
"This is one of those situations where the data came out essentially perfectly," he says. "The results were exactly as we predicted they would be, based on the animal data." That is, like the rats, humans who were more spontaneous and eager to take risks had fewer dopamine-regulating receptors than those who were more cautious.
The findings support Zald's theory that people who take risks get an unusually big hit of dopamine each time they have a novel experience, because their brains are not able to inhibit the neurotransmitter adequately. That blast makes them feel good, so they keep returning for the rush from similarly risky or new behaviors, just like the addict seeking the next high.
"This finding is really interesting," says Dr. Bruce Cohen, director of the Frazier Research Institute at McLean Hospital in Boston and a professor of psychiatry at Harvard Medical School. "It's a piece of the puzzle to understanding why we like novelty, and why we get addicted to substances ... Dopamine is an important piece of reward."
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