Sunday, January 13, 2008

Transgenerational Transgenics

A cloned pig whose genes were altered to make it glow fluorescent green has passed on the trait to its young, a development that could lead to the future breeding of pigs for human transplant organs, a Chinese university reported. The glowing piglets' birth proves transgenic pigs are fertile and able to pass on their engineered traits to their offspring, according to Liu Zhonghua, a professor overseeing the breeding program at Northeast Agricultural University.

"Continued development of this technology can be applied to ... the production of special pigs for the production of human organs for transplant," Liu said in a news release posted Tuesday on the university's Web site.

Calls to the university seeking comment Wednesday were not answered.

The piglets' mother was one of three pigs born with the trait in December 2006 after pig embryos were injected with fluorescent green protein. Two of the 11 piglets glow fluorescent green from their snout, trotters, and tongue under ultraviolet light, the university said.

Robin Lovell-Badge, a genetics expert at Britain's National Institute for Medical Research, said the technology "to genetically manipulate pigs in this way would be very valuable."

Lovell-Badge had not seen the research from China's cloned pigs and could not comment on its credibility. He said, however, that organs from genetically altered pigs would potentially solve some of the problems of rejected organs in transplant operations. He said the presence of the green protein would allow genetically modified cells to be tracked if they were transplanted into a human. The fact that the pig's offspring also appeared to have the green genes would indicate that the genetic modification had successfully penetrated every cell, Lovell-Badge added.

But he said much more research and further trials — both in animals and in humans — would be necessary before the benefits of the technology could be seen.

Other genetically modified pigs have been created before, including by Scotland's Roslin Institute, but few results have been published. Tokyo's Meiji University last year successfully cloned a transgenic pig that carries the genes for human diabetes, while South Korean scientists cloned cats that glow red when exposed to ultraviolet rays.

Remember this article from last week? China offers unproven medical treatments;
Savage spent 2 1/2 months in late 2006 and early 2007 at a hospital in the southern China city of Shenzhen to get what he was told were stem cell injections in his spine from umbilical cord blood. He made the arrangements through Beike Biotechnology Co., which offers the treatments at a number of hospitals in China.
Afterward, Savage said he was able to move his right arm for the first time since his diving accident; a video made at the hospital appears to show slight movement. He also said he noticed greater strength in his abdomen and more sensation on his skin.
Just how many foreigners like Savage are coming to China for treatment isn't known; and China is only one of several countries where such techniques are being offered.
Many Chinese doctors don't wait for results of rigorous testing before treating patients and they offer what they say are stem cell or other cell treatments to those willing to pay.
What is known about the procedures being performed comes from material on their Web sites or from patients who give detailed accounts of their visits. Little has been published in scientific journals for other doctors to scrutinize.
William Gibson was/is the Nostradamus of our time....,