Secrecy, Collusion and Bad Medicine

The drug industry's long and ignoble history of secrecy

In 2004, UK researchers commissioned by Nice to develop guidelines for prescribing antidepressant drugs to children tried to obtain unpublished trials from the drug companies. They were refused. They then contacted the individual researchers who had worked on the trials. Only then did a picture emerge of increased risk of attempted suicide, and a lack of efficacy. Nice concluded by banning the drugs for under-18s with the exception of Prozac.

Yesterday's report suggesting that modern antidepressants offer no significant clinical benefit over placebo has been dismissed by the drug industry as "just one study" which should not be allowed to undermine the wealth of research showing that the selective serotonin reuptake inhibitor (SSRI) antidepressants are effective.

But that is to miss the point. The Hull University researchers have demonstrated how partial access to research can give a distorted view of a drug. The non-disclosure of data on the SSRIs has raised doubts about the trustworthiness of all research on antidepressants.

We should be relieved that the licensing authorities have an absolute right to see all trial data, positive and negative, before approving a drug. But, bizarrely, Nice, with the responsibility for deciding which drugs should be used by the NHS, only gets what the drug companies agree to give it. The Health Select Committee has called for action to remedy this omission. Ministers must respond.

Antidepressant Drugs Don't Work – Official Study

They are among the biggest-selling drugs of all time, the "happiness pills" that supposedly lift the moods of those who suffer depression and are taken by millions of people in the UK every year.

But one of the largest studies of modern antidepressant drugs has found that they have no clinically significant effect. In other words, they don't work.

The finding will send shock waves through the medical profession and patients and raises serious questions about the regulation of the multinational pharmaceutical industry, which was accused yesterday of withholding data on the drugs.

In the study, researchers conducted a meta-analysis of all 47 clinical trials, published and unpublished, submitted to the Food and Drug Administration in the US, made in support of licensing applications for six of the best known antidepressant drugs, including Prozac, Seroxat – which is made by GlaxoSmithKline – and Efexor made by Wyeth. The results showed the drugs were effective only in a very small group of the most extremely depressed.

Two drugs were excluded from the study because of incomplete data. A third drug, chemical name nafazodone, has been withdrawn from the market because of side-effects.

Professor Irving Kirsch of the University of Hull, who led the study published in the online journal Public Library of Science (PLoS) Medicine , said the data submitted to the FDA would also have been submitted to the licensing authorities in Britain and Europe. It showed the drugs produced a "very small" improvement compared with placebo of two points on the 51-point Hamilton depression scale.

That was sufficient to grant the drugs a licence but did not meet the minimum three-point difference required by the National Institute for Clinical Excellence (Nice) to establish "clinical" significance. Full-monty available here - in tomorrow's UK Independent.

All We Are Saying - Is Give Kip a Chance...,

Prior to assuming his current position, Ward was Deputy Commander, Headquarters US European Command, Stuttgart, Germany. He previously served as the Deputy Commanding General/Chief of Staff, US Army Europe and Seventh Army. While in this capacity he was selected by the Secretary of State to serve as the United States Security Coordinator, Israel - Palestinian Authority where he served from March through December 2005.

If you have concerns, take them directly to the Africom Dialogue A clearinghouse of the U.S. Africa Command's senior leader's updates on issues important at AFRICOM. We encourage your comments and feedback.

Further Tribal Demands On Obamamandius

From the Jerusalem Post - Obama and the Jews

With all due deference to the Obama celebrity supporters like Steven Spielberg and George Soros, can Jews herein Israel and in America and other friends of Israel risk a vote for Obama in November? A quick look at the facts should switch on a big red light in most peoples' minds.

First and foremost among the considerations that should trouble friends of Israel is the foreign policy team Obama has selected to advise him. The composition of a candidate's advisory panel is usually a very good indicator of where the candidate will come out on the issues if elected.

This was the test this writer applied to George W. Bush in 2000 at a time when most pundits in Israel and in the Jewish community predicted that his Middle East policy would be a carbon copy of his father's, meaning trouble for Israel. But Bush, the son, had selected a blue-ribbon team of pragmatic and conservative advisors whose views on the Middle East were markedly pro-Israel and pro-democracy. Subsequently, the W. Bush Era became among the closest allies of Israel in her 60-year history.

The opposite is the case with the Obama team. Headed up by Jimmy Carter's ("Israel is an apartheid state") national security advisor, Zbigniew Brzezinski, Obama's team includes such problematic figures as Anthony Lake, Robert O. Malley and Susan Rice.

One commentator, citing an article by the staunchly left-wing Israeli newspaper, Haaretz, has noted that an Obama presidency including a foreign policy team that included the foregoing and their ideological soul-mates, "would likely have an approach towards Israel radically at odds with those of previous Presidents (both Republican and Democrat)" and is the candidate apt to be "least supportive" of Israel.

Brzezinski has been disseminating vitriol about Israel for three decades and recently publicly defended the Walt-Mearsheimer study which concluded that US policy towards Israel was the result of Jewish pressure and inconsistent with American interests. More recently Brzezinski called for the US to initiate dialogue with Hamas, described Israel's action in the Second Lebanon War as a killing campaign against civilian hostages and earlier this month made a trip to confer with Syria's President Assad, ostensibly unbeknownst to the Obama campaign.

Robert O. Malley, another former Carter Administration diplomat and President Clinton's special advisor on Arab-Israeli affairs, is an unabashed advocate for the Palestinians, co-authoring a spate of anti-Israel propaganda with former Arafat advisor, Hussein Agha, including a tract that blames Israel for the failure of the 2000 Camp David talks and another piece which blames the Bush Administration for continuing Israeli-Palestinian strife.

And then there is Susan Rice, foreign policy advisor to the ill-fated John Kerry presidential campaign in 2004, where she concocted the idea of solving the Middle East problem by appointing none other than Jimmy Carter and James Baker as negotiators, an idea which was later repudiated by her own boss as being unbalanced against Israel. Nor are these the only "bad apples" in Obama's foreign policy bin…

Another problematic indicator is candidate's close association with Jeremiah Wright, Jr., pastor of the Trinity United Community Church (a member of the United Church for Christ, which itself has been rebuked for anti-Israel bias), who is well known for his virulent anti-Israel remarks, including a call for a divestment campaign against Israel for the "injustice and the racism under which the Palestinians have lived because of Zionism."

Nor should bring much solace to Jewish voters and friends of Israel that Reverend Wright counts among his closest friends, the nefarious anti-Semite, Louis Farrakhan for whom Judaism is a "gutter religion" and Jews are "bloodsuckers." Obama could have picked any one of hundreds of churches in Chicago's South Side; he picked Jeremiah Wright's parsonage, which awarded Farrakhan with the Jeremiah Wright Lifetime Achievement Trumpeteer Award in 2007. And Wright's church is the single largest beneficiary of Obama's charitable giving. Even Jewish columnist Richard Cohen of the Washington Post felt compelled to ask Obama to clarify his relationship with these anti-Jewish and anti-Israel community leaders, questioning why Obama has stayed steadfast in his allegiance to Pastor Wright over the years.

Is He Supremacist Enough?

With tribal violence roiling central europe, a sustained eruption of primitive, tribal impulses has begun to color the presidential election. Let's just be very sure to call these archaic and atavistic attacks precisely what they are. Rep. Jack Kingston of Georgia's 1st District puts it right out there and demands that Michelle Obama kneel and pledge allegiance to his tribe.

Sen. Barack Obama's refusal to wear an American flag lapel pin along with a photo of him not putting his hand over his heart during the National Anthem led conservatives on Internet and in the media to question his patriotism. Now Obama's wife, Michelle, has drawn their ire, too, for saying recently that she's really proud of her country for the first time in her adult life. Conservative consultants say that combined, the cases could be an issue for Obama in the general election if he wins the nomination, especially as he runs against Vietnam war hero Sen. John McCain.

U.S. Not Planning Bases In Africa

G-Dub's not much of a poker player judging from this classic tell...,

Bill O'Reilly's Anti-Obama Strategery

Folks with no substantive issues to pursue, but with a crystal clear political agenda, will manufacture issues from thin air. Thus the 72 hour grind from Bill O'Reilly on Michelle Obama's decontextualized remarks. In his own fit of "reckless eyeballin" pique - O'Reilly not only insists that Mrs. Obama be made answerable to him for her statements, but in the process unintentionally discloses a very great deal about the collective psychology that he exemplifies;



Oh yeah, I'm not on about the lynching comment as some folks are, because I think that's perpetrating on the same level as O'Reilly is perpetrating from - but I think Gene Robinson's and Keith Olberman's dialog about O'Reilly is right on target.



From Media Matters;

O'Reilly: "I don't want to go on a lynching party against Michelle Obama unless there's evidence, hard facts, that say this is how the woman really feels"

Summary: In a discussion of recent comments made by Michelle Obama, Bill O'Reilly took a call from a listener who stated that, according to "a friend who had knowledge of her," Obama " 'is a very angry,' her word was 'militant woman.' " O'Reilly later stated: "I don't want to go on a lynching party against Michelle Obama unless there's evidence, hard facts, that say this is how the woman really feels. If that's how she really feels -- that America is a bad country or a flawed nation, whatever -- then that's legit. We'll track it down."

The Next Slum

The subprime crisis is just the tip of the iceberg. Fundamental changes in American life may turn today’s McMansions into tomorrow’s tenements.

Strange days are upon the residents of many a suburban cul-de-sac. Once-tidy yards have become overgrown, as the houses they front have gone vacant. Signs of physical and social disorder are spreading.

At Windy Ridge, a recently built starter-home development seven miles northwest of Charlotte, North Carolina, 81 of the community’s 132 small, vinyl-sided houses were in foreclosure as of late last year. Vandals have kicked in doors and stripped the copper wire from vacant houses; drug users and homeless people have furtively moved in. In December, after a stray bullet blasted through her son’s bedroom and into her own, Laurie Talbot, who’d moved to Windy Ridge from New York in 2005, told The Charlotte Observer, “I thought I’d bought a home in Pleasantville. I never imagined in my wildest dreams that stuff like this would happen.”

Read the full monty by Christopher B. Leinberger at the Atlantic.com

The Tragedy of Suburbia

Africa in 2040

Paul Chefurka's grim assessment of what's in store for Africa. Please read and bookmark this paper.

There is a darkness moving on the face of the land. We catch glimpses of it in newscasts from far-off places that few of us have ever seen. We hear hints of it on the radio, read snippets about it in newspapers and magazines. The stories are always fragmentary, lacking context or connection. They speak of things like inflation in Zimbabwe, war in Chad, electricity problems in Johannesburg, famine in Malawi, pipeline fires in Nigeria, political violence in Kenya, cholera in Congo. Each snapshot of grief heaves briefly into view, then fades back into obscurity. With every fresh story we are left asking ourselves, "Is there something bigger going on here, some unseen thread connecting these dots? Or is this just more of the same from a continent that has known more than its share of misery?"

This paper is my attempt to connect those dots, to tease some order out of the chaos of the news reports. I will use some very simple numerical techniques to fill in the missing lines, and in the end a picture will emerge. I can tell you in advance that the picture is fearsome beyond imagining, and you may well be tempted to avert your gaze. I would advise you instead to screw up your courage and take a good look. It is crucial to our future as a civilized race.

I expect the collapse to turn Africa into the next arena for a quick game of "Disaster Capitalism." Large trans-national entities will make offers of "significant assistance" to particular countries in return for untrammeled access to their resource base. The vultures will be lining the banks of the Zambezi waiting for the feast, no doubt about it.

"I know there's rumors in Ghana `All Bush is coming to do is try to convince you to put a big military base here,' Bush said at a news conference with Kufuor. "That's baloney. As they say in Texas, that's bull."

Instead, he said the new command — unique to the Pentagon's structure — was aimed at more effectively reorganizing U.S. military efforts in Africa to strengthen African nations' peacekeeping, trafficking and anti-terror efforts.

"The whole purpose of Africom is to help African leaders deal with African problems," Bush said.

Bush sought to dispel the notion about militarization of Africa even before giving reporters a chance to ask him about it. Kufuour said he was satisfied with Bush's explanation, and thanked him for announcing it "so that the relationship between us and the United States will grow stronger."

For now, the administration has decided to continue operating Africom out of existing U.S. bases on the continent with a headquarters in Stuttgart, Germany. War-wrecked Liberia is the only African nation that has publicly offered to host a headquarters. Bush said before the trip that "if" a headquarters for Africom is ever established on the continent, he would "seriously consider" Liberia as the host.

Talk Radio in a Tizzy

Update: F@&k Talk Radio!!! I'm now officially proud of Wisconsin!

I am utterly ashamed of - and deeply disgusted by - the individual and collective mentality attacking Obama. Good reminder of precisely what kind of mentality was involved in attacking and murdering little boys for the crime of "reckless eyeballing"

Talk radio has made hay with this comment ALL DAY LONG today.

Your thoughts?

Black Gold in the 21st Century

The average American daily uses the oil energy equivalent of 120 healthy adult slaves...,

Prisons and Slavery: Seeking Cheap Labor and Control of African-Americans

Throughout history those in power within a given period of time have sought to control in some way groups that they perceived to be a threat and/or groups they wished to dominate for political or economic gain. The methods of control have varied from economic marginalization to thought control via propaganda to subjecting them to the control of the legal system to total or partial segregation and finally, in extreme cases, total extermination (e.g., genocide). In America such control has targeted Native Americans, African slaves, labor agitators and many others.

It can also be said that the use of inmates as a form of cheap labor has been part of the capitalist system from the beginning, as owners seek to maximize profits however they can, including using the cheapest form of labor, whether it be slaves, immigrant labor, or inmates. In fact, taking advantage of those imprisoned (in various forms, including slavery) has been common among nations for centuries.

President Clinton's Prison Legacy

Too Little Too Late
Preserving law and order has historically been a Republican issue. Barry Goldwater, Lyndon Johnson's losing opponent in the 1964 presidential race, was the first to campaign on crime control in an attempt to counter the prevailing "liberal" mood of the 1960's. Following Goldwater's lead, Richard Nixon called for an increase in punitive crime control measures and a "war on drugs" that led to an increase in incarceration for low-level drug offenders.2 The Republican National Committee's unleashing of the now famous "Willie Horton" advertisement during the race between Vice President George Bush and Massachusetts Governor Michael Dukakis solidified the rhetorical advantage held by Republicans in the law and order arena.

President Bill Clinton: The Incarceration President
When William Jefferson Clinton took office in 1993, he was embraced by some as a moderate change from the previous twelve years of tough on crime Republican administrations. Now, eight years later, the latest criminal justice statistics show that it was actually Democratic President Bill Clinton who implemented arguably the most punitive platform on crime in the last two decades. In fact, "tough on crime" policies passed during the Clinton Administration's tenure resulted in the largest increases in federal and state prison inmates of any president in American history.

Although Republicans are normally thought to hold the tough on crime mantle, in President Clinton's first-term (1992-1996), 148,000 more state and federal prisoners were added than under President Reagan's first term (1980-1984), and 34,000 more than were added under President Bush's four-year term (1988-1992).

When President Clinton Stole the "Get Tough on Crime" Show
When President Bill Clinton included "the war on crime" as a major tenet in both his 1992 and 1996 presidential campaigns, the past ten years had already witnessed the largest incarceration increase in the nation's history.4 During his 1992 campaign, to illustrate his resolve, President Clinton actually interrupted his campaigning to return to his home state of Arkansas to oversee the execution of mentally retarded death row inmate Ricky Ray Rector.5

Throughout its tenure, the Clinton administration consistently supported increased penalties and additional prison construction. The Violent Crime Control and Law Enforcement Act of 1994 provided state and municipal governments with $30 billion to add 100,000 new police officers, to build more prisons, and to employ more prison guards, as well as funding for crime prevention programs.

Crime Control Impact: A shift in resources from communities to corrections
The money and resources spent by governments and private interests on the criminal justice system is so large that it is having a profound impact on our economy, and as a result, our society. In 1994, just two years after President Bill Clinton took office, there were 1.4 million prison and jail inmates in the U.S. and by 1997, the criminal justice system employed more than two million people,6 and cost taxpayers more than $70 billion a year. One estimate suggests that by 2002, the criminal justice system will cost taxpayers more than $200 billion annually.7 Today, there are more people working in the criminal justice system than are working in community and social service occupations (like employment, vocational, mental health and substance abuse counseling).8 Ironically, these are the occupations that are most likely to be geared towards preventing crime, and helping to rehabilitate ex-offenders, as opposed to occupations that are designed to arrest, prosecute, detain and imprison. With two million people behind bars in the U.S., and 4.5 million people on probation and parole, America ends the Clinton-era with at least 8.5 million people who are either under the control of the correctional system or working for the criminal justice system.

While everyone is affected by the nation's quadrupling of the prison population, the African American community has borne the brunt of the nation's incarceration boom. From 1980 to 1992, the African American incarceration rate increased by an average of 138.4 per 100,000 per year. Still, despite a more than doubling of the African American incarceration rate in the 12 years prior to President Clinton's term in office, the African American incarceration rate continued to increase by an average rate of 100.4 per 100,000 per year. In total, between 1980 and 1999, the incarceration rate for African Americans more than tripled from 1156 per 100,000, to 3,620 per 100,000.

The FISA Bill Has Expired

The FISA bill, ostensibly designed to allow the feds to monitor overseas communications to/from the United States, has expired.



The House of Representatives would not accept a provision that gave RETROACTIVE immunity to telephone companies who had obeyed Homeland Security Department orders to include all domestic communications in their sweep. The President would not sign the Bill without the retroactive immunity provision [which the Senate had dutifully included in its version of the Bill].

Among telephone companies, QWest is the only one to have not buckled under Homeland Security pressure to surveille clients. Thus, QWest is the only telephone company to not need retroactive immunity for blatantly illegal acts that sold out American liberty.

Antidepressants and School Shootings, Suicide, Addiction

Cutting the Internet Cables Didn't Work...,

Iran established its first oil products bourse Sunday in a free trade zone on the Persian Gulf Island of Kish, the country's oil ministry said.

A statement posted on the ministry's Web site said 100 tons of polyethylene consignment was traded at the market's opening on the island, which houses the offices of about 100 Iranian and foreign oil companies.

Oil and petrochemical products will be traded in Iranian Rials, as well as all other hard currencies, the statement quoted Iranian Oil Minister Gholam Hossein Nozari as saying. About 20 brokers are already active in the market, it said.

"The bourse provides an economic opportunity for Iranians, other countries and foreign customers," Nozari was quoted as saying.

Iran produces more than 20 million tons of petrochemical products per year.

Iran has already registered for another oil bourse, in which it has said it hopes to trade oil in Euros instead of dollars, to reduce any American influence over the Islamic Republic's economy.

A bourse official, Mahdi Karbasian, told the IRNA official news agency that such an oil market would begin operating within the next year.

While most oil markets are traded in U.S. dollars, Iran first floated the idea of trading oil in Euros in the early 2000s during the tenure of reformist president Mohammad Khatami. It gained new life after the nationalist Mahmoud Ahmadinejad was elected in 2005.

As the fourth largest oil producer in the world, Iran has a measure of influence over international oil markets. The country ranks second for output among OPEC Countries, and controls about 5 percent of the global oil supply.

Paxil's a Helluva Drug....,

It took long enough, but at last the lid seems to be opening up on the psychopharmacological motive underlying the Valentine's day massacre at NIU.

Stephen Kazmierczak - the Illinois gunman stopped taking Paxil (Seroxat)… according to news channel ABC7 Chicago - full story here:

“Authorities have not figured out what motivated the man, described as a hardworking, award-winning former honor student by NIU faculty, to go on a shooting rampage that killed five students.

Kazmierczak, 27, was treated for mental illness nine years ago. He was considered volatile, according to a staff member who worked at the facility at the time, and violent if he stopped taking the antidepressant and anti-anxiety pills prescribed for him. Including Paxil, it was medication he was supposed to still be taking and apparently stopped a couple of weeks ago.”

So Paxil/Seroxat may have been involved in this tragedy, however we need to know the details - we need to know the truth.

Real Change

Do you remember when Halliburton relocated its world HQ to Dubai last year?

If you could, you would too.

I came across this post this morning and it documents the most jaw-dropping economic development one could ever imagine outside the annals of pure science fiction.

Dubai in 1990:

The same street in 2003;

The same street in 2007;

Go check out the full monty at Mish's Global Economic Trend Analysis where there are many more mind-boggling images to document this trend.

Obamamandius

I met a traveler from an antique land
Who said: "Two vast and trunkless legs of stone
Stand in the desert... Near them, on the sand,
Half sunk a shattered visage lies, whose frown,
And wrinkled lip, and sneer of cold command,
Tell that its sculptor well those passions read
Which yet survive, stamped on these lifeless things,
The hand that mocked them and the heart that fed;
And on the pedestal these words appear:
My name is Ozymandius, King of Kings,
Look on my works, ye Mighty, and despair!
Nothing beside remains. Round the decay
Of that colossal wreck, boundless and bare
The lone and level sands stretch far away.
Percy Bysshe Shelley

As the ultimate rorschachian figuration, Obama has been claimed and disclaimed by elements from all across the spectrum desperate to be seen as relevant or percipient. Few, however, comprehend his actual signification. Last year at Cobb, I spelled out precisely what would be required of the presidential heir apparent.

Last night, I happened to catch some of Real Time on my way to shuteye and saw Andrew Sullivan venture about as close as anyone has here-to-date in grasping the signification of an Obama presidency. Baraka is an idealized construct of elite governance. This is why he has garnered the support of U.S. elites and elements from throughout the establishment. quoth Sullivan;

What does he offer? First and foremost: his face. Think of it as the most effective potential re-branding of the United States since Reagan. Such a re-branding is not trivial—it’s central to an effective war strategy. The war on Islamist terror, after all, is two-pronged: a function of both hard power and soft power. We have seen the potential of hard power in removing the Taliban and Saddam Hussein. We have also seen its inherent weaknesses in Iraq, and its profound limitations in winning a long war against radical Islam. The next president has to create a sophisticated and supple blend of soft and hard power to isolate the enemy, to fight where necessary, but also to create an ideological template that works to the West’s advantage over the long haul. There is simply no other candidate with the potential of Obama to do this. Which is where his face comes in.

Consider this hypothetical. It’s November 2008. A young Pakistani Muslim is watching television and sees that this man—Barack Hussein Obama—is the new face of America. In one simple image, America’s soft power has been ratcheted up not a notch, but a logarithm. A brown-skinned man whose father was an African, who grew up in Indonesia and Hawaii, who attended a majority-Muslim school as a boy, is now the alleged enemy. If you wanted the crudest but most effective weapon against the demonization of America that fuels Islamist ideology, Obama’s face gets close. It proves them wrong about what America is in ways no words can......Unlike any of the other candidates, he could take America—finally—past the debilitating, self-perpetuating family quarrel of the Baby Boom generation that has long engulfed all of us. So much has happened in America in the past seven years, let alone the past 40, that we can be forgiven for focusing on the present and the immediate future. But it is only when you take several large steps back into the long past that the full logic of an Obama presidency stares directly—and uncomfortably—at you.

At its best, the Obama candidacy is about ending a war—not so much the war in Iraq, which now has a mo­mentum that will propel the occupation into the next decade—but the war within America that has prevailed since Vietnam and that shows dangerous signs of intensifying, a nonviolent civil war that has crippled America at the very time the world needs it most. It is a war about war—and about culture and about religion and about race. And in that war, Obama—and Obama alone—offers the possibility of a truce.

Remember, when everything is said and done, and all the rorschachian self-affirmations are complete, all that will remain, and all that has ever mattered from the outset with this perfectly honed candidacy - has been the imperative to maintain the global rule of dopamine hegemony.

Motive? What motive?

This just in from faux news;



That didn't take very long now did it? The man who gunned down five people at Northern Illinois University in a suicidal rampage became erratic after halting his medication and carried a shotgun to campus inside a guitar case, police said Friday.

update; Kazmierczak, whose first name was earlier listed as Steven, was taking some kind of medication, Grady said.

"He had stopped taking medication and become somewhat erratic in the last couple of weeks," Grady said, declining to name the drug or provide other details.

next update; A former employee at a Chicago psychiatric treatment center said Kazmierczak was placed there after high school by his parents. She said he used to cut himself, and had resisted taking his medications.

further update; Family members told the authorities that Mr. Kazmierczak had stopped taking his medication. Law enforcement authorities would not say what the medication was for, but said Mr. Kazmierczak had grown erratic, according to his family, in the days after he quit taking the drugs.

Still not giving up those anti-depressant meds though. Media coverage is focused on gun control and copycat shootings inspired by media coverage.

Dressed in black and wearing a stocking cap - whaddaya bet he was loaded up on a bellyful of prescription anti-depressants?

We continue to await the specific toxicology report....,