Tuesday, August 12, 2014
voices from within: gut microbes and the central nervous system
springer | Recent advances in research have greatly increased our understanding of
the importance of the gut microbiota. Bacterial colonization of the
intestine is critical to the normal development of many aspects of
physiology such as the immune and endocrine systems. It is emerging that
the influence of the gut microbiota also extends to modulation of host
neural development. Furthermore, the overall balance in composition of
the microbiota, together with the influence of pivotal species that
induce specific responses, can modulate adult neural function,
peripherally and centrally. Effects of commensal gut bacteria in adult
animals include protection from the central effects of infection and
inflammation as well as modulation of normal behavioral responses. There
is now robust evidence that gut bacteria influence the enteric nervous
system, an effect that may contribute to afferent signaling to the
brain. The vagus nerve has also emerged as an important means of
communicating signals from gut bacteria to the CNS. Further
understanding of the mechanisms underlying microbiome–gut–brain
communication will provide us with new insight into the symbiotic
relationship between gut microbiota and their mammalian hosts and help
us identify the potential for microbial-based therapeutic strategies to
aid in the treatment of mood disorders.
By
CNu
at
August 12, 2014
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Labels: as above-so below , essence , microcosmos
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