source of "cheap water," making farming economically feasible and keeping food prices down. Combined with the available of cheap fossil fuels over the last century (necessary to drive the tractors that work the fields), food production has skyrocketed in North America. This has led to a population explosion, too. Where food is cheap and plentiful, populations readily expand.

It only follows that when food becomes scarce or expensive (putting it out of reach of average income earners), populations will fall. There's only so much food to go around, after all. And after the Ogallala runs dry, America's food production will plummet. Starvation will become the new American landscape for those who cannot afford the sky-high prices for food.

u.s. farmers fear return of the dustbowl

Telegraph | There is not much to be happy about these days in Happy, Texas. Main Street is shuttered but for the Happy National Bank, slowly but inexorably disappearing into a High Plains wind that turns all to dust. The old Picture House, the cinema, has closed. Tumbleweed rolls into the still corners behind the grain elevators, soaring prairie cathedrals that spoke of prosperity before they were abandoned for lack of business.

Happy's problem is that it has run out of water for its farms. Its population, dropping 10 per cent a year, is down to 595. The name, which brings a smile for miles around and plays in faded paint on the fronts of every shuttered business – Happy Grain Inc, Happy Game Room – has become irony tinged with bitterness. It goes back to the cowboy days of the 19th century. A cattle drive north through the Texas Panhandle to the rail heads beyond had been running out of water, steers dying on the hoof, when its cowboys stumbled on a watering hole. They named the spot Happy Draw, for the water. Now Happy is the harbinger of a potential Dust Bowl unseen in America since the Great Depression.

'It was a booming town when I grew up,' Judy Shipman, who manages the bank, says. 'We had three restaurants, a grocery, a plumber, an electrician, a building contractor, a doctor. We had so much fun, growing up.' Like all the townsfolk, she knows why the fun has gone. 'It's the decline in the water level,' she says. 'In the 1950s a lot of wells were drilled, and the water went down. Now you can't farm the land.'

Those wells were drilled into a geological phenomenon called the Ogallala Aquifer. It is an underground lake of pristine water formed between two and six million years ago, in the Pliocene age, when the tectonic shifts that pushed the Rocky Mountains skywards were still active. The water was trapped below the new surface crust that would become the semi-arid soil of the Plains, dry and dusty. It stretches all the way down the eastern slope of the Rockies from the badlands of South Dakota to the Texas Panhandle. It does not replenish.

Happy is the canary in the coalmine because the Ogallala is deepest in the north, as much as 300ft in the more fertile country of Nebraska and Kansas. In the south, through the panhandle and over the border to New Mexico, it is 50-100ft. And around Happy, 75 miles south of Amarillo, it is now 0-50ft. The farms have been handed over to the government's Conservation Reserve Programme (CRP) to lie fallow in exchange for grants: farmers' welfare, although they hate to think of it like that.

scorched earth and stalemate...,

DailyMail | Colonel Gaddafi's forces today blasted an oil terminal to smithereens as Libya's bloody civil war entered its blackest day.

Rebels retaliated by firing back with rockets as a fireball exploded from one of the oil tanks and the sky above the Es Sider terminal, in the east of the country, filled with hideous smoke.

A witness said one of the smoke plumes was the biggest he had seen in the conflict so far.

The fresh onslaught came as Gaddafi deployed tanks and snipers to 'shoot anything that moves'. Forces loyal to the Libyan dictator poured into the city of Zawiyah in a desperate bid to oust the hardcore band of protesters and army defectors who have taken control.

Witnesses said dead bodies were lying in the ruins of many buildings destroyed in air raids earlier in the week and there was no one in the streets of the centre of the city of 290,000.

'We can see the tanks. The tanks are everywhere,' one rebel fighter said by telephone.

Eye witnesses said that the city had been almost flattened after a 13-and-a-half hour barrage from rockets, tanks and war planes

The hellish scenes unfolded as senior officials in the U.S. spoke of their fears that the country had reached a painful stalemate.

Senior officials believe that Gaddafi has solidified his control over some cities but ant-government protesters have a strong enough hold on other regions to remain locked in the stand off.

As the standoff continues and hundreds of more lives continue to be lost, it has created a split in the U.S. government about whether to take military action.

The Obama intervention is still looking at options for intervention while the European Union is preparing to impose stricter sanctions on the Libya government, including an asset freeze.

'What we're looking at right now—and things can change on a dime in these kinds of fluid conflicts—is basically a stalemate in certain parts of Libya,' another U.S. official told the Wall Street Journal.

'Gaddafi has solidified his control of some areas while the rebels have the upper hand in other places.'

libyan oil mostly underexplored...,

useia.gov | Libya, a member of the Organization of Petroleum Exporting Countries (OPEC), holds the largest proven oil reserves in Africa, followed by Nigeria and Algeria (see below). According to Oil and Gas Journal (OGJ), Libya had total proven oil reserves of 46.4 billion barrels as of January 2011, the largest reserves in Africa. Close to 80 percent of Libya's proven oil reserves are located in the Sirte basin, which accounts for most of the country's oil output.

Libya hopes to increase oil reserve estimates with incentives for additional exploration both in established oil producing areas as well as more remote parts of the country. Recent increases in foreign investment have begun to slow as a result of uncertainties stemming from OPEC quotas, infrastructure constraints, and contract renegotiations.

Libyan oil is generally light (high API gravity) and sweet (low sulfur content). The country's nine export grades have API gravities that range from 26.0o – 43.3o. While the lighter, sweeter grades are generally sold to Europe, the heavier crude oils are often exported to Asian markets.

Refining
According to OGJ, Libya has five domestic refineries, with a combined capacity of 378,000 bbl/d. Libya's refineries include:

1) the Ras Lanuf export refinery, completed in 1984 and located on the Gulf of Sirte, with a crude oil refining capacity of 220,000 bbl/d;

2) the Az Zawiya refinery, completed in 1974 and located in northwestern Libya, with crude processing capacity of 120,000 bbl/d;

3) the Tobruk refinery, with crude capacity of 20,000 bbl/d;

4) Sarir, a topping facility with 10,000 bbl/d of capacity; and

5) Brega, the oldest refinery in Libya, located near Tobruk with crude capacity of 8,000 bbl/d.

Libya's refining sector was impacted by UN sanctions, specifically UN Resolution 883 of November 11, 1993, which banned Libya from importing refinery equipment. Libya is seeking a comprehensive upgrade to its entire refining system, with a particular aim of increasing output of gasoline and other light products.

subBlue

Surface detail from subBlue on Vimeo.

Fractal Lab Introduction from subBlue on Vimeo.

epigenetics and society

The Scientist | The potent wish in the productive hour
Calls to its aid Imagination’s power,
O’er embryon throngs with mystic charm presides,
And sex from sex the nascent world divides…
—Erasmus Darwin,
“The Temple of Nature,” Canto II

I was first introduced to Charles Darwin’s flamboyant grandfather when I was an undergraduate searching through Michigan State’s wonderful Special Collections. In between bothering the curators for archived copies of Howard the Duck, I read Erasmus’s prose and poetry, and was treated to a great mind grappling with ideas that presaged one of the truly great ideas of modern times, the theory of evolution. As the passage above hints, Erasmus believed that environmental influences, in particular the “Imagination” of the parents, greatly influenced the phenotype of the child.

How very pre-Victorian (and post-). Erasmus anticipated Charles in many ways, but surprising results in the field of epigenetics—heritable (and reversible) changes in gene expression—suggest that he may have been very far ahead of his time indeed. In the current issue, David Berreby cites the increasing body of work that correlates childhood trauma with DNA methylation with suicide. One’s personal epigenome is modified by environmental perturbations, and that influences behavior. Certainly the Victorians could have related to the notion of an Original Sin that made its heritable mark on the genomes of parents created innocent, passing the curse down to their descendants. That said, the Victorians did have their biases, and it was of course the father who had the predominant influence over the child. But recently published studies of genetic imprinting show that the two parents’ influence on their offspring is more akin to a tug of war.

The Lamarckian idea that giraffes’ reaching for leaves resulted in longer-necked progeny seems silly to us today, primarily because we know so very much about the underlying mechanisms of genetics. And yet Lamarck may have a last laugh—think inheritance patterns in ciliates, or the effect of diet on the coat color of agouti mouse offspring. We are in the midst of a paradigm shift in our understanding of how evolution can act…on evolution, yielding mechanisms that allow both adaptation and heritability within the course of a lifetime. And such paradigm shifts almost always have societal consequences. Manel Esteller shows that epigenetics also impacts the “dark genome” in a way that may improve cancer diagnostics. An even more far-reaching consequence is that it may prove possible to engineer epigenetics, as Bob Kingston’s Thought Experiment tacitly suggests. If so, will epigenetic engineering be subject to the same restrictions as genetic engineering? Or will this be a way that we can not merely treat disease, but possibly engineer human health into future generations?
Andrzej Krauze

Such possibilities will be the rational outcome of a great deal of research and debate that is yet to come. However, there are at least two outcomes of the revolution in progress that would seem to have more near-term consequences. First, the overturning of a purely Darwinian paradigm will undoubtedly be viewed as the overturning of Darwin and his Theory itself. It matters not a whit that science will have been shown, once again, to be self-correcting, and to provide a means of advancing knowledge through the application of the experimental method and mechanistic naturalism. We can expect that epigenetics will be held up as the forerunner of that bastard child of Creationism, Intelligent Design. Dribs and drabs of this are already appearing on the Interwebs, but it may soon come to a school board near you. Second, the notion that environmental tags are embedded in our genome within a human time frame has got to be one of the best things to happen to tort law in a long time. DNA typing has led to the conviction of the guilty and the freeing of the innocent. Epigenetic typing may now lead to expert testimony regarding the presymptomatic impact of environmental disasters on susceptible populations. This may seem fanciful, but where there are moneyed interests (on either side), the science will inevitably follow.

testing a central tenet of epigenetic regulation

The Scientist | A fundamental problem in biology concerns how the genomic information present in fertilized eggs can give rise to the full spectrum of stably differentiated cell types required to form vertebrates and invertebrates. In the 1930s, C.H. Waddington’s largely observational mammalian embryology studies, which defined this problem, were central to establishing the field of epigenetics. It is now well known that there are master regulatory genes that must be kept on to specify a given cell lineage and off in the many other cell lineages that make up the body.

The problem of keeping these genes in the off state when required has received considerable attention, in large part due to the landmark genetic studies initiated by Pam and Ed Lewis in the 1940s that identified a set of genes required for this repression. This family of genes is called the Polycomb Group (PcG) because the visual phenotype of a heterozygous null allele in these genes is duplication on the second and third legs of the sex combs that wild-type male Drosophila flies have on their front legs. It turns out that PcG proteins repress key developmental master regulatory genes in organisms from plants to humans. The PcG is responsible for a diversity of important biological events, from why plants flower only in the spring (and not in a December warm spell) to how mammals form the correct body tissues in the correct locations.

epigenetics: a primer

The Scientist | What makes the ~200 cell types in our body remember their identity? What prevents them from becoming cancer cells? Why do we inherit some traits from our father, others from our mother? How do our experiences and environment influence our thinking? Why do plants bloom in spring but not in winter? These important and quite different questions are all addressed by the field of epigenetics, which studies heritable changes in a phenotype arising in the absence of alterations in the DNA sequence. The idea of transgenerational inheritance of acquired characteristics goes back to Lamarck in the early 19th century, but still only correlative evidence exists in humans. In contrast, many cellular epigenetic phenomena are now well understood on the molecular level. In humans, they include the parent-of-origin specific expression of genes (imprinting) and the shutting-down of almost all genes on one of the two X chromosomes in females (X-chromosome inactivation).

All these epigenetic phenomena are characterized by chemical modifications to DNA itself (DNA methylation) or to histones, the proteins around which DNA is wound. These modifications change during development as stem cells give rise to liver cells and neurons, but also in response to environmental signals—in plants, for example, during the cold of winter or in humans when immune cells are activated after an infection. One of the biggest controversies in the field is whether histone modifications are inherited through cell division (called the “histone code hypothesis”) or whether they only form transient indicators of transcriptional states (“signaling model”).