caitlinjohnstone | I really hope Americans get rid of that dangerous right wing lunatic in congress, by which I mean all of the people in congress.
Marjorie
Taylor Greene is not more crazy than all the DC politicians who agree
the US should maintain planetary hegemony using bombs, regime change
ops, starvation sanctions and nuclear threats. She’s just a less popular
genre of crazy.
There is an ideological struggle to determine
whether the Republican Party will be the kind of bat shit crazy that
believes in QAnon and Jewish Space Lasers or just the kind of bat shit
crazy that believes in carpet bombing Iran and destroying the ecosystem
for money.
Stop normalizing status quo politics.
Stop normalizing ecocide.
Stop normalizing imperialism.
Stop normalizing mass murder.
Stop normalizing nuclear standoffs.
Stop normalizing starvation sanctions.
Stop normalizing exploitation.
Stop normalizing oppression.
Stop normalizing the mainstream so-called “centrists” who promote these extremist evils.
If
people could really grasp how horrific our status quo is, wingnut
freaks like Marjorie Taylor Greene wouldn’t stand out against the
background, because everyone who helps bolster this murderous and
depraved status quo is also a wingnut freak. And there would be just as
urgent a push to cast out all the other freaks as there is to cast out
her.
The
ruling class keeps Americans as poor as possible so they can’t use
their money to do naughty things like fund leftist political campaigns
or sabotage hedge funds.
People
are like two clicks away from burning Wall Street to the ground and
setting up guillotines and mainstream analysts are still wringing their
hands about how gamer trolls might be compromising the integrity of the
market somewhat.
deagel |There have been many questions about the countries forecast specially the one focusing
on the United States of America (USA). They won't be answered one by one but
below you can find some explanation, thoughts and reflections. We are going to
keep this as short as possible.
The majority of the economic and demographic data used in the making of
the
forecasts is widely available by institutions such as the CIA, IMF, UN,
USG,
etc. You can see the most relevant data at every single country's page.
There is a tiny part of data coming from a variety of shadow sources
such
as Internet gurus, unsigned reports and others. But all these sources
are from
the internet and are of public domain for at least a minority. For
example, several years
ago Dagong, the Chinese ratings agency,
published a report analyzing the physical economy of the States
comparing it with those of
China, Germany and Japan. The conclusion was that the US GDP was
something
between $5 to $10 trillion instead of $15 trillion as officially
reported by the
USG. We assume that the official data, especially economic, released by
governments is fake, cooked or distorted in some degree. Historically it
is well
known that the former Soviet Union was making up fake statistics years
before
its collapse. Western as well as other countries are making up their
numbers
today to conceal their real state of affairs. We are sure that many
people out
there can find government statistics in their own countries that by
their own
personal experience are hard to believe or are so optimistic that may
belong to
a different country.
Despite the numeric data "quantity" there is a "quality" model which has not a
direct translation into numeric data. The 2014 strain of Ebola has a death rate
of 50-60% but try to imagine what would happen if there is a pandemic of Ebola
with hundreds of thousands or millions infected with the virus. So far the few
cases of Ebola-infected people have "enjoyed" intensive healthcare with
anti-viral and breathing assistance but above all with abundant human support by
Physicians and nurses. In a pandemic scenario that kind of healthcare won't be
available for the overwhelming number of infected leading to a dramatic increase
of the death rate due to the lack of proper healthcare. The "quality" factor is
that the death rate could increase to 80-90% in a pandemic scenario from the
stated 50-60% rate. The figure
itself is not important what is relevant is the fact that the scenario can
evolve beyond the initial conditions from a 50% death toll to more than 90%. By
the way, no pandemic or nuclear war is included in the forecast.
The key element to understand the process that the USA will enter in the
upcoming decade is migration. In the past, specially in the 20th
century, the
key factor that allowed the USA to rise to its colossus status was
immigration
with the benefits of a demographic expansion supporting the credit
expansion and
the brain drain from the rest of the world benefiting the States. The
collapse
of the Western financial system will wipe out the standard of living of
its
population while ending ponzi schemes such as the stock exchange and the
pension
funds. The population will be hit so badly by a full array of bubbles
and ponzi
schemes that the migration engine will start to work in reverse
accelerating
itself due to ripple effects thus leading to the demise of the States.
This
unseen situation for the States will develop itself in a cascade pattern
with
unprecedented and devastating effects for the economy. Jobs offshoring
will
surely end with many American Corporations relocating overseas thus
becoming
foreign Corporations!!!! We see a significant part of the American
population
migrating to Latin America and Asia while migration to Europe -
suffering a
similar illness - won't be relevant. Nevertheless the death toll will be
horrible. Take into account that the Soviet Union's population was
poorer than
the Americans nowadays or even then. The ex-Soviets suffered during the
following struggle in
the 1990s with a significant death toll and the loss of national pride.
Might we
say "Twice the pride, double the fall"? Nope. The American standard of
living is
one of the highest, far more than double of the Soviets while having
added a services economy that will be gone along with the financial
system. When
pensioners see their retirement disappear in front of their eyes and
there are
no servicing jobs you can imagine what is going to happen next. At least
younger
people can migrate. Never in human history were so many elders among the
population. In past centuries people were lucky to get to their 30s or
40s. The American downfall is set to be far worse than the Soviet
Union's one. A confluence of crisis with a devastating result.
The Demographic crisis in the former Soviet Union countries has extended for
over two decades, if we accept that it ended early in this decade (2010s). The
demographic crisis will hit the World in the near future and is projected to
last between three and eight decades more or less depending on technological
breakthrough and environmental issues. The aftermath is more likely a frozen
picture with the population numbers staying the same for a very, very long
period of time. The countries forecast population numbers do reflect
birth/deaths but also migratory movements. Many countries are going to increase
their gross population due to immigration while their native population may
shrink.
Over the past two thousand years we have witnessed the Western civilization
built around the Mediterranean Sea shifting to Northern Europe and then by the
mid 20th century shifting to an Atlantic axis to finally get centered into the
States in the past 30 years. The next move will see the civilization being
centered in Asia with Russia and China on top. Historically a change in the
economic paradigm has resulted in a death toll that is rarely highlighted by
mainstream historians. When the transition from rural areas to large cities
happened in Europe many people unable to accept the new paradigm killed
themselves. They killed themselves by a psychological factor. This is not
mainstream but it is true. A new crisis joins old, well known patterns with new
ones.
Sorry to disappoint many of you with our forecast. It is getting worse and worse
every year since the beginning of the pre-crisis in 2007. It is already said
that this website is non-profit, built on spare time and we provide our
information and services AS IS without further explanations and/or guarantees.
We are not linked to any government in any way, shape or form. We are not a
death or satanic cult or arms dealers as some BS is floating around the internet
on this topic. Take into account that the forecast is nothing more than a model
whether flawed or correct. It is not God's word or a magic device that allows to
foresee the future.
nakedcapitalism | Something else is going on beneath the actual events, for sure. I happened across this story and took a gander at the WSB reddit board and was blown away by the amount of energy there — it was lively and real — something so foreign in an age of sleuths, slights and deception. It does not matter that what was being done would have minimal overall impact on HFs or the financial system in the grand scheme of things. All that matters was people came together spontaneously to do something with no regard for the consequences. And something did happen. Some brokerages halted trading of GME and other affected companies, and it drew quite the media attention as well as a flutter in congress. Maybe it is no big deal as Yves seems to think, but I disagree.
Consider for a moment that this was a somewhat random collection of people (and maybe some big money too) uniting for something that is foolish and self-defeating. People who can afford not to lose, and yet still choose to do so.
Consider also that social media, tech companies, and corporate interests are all geared to measure and predict public sentiment, or further, as for public relations, to shape it. This is predicated upon the continual cycle of researching, organizing, and staging an event (ie product release, new policy, crises) that the public is primed to react to, and upon the assumption that people will generally seek their own interest and well being, often irrationally.
What happens when people act spontaneously (without some widely publicized event or first mover), in tandem, against their own interest and well being? Obviously some people will stand to gain and some to lose. That’s not the point. What is, is that a good chunk of people, bought into their own game with no regard for how it ought to be played, and in the process they (for that moment) changed the rules. And for once they moved and everyone else reacted.
FORGET THE ARTICLE - THE REAL VALUE IS IN THE COMMENTS - OF WHICH THIS IS ONE
thehill |Online messaging platform Discord on Wednesday banned the r/WallStreetBets
(WSB) server, which became the center for discussions among amateur
online traders who fueled an unexpected surge in GameStop’s stock this
week.
A Discord
spokesperson confirmed in a statement to The Hill that the decision to
remove the server was due to users sharing “hateful and discriminatory
content after repeated warnings,” adding that it “did not ban this server due to financial fraud related to GameStop or other stocks.”
“The
server has been on our Trust & Safety team’s radar for some time
due to occasional content that violates our Community Guidelines,
including hate speech, glorifying violence, and spreading
misinformation,” the spokesperson added.
The statement went on to say, “Discord welcomes a broad variety of
personal finance discussions, from investment clubs and day traders to
college students and professional financial advisors. We are monitoring
this situation and in the event there are allegations of illegal
activities, we will cooperate with authorities as appropriate.”
This comes after Discord in the days after the Jan. 6 riot at the Capitol banned a server called “The Donald,” a pro-Trump community linked to banned subreddit r/The_Donald and TheDonald.win.
theverge |Google is actively removing negative reviews of the Robinhood app from the Google Play Store, the company confirmed to The Verge. After some disgruntled Robinhood users organizedcampaigns
to give the app a one-star review on Google’s Play Store and Apple’s
App Store — and succeeded in review-bombing it all the way down to a
one-star rating — the company has now deleted enough reviews to bring it
back up to nearly four stars.
Jesus Christ they really are going all in to reveal the extent of the cabal that runs this country and rigs the rules https://t.co/w0tSQypp9Z
Robinhood came under intense scrutiny on Thursday, after the stock trading app announced it would block purchases of GameStop, AMC, and other stocks
made popular by the r/WallStreetBets subreddit, and some users have
already replaced their deleted one-star reviews with new ones to make
their anger heard.
RT | A popular stock trading chat group has been booted off Facebook
due to alleged violations of its “sexual exploitation” rules, claims the
page’s founder, who accused “major institutions” of trying to avenge
the GameStop debacle.
The Robinhood Stock
Traders group boasted more than 157,000 members before it was taken
offline on Wednesday, its 23-year-old founder, Allen Tran, told Reuters, adding that the social media giant cited its policies surrounding “adult sexual exploitation.” A notification of the ban seen by Reuters included no further reasoning for what prompted the move.
The page has no formal affiliation with the stock trading app of the same name.
Tran,
however, maintains that he has never seen explicit or sexual content on
the page, arguing instead that the group was targeted by “major institutions”
after members racked up thousands of dollars from trades first proposed
in Reddit’s r/WallStreetBets community, which has driven a dramatic
price surge in certain heavily shorted stocks, namely those of GameStop,
AMC, BlackBerry and Nokia.
“The major institutions are
attempting to silence our community. We are positively impacting
people’s lives and they are attacking our group because we are more
powerful than them,” Tran wrote in a Facebook post after the group’s ban, arguing “there is power in masses.”
americancompass | Certainly don’t laze about smoking weed, or even worse, mango Juul
pods, playing that god-forsaken game machine. That PS fucking 4, or
whatever. My generation, we didn’t sit staring at a computer, wasting
our days away. We made things. We worked out our bodies. We built
things. Come on. Make something of yourself. What are you going to do
all your life? Stock shelves during the day, and eat nuggets and play
that game at night? What are you, a loser? Be like Jim. You remember
Jim. He studied hard, went to Harvard, and now works at a big financial
firm. Come on, you lazy loser. Make something of yourself.
It is pretty simple. At the very, very top of our meritocracy is a
big game called Wall Street, that the smartest and cleverest get to
play, and get paid big bucks for it. They get to choose their character:
Trader, Salesperson, Broker, or Lawyer. The traders get to choose their
weapon: Stocks, Bonds, Mortgages, Derivatives. Then they are off,
navigating different levels, slaying this and that company, currency, or
country.
Below that is that vast landscape of losers who spend their days
building roads, growing food, flipping hamburgers, teaching kids,
building small businesses, landscaping yards, and their nights shooting
hoops, or reading books, or caring for kids, or going to church. Or, God
forbid, playing XBOX or PS4. Those are the worst.
A lot of those losers, of every variety but especially the people who
play video games, also spend a lot of time on Reddit, or Discord, or
Twitch, live-streaming, shitposting, and just having fun.
When they were doing this, some of them noticed that Wall Street was
also just a game, and a very profitable one. Sure, it was a little
different than Zelda, or Grand Theft Auto, or Demon Souls, but it was a
game nonetheless. So they started dipping their toes in and learning
this pretty cool and serious game. Then they started telling their
friends about it, who told their friends and so on and so on.
Some made a little money here and there, others got run over, but
hey, it was just another game. Cool. Of course they were the outsiders,
the losers, the clowns fucking around for shits and giggles. They
understood that. They knew nobody treated them seriously. Hell, they had
been called lazy losers all their lives. Might as well embrace that. So
they proudly named themselves “Degenerates” and “Autistic Retards.” Own
the stigma, because you ain’t gonna ever shake it or lose it no matter
how hard you try.
They dabbled here and there, got a little better at it, and soon
attracted a few serious players with serious money into their fold. Wall
Street players, slumming it, who saw a community of misfits they could
lead, teach, or scam, depending on their ethics.
So it went, and their numbers and ability grew, and then this summer
some of the cleverest Wall Street players, who specialized in making big
bets on companies failing, came after GameStop, something they had
personal views on. That perked up their interest. Making it even cooler,
some legitimately skilled Wall Street players who had joined their
island of misfit toys pointed out that GameStop was a good buy, not a
good sell, and convinced some of the degenerates to join them.
CTH | Everything from within the DC system is designed to lie to you.
Accept that and you begin to realize how events are NEVER what they
appear on the surface.
The owner of the New York Stock Exchange (NYSE) is Jeffrey Sprecher.
Remember the position of Senate Majority Leader Mitch McConnell in
regards to Senator Loeffler? Well, Mr. Sprecher is the husband of
former Senator Kelly Loeffler.
Kelly Loeffler’s seat was purchased by their elite status and
position. Why would a billionaire run for an elected office paying a
few hundred thousand?
Majority Leader Mitch McConnell positioned Loeffler with committee assignments based on that status of influence and affluence.
Jeffrey Sprecher and Kelly Loeffler entered politics for their elite interests.
The ruse of the DecptiCons is always that a motive to the benefit of
the republic lies behind their candidacy. This is the same ruse that lay
behind Mitt Romney, another DeceptiCon. There are no purely altruistic
motives behind these politicians, particularly in the Senate.
Their motives are all about status, power and greed. They are not
representatives of the people; they are representative of their own
elite fellowship and interests, and this crosses both parties.
Everything else is chaff and countermeasures to ensure their position.
That is the brutal and uncomfortable reality to accept. The entire system is corrupt.
The swamp is deep and filled with DeceptiCons who will strike at any
given moment once they attain a useful position. President Trump went to
Georgia to campaign for Senator Kelly Loeffler. Simultaneous to
President Trump’s visible support, Loeffler’s husband Jeffrey Sprecher, owner of the New York Stock Exchange (NYSE), announced the NYSE will not blacklist Chinese telecommunications firms outlined in Trump’s executive order.
CTH | It started with a bunch of smart ordinary Wall Street market watchers
assembling on Reddit and noticing that hedgefunds were making millions
destroying the stock value of GameStop (GME) -and others- by short
selling the stock and trading the position.
The hedgefunds were so greedy the short-sellers borrowed more than
140% of the total number of shares of stock of GME (GameStop) in order
to destroy it. The stock value dropped from $20 to $4 as the sharks
made millions in the short-sells. That’s when the Reddit investment
community,Wall Street Bets, noticed an opportunity.
One of the issues with short-selling is that short-sellers must always
eventually purchase the stocks they borrowed. That means if the stock
value increases you are committed to buying it, you will lose money, and
you cannot get away from the loss in your short-sell position so long
as the stock value is high.
Knowing the borrowed shares were more than the total number of
outstanding shares of the entire GME stock, the rebellious alliance knew
the short-sellers (hedgefunds) would have to eventually buy them. So
the independent group, mass numbers of individual investors, started
purchasing shares and driving up the GameStop stock value.
WaPo | The market gyrations involving GameStop’s 64-fold rise
in price since August are certainly eye-opening. How a money-losing
company whose stock previously traded less than 10 million shares a day
can shoot up to trading 50 million-plus shares
in a day — and cause the stock price of a completely unrelated but
similarly named Australian company (GME Resources) to rise 50 percent on
Thursday — is hard to reconcile with today’s uber-efficient
high-frequency markets.
Media
coverage routinely refers to GameStop’s price surge as a bubble. But
what are financial bubbles — and what causes them? As I noted when
writing about bubbles in 2008 in the Review of Financial Studies,
the phenomenon had been around for centuries — in the 18th century,
Scottish economist Adam Smith called it “overtrading.” But that doesn’t
explain what starts a bubble in the first place. Plenty of economists,
historians and others have tried.
The
Swedish economist Knut Wicksell, in an observation that resonates
today, argued in 1898 that bubbles are attributable to interest rates
that are too low. In 1929 — we know what happened
in the markets then — the Dutch economist historian N.W. Posthumus
cited the entrance of nonprofessional buyers fueled by credit. In this
view, today’s Federal Reserve and the Reddit crowd would seem natural
culprits.
An
alternative view in history is that bubbles can emerge if traders are
rational but markets are irrational. The economist and historian Charles
P. Kindleberger makes this argument in his classic 1978 book, “Manias, Panics, and Crashes: A History of Financial Crises.”
What drives market irrationality, Kindleberger says, is the fallacy of
composition: Each trader believes he can sell at a higher price, and if
he can in fact do so, then it is rational for him to buy. But not
everyone in the market can do that, so the market as a whole behaves
irrationally.
A variant on this irrationality of the market theme underlies the “beauty contest”
analogy offered in 1936 by the English economist John Maynard Keynes.
He argued that individuals do not pick stocks based on what they think a
firm is worth, but rather on what they think other people will
think it is worth. (Has Keynes’s “beauty contest” morphed into today’s
“chat room”?) In that description, each individual is acting rationally,
but the market overall is not.
Short sellers in GameStop — mostly hedge funds that had been betting massively on the company’s stock to fall — had reportedly lost $23.6 billion
as of Wednesday. They may find little consolation in the dictum often
attributed to Keynes: “Markets can stay irrational longer than you can
stay solvent.”
westonaprice | Dr. David Martin, founder and chairman of M-CAM Inc, challenges our
presuppositions about the new mRNA Covid-19 vaccines. Quoting the
pharmaceutical companies themselves, David suggests that these are not
vaccines, but, in actuality, gene therapy. He explains what the vaccines
may do to us, what they are promising they can do for us, and how to
distinguish the difference. Fist tap Dale.
factcheck | If Event 201 is the backbone of the conspiracy theory in “Plandemic,”
then David Martin is the central character. He’s featured throughout
the video, making claims primarily about patents.
Martin runs a company calledM-CAM, which analyzes patents and intellectual property to estimate the investment value of companies.
M-CAM has five investment companies as clients, managing assets of $1.1 million, according to a recent statement filed with the Securities and Exchange Commission.
“Not big in investments, seems more like another guy using predictive
modeling as a selling tool for many types of information,” Suzanne
Lynch told FactCheck.org in an email, after looking through M-CAM’s SEC
filings. Lynch has worked on Wall Street and is now a professor of economic crime at Utica College.
Samuel Rosen,
an assistant professor of finance at Temple University’s Fox School of
Business, similarly described M-CAM, broadly, as an investment research
company and noted in an email to FactCheck.org that it appears Martin
manages a small hedge fund, too.
But Martin has also peddled conspiracy theories over the years. He published a novel
in 2011, which he claimed was based on real events, alleging a rigged
2008 presidential election that was somehow tied to the terror attacks
on Sept. 11, 2001.
Since the pandemic began, he has used hisYouTube channelto promote COVID-19 conspiracy theories. He repeats many of those claims in “Plandemic: Indoctornation.”
In one video from April, Martin referred to Event 201, saying: “COVID-19
is a branded campaign … that is funded by people in the software, data
sciences and social media industry. That’s who built COVID-19.”
The gist of Martin’s video was that wealthy philanthropists like Bill
Gates, technology companies, pharmaceutical companies and global health
organizations colluded to create a virus that would force governments
to fund research and development of vaccines and therapies in order to
enrich themselves.
For “Plandemic,” though, Martin shifts his focus away from “the
software, data sciences and social media industry.” Instead, he takes
aim largely at government entities.
Martin claims that the Centers for Disease Control and Prevention saw “the possibility of a gold strike” when the SARS epidemic arose in 2003.
“They saw that a virus they knew could be easily manipulated was something that was very valuable,” he says, pointing to a patent filed by the CDC that year. The patent covered the isolated virus that causes SARS and ways to detect it.
Skimming across the screen while Martin makes that claim is a headline for a November 2003 news story
about the race to patent the virus. However, that story doesn’t support
his argument. It actually explains that the CDC wasn’t pursuing the
patent for profit. Rather, it was doing so to keep others from
monopolizing research.
“The whole purpose of the patent is to prevent folks from controlling
the technology,” the story quotes CDC spokesman Llelwyn Grant as
saying. “This is being done to give the industry and other researchers
reasonable access to the samples.”
Similarly, the director of the CDC at the time, Dr. Julie Gerberding, told
reporters that filing for the patent was “a protective measure to make
sure that the access to the virus remains open for everyone.”
“The concern that the federal government is looking at right now is
that we could be locked out of this opportunity to work with this virus
if it’s patented by someone else, and so by initiating steps to secure
patent rights, we assure that we will be able to continue to make the
virus and the products from the virus available in the public domain,
and that we can continue to promote the rapid technological transfer of
this biomedical information into tools and products that are useful to
patients,” Gerberding said in a May 2003 telebriefing.
So, Martin’s claim is at odds with the CDC’s publicly stated motivation, and he offers no evidence to support his argument.
Next, Martin claims that federal law wouldn’t have allowed for a patent on that isolated virus.
Again, he’s wrong.
Instead of reading from U.S. patent law,
as he says he is in the video, Martin reads from a 2013 U.S. Supreme
Court decision. That’s an important distinction since the decision,
which changed one aspect of patent law that’s relevant here, came 10
years after the CDC filed for a patent related to the virus that causes
SARS.
“Nature is prohibited from being patented,” Martin says, claiming that he was quoting from a section of patent law. Building on that, he claims, “either
SARS, coronavirus, was manufactured, therefore making a patent on it
legal, or it was natural, therefore making a patent on it illegal.”
But that’s a false dichotomy.
While the Supreme Court did find
that “[a] naturally occurring DNA segment is a product of nature and
not patent eligible merely because it has been isolated,” that decision
came a decade after the CDC sought the patent.
“Isolated genes (that is, genes extracted from a longer DNA sequence)
used to be patentable in the past because the courts decided that just
the act of extracting them and removing the non-coding segments caused
enough of a modification to turn them into patent-eligible things,” Mario Biagioli,
a professor at UCLA School of Law, told FactCheck.org in an email. “No
more. A few years ago the Supreme Court decided that simply isolating a
gene did not change it enough. It remained a ‘product of nature’ and
therefore unpatentable.”
So, claiming that the patent is either illegal or the virus was “manufactured” is wrong.
Nature | mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development
and potential for low-cost manufacture and safe administration.
However, their application has until recently been restricted by the
instability and inefficient in vivo delivery of mRNA. Recent
technological advances have now largely overcome these issues, and
multiple mRNA vaccine platforms against infectious diseases and several
types of cancer have demonstrated encouraging results in both animal
models and humans. This Review provides a detailed overview of mRNA
vaccines and considers future directions and challenges in advancing
this promising vaccine platform to widespread therapeutic use.
Vaccines prevent many millions of illnesses and save numerous lives every year1.
As a result of widespread vaccine use, the smallpox virus has been
completely eradicated and the incidence of polio, measles and other
childhood diseases has been drastically reduced around the world2.
Conventional vaccine approaches, such as live attenuated and
inactivated pathogens and subunit vaccines, provide durable protection
against a variety of dangerous diseases3.
Despite this success, there remain major hurdles to vaccine development
against a variety of infectious pathogens, especially those better able
to evade the adaptive immune response4.
Moreover, for most emerging virus vaccines, the main obstacle is not
the effectiveness of conventional approaches but the need for more rapid
development and large-scale deployment. Finally, conventional vaccine
approaches may not be applicable to non-infectious diseases, such as
cancer. The development of more potent and versatile vaccine platforms
is therefore urgently needed.
Nucleic acid therapeutics have
emerged as promising alternatives to conventional vaccine approaches.
The first report of the successful use of in vitro transcribed
(IVT) mRNA in animals was published in 1990, when reporter gene mRNAs
were injected into mice and protein production was detected5.
A subsequent study in 1992 demonstrated that administration of
vasopressin-encoding mRNA in the hypothalamus could elicit a
physiological response in rats6.
However, these early promising results did not lead to substantial
investment in developing mRNA therapeutics, largely owing to concerns
associated with mRNA instability, high innate immunogenicity and
inefficient in vivo delivery. Instead, the field pursued DNA-based and protein-based therapeutic approaches7,8.
Over
the past decade, major technological innovation and research investment
have enabled mRNA to become a promising therapeutic tool in the fields
of vaccine development and protein replacement therapy. The use of mRNA
has several beneficial features over subunit, killed and live attenuated
virus, as well as DNA-based vaccines. First, safety: as mRNA is a
non-infectious, non-integrating platform, there is no potential risk of
infection or insertional mutagenesis. Additionally, mRNA is degraded by
normal cellular processes, and its in vivo half-life can be regulated through the use of various modifications and delivery methods9,10,11,12. The inherent immunogenicity of the mRNA can be down-modulated to further increase the safety profile9,12,13. Second, efficacy: various modifications make mRNA more stable and highly translatable9,12,13. Efficient in vivo
delivery can be achieved by formulating mRNA into carrier molecules,
allowing rapid uptake and expression in the cytoplasm (reviewed in Refs 10,11).
mRNA is the minimal genetic vector; therefore, anti-vector immunity is
avoided, and mRNA vaccines can be administered repeatedly. Third,
production: mRNA vaccines have the potential for rapid, inexpensive and
scalable manufacturing, mainly owing to the high yields of in vitro transcription reactions.
The
mRNA vaccine field is developing extremely rapidly; a large body of
preclinical data has accumulated over the past several years, and
multiple human clinical trials have been initiated. In this Review, we
discuss current mRNA vaccine approaches, summarize the latest findings,
highlight challenges and recent successes, and offer perspectives on the
future of mRNA vaccines. The data suggest that mRNA vaccines have the
potential to solve many of the challenges in vaccine development for
both infectious diseases and cancer.
technologyreview | Lunik: Inside the CIA’s audacious plot to steal a Soviet satellite. How a team of spies in Mexico got their hands on Russia's space secrets—and tried to change the course of the Cold War.
Scott and
the CIA had already been exploring other plans to steal the spacecraft.
On November 19, six miles up the Panuco River from the Gulf of Mexico,
two American spies watched the Soviet ship carrying the Luna arrive at
the Port of Tampico.
The first was Robert Zambernardi, an Italian-American CIA officer
from Massachusetts. With tan skin and a droopy black mustache, he could
pass for a local during covert operations, and was an expert in
photography, secret writing, disguise, and womanizing. Zambernardi also
controlled a team of mercenaries he called Rudos—“tough
guys”—from Mexico’s corrupt and violent Federal Judicial Police. They
made treasonous Americans “disappear,” according to Mexican journalist
and TV personality Jaime Maussan, who interviewed Zambernardi for a 2017
book about the mission, Operación LightFire.
The
second man was Warren L. Dean, Winston Scott’s deputy chief of station.
A tall and dashing martini man, Dean had joined the FBI and chased
Nazis in Bolivia and Chile, before serving under Scott in London and
then joining him in Mexico City. Dean watched workers load the cargo
from the Soviet boat onto a train, and asked his colleague if they could
somehow grab it during its journey to the auditorium.
“We can delay it a few hours,” said Zambernardi, but he dissuaded Dean from staging a Mexican great train robbery, according to Operación Lightfire. “Moving photos are always very blurry,” Zambernardi told him. “We need the train to stop.”
The freight cars were slowly loaded with objects from Russian
life—everything from hammer and sickle postage stamps, to fur coats, and
instruments that displayed the might of Soviet science: cutting-edge
microscopes that revealed the invisible, and world-beating telescopes
that scanned the great beyond. Under the unflinching stares of armed KGB
agents, workers lifted the Luna onto the train.
“There are too many loose ends here,” Dean conceded, according to Maussan’s account. “We will do the kidnapping with Silveti.”
unlimitedhangout | The devastating hack on SolarWinds was quickly pinned on Russia by US
intelligence. A more likely culprit, Samanage, a company whose software
was integrated into SolarWinds’ software just as the “back door” was
inserted, is deeply tied to Israeli intelligence and intelligence-linked
families such as the Maxwells.
In mid-December of 2020, a massive hack compromised the networks of
numerous US federal agencies, major corporations, the top five
accounting firms in the country, and the military, among others. Despite
most US media attention now focusing on election-related chaos, the
fallout from the hack continues to make headlines day after day.
The hack, which affected Texas-based software provider SolarWinds,
was blamed on Russia on January 5 by the US government’s Cyber Unified
Coordination Group. Their statement asserted that the attackers were “likely Russian in origin,” but they failed to provide evidence to back up that claim.
Since
then, numerous developments in the official investigation have been
reported, but no actual evidence pointing to Russia has yet to be
released. Rather, mainstream media outlets began reporting the
intelligence community’s “likely” conclusion as fact right away, with
the New York Timessubsequently reporting that
US investigators were examining a product used by SolarWinds that was
sold by a Czech Republic–based company, as the possible entry point for
the “Russian hackers.” Interest in that company, however, comes from the
fact that the attackers most likely had access to the systems of a
contractor or subsidiary of SolarWinds. This, combined with the
evidence-free report from US intelligence on “likely” Russian
involvement, is said to be the reason investigators are focusing on the
Czech company, though any of SolarWinds’ contractors/subsidiaries could
have been the entry point.
Such narratives clearly echo those that
became prominent in the wake of the 2016 election, when now-debunked
claims were made that Russian hackers were responsible for leaked emails
published by WikiLeaks. Parallels are obvious when one considers that
SolarWinds quickly brought on the discredited firm CrowdStrike to aid them in securing their networks and investigating the hack. CrowdStrike had also been brought on by the DNC after the 2016 WikiLeaks publication, and subsequently it was central in developing the false declarations regarding the involvement of “Russian hackers” in that event.
There
are also other parallels. As Russiagate played out, it became apparent
that there was collusion between the Trump campaign and a foreign power,
but the nation was Israel, not Russia. Indeed, many of the reports that came out of Russiagate revealed collusionwith Israel,
yet those instances received little coverage and generated little media
outrage. This has led some to suggest that Russiagate may have been a
cover for what was in fact Israelgate.
Similarly, in the case of
the SolarWinds hack, there is the odd case and timing of SolarWinds’
acquisition of a company called Samanage in 2019. As this report will
explore, Samanage’s deep ties to Israeli intelligence, venture-capital
firms connected to both intelligence and Isabel Maxwell, as well as
Samange’s integration with the Orion software at the time of the back
door’s insertion warrant investigation every bit as much as SolarWinds’
Czech-based contractor.
nytimes | Apollo grew out of the ashes of Drexel Burnham Lambert, the investment
bank that collapsed in 1990 amid a trading investigation that sent the
since-pardoned Michael Milken to prison.
Although Mr.
Black started Apollo with his younger partners — Mr. Harris is 56 and
Mr. Rowan 58 — he has been long been the face and voice of the firm.
In
building Apollo into a global financial powerhouse, Mr. Black has made
himself and his co-founders immensely rich: His personal fortune is
estimated at more than $8 billion, and he owns a massive private art
collection — including a version of Edvard Munch’s “The Scream” — and is
the chairman of the Museum of Modern Art.
But
when Apollo held its most recent earnings call in late October, there
were already signs his dealings with Mr. Epstein were causing ripples,
both in the firm and among investors. In an unusual move, Mr. Black read
a brief statement about the Epstein matter before handing over the
meeting to Mr. Harris and Mr. Rowan.
Apollo
has long specialized in buying up distressed companies and retooling
them, but it also boasts large credit, infrastructure and real estate
businesses. Mr. Rowan was the driving force behind Apollo’s thriving
insurance business and its insurance subsidiary, Athene Holding, which
has fueled the Wall Street’s firm earnings in recent years.
At
one time, both Mr. Rowan and Mr. Harris were seen as the heirs apparent
to Mr. Black. But with Mr. Rowan’s decision to pull back from
day-to-day affairs, many on Wall Street assumed the job would fall to
Mr. Harris, who has the run the nuts and bolts of Apollo’s vast buyout
operation.
Mr. Harris, who is an owner
of the Philadelphia 76rs basketball team and the New Jersey Devils
hockey team, said he would “fully support” Mr. Rowan as chief executive.
“I will focus on expanding our global search for investor returns,
which is at the core of our success,” he said in a statement.
As
the only three members of Apollo’s executive committee, the founders
hold considerable sway over the company. As of now, the decision to name
Mr. Rowan as Mr. Black’s successor does not need approval of the
company’s board. And all three men — who have much of their net worth
tied up in the company — have a vested interest in the stability of the
firm.
nypost | A federal judge ripped into Jeffrey Epstein cohort Ghislaine Maxwell
for misleading the court on her marriage and wealth in a scathing
decision denying her release on a $28.5 bail package.
“The defendant now argues that her newly revealed relationship with
her spouse signals her deep affective ties in the country, but at the
time she was arrested, she was not living with him and claimed to be
getting divorced,” wrote US District Judge Alison Nathan of Maxwell’s
mysterious marriage to tech CEO Scott Borgerson in newly unsealed court
papers.
After Maxwell’s July bust, she was denied release to home confinement on a $5 million bond and had refused to disclose the name of her secret husband.
But in the 58-year-olds’s renewed motion for bail, her attorneys
argued that the couple had lived an idyllic and devoted life in an
oceanfront mansion in Manchester, Mass., supporting her claim of strong
family ties to the country.
Prosecutors countered that she told pretrial services that she and Borgerson, 43, planned to split up.
The judge pointed out in the new papers that at the time of Maxwell’s arrest, she was hiding out on a sprawling compound in New Hampshire — not holed up with her hubby. Nathan’s denial of Maxwell’s bail proposal was disclosed Monday but the full 22-page ruling wasn’t unsealed until Wednesday.
Further, Nathan said, were Maxwell to be released, the British
socialite proposed living with a friend, not Borgerson “undercutting her
argument that that relationship would create an insurmountable burden
to her fleeing.”
In another blow to Maxwell’s bid for freedom, the judge called her
out for a “pattern of providing incomplete or erroneous information to
the court or to pretrial services.”
The accused child abuser claimed at the time of her arrest she was
worth just $.3.5 million — leaving out Borgerson’s assets and those that
had been transferred to a trust. In her latest financial disclosures,
she admitted that she and Borgerson’s net worth was about $22.5 million.
The vast disparity between the two figures “makes it unlikely that
the misrepresentation was the result of the defendant’s misestimation
rather than misdirection,” Nathan wrote.
“That lack of candor raises significant concerns as to whether the
court has now been provided a full and accurate picture of her
finances.”
thecut | Christine is just one of Maxwell’s seven livingsiblings (her
sister Karine and brother Michael died at ages 3 and 15). A brother,
Philip, and the eldest daughter, Anne, have not been heard from publicly
for at least a decade. But tracing the four others — Christine and her
twin sister, Isabel; Kevin; and Ian — along with Ghislaine, who, at 57,
is the youngest, is like watching a real-life season of Succession, as
these heirs to their disgraced media-mogul father’s empire have strived
toward their own ambitions. Twin sisters Christine and Isabel are the
most fascinating of the bunch, and have their own ties to
entrepreneurial, unorthodox (and, in some cases, shady) men.
Christine and Isabel had more freedom to strike out on their own after the demise of the Maxwell empire. In the 1980s, they decamped
to Silicon Valley and in 1993 they helped co-found Magellan, an early
search engine, with Isabel’s then-husband, David Hayden. According to
the Daily Beast, the sisters appear in Michael Wolff’s book on dot-com startups, Burn Rate.
Wolff describes Christine as “more commanding than her sister,” but
both Maxwells are memorable characters — early Winklevoss prototypes. In
a 1997 interview, Isabel credits her sister with coming up with “the idea of reviewing and rating.”
The
twins made millions when Magellan was sold to another company, Excite,
but — according to Isabel — it cooled the relationship between the two
of them. “When McKinley [Magellan’s parent company] didn’t make it, our
relationship changed,” Isabel said
in 2002. “And I changed, in terms of my relationship with my family.
Before then, I was completely in sync with the family. When something
got to them, it got to me, too.”
Since
then, both sisters seem to have remained in the software and technology
spheres. Christine is a doctoral candidate in the humanities department
at the University of Texas at Dallas, and continues to consult for
internet companies. Her UTD website lists a personal website,
ChristinesWorld.com, which is no longer active, but it does have the
brief personal statement that she “came to the University in January
2012 and am enjoying academia and the associated activities of ‘big
city’ life very much; it’s much different from the French countryside
where I was working on my own Internet content projects!” After
Magellan, Isabel was the president
of an Israeli email venture called Commtouch, and has continued to work
in the country. She has used the title “Technology Pioneer of the World
Economic Forum.” In a 2000 interview, she displaysa
Zuckerbergian enthusiasm for the internet: “The wonderful thing about
email is it’s not sexist,” she said. “It’s democratizing.”
The Maxwell twins’ husbands have truly bizarre histories, which has led observers to point out that they share Ghislaine’s association with powerful and unconventional men. Christine is married to Roger Malina, an astrophysicist at the University of Texas, whose father, Frank Malina, was also a scientist. Malina, the Daily Beastreveals,
hung out in California with the likes of Scientology founder L. Ron
Hubbard and rocket engineer Jack Parsons, occultists and transhumanists
(a strange echo of Jeffrey Epstein’s friends in similar academic and business circles).
And Isabel’s romantic history might be the strangest. First, she married the son of Carl Djerassi, a scientist who invented
the birth-control pill. Her third husband, Al Seckel, was a con man and
“optical illusionist” who befriended scientists and academics despite
not having a degree in those fields himself (sound familiar?); he
co-founded a group called the Southern California Skeptics that
investigated science’s relationship to the paranormal. Seckel and Isabel
moved to France at some point in 2010, according to reports, where they
lived in a château and “acquired thousands of stone-age tools to sell in the U.S.” That same year, Seckel hosted a “scientific conference” on Jeffrey Epstein’s private island, where Epstein also allegedly held underage girls for sex (presumably, the connection was Isabel’s little sister, Ghislaine).
Why the embodiment of il33t, suave, 1% panache like George Sanders - tryna get at Lucy's ravishing young fire-cro*** - have Mumm decanted into martini glasses? jes dayyum....,
tablet | More
and more Americans are figuring out that “wokeness” functions in the
new, centralized American elite as a device to exclude working-class
Americans of all races, along with backward remnants of the old regional
elites. In effect, the new national oligarchy changes the codes and the
passwords every six months or so, and notifies its members through the
universities and the prestige media and Twitter. America’s working-class
majority of all races pays far less attention than the elite to the
media, and is highly unlikely to have a kid at Harvard or Yale to clue
them in. And non-college-educated Americans spend very little time on
Facebook and Twitter, the latter of which they are unlikely to be able
to identify—which, among other things, proves the idiocy of the
“Russiagate” theory that Vladimir Putin brainwashed white working-class
Americans into voting for Trump by memes in social media which they are
the least likely American voters to see.
Constantly
replacing old terms with new terms known only to the oligarchs is a
brilliant strategy of social exclusion. The rationale is supposed to be
that this shows greater respect for particular groups. But there was no
grassroots working-class movement among Black Americans demanding the
use of “enslaved persons” instead of “slaves” and the overwhelming
majority of Americans of Latin American descent—a wildly homogenizing
category created by the U.S. Census Bureau—reject the weird term
“Latinx.” Woke speech is simply a ruling-class dialect, which must be
updated frequently to keep the lower orders from breaking the code and
successfully imitating their betters.
wired | Our chimeric infectious cancer analogy for white nationalism might
require something related but more focused: a war on white nationalism
that is much lower on empathy than we’ve ever treated it, and higher on
an appreciation for how large and disruptive a menace it truly is. Such a
war would include the same administrative and legislative heft that has
been given to the wars on drugs and foreign terrorism. (The latter
served as the motivation for an entirely new executive department.) It
would involve an intersection of experts from the intelligence, legal,
criminal justice, and scholarly communities. And these experts would be
charged with identifying all of the places that the infectious cancer
hides in society, addressing the vulnerabilities in the American immune
system, and cutting off the communication channels that serve as a
bloodstream (e.g., social media) for white nationalism to further
propagate, causing disseminated destruction. The Biden administration
has already outlined formal plans
for improved surveillance of emerging infectious disease in response to
Covid-19. A similar process to address domestic terrorism could just as
easily be activated.
Cancer analogies also have limits that oversimplify the blight of
white nationalism. For one, cancer is driven by an undirected process
driven by the laws of natural selection: Cancerous cells don’t know
they’re disrupting anything. The 2021 strain of white nationalism,
however, is engineered specifically for destruction. It is not a set of
ideas that undermine the laws of the land by happenstance. Their purpose
is to undermine them actively and directly.
These
distinctions are more than just semantic: Too many narratives of white
nationalism incorrectly depict its actors as exclusively low-class
and uneducated. This trope says that the white nationalists aren’t
really all that bad but are misguided, acting on ignorance, alienation,
or economic anxiety.
This
ragtag caricature of white nationalism evokes a cancerous cell blindly
fomenting catastrophe through directionless meandering. The reality of
white nationalism is closer to the opposite: It is a well-oiled machine,
driven by nefarious actors with very specific goals in mind. And in
this way, white nationalism isn’t much like cancer at all. There are no
innocent, guileless actors, guilty only of being short-sighted. The
purveyors of white nationalism live by a wicked creed that explicitly
dehumanizes others.
If white nationalism isn’t a birth defect, a
virus, or a cancer, should we dispense with disease analogies
altogether? Why bother with explanatory vehicles at all?
The
answer is that disease, in the abstract sense, does effectively capture
the rot of white nationalism in important ways (many people even felt
physically ill after seeing images of Charlottesville and the Capitol
insurrection).
The challenge resides in identifying the right
pathology. Finding one has no necessary allegiance to any existing class
of disease—we’re free to cut and paste features of different diseases,
even use our science-fiction mind to dream up one better fit to describe
this unique blight.
The chimeric, hypothetical disease most like white nationalism resembles an infectious cancer—a rare class of diseases where malignant cells can be transmitted between people. The most famous of these is the devil tumour facial disease
of Tasmanian devils. A grotesque illness typified by large tumors on
the face that eventually spread throughout the body, killing the animal,
the problem is so rampant it threatens the species with extinction.
Like
an infectious cancer, white nationalism offers mutant, bastardized
forms of American ideals and institutions like liberty, states’ rights,
freedom of speech, and the right to bear arms. And they prey on and
amplify existing white resentment, anti-Blackness, and xenophobia. And
most frustratingly, these sentiments are allowed to grow and fester
because of privilege: Law enforcement never treated white domestic
terrorism as aggressively as it has Black radicals or international terrorists.
WaPo | For the past four years, the United States was governed by a conspiracy theorist in chief. Whether by retweetingQAnon
accounts from the Oval Office or painting himself as the victim of
shadowy “deep state” plots at rallies, President Donald Trump injected
the toxin of baseless conspiratorial thinking straight into America’s
political bloodstream. On Jan. 6, America saw how far that venom had
spread, as a ragtag group of militias, racist extremists and flag-waving
disciples of Trumpism stormed the Capitol.
The
insurrectionists were unified by their support for Trump. But many of
them shared another crucial trait: They were conspiracy theorists. And
while hundreds of people stormed the Capitol, there are millions of Americans who share their views. There is no doubt: The United States has a serious problem with pathological political delusions.
So, do we have any hope of deprogramming the millions of Americans who are devoted to dangerous lunacy? Don’t hold your breath.
Psychologists
and political scientists have been interested in conspiracy theories
for decades, but their research has taken on new urgency. And what is
clear from their findings is this: Once people have gone far enough down
the rabbit hole of conspiratorial thinking, it can be nearly impossible
to get them back out.
There
are a few reasons conspiracy theories are so “sticky” once they’re in
someone’s head. First, conspiracy theorists are far more likely to have a
Manichaean worldview,
meaning they interpret everything as a battle between good and evil.
That makes it harder for dispassionate evidence-based arguments to break
through. (For QAnon believers, Trump is the central superhero in an
epic saga to vanquish a shadowy cabal.)
Second,
those who seek to debunk conspiracy theories are precisely the people
that true believers distrust. If someone believes the media is
controlled by sinister but unseen puppet masters, fact checks from CNN
will never convince them they’re wrong.
WaPo | Months-long lockdowns.
Entire city populations herded through the streets for mandatory
testing. The people of China could be forgiven for thinking they had
seen it all during the coronavirus pandemic.
But
now they face a new indignity: the addition of anal swabs — yes, you
read that right — to the testing regimen for those in quarantine.
Chinese state media outlets introduced the new protocol
in recent days, prompting widespread discussion and some outrage. Some
Chinese doctors say the science is there. Recovering patients, they say,
have continued to test positive through samples from the lower
digestive tract days after nasal and throat swabs came back negative.
Yet for many, it seemed a step too far in government intrusions after a year and counting of a dignity-eroding pandemic.
“Everyone
involved will be so embarrassed,” one user in Guangdong province said
Wednesday on Weibo, a Chinese social media platform. In a Weibo poll,
80 percent of respondents said they “could not accept” the invasive
method. Fist tap Dale.
pitt.edu | For a long time, philosophers of science have expressed little interest
in the so-called demarcation project that occupied the pioneers of their
field, and most now concur that terms like “pseudoscience” cannot be
defined in any meaningful way. However, recent years have witnessed a
revival of philosophical interest in demarcation. In this paper, I argue
that, though the demarcation problem of old leads to a dead-end, the
concept of pseudoscience is not going away anytime soon, and deserves a
fresh look. My approach proposes to naturalize and down-size the
concept, anchoring it to real-life doctrines and fields of inquiry.
First, I argue against the definite article “the” in “the demarcation
problem”, distinguishing between territorial and normative demarcation,
and between different failures and shortcomings in science apart from
pseudoscience (such as fraudulent or faulty research). Next, I argue
that pseudosciences can be fruitfully regarded as simulacra of science,
doctrines that are not epistemically warranted but whose proponents try
to create the impression that they are. In this element of imitation of
mimicry, I argue, lies the clue to their common identity. Despite the
huge variety of doctrines gathered under the rubric of “pseudoscience”,
and the wide range of defects from which they suffer, pseudosciences all
engage in similar strategies to create an impression of epistemic
warrant. The indirect, symptomatic approach defended here leads to a
general characterization of pseudosciences in all domains of inquiry,
and to a useful diagnostic tool.
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