Friday, October 17, 2014

ebolavirus in west africa, and the use of experimental therapies or vaccines


biomedcentral |  Abstract - Response to the current ebolavirus outbreak based on traditional control measures has so far been insufficient to prevent the virus from spreading rapidly. This has led to urgent discussions on the use of experimental therapies and vaccines untested in humans and existing in limited quantities, raising political, strategic, technical and ethical questions.

Ebolavirus outbreaks and disease - The ongoing outbreak in West Africa of ebolavirus hemorrhagic fever (EHF) [1], lately also referred to as Ebola virus disease (EVD), has led to a surge in public interest and concern regarding this virus, which was first discovered in 1976 during simultaneous outbreaks in Zaire (now the Democratic Republic of the Congo) and Sudan [2]. Humans initially contract the virus either through contact with the infected reservoir, which is thought to be fruit bats, or by hunting and butchering of infected wildlife, particularly great apes. Since their discovery, ebolaviruses have caused frequent outbreaks almost exclusively in Central Africa. However, the recent emergence of Zaire ebolavirus in West Africa, resulting in what is the largest outbreak to date (Figure 1), with 4,390 cases and 2,226 deaths as of 7 September 2014, shows that ebolaviruses are more widely distributed than previously thought. While EHF is commonly associated with high case fatality rates (up to 90% for Zaire ebolavirus, approximately 50% for Sudan ebolavirus, and approximately 35% for Bundibugyo ebolavirus), the pathogenicity of Taï Forest ebolavirus, which was discovered in the mid-1990s in Ivory Coast, is unknown because only a single case has been reported, and Reston ebolavirus, which is found in the Philippines, is considered apathogenic for humans. Outbreaks are usually driven by human-to-human transmission as a result of direct contact with live or deceased patients and their body fluids, mainly during patient management and care, and participation in traditional local burial practices. Basic hygiene measures and barrier nursing techniques are usually sufficient to disrupt ebolavirus transmission and spread in the community. Nevertheless, because of its high case fatality rate and the absence of licensed vaccines or treatments, this virus is considered of the highest biosafety concern, restricting work on infectious virus to a few maximum containment laboratories worldwide. Despite the restricted and highly regulated handling of the pathogen, there have been considerable scientific achievements over the past years; however, many challenges remain in the public health sector in relation to identifying and managing cases and interrupting virus spread.

10 comments:

Dale Asberry said...

This whole shebang can be brought down to two words: "Our concept"

CNu said...

say what? dood, you know skunkworks been on this case ever since some of its personnel participated in the advanced technology recovery operations at Roswell...., stop playing. (p.s., did you hear the joker in the video on about the planes that never have to land and refuel? shades of thorium reactor bombers...,)

Dale Asberry said...

Lol, what I mean is that it's still a concept whereas the E-Cat is a functioning prototype. In addition, this style of fusion requires a big company to design, engineer, install, maintain, etc. It absolutely will not be "free energy" as in libre. It's yet another technology for control.

BigDonOne said...

BD would withhold judgement on a thing like that until all the facts are in. The military eventually got Fatboy down to tactical warheads that would launch in the Navy's 16-inch cannons....

CNu said...

Careful now afor'n all that long hair comes tumbling out from under your baseball cap. http://youtu.be/952h-AJ3Bcg Top People have been in on the compact fusion reactor for some time now, Top People....,

CNu said...

16 inch cannons...., ta loco? http://subrealism.blogspot.com/2014/01/sadm-special-atomic-demolition-munition.html

Dale Asberry said...

Lol, and you're the one that lives in the Show Me state!

Dale Asberry said...

Oh, and #smartass.

Dale Asberry said...

The timing of it with the lack of skepticism by the d-bag stinks of a misinformation campaign.

CNu said...

Is what I'm talking bout! Top people evidently don't want any part of this http://subrealism.blogspot.com/2012/01/fire-of-sun.html