CTH | Many people have asked: how is the best way to stop the insanity
behind the incessant vaccine narrative? The likely best approach is to
start demanding the pharmaceutical companies have their liability
waivers removed.
If the vaccine is safe and effective, why would the U.S. government still need to provide liability waivers from adverse vaccine outcomes?
Start pressuring legislators and elected officials to force the
elimination of the waivers. Alinsky them… Make them live up to their
own narrative; their own words, their own rules. If the vaccines are
safe/effective, why do we need the waivers? If you want to get more
people vaccinated, drop the waiver moving forward.
Eliminate those liability waivers and watch how fast every vaccine
mandate is dropped, while every voice demanding vaccination goes quiet.
msn | In a video that’s garnered more than 2.4 million views on TikTok, Nevada
real-estate agent Sean Gotcher criticizes the “iBuying” business model,
in which companies buy and sell homes for a profit. In the video, he
proposes that a nameless company has a website where many people search
for homes “when they’re bored,” and he says that same company “uses that
information to go into that ZIP code and start purchasing houses.”
In other words, he’s suggesting that companies such as Zillow are
using the data they glean from people’s perusal of home listings on
their sites to make decisions about which houses to buy as iBuyers.
Gotcher
later argues that the company will buy 30 homes at one price, and then
purchase a 31st home at a higher price. “What that just did is create a
new comp,” Gotcher says, referring to comparable prices on nearby
properties, which appraisers use to determine the value of a home for
sale. He then says the company can turn around and sell the other homes
at that new, higher price.
In subsequent videos, Gotcher takes on Zillow and Redfin more directly, criticizing their respective business practices.
“I’m
happy to see the conversation that’s occurring at every printer in
every real estate office about data storage, mixed with buying power and
recognizable marketing is finally happening outside our office doors so
more can participate in the discussion,” Gotcher, who works for Level
Up Real Estate in Henderson, Nev., told MarketWatch in an email.
The video subsequently garnered even more attention on Twitter when a person with the username Gladvillain shared it
after learning that the user’s mother had sold her home to Zillow. Many
users claimed that Zillow was purchasing “all of the homes,” and said
they planned to boycott the platform.
Both Zillow and Redfin
contradicted the video’s claims. “The internet has empowered millions of
consumers with more information, transparency and tools in real estate
to help them make smarter real estate decisions, many provided by Zillow
for more than a decade,” a Zillow spokesperson told MarketWatch in an
email. “Unfortunately, the internet can also sometimes be a source of
misinformation and falsehoods — as is this case.”
A Redfin spokesperson added that the company doesn’t “have the share
to manipulate the market nor do we have any desire to, because
intentionally overpaying for homes would be a terrible business model.”
Real-estate
experts debunked many of the points made in the viral video, and argued
that other forces are to blame for the country’s competitive, pricey
housing market.
“If you could rig the residential housing market
that easily, the Realtors would have done it long ago,” said Gilles
Duranton, a real-estate professor at the University of Pennsylvania’s
Wharton School.
ips | U.S. billionaires have seen their wealth surge $1.8 trillion during
the pandemic, their collective fortune skyrocketing by nearly two-thirds
(62 percent) from just short of $3 trillion at the start of the COVID
crisis on March 18, 2020, to $4.8 trillion on August 17, 2021, according
to a report from Americans for Tax Fairness (ATF) and the Institute for
Policy Studies Program on Inequality (IPS). A table of the top 15
billionaires is below and the full data set is here.
Elon Musk has seen his wealth increase by an eye-popping $150 billion during the pandemic, a gain of over 600 percent.
America’s
billionaire bonanza demonstrates the flaws in our current economic and
tax systems President Biden and Democrats in Congress are trying to
remedy by advancing a $3.5 trillion budget package,
which has already passed the U.S. Senate and is being considered in the
U.S. House today. If it becomes law through the budget reconciliation
process this fall, it will aid communities and working families by making healthcare, eldercare, childcare, housing and education more affordable,
investing in clean energy, expanding the Child Tax Credit and providing
12 weeks of paid family and medical leave. It will be paid for by
making the wealthy and corporations pay their fair share of taxes, and
it will not raise taxes on anyone making under $400,000 a year.
Not
only did the wealth of billionaires grow, but so did their numbers: in
March of last year, there were 614 Americans with 10-figure bank
accounts; this August, there are 708. Their $1.8 trillion of
increased wealth alone over 17 months, which will not be taxed unless
they sell their assets, would pay for more than half of Biden’s 10-year $3.5 trillion investment package.
motherjones |When I first came to the Dominican
Republic 30 years ago evidence of forced labor in the sugar harvest was
glaringly obvious: Men with shotguns guarded locked gates to trap
workers in the cane fields. But the International Labor Organization’s
indicators of forced labor include more subtle abuses like the hazardous
working conditions, low pay, and other issues cane workers regularly
describe today.
“We’re talking about coercive forces that are psychological, coercive
forces that are driven by debt,” said Duncan Jepson, managing director
of the international anti-trafficking group Liberty Shared. “And that’s
slightly more subtle than methods of violence.”
One Sunday morning, Euclides and I went to a batey for an Evangelical
church service, under a patchwork of red and blue tarps affixed to
wooden poles. We’d been invited by a couple I’ll call Efrain and Noni.
Noni paced back and forth before the congregation, microphone in her
hand, leaning back, giving it everything.
In contrast to his wife, Efrain sat quietly in a folding chair. He’s a
“mixer,” part of a team of fumigators who sometimes use sticks ripped
from trees to stir chemicals in open 55-gallon drums. Despite Central
Romana’s promises to provide health care to workers, Efrain told us he
has to pay for much of it himself, which has pushed him into spiraling
debt. Together with expenses caused by his brother’s thrombosis, he now
owes 30,000 pesos—about $600, or nearly three months’ pay. The lender
charges 10 percent per week, Efrain explains: “If you borrow 1,000
pesos, you have to give this person 100 pesos per week in interest.”
Yearly, that adds up to 520 percent interest.
More than two dozen cane workers told us their salaries are so low
that they’ve turned to money lenders in nearby towns. A municipal
firefighter who has a side business making loans to cane workers
explained that while Central Romana doesn’t operate the loan shark
rings, the company’s low wages leave workers desperate and willing to
pay exorbitant rates. One of the ILO’s elements of forced labor is
“fraudulent debt from which workers cannot escape.”
It’s a brutal cycle, Efrain tells us. The canecutters are in debt until they die.
Sugar is not the only thing that’s
made the Fanjuls so rich. Their profits are sweetened thanks to the
politics of the United States. Not only does Central Romana benefit from
a tariff program under which the Dominican Republic gets a greater
share than any other sugar-exporting nation—with the company filling
nearly two-thirds of that quota—but it also profits from a
congressionally authorized federal price-support program that inflates
the value of each pound by about 10 cents. Vincent Smith, an
agricultural economist and critic of the program, estimates the Fanjul
family is “getting at least $150 million a year” in net benefits from
the program, with another $25 million going to Central Romana’s imports.
“That’s a very substantial concentration of benefits on a very small
number of folks,” Smith says.
Some of that money goes back to seed the American political system.
Over the last 20 years, Big Sugar has spent more than $220 million on
campaign contributions and lobbying to sustain the price-supports and
oppose stricter dietary guidelines, with 40 percent of that, according
to OpenSecrets, coming from Fanjul-affiliated companies and lobbying
groups. Smith, citing Federal Election Commission data, points out that
the Fanjul empire and allied sugar organizations spend 10 million every
year on lobbying and campaign contributions. “They’re not doing this out
of the goodness of their hearts,” says Sheila Krumholz, OpenSecrets’
executive director. “It’s a very good investment.”
thegrayzone |The death by starvation of Etwariya
Devi, a 67-year-old widow from the rural Indian state of Jharkhand,
might have passed without notice had it not been part of a more
widespread trend.
Like 1.3 billion of her fellow
Indians, Devi had been pushed to enroll in a biometric digital ID system
called Aadhaar in order to access public services, including her
monthly allotment of 25kg of rice. When her fingerprint failed to
register with the shoddy system, Devi was denied her food ration.
Throughout the course of the following three months in 2017, she was
repeatedly refused food until she succumbed to hunger, alone in her
home.
Premani Kumar, a 64-year-old woman also from Jharkhand, met the same demise as Devi, dying of hunger and exhaustion
the same year after the Aadhaar system transferred her pension payments
to another person without her permission, while cutting off her monthly
food rations.
A similarly cruel fate was reserved for Santoshi Kumari,
an 11-year-old girl, also from Jharkhand, who reportedly died begging
for rice after her family’s ration card was canceled because it had not
been linked to their Aadhaar digital ID.
These three heart-rending casualties
were among a spate of deaths in rural India in 2017 which came as a
direct result of the Aadhaar digital ID system.
With over one billion Indians in its
database, Aadhaar is the largest biometric digital ID program ever
constructed. Besides serving as a portal to government services, it
tracks users’ movements between cities, their employment status, and
purchasing records. It is a de facto social credit system that serves as
the key entry point for accessing services in India.
Having branded Aadhaar’s creator,
fellow billionaire Nandan Nilekani, as a “hero,” initiatives backed by
tech oligarch Bill Gates have long sought to bring the “Aadhaar approach
to other countries.” With the onset of the
Covid-19 crisis, Gates and other mavens of the digital ID industry have
an unprecedented opportunity to introduce their programs into the wealthy countries of the Global North.
For those yearning for an end to
pandemic-related restrictions, credential programs certifying their
vaccination against Covid-19 have been marketed as the key to reopening
the economy and restoring their personal freedom. But the implementation
of immunity passports is also accelerating the establishment of a
global digital identity infrastructure.
As the military surveillance firm and NATO contractor Thales recently put it, vaccine passports “are a precursor to digital ID wallets.”
And as the CEO of iProove, a biometric ID company and Homeland Security contractor, emphasized to Forbes,
“The evolution of vaccine certificates will actually drive the whole
field of digital ID in the future. So, therefore, this is not just about
Covid, this is about something even bigger.”
For the national security state,
digital immunity passports promise unprecedented control over
populations wherever such systems are implemented. Ann Cavoukian, the
former privacy commissioner of Ontario, Canada has described
the vaccine passport system already active in her province as “a new,
inescapable web of surveillance with geolocation data being tracked
everywhere.”
GodsSpies |“The news media are not independent; they are a sort of bulletin
board and public relations firm for the ruling class—the people who run
things. Those who decide what news you will or will not hear are paid
by, and tolerated purely at the whim of, those who hold economic power.
If the parent corporation doesn’t want you to know something, it won’t
be on the news. Period. Or, at the very least, it will be slanted to
suit them, and then rarely followed up.” — George Carlin, quoted here
It's going to be interesting to see, in the next five to fifteen
years, the methods the rich must use to keep their power when the
climate crisis hits with full and majestic force. The coming chaos and
revolutionary fervor that suffering millions and billions will bring to
the table will each be world-historical in scope. What under those
conditions will the powerful do, the very very few, to keep the very
many from taking control? Whatever the result, none of our governments
will survive in their current form.
Keep in mind, revolutions are
not orderly, and this one almost certainly won't be well led. Yes, from
time to time, the world kicks out a George Washington, fit for the
challenge of his time, a man who willing to fortify the republic he
helped to build rather than just profit from it.
And yes, from
time to time the world kicks out a Napoleon or Vespasian, a man fit to
rule his time well, at least for the most part, even if that rule is
decidedly autocratic.
But most of the time the world kicks out
masters of chaos, egomaniacal destroyers and opportunists, people like
Alcibiades of Athens, or Ronald Reagan, people who gain power in
disgruntled times, and through their actions make the world worse for
everyone. Reagan took a struggling country, the proto-neoliberal nation
of the Carter years, a nation steeped in stagflation, and set in fatal
motion the wealth machine that will soon destroy us all, including the
machine itself.
If we don't get off of fossil fuel in time, the
rich will suffer with the rest of us the destruction they will cause.
Our leaders won't contemplate any measure that reduces their power, and
we won't contemplate forcing them to leave. Under those constraints, the
problem has no solution.
The rich won't stand down. Will the people stand up? On that one question hangs all of the rest of this tale.
caitlinjohnstone | “Money has begun flowing into companies intending to monetize
psychedelic therapy as new research has increasingly shown that blowing
one’s mind can alter it for the better,” reads a new article
for the Los Angeles Times titled “Money is pouring into psychedelics.
Meet the mystical hedge fund investor bankrolling the boom.”
“This scientific and commercial excitement rests on research showing
that psychedelics can supercharge mental health treatment for PTSD,
depression, anxiety, addiction, and other chronic ailments of the mind,
enabling patients to dive deep, confront their traumas and — a rarity
for mental illnesses — return healed,” the article reads. “That goes for
synthetic chemicals such as MDMA and ketamine as well as plant-derived drugs such as psilocybin (the
active ingredient in magic mushrooms), the South American plant brew
ayahuasca, and the West African root-derived substance iboga.”
LA Times’ Sam Dean shares the personal journey of hedge fund investor Sa’ad Shah and his involvement in what has become a multibillion-dollar
psychedelics industry long before even the legal infrastructure
necessary for such companies to turn a profit is in place. We learn of
Shah’s experience with ayahuasca, his interest in mystical traditions
and personal growth, and his conviction in the shift that has for the
last few years been known as the psychedelic renaissance.
And then, about halfway down the article, we get to the actual meat of the matter:
“Shah
welcomes big pharma and big institutions to enter the fray in the
interest of spreading the chemical gospel far and wide. He sees the
financial and therapeutic potential for psychedelics not in the cannabis
model, which would make psychedelics broadly available for retail
purchase, but in the pharmaceutical mode — psychedelics as prescribed
drugs, with patent rights, administered in medical settings.”
That
“with patent rights” bit right there is behind the so-called
psychedelic renaissance we’ve been hearing so much about: “favoring the
FDA regulatory route over the Oregon route,” as a psychiatrist cited in
the article put it. It’s being driven not by the need to free human consciousness from the prohibition-induced coma
it’s been under since the sixties so that we can collectively navigate
through the many existential hurdles our species is fast approaching
with wisdom and insight, but by the agenda to make rich people even
richer by forcefully controlling psychedelic substances via the
pharmaceutical industry.
ritholtz | “In every well-ordered society charged with the duty of
conserving the safety of its members, the rights of the individual in
respect of his liberty may at times, under the pressure of great
dangers, be subjected to such restraint, to be enforced by reasonable
regulations, as the safety of the general public may demand.”
I noted back in February that America’s CEOs were “Having a Good Year.”
Not just in their response to a deadly pandemic, or to the logistical
challenges of remote work or feeding a nation stuck at home, but even
their response to the January 6th attempted coup (Let’s stop pussyfooting around with equivocal words like “insurrection”).
The Vaccine hesitancy that has been stoked by bad actors – an
unseemly mix of malicious, opportunistic, and plain old stupid – has
presented another chance for the corporate sector to demonstrate
leadership. The track record is at best mixed.
If for no other reason than self-interest, it’s time for Corporate America to step up its Vax game – and fast. More than their new hires,
companies need to get their customers, aka the public, vaccinated.
Otherwise, we are going to be living through an echo of 2020, with Covid
as an ongoing and perhaps even long-term drag on the economy. This will
affect revenue and earnings at all companies.
Even better, as an exercise, let’s name names. Consider these 10
companies as well-situated to effect real social change relative to
Vaccines. But really, any company can show leadership.
ecosophia |Stage Seven: Don’t Breathe A Word Of This
There
was another reason for people to be suspicious, though that wasn’t
clear at first. Everyone who’s had to use Microsoft programs knows that
Bill Gates’ management style tends to produce second-rate, bug-ridden
products that don’t work the way they’re supposed to work, and have to
be pushed on reluctant consumers via high-pressure marketing and
monopolistic practices. It turns out that the same was true of the
biotechnology on which the Covid-19 vaccines are based. That would have
been discovered in the usual way during the two to five years of testing
a new vaccine normally gets, but the Covid vaccines didn’t get that;
the first one to be authorized had a total of eight weeks of not
especially rigorous testing, the others didn’t get much more, and so a
far from minor problem slipped past. In the spring of 2021 word thus
began to trickle out that the Covid-19 vaccines had a serious problem
with ADE: once the initial protection wore off, a process which took a
few months, people who’d been vaccinated were much more likely to get
seriously ill from repeat exposure to Covid-19 than people who hadn’t.
Thus the federal government and the medical industry suddenly had a
self-inflicted disaster on their hands.
Stage Eight: Panic In The C-Suites
The
first response of the people in power, of course, was to find somebody
else to take the blame. That’s when politicians and the media turned on a
dime (again) and suddenly started admitting that the virus could have
come from the Wuhan Institute of Virology. That’s when Bill Gates
suddenly stopped being the poster child for the vaccine effort and got
dumped in a hurry by his wife and kids, and when Anthony Fauci suddenly
had to deal with a flurry of negative publicity and the unexplained
cancellation of his ghostwritten memoirs. The goal was to find
someone—Gates, Fauci, the Chinese, anyone—who could be made into the
fall guy and blamed for the impending mess. Apparently that first round
of bad news was followed by even worse news, however; I suspect that the
news was that the ADE caused by the vaccine had a noticeable fatality
rate, but that’s just a guess. One way or another, finding fall guys
wasn’t an adequate dodge any more, since at this stage it wasn’t just
careers that were at risk: it was potentially the viability of the
entire political-economic establishment.
Stage Nine: Things Get Serious
All
of a sudden, as a result, it was no longer enough to vaccinate 70% of
the US population. Everyone without exception had to get vaccinated—if
everyone gets the vaccine, after all, it will be easier to claim that
what’s happening is a nasty new variant rather than vaccine-driven ADE,
since nobody will be able to point out that the unvaccinated aren’t
getting it. All of a sudden, officials dropped the (inaccurate) claim
that the vaccines keep you from getting Covid-19. New outbreaks flared
in which most people who got sick had been fully vaccinated; stories
surfaced in the media about how strange it was that so many people were
getting really nasty summer colds; the labor shortage somehow just kept
getting worse and other shortages snowballed, but if you suggested that
it was because too many people were sick you could count on being
shouted down. Authorities began to talk earnestly about how a new
variant might show up soon that would kill a third of the people who
caught it. Under normal circumstances, there’s no way they could know
that in advance. It makes perfect sense, however, if the vaccines have
been found to cause serious ADE and they already have a good idea of
what the fatality rate will be.
This is where we are as I write this. If my hypothesis is right, here’s what we can expect.
Stage Ten: Hoping for a Miracle
As
ADE becomes more common, breakthrough infection clusters will pop up
with increasing frequency, and the higher the percentage of the
population in that region is vaccinated, the worse they will be.
Variants will be blamed for this. Word of the imminent crisis will
spread through the upper levels of society, however, causing
increasingly frantic and irrational behavior, until it becomes next to
impossible to get anything done if it depends on the government or big
corporations. Medical laboratories will scramble to find a way to
counteract ADE, though that’s been tried for decades now without
success. Meanwhile the people who refuse to get vaccinated won’t budge
no matter how much furious rhetoric and punitive policy gets dumped on
them. Once this becomes clear, authorities will insist that everyone but
a few holdouts has been vaccinated, in the fond hope that people will
believe them one more time.
Stage Eleven: Into The Endgame
When
ADE becomes too widespread to ignore and people begin to die in
significant numbers, expect governments to proclaim the arrival of the
predicted new hyper-lethal variant and impose a new round of shutdowns,
mask mandates, and the like. The media will insist that the people who
are dying are all unvaccinated as long as they can get away with it; pay
attention to the vaccination status and health outcomes of people you
know for a reality check. Unless some way of stopping ADE-enhanced
infections can be found in a hurry, medical systems will buckle under
the caseload and triage will become the order of the day. How soon this
will happen, if it does, is impossible to say in advance. It’s also
impossible to know in advance how soon it will become clear that the
vaccines are responsible—or just how violent a backlash against the
political and economic establishment this could provoke.
WSJ | A bidding war broke out this winter at a new subdivision north of
Houston. But the prize this time was the entire subdivision, not just a
single suburban house, illustrating the rise of big investors as a
potent new force in the U.S. housing market.
D.R. Horton Inc.
DHI 1.01%
built 124 houses in Conroe, Texas, rented them out and then put
the whole community, Amber Pines at Fosters Ridge, on the block. A Who’s
Who of investors and home-rental firms flocked to the December sale.
The winning $32 million bid came from an online property-investing
platform, Fundrise LLC, which manages more than $1 billion on behalf of
about 150,000 individuals.
The country’s most prolific home builder booked roughly twice
what it typically makes selling houses to the middle class—an
encouraging debut in the business of selling entire neighborhoods to
investors.
“We certainly wouldn’t expect every single-family community we sell
to sell at a 50% gross margin,” the builder’s finance chief,
Bill Wheat,
said at a recent investor conference.
“You
now have permanent capital competing with a young couple trying to buy a
house,” said
John Burns,
whose eponymous real estate consulting firm estimates that in
many of the nation’s top markets, roughly one in every five houses sold
is bought by someone who never moves in. “That’s going to make U.S.
housing permanently more expensive,” he said.
The consulting firm
found Houston to be a favorite haunt of investors who have lately
accounted for 24% of home purchases there. Investors’ slice of the
housing market grows—as it does in other boomtowns, such as Miami,
Phoenix and Las Vegas—among properties priced below $300,000 and in
decent school districts.
“Limited housing supply, low rates, a
global reach for yield, and what we’re calling the institutionalization
of real-estate investors has set the stage for another speculative
investor-driven home price bubble,” the firm concluded.
In March, Dr. Fauci again incorrectly predicted that doom was upon us when Texas relaxed its pandemic rules.
Kahneman writes: “It is wrong to blame anyone for failing to forecast
accurately in an unpredictable world. However, it seems fair to blame
professionals for believing they can succeed in an impossible task.”
Perhaps, Kahneman is too kind. With Covid, predictions are founded on
politics, not science, as Bill Maher recently pointedly and humorously explained.
We are ignorant of our ignorance. It is time to look for new patterns in the evidence of those who have not survived.
Who Didn’t Come Back from Covid
The military was wise enough to listen to Wald. It would have been
perverse to ignore the cockpit and reinforce parts of the plane that
could survive bullet hits.
Policy makers, politicians, and the media have largely ignored the cockpit of good health: the human immunological system.
Maher pointed to a recent CDC study that reported the vast majority (78%) of those hospitalized or dead from Covid have been overweight or obese.
The Covid survival narrative has focused attention on lockdowns,
masks and vaccinations. Maher pointed out the role that obesity played:
“People died because talking about obesity had become a third rail in
America.” Maher continued, “the last thing you want to do is say
something insensitive. We would literally rather die. Instead, we were
told to lock down. Unfortunately, the killer was already in the house
and her name is Little Debbie.”
Little Debbie, of course, is Maher’s reference to heavily processed foods that are ubiquitous in the American diet.
A significant factor in the startling numbers of overweight Americans
is the consumption of high-fructose corn syrup in heavily processed
foods.
From 1995-2020, corn subsidies
in the United States totaled $116.6 billion. The subsidized and surplus
corn ends up not only as processed food but as animal feed.
newsweek | The Spanish firm Grifols helped set off a kerfuffle last year when
it, along with other firms, offered nearly double the going price for
blood donations for a COVID-19 treatment trial. Brigham Young University
in Idaho had to threaten some enterprising students with suspension to
keep them from intentionally trying to contract COVID-19. The trial
failed, however, and now the Barcelona-based firm is hoping to extract
something far more valuable from the plasma of young volunteers: a set
of microscopic molecules that could reverse the process of aging itself.
Earlier this year, Grifols closed on a $146 million-deal to buy Alkahest, a company founded by Stanford University
neuroscientist Tony Wyss-Coray, who, along with Saul Villeda, revealed
in scientific papers published in 2011 and 2014 that the blood from
young mice had seemingly miraculous restorative effects on the brains of
elderly mice. The discovery adds to a hot area of inquiry called
geroscience that "seeks to understand molecular and cellular mechanisms
that make aging a major risk factor and driver of common chronic
conditions and diseases of older adulthood," according to the National
Institutes of Health. In the last six years, Alkahest has identified
more than 8,000 proteins in the blood that show potential promise as
therapies. Its efforts and those of Grifols have resulted in at least
six phase 2 trials completed or underway to treat a wide range of
age-related diseases, including Alzheimer's and Parkinson's.
Alkahest
and a growing number of other geroscience health startups signal a
change in thinking about some of the most intractable diseases facing
humankind. Rather than focusing solely on the etiology of individual
diseases like heart disease, cancer, Alzheimer's and arthritis—or, for
that matter, COVID-19—geroscientists are trying to understand how these
diseases relate to the single largest risk factor of all: human aging.
Their goal is to hack the process of aging itself and, in the process,
delay or stave off the onset of many of the diseases most associated
with growing old.
The idea that aging and illness go hand and hand is, of course,
nothing new. What's new is the newfound confidence of scientists that
"aging" can be measured, reverse-engineered and controlled.
Until
recently, "people working on diseases did not think that aging was
modifiable," says Felipe Sierra, who recently retired as director of the
Division of Aging Biology at the National Institute on Aging, a part of
the NIH. "That is actually what many medical books say: The main risk
factor for cardiovascular disease is aging, but we cannot change aging
so let's talk about cholesterol and obesity. For Alzheimer's, aging is
the main risk factor—but let's talk about the buildup in the brain of
beta-amyloid proteins. Now that is beginning to change."
lifespan | Back in 2005, Drs. Irina and Michael
Conboy showed that joining the circulatory systems of young and old mice
together in a procedure called parabiosis could rejuvenate aged tissues
and reverse some aspects of aging in old mice.
Following this discovery, many
researchers concluded that there must be something special in young
blood that was able to spur rejuvenation in aged animals, and various
companies have been trying to find out what. Indeed, we recently
reported that researchers were apparently successful in halving the epigenetic age of old rats by treating them with Elixir, a proprietary mix of pro-youthful factors normally found in young blood.
However, a question still remains: was
the rejuvenation the result of there being something beneficial in the
young blood, or is it more a case of dilution of the harmful factors
present in old blood?
Today, we want to spotlight a new study
by Drs. Irina and Michael Conboy, which again lends more weight to the
idea that the rejuvenation is most likely due to a dilution of pro-aging
factors in old blood rather than there being any special sauce in young
blood [1].
During the study, the research team
discovered that by replacing half of the blood plasma in old mice with a
saline and albumin mixture, the albumin replacing the lost protein that
was removed when the original old blood plasma was taken, they could
achieve a similar or even greater rejuvenation effect in brain, liver,
and muscle tissues as joining two mice together through parabiosis or
giving old mice young blood.
We had the opportunity to interview Drs.
Irina and Michael Conboy about this new discovery and to see if we
could get to the bottom of the mystery surrounding aged blood
rejuvenation.
Steve: This recent paper builds on the
2015 paper of TGF beta, but it goes even further back to the days when
you guys had a lab next door to Amy Wagers and Tony Wyss-Coray and you
all shared the techniques, including the parabiosis technique.
Irina: Yes. Actually, I would like also
to thank you, Elena, and the whole organization for highlighting our
work and giving us an opportunity to speak in interviews.
Steve: You are very welcome. So, is this
dilution? Is it what you put in that’s more important, is it what you
take out, or is it both? I personally think that the evidence strongly
suggests that it’s more what you take out, but that doesn’t necessarily
mean that there isn’t good stuff in young blood.
Irina: Since our 2005 heterochronic
parabiosis paper, many people jumped into this boat of young blood,
thinking that the reason for rejuvenation is that there are less young
factors in an old animal and we provided them. Meanwhile, all our work
even leading to that paper suggested the opposite outcome: that there
are excessive factors in old blood that are actually good proteins; for
example, TGF beta. You cannot live without TGF beta. But, when people
age, the levels of this protein become elevated, and they start doing
counterproductive things for tissue repair, induce inflammation,
increase fibrosis, and prevent proliferation of tissue stem cells. That
was our point of view for the past 15 years, and every single paper that
we published since was putting forward the general idea that it is not
the young blood, it is the old blood that needs thought and attention.
theintercept |Pfizer, Moderna, and other coronavirus vaccine makers have said repeatedly that they intend to hike prices on vaccines as early as this year, as the potential need for additional booster shots and future demand could lead to an unprecedented financial windfall. One estimate projects that if Pfizer raised the price of its coronavirus vaccine from $19.50 to $175 per dose, as one Pfizer executive recently suggested, and if every adult American were to take it, the cost would be $44.7 billion — nearly 10 percent of all U.S. drug spending.
But the federal government, which
funded crucial biomedical research to develop the patented messenger RNA
technology behind the leading Covid-19 vaccines, is on the verge of
eliminating a legal mechanism to control the prices of key medical
products, including vaccines.
Next week, the National Institute of
Standards and Technology, or NIST, will wrap up a comment period to
modify the rules governing the Bayh-Dole Act, a law that regulates the
transfer of federally funded inventions into commercial property. Under
the current interpretation of the law, the government may “march in” and
suspend the use of patents developed via government-funded inventions
if it determines that the products are excessively priced.
The rulemaking is the latest flashpoint
in a decades long battle to control drug prices. The drug industry has
fought successfully to prevent “march-in” rights in the past; the
government has never managed to exercise them. But over the last year, a
growing number of Republicans and Democrats, including newly appointed
Health and Human Services Secretary Xavier Beccera, have called for the
use of march-in rights to rein in drug prices.
This supposed leverage to control
prices — on coronavirus medications and dozens of other drugs whose
development relied heavily on government-backed research — would be gone
if the rule-change proceeds.
FT | The tax fight is a preamble for an upcoming mayoral election that all sides view as one of the most consequential in New York’s history. The Democratic primary, which is expected to crown the eventual winner in a city where seven out of every eight voters are Democrats, is in June.
Business leaders and the wealthy have been nursing existential dread at the possibility of what one prominent property developer calls another “ideological” mayor. That is, someone in the mould of the current mayor, Bill de Blasio, who is limited to serving two terms.
Two days after winning the 2013 Democratic primary, De Blasio attended a private lunch with the city’s business leaders and promptly alienated many of them. They expected he would solicit their advice and extend a hand. Instead, the mayor reprised his “tale of two cities” campaign rhetoric, and declared that he cared about the other side. “Faces dropped,” one attendee recalls.
That divide has only deepened in the ensuing years. De Blasio’s legion of executive class critics deride him as a lazy manager who deploys politicised rhetoric to cover for his own incompetence. While the budget has increased by 35 per cent during his tenure, problems like homelessness and public housing have worsened — even before the pandemic.
“The city is at a crossroads. This is truly the most important election of our lifetime and in NYC’s history,” Stephen Ross, chair of The Related Companies, and de facto king of the city’s developers, wrote to fellow business leaders last month as he urged them to join his effort to elect a business-friendly mayor. The race’s outcome, Ross wrote, will determine whether “NYC will rebound or languish”.
Looming large for executives like Ross is the grim memory of the 1970s, when a fraying city ended up losing half its Fortune 500 companies — many fleeing to surrounding suburbs — and shedding more than 1m inhabitants. That era also birthed a civic movement.
It was christened at a breakfast meeting at the Regency Hotel on Park Avenue in 1971 when the developer Lew Rudin and hotelier Robert Tisch hatched what would become the Association for a Better New York, a group of business leaders who aimed to step in where city government was failing. ABNY’s moguls lobbied the federal government on the city’s behalf. They also brought labour leaders into their tent.
pluralistic | The zombie economy shambles on. Obama's loan-shark bailout and the
eviction crisis let the architects of subprime buy up whole towns' worth
of homes and turn them into hugely profitable slums: high-rent,
low-quality deathtraps.
Wall St landlords package rents from subprime rentals into bonds,
backed by the loan-shark's guarantee: arm-breakers will evict the shit
out of anyone who stops paying.
America-a land where eviction was once a rarity-now faces an eviction epidemic.
The foreclosure crisis was only possible because Wall St and the
courts collaborated to streamline the historically complicated and
time-consuming process of taking away someone's home. Same goes for the
eviction epidemic.
It's a simple equation: the more loan-sharks spend on arm-breakers, the lower the expected profits.
Improvements to arm-breaking processes – cost-savings on traditional
coercion or innovative new forms of terror – are powerful engines for
unlocking new debt markets.
When innovation calls, tech answers. Our devices are increasingly
"smart," and inside every smart device is a potential arm-breaker.
Digital arm-breakers have been around since the first DRM systems, but
they really took off in 2008.
That's when subprime car loans boomed. People who lost everything in
the GFC still needed to get to work, and thanks to chronic US
underinvestment in transit, that means owning a car. So loan-sharks and
tech teamed up to deliver a new lost-cost, high-efficiency arm-breaker.
They leveraged the nation's mature wireless network to install
cellular killswitches in cars. You could extend an unrepayable loan to a
desperate person, and use an unmutable second stereo system to bombard
them with earsplitting overdue notices.
Within a decade, the bond-market for payments from subprime car
drivers was edging up on $1T; not because borrowers didn't default, but
because they defaulted later, and the car could be easily re-leased to
another desperate person.
The zombie economy shambled on. Tech built undeletable, always-on
kill-switches, lo-jacks, and spyware into an ever-expanding
constellation of devices, like laptops.
Rent-to-own subprime laptops were the epicenter of innovation in
digital arm-breaking. Laptops shipped with spyware for covert operation
of cameras and mic and access ot files.
That went beyond repoing a laptop! Lenders could make and share covert sex-tapes of their customers!
They spied on children, plundered MP3 collections, stole passwords,
read email. It was beyond the wildest dreams of analog loan-sharks.
theconversation | The tense test of strength began when Biden was asked about Putin in an interview
with ABC News’ George Stephanopoulos and agreed he was “a killer” and
didn’t have a soul. He also said Putin will “pay a price” for his
actions.
Putin then took the unusual step of going on the state broadcaster VGTRK with a prepared five-minute statement in response to Biden.
In an unusually pointed manner, Putin recalled the US history of
genocide of its Indigenous people, the cruel experience of slavery, the
continuing repression of Black Americans today and the unprovoked US
nuclear bombing of Hiroshima and Nagasaki in the second world war.
He suggested states should not judge others by their own standards:
Whatever you say about others is what you are yourself.
Some American journalists and observers have reacted to this as “trolling”. It was not.
It was the preamble to Putin’s most important message in years to
what he called the American “establishment, the ruling class”. He said
the US leadership is determined to have relations with Russia, but only
“on its own terms”.
Although they think that we are the same as they are, we are
different people. We have a different genetic, cultural and moral code.
But we know how to defend our own interests.
And we will work with them, but in those areas in which we ourselves
are interested, and on those conditions that we consider beneficial for
ourselves. And they will have to reckon with it. They will have to
reckon with this, despite all attempts to stop our development. Despite
the sanctions, insults, they will have to reckon with this.
This is new for Putin. He has for years made the point, always
politely, that Western powers need to deal with Russia on a basis of
correct diplomatic protocols and mutual respect for national
sovereignty, if they want to ease tensions.
But never before has he been as blunt as this, saying in effect: do
not dare try to judge us or punish us for not meeting what you say are
universal standards, because we are different from you. Those days are
now over.
CJR |Meanwhile,coverage
of the shooting by national media outlets remained vague; reporters
seemed reluctant (or were unable) to find details about the victims or
pick up reports from the Korean press. Instead, the mainstream press
published profiles of the shooter. And when the Atlanta Sheriff’s Office
held a press conference on Wednesday morning, the press raced to take
down the official statement, whichuncritically
echoed the suspect’s claims that he suffered from sexual addiction, and
which minimized the role of racial animus in his motivation for the
killing spree.
Lee, who had worked the police beat
in Korea earlier in his career, was in disbelief. “I’ve never before
seen a case where the police suggest: ‘The suspect said it wasn’t the
case, therefore it’s not the case,’ ” he says. Worse, the press
replicated the official statement in headlines and presented it as breaking news.
In most news pieces, the spokesperson’s words were treated as
self-explanatory, without additional context or questions. “It was
almost as though the press believed what was said to be correct, like
they wanted it to be the case,” Lee says.
To Lee, the official statement was
“clearly too absurd to repeat.” He felt no obligation to cover the press
conference or to recite the spokesperson’s words. Instead, Atlanta K ran a story that recounted the community response to the official statement, titled: “ ‘Does a bad day mean you can kill someone?’: white police officers’ protection of a white murderer.”
The press corrected course a day
later, but already, public perception of the suspect’s racist and
anti-Asian motives had been muddied. The shooter’s explanation for the
murders—sex addiction—had been widely circulated, giving weight to
long-standing associations between Asian-owned massage shops and illicit
sex work. Investigations into the spas in the past week cited
suggestive customer reviews and a history of police raids (some of
which had been undertaken wrongfully, Lee says), in effect imputing
criminality to the women. The media should ask if it is meaningful to
determine whether the victims had been offering sexual services, and
whether such questions are worth stigmatizing the deceased women and
risking harm to family members and other spa workers. This also means
that survivors, who have long lived under the radar—fearful
of losing their livelihoods and immigration statuses—feel discouraged
from talking publicly. “Unless they have immense courage, it’s
improbable for these women to want to put themselves out there,” Lee
says.
From the beginning, Lee had feared
this sort of scrutiny. Reporters for national media outlets had asked
him about criminal activity at the spas, to which he declined to
respond. Why speculate on a question that lacks clear relevance to the
story at hand? Already, the women have been unfairly immortalized in
association with their place of work. The spas could never be a full
reflection of who the women were; they were survival jobs—jobs the women
might have worked tirelessly to retire from, had they been allowed to
live out their lives.
NYTimes | Sue-ling Wang prided himself on being a self-made businessman.
The
son of a farmer in Taiwan, he attended a vocational school that trained
students at a factory producing zippers and ballpoint pens. But he made
his ascent after arriving in America on a scholarship and obtaining a
Ph.D., then starting his own company in the Atlanta area three decades
ago.
He appeared at civic events,
donated to Republican candidates and ensconced himself in an exclusive
country club community northeast of Atlanta where he bought two stately
homes, each valued at about $1 million.
Later
this year, he will assume the role of head of the World Taiwanese
Chambers of Commerce. It is a prestigious post: Taiwan’s government
recently produced a 14-minute video of him discussing his life that included a photo of him with the island democracy’s president, Tsai Ing-wen.
“When
we go abroad, we are not afraid of hardship, because we must raise our
children, we want to glorify our ancestors,” Mr. Wang, himself a father,
said in the video.
In telling his immigrant success story, Mr. Wang, 68, did not mention
his tie to a business whose employees had little opportunity to follow
his path: Gold Spa, one of the three Atlanta-area massage parlors where a
gunman last week killed eight people and wounded another.
Six victims were of Korean or Chinese descent, fueling outrage and
despair about the surge of anti-Asian violence, particularly against
women, in the United States.
But as details about the employees emerged, so too did another narrative: the story of the wealth divideamong
people of Asian descent in America — a community often viewed by
outsiders as monolithic and whose economic disparities have long been
misunderstood.
The income gap between the rich and the poor in the United States is, in fact, greatest among Asians, who are considered the most economically divided group in the country, according to the Pew Research Center.
thebureauinvestigates | Pfizer has been accused of “bullying” Latin American governments in
Covid vaccine negotiations and has asked some countries to put up
sovereign assets, such as embassy buildings and military bases, as a
guarantee against the cost of any future legal cases, the Bureau of
Investigative Journalism can reveal.
In the case of one country, demands made by the pharmaceutical giant
led to a three-month delay in a vaccine deal being agreed. For Argentina
and Brazil, no national deals were agreed at all. Any hold-up in
countries receiving vaccines means more people contracting Covid-19 and
potentially dying.
Officials from Argentina and the other Latin American country, which
cannot be named as it has signed a confidentiality agreement with
Pfizer, said the company’s negotiators demanded additional indemnity
against any civil claims citizens might file if they experienced adverse
effects after being inoculated. In Argentina and Brazil, Pfizer asked
for sovereign assets to be put up as collateral for any future legal
costs.
One official who was present in the unnamed country’s negotiations
described Pfizer’s demands as “high-level bullying” and said the
government felt like it was being “held to ransom” in order to access
life-saving vaccines.
Campaigners are already warning of a “vaccine apartheid”
in which rich Western countries may be inoculated years before poorer
regions. Now, legal experts have raised concerns that Pfizer’s demands
amount to an abuse of power.
“Pharmaceutical companies shouldn't be using their power to limit
life-saving vaccines in low- and middle-income countries,” said
Professor Lawrence Gostin, director of the World Health Organization’s
Collaborating Center on National and Global Health Law. “[This] seems to
be exactly what they're doing.”
Protection against liability shouldn’t be used as “the sword of
Damocles hanging over the heads of desperate countries with a desperate
population,” he added.
Pfizer has been in talks with more than 100 countries and
supranational organisations, and has supply agreements with nine
countries in Latin America and the Caribbean: Chile, Colombia, Costa
Rica, Dominican Republic, Ecuador, Mexico, Panama, Peru, and Uruguay.
The terms of those deals are unknown.
Pfizer told the Bureau: “Globally, we have also allocated doses to
low- and lower-middle-income countries at a not-for-profit price,
including an advance purchase agreement with Covax to provide up to 40
million doses in 2021. We are committed to supporting efforts aimed at
providing developing countries with the same access to vaccines as the
rest of the world.” It declined to comment on ongoing private
negotiations.
Most governments are offering indemnity – exemption from legal
liability – to the vaccine manufacturers they are buying from. This
means that a citizen who suffers an adverse effect after being
vaccinated can file a claim against the manufacturer and, if successful,
the government would pay the compensation. In some countries people can
also apply for compensation through specific structures without going
to court.
Begrudgingly Acknowledged Country Bangers
-
When someone says they hate country music, they’re typically referring,
whether they know it or not, to the neotraditionalist “young country” that
arose in...
A Foundation of Joy
-
Two years and I've lost count of how many times my eye has been operated
on, either beating the fuck out of the tumor, or reattaching that slippery
eel ...
April Three
-
4/3
43
When 1 = A and 26 = Z
March = 43
What day?
4 to the power of 3 is 64
64th day is March 5
My birthday
March also has 5 letters.
4 x 3 = 12
...
Return of the Magi
-
Lately, the Holy Spirit is in the air. Emotional energy is swirling out of
the earth.I can feel it bubbling up, effervescing and evaporating around
us, s...
New Travels
-
Haven’t published on the Blog in quite a while. I at least part have been
immersed in the area of writing books. My focus is on Science Fiction an
Historic...
Covid-19 Preys Upon The Elderly And The Obese
-
sciencemag | This spring, after days of flulike symptoms and fever, a man
arrived at the emergency room at the University of Vermont Medical Center.
He ...