CNN | Terminally ill cancer patients struggling with anxiety may get some relief from a guided "trip" on the hallucinogenic drug psilocybin, a new study suggests.The study included 12 patients who took a small dose of psilocybin -- the active ingredient in "magic mushrooms" -- while under the supervision of trained therapists. In a separate session, the participants took a placebo pill, which had little effect on their symptoms.
By contrast, one to three months after taking psilocybin the patients reported feeling less anxious and their overall mood had improved. By the six-month mark, the group's average score on a common scale used to measure depression had declined by 30 percent, according to the study, which was published in the Archives of General Psychiatry.
Psychiatrists and psychologists began exploring the effects of hallucinogens on the mood and anxiety of dying patients in the 1950s, but the research stopped abruptly when psilocybin, lysergic acid diethylamide (LSD), and other mind-altering drugs were outlawed in the 1970s.
The Food and Drug Administration (FDA) has approved a handful of small studies involving hallucinogens since the 1990s, but the field is still emerging.
Grob's study is the first of its kind in more than 35 years. It was funded by private foundations and the Heffter Research Institute, a nonprofit organization based in Santa Fe, New Mexico, that has been a major sponsor of the second-generation hallucinogen research.
