brucewilds |People tend to forget or push aside the matter of just how much unemployment cost society. This cost takes many forms. There are economic and social costs in this situation. They include a slew of things from, lower on-the-job training to things
such as alienation and lost GDP. This can result in homelessness,
depression, and even increase drug or alcohol addiction.
Lurking behind all this is the fact that State governments get the money to pay claims by debiting the employer’s Unemployment Insurance account or by
raising the employer’s UI taxes. A deduction in the account balance may
also cause a rate increase, this means each claim assessed to an
employer’s account can result in a tax rate increase in future years. The
cost of an individual claim can be significant but the higher
tax rate for a business often has a much greater long-term
impact. Many states use a three-year moving period to assign a tax rate
and an awarded unemployment claim can affect three years of UI tax
rates. This means the average claim can increase an employer’s state tax
premium from $4,000
to $7,000 over the course of three years.
The ramifications resulting from this surge in unemployment have not yet been fully internalized, this is a huge deal.
In the blink of an eye, the U.S. economy has wiped out all the job
gains since the Great Recession and more. There were already 7.1 million
unemployed Americans as of March 13, according to the U.S. Bureau of
Labor Statistics. When
this figure is combined with the newest job losses, we are looking at
more than 33 million
unemployed, or a real unemployment rate of 20.6%. This would be the
highest level since 1934.
NYTimes | Despite the stock market’s swoon
for it, remdesivir probably isn’t our ticket out, she told me. “It’s
not curative,” she said, pointing out that the strongest claims so far
are that it merely shortens the recovery of Covid-19 patients. “We need either a cure or a vaccine.”
But she can’t envision that vaccine anytime in the next year, while Covid-19 will remain a crisis much longer than that.
“I’ve been telling everybody that my event horizon is about 36 months, and that’s my best-case scenario,” she said.
“I’m
quite certain that this is going to go in waves,” she added. “It won’t
be a tsunami that comes across America all at once and then retreats all
at once. It will be micro-waves that shoot up in Des Moines and then in
New Orleans and then in Houston and so on, and it’s going to affect how
people think about all kinds of things.”
They’ll
re-evaluate the importance of travel. They’ll reassess their use of
mass transit. They’ll revisit the need for face-to-face business
meetings. They’ll reappraise having their kids go to college out of
state.
So, I asked, is “back to normal,” a phrase that so many people cling to, a fantasy?
“This
is history right in front of us,” Garrett said. “Did we go ‘back to
normal’ after 9/11? No. We created a whole new normal. We securitized
the United States. We turned into an antiterror state. And it affected
everything. We couldn’t go into a building without showing ID and
walking through a metal detector, and couldn’t get on airplanes the same
way ever again. That’s what’s going to happen with this.”
Not the metal detectors, but a seismic shift in what we expect, in what we endure, in how we adapt.
Maybe in political engagement, too, Garrett said.
If
America enters the next wave of coronavirus infections “with the
wealthy having gotten somehow wealthier off this pandemic by hedging, by
shorting, by doing all the nasty things that they do, and we come out
of our rabbit holes and realize, ‘Oh, my God, it’s not just that
everyone I love is unemployed or underemployed and can’t make their
maintenance or their mortgage payments or their rent payments, but now
all of a sudden those jerks that were flying around in private
helicopters are now flying on private personal jets and they own an
island that they go to and they don’t care whether or not our streets
are safe,’ then I think we could have massive political disruption.”
“Just
as we come out of our holes and see what 25 percent unemployment looks
like,” she said, “we may also see what collective rage looks like.”
medrxiv | Background: 2019 Novel coronavirus disease (COVID−19) is turning into a
pandemic globally lately. Angiotensin-converting enzyme 2 (ACE2) is
identified as an important functional receptor for SARS−Cov−2. ACE2 and
ACE are homologues with inverse functions in the renin−angiotensin
system. ACE converts angiotensin I into a vital vasoactive peptide
called angiotensin II(AngII), whereas ACE2 hydrolyzes AngII into a
series of vasodilators. There were few reports illustrated the
expression of AngII in COVID−19. This study aimed to demonstrate the
expression of angiotensin II in COVID−19 and how it correlated to the
disease.
Methods: We enrolled 55 patients with COVID−19 admitted to renmin
Hospital of Wuhan University from January 21st to February 21st, 2020.
Demographic data were collected upon admission. COVID−19 nuclear acid,
plasma AngII, Renin and aldosterone in the lying position without sodium
restriction, and other laboratory indicators were together measured by
the laboratory department of our hospital.
Findings: Of the 55 patients with COVID−19, 34(61.8%) had an increased
level of AngII. The severity of COVID−19 and male is positively related
with the level of AngII. The level of blood lymphocyte, PCT, ALT, and
AST were remarkably severe with those of normal level of AngII (P <
0.05). CD4/CD8 cells ratio was significantly higher whereas CD3+CD8+
cells amount, CD3+CD8+ cells proportion, CD56+CD16+CD3- cells amount and
CD19+CD3- cells amount were considerably lower than those of normal
level of AngII (P < 0.05). Abnormal rates of blood lymphocyte and PCT
were significantly higher in Patients with elevated AngII level. The
results of binary logistic regression analysis showed that the severity
of COVID−19 (OR=4.123) and CD4/CD8 ratio(OR=4.050) were the
co-directional impact factor while female(OR=0.146) was inverse impact
factor of elevated AngII level.
Interpretation: High rate of increased level of AngII was detected in
COVID−19 patients. Patients with elevated AngII level were more likely
to be critically ill with COVID−19. Considering the gender differences
in ACE2 expression and no gender differences in angiotensin expression,
the gender differences in AngII level might indicate less loss of ACE2
in female patients. Elevated AngII level was correlated with CD4/CD8
ratio, suggesting it might involve in immune disorder.
Keywords: 2019 Novel coronavirus disease(COVID−19),
Angiotensin-converting enzyme 2 (ACE2), Angiotensin II(AngII), gender
differences
sciencedirect | Nicotine could act as a
competitive agonist for the nAChRs that could restore the compromised
function of the nicotinic cholinergic system. This may be feasible
through repurposing already approved (for other indications)
pharmaceutical nicotine products such as nicotine patches for use by
non-smokers, or even by using these products as already indicated (i.e.
as smoking substitutes) among current smokers. These products are
available over-the-counter in most countries. They have been
administered therapeutically in non-smokers for neurological conditions
and inflammatory bowel disease for larger periods than would be needed
for COVID-19 [[81], [82], [83]]. No abuse liability was observed in non-smokers despite being administerd for several weeks [82,83].
Besides gums and patches, nicotine can be administered though
inhalation, with the use of a nebulizer or other aerosol systems, if
necessary. Nicotine administration could be added on top of antiviral or
other therapeutic options for COVID-19. By restoring and re-activating
the cholinergic anti-inflammatory pathway, a more universal suppression
of the cytokine storm could probably be achieved compared to
administering inhibitors of a single cytokine. The potential need to
provide pharmaceutical nicotine products to smokers and users of other
nicotine products who experience abrupt withdrawal symptoms of nicotine
when hospitalized for COVID-19 or aim to follow medical advice to quit
smoking, should also be examined. Additionally, if the hypothesis about
the beneficial effects of nicotine is valid, smokers who quit nicotine
use when hospitalized will be deprived from these benefits. In France,
the Addiction Prevention Network (RESPADD) officially recommends the use
of nicotine replacement therapies for smokers when hospitalized for any
illness [84].
Clinical trials will dictate future approaches and the role of nicotine
in COVID-19, while further experimental studies should examine the
affinity of the virus to nAChRs.
Conclusions
In
conclusion, we noticed that most of the clinical characteristics of
severe COVID-19 could be explained by dysregulation of the cholinergic
anti-inflammatory system. The observation that patients eventually
develop cytokine storm which results in rapid clinical deterioration,
led to the development of a hypothesis about the series of events
associated with adverse outcomes in COVID-19 (Fig. 2).
Once someone is infected with SARS-CoV-2, the immune system is
mobilized. As the virus replicates, cell and viral debris or virions may
interact with the nAChRs blocking the action of the cholinergic
anti-inflammatory pathway. If the initial immune response is not enough
to combat the viral invasion at an early stage, the extensive and
prolonged replication of the virus will eventually block a large part
the cholinergic anti-inflammatory pathway seriously compromising its
ability to control and regulate the immune response. The uncontrolled
action of pro-inflammatory cytokines will result in the development of
cytokine storm, with acute lung injury leading to ARDS, coagulation
disturbances and multiorgan failure. Based on this hypothesis, COVID-19
appears to eventually become a disease of the nicotinic cholinergic
system. Nicotine could maintain or restore the function of the
cholinergic anti-inflammatory system and thus control the release and
activity of pro-inflammatory cytokines. This could prevent or suppress
the cytokine storm. This hypothesis needs to be examined in the
laboratory and the clinical setting.
Guardian | Scientists working for the US military
have designed a new Covid-19 test that could potentially identify
carriers before they become infectious and spread the disease, the
Guardian has learned.
In what could be a significant breakthrough, project coordinators
hope the blood-based test will be able to detect the virus’s presence as
early as 24 hours after infection – before people show symptoms and
several days before a carrier is considered capable of spreading it to
other people. That is also around four days before current tests can
detect the virus.
The test has emerged from a project set up by the US military’s
Defense Advanced Research Projects Agency (Darpa) aimed at rapid
diagnosis of germ or chemical warfare poisoning. It was hurriedly
repurposed when the pandemic broke out and the new test is expected to
be put forward for emergency use approval (EUA) by the US Food and Drug
Administration (FDA) within a week.
“The concept fills a diagnostic gap worldwide,” the head of Darpa’s
biological technologies office, Dr Brad Ringeisen, told the Guardian,
since it should also fill in testing gaps at later stages of the
infection. If given FDA approval, he said, it had the potential to be
“absolutely a gamechanger”.
While pre-infectious detection would improve the efficiency of
test-and-trace programmes as governments worldwide relax lockdowns,
Darpa cautioned that it must wait until after FDA approval is given and
the test can be put into practise for evidence of exactly how early it
can pick up the virus.
“The goal of research is to develop and validate an early host blood
response diagnostic test for Covid,” Prof Stuart Sealfon, who leads the
research team at Mount Sinai hospital in New York, said in an email.
He said the testing approach, which looks at the body’s response as
it fights Covid-19, should produce earlier results than current
nose-swab tests that hunt for the virus itself. “Because the immune
response to infection develops immediately after infection, a Covid
signature is expected to provide more sensitive Covid infection
diagnosis earlier,” he told the Guardian.
The
research behind the development of the tests will eventually be made
public, with the collaborating teams from medical schools at Mount
Sinai, Duke University and Princeton expected to publish online,
allowing scientists around the world to trial similar methods.
If EUA is granted, the test should start being rolled out in the US
in the second half of May. Approval is not guaranteed, but Darpa
scientists are enthusiastic about the potential impact as governments
loosen lockdowns amid worries about controlling potential second-wave
outbreaks.
caitlinjohnstone | I’ve
been avoiding writing much about Tara Reade, for a lot of reasons.
Firstly I’m a survivor of multiple rapes and it brings up a lot of ouch
for me, especially since whenever I write about rape as a problem I
always get a deluge of highly triggered men (and sometimes one or two
highly traumatized women) calling me a man-hater and saying all kinds of
nasty things to me. Secondly I’ve been trying
not to spend too much time on the details of an election we all know is
fake anyway between two establishment candidates we already know are
deeply depraved.
But
mostly I avoid the subject because it’s just so goddamn gross. It’s
gross to watch liberals going around pretending they believe that Handsy
Uncle Hair Sniffer would never dream of shoving his fingers into a
woman without her consent. It’s gross watching the language of leftism
being borrowed to defend pure, relentless victim smearing. It’s gross
watching people who’ve built their political identities around
pretending to care about women try to spin these allegations as Reade
being dishonest for partisan reasons, when in reality that’s exactly
what they themselves are doing.
Due
to my experiences with and sensitivity to the subject matter, going
through this stuff feels kind of like getting punched in the privates
over and over again. There are smears everywhere, from the establishment
narrative managers to their brainwashed rank-and-file herd. Yesterday
some “KHive” asshole told me that Reade is mentally ill and talking about her experience will probably drive her to suicide, citing a baseless smear by McResistance pundit Sally Albright as his evidence. There’s a Twitter thread with thousands of shares
going around right now where some liberal combed through all Reade’s
old tweets highlighting typos she made and claiming they show Reade
tweeting “in a Russian accent”.
It sucks because if we’re to build a healthy world we’re going to have
to get rid of all the people who shouldn’t be in power, and the very
first lot we should eliminate are the ones who abuse their power to
assault the sexuality of other human beings. If you use your power to
rape people, you will with absolute certainty use it to do other
unconscionable things as well, so eliminating those who do so is the
first step toward health. That’s step one, and we
can’t even get there, because blind partisan hackery turns
pussyhat-wearing liberals into a bunch of snarling male supremacists.
theweek | Now, one could make an argument that Reade is likely telling the
truth, but Biden is still worth nominating. One could say, for instance,
that his platform is so good that Democrats will simply have to look
the other way this time. But to quote George Orwell,
that kind of argument is "too brutal for most people to face" — and it
would make Democrats look like staggering hypocrites, given how they
have wrapped themselves in the mantle of #MeToo.
Instead, Democratic partisans have thus far tried to relieve their
cognitive dissonance by casting doubt on the story or attacking Reade.
In The New York Times, Michelle Goldberg argued
that, while the accusation can't be dismissed out of hand, Reade's
praise of Vladimir Putin and changing story also cast doubt on her
story. Joan Walsh came to the same conclusion in The Nation: "Her allegation against Biden doesn't stand up to close scrutiny." Ben Cohen of The Daily Banterwent further along the same lines,
saying the allegation was "falling apart" and she was almost certainly
lying. (To be fair, all these articles were written before the latest
corroborating stories came out, and at time of writing Goldberg at least
has expressed dismay over the news.)
The posture is quite similar to the one Republicans assumed in
response to the accusations against then-Supreme Court nominee Brett
Kavanaugh back in 2018.
They attacked the integrity of accuser Christine Blasey Ford, nitpicked
the story, and denied it had happened. It was a shameful episode.
However, it's worth noting that what Biden is accused of is, if
anything, even worse than the Kavanaugh story. Kavanaugh was 17 years
old when he allegedly drunkenly pinned down Ford and tried to take her
clothes off. While awful, minors are generally not liable for normal
prosecution because they are not fully responsible adults. Biden, by
contrast, was a sober, extremely powerful, 50-year-old United States
senator when he allegedly committed his crime — and unlike Kavanaugh, he
is accused of actually raping Reade.
The effective strategy of #MeToo is to create a new social norm
around sexual misconduct. Since the criminal justice system has so
obviously failed to stem the abuse, social sanction can take up the
slack. Exposing and punishing powerful people who exploit their position
to harass and assault others might make other elites think twice.
This progress will be grossly undermined if Democrats choose to look
past Biden's allegations for political reasons. Republicans already
basically dismiss sexual assault allegations against their co-partisans
out of hand; if Democrats do the same for the leader of their party it
will do a great deal to move us back to the pre-#MeToo past, when far
too many people looked the other way at abuses committed by powerful
politicians. One cannot create a broad political norm against sexual
misconduct if the issue becomes a partisan football for both parties.
What's more, this story gives Donald Trump a huge weapon in the
general election — either to dismiss the even more numerous accusations
against himself, or to attack Biden as the real predator, or both. It
was criminally irresponsible of Biden's primary opponents not to attack
him vigorously on this issue.
However, it is not too late. Though all his opponents have dropped
out, Biden has still not been officially nominated. He could still drop
out for the good of the party, and arrange for someone else to take up
his delegates. Or the Democratic establishment could bull ahead with a
damaged, unfit nominee, whose opponent will gleefully exploit their
shameless hypocrisy, and dramatically set back the feminist causes they
claim to believe in. It's up to them.
downwithtyranny | Is the Tara Reade story reaching critical mass, approaching a tipping point? It seems so.
The initial response to this story was silence from anyone with
political or media power. The media in particular completely ignored it.
Comparisons of CNN coverage of the Reade story with their coverage of
the Blasey Ford story show a marked discrepancy. Reade told her full
story first in a March 25 interview with Katie Halper. Yet CNN published no Tara Reade stories until April 25, and then, it seems, they published only in embarrassed response to The Intercept's
revelation that Reade's mother had called in to CNN's own show, Larry
King Live, on August 11, 1993 to discuss in unspecific terms her
daughter's problem.
CNN finally broke silence on the Reade story less than a day after Ryan
Grim and the Intercept published the Larry King show transcript and the
Media Research Center located and tweeted a clip of it. Blasey Ford's
story, in contrast, went viral on all national media. including on CNN,
as soon as it was available. Deservedly so, in her case. Not so much, in
Reade's.
To conclude that the media buried the story to help Biden remain the
presumptive nominee is inescapable. The plan, apparently, was to starve
the public of Reade news and wait out the indie-press storm until newer
news drew their attention.
Once the wall of silence was breached, the indie press started
asking why Democratic Party leaders and opinion makers, especially
prominent #MeToo women, were either absent from the discussion or
suddenly coming out in support of Biden. Kirstin Gillibrand and Hillary Clinton
are the latest to announce support as of this writing, but the silence
of many — Elizabeth Warren prominently among them — is still deafening.
Note that "I support Joe Biden" and "I believe Joe Biden" are different
statements.
Only Nancy Pelosi, speaking with Ari Melber on MSNBC, has been asked
directly about Reade's accusation and replied, "I'm satisfied with his
answer." (It's very much to the point of this piece that the only
sources I could find to link to for this quote are right-wing sources
like Breitbart. Yet Melber's show is on MSNBC.)
Now the story itself, or the story about the story, is coming to
mainstream pages and screens, thanks partly to the shaming of the indie
press and partly to the recent report by Rich McHugh in Business Insider.
bloomberg |The world is on the cusp of a geopolitical reset. The global
pandemic could well undermine international institutions, reinforce
nationalism and spur de-globalization. But far-sighted leadership could
also rekindle cooperation, glimmers of which appeared in the G-20’s
offer of debt relief for some of the world’s poorest countries, a joint
plea from more than 200 former national leaders for a more coordinated
pandemic response and an unprecedented multinational pact to arrest the
crash in oil markets.
The remarkable effort to address the turmoil in the oil
markets will be critical to oil’s eventual balance — although the past
two weeks have shown that its promised production cuts were too slow and
insufficient in the face of oil demand’s plunge. The challenges and
opportunities that the collapse in the oil market is pushing to the fore
are perhaps just the first taste of Covid-19 induced geopolitical
crises that world leaders and policy makers will need to grapple with in
the coming months and years.
As history has shown, a big change in energy markets
often precipitates a big change in geopolitics. For instance, the shift
from coal to oil catapulted Middle Eastern countries to strategic
significance. And the recent technology-driven boom in shale oil
elevated the United States to net oil exporter status, changing
its outlook on the importance of oil in global affairs. We now face a
disruption of such proportions that it, too, will reorder some power
relationships.
Right
now, the focus in Washington is on how to save the U.S. oil industry,
much of which is under enormous pressure given the drop in prices. While
this is understandable and necessary, Washington needs to make room on
its list of priorities for a number of strategic shifts that the crisis
has created. For starters, policy makers should consider four challenges
and opportunities that are already manifest.
Prepare for more fragile, or even failed, states and the risks that can accompany them.
For
dozens of oil producers, the plunge in oil prices is devastating. No
major oil producer can balance its budget at prices below $40; according to the International Monetary Fund, with the exception of Qatar, every country in the Middle East requires at least $60, with Algeria at $157 and Iran at a whopping $390. The average Brent price of oil over the past month has been a hair above $20.
Of
course, fiscal break-even prices are only one factor when gauging which
oil producers are the most vulnerable to deep economic dislocation and
its accompanying social and political turmoil. Those with
(comparatively) more diversified economies — such as the United Arab
Emirates, Mexico and Russia — are obviously better off. Countries with
fixed exchange rates — like Nigeria and Saudi Arabia — are at a
particular disadvantage, as they need to use their precious foreign
exchange reserves to prop up their currencies. Some countries have the
capacity to cut expenditures, and others to borrow. And some have
legitimate political institutions to manage the inevitable hardships as
subsidies are slashed, jobs are lost and capital spending is curtailed.
thinkpol | “New drug could cure nearly any viral infection,” read the headline
on MIT News nine years ago that heralded the arrival of DRACO, a new
antiviral approach that vanquished every single virus that it came up
against.
Double-stranded RNA Activated Caspase Oligomerizer(DRACO) was
promised to do to viruses what antibiotics had done to bacteria — turn
life threatening viral infections into easily treatable conditions[1].
DRACO acts as an antiviral “kill switch” by identifying infected cells and killing those cells to terminate the infection.
The drug’s remarkable success is attributed to its ability to target a
type of RNA produced only in cells that have been infected by viruses.
Bioengineer Todd Rider and his team at MIT’s Lincoln Lab tested their
drug against 15 viruses, and found it was effective against all of them
— including rhinoviruses that cause the common cold, H1N1 influenza, a
stomach virus, a polio virus, dengue fever and several other types of
hemorrhagic fever[2].
And some researchers believe that DRACO could take on the SARS-CoV-2,
the coronavirus that’s causing the current global COVID-19 pandemic[3].
You’d think that national health agencies and pharmaceutical
companies would be rushing to mass manufacture a DRACO as a weapon
against COVID-19. But you’d be wrong.
In fact, the development of DRACO had ground to a halt after falling
into the well-known “Valley of Death”, in which many promising new drugs
struggle to find funding to bridge the gap between proof-of-concept
experiments and later large-scale development and trials.
Given that “personnel is policy,” I’ll first reduce people mentioned
in the Wall Street Journal story, and the scientists who signed the
March-April deliverable to tabular form. After that, I will take a quick
look at the scientists’ deliverable, focusing especially on issues of
governance and restoring our economy.
As a sidebar, I must protest at the PR-driven use of “Manhattan
Project. The Manhattan Project cost $23 billion in US dollars and
employed 130,000 people. I don’t think anything of that scale is being
proposed, unfortunately. End sidebar.
Now let’s look at the billionaire and multimillionaire backers of…
well, whatever the project is really called; I’ll call it, following the
Wall Street Journal, the Secret Group. In addition to backers, there
are also fixers, who connect the backers and the scientists to the
administration, agencies, and other firms, primarily in Big Pharma. I
have ordered the backers and fixers not alphabetically but by net worth.
Having looked at personnel, I’m going to look at two policy
recommendations. (I’m skipping over the Committee prioritizing
remdesivir[2]; my layperson’s sense is that there are a lot of potentia
treatments out there, and it makes more sense to accelerate many rather
than one. I also note that the stock market just had a massive pop based
on a preliminary remdesivir result from Gilead, and I certainly hope
that none of the backers were front-running it.)
charleshughsmith |Meanwhile, the splintering of America's failing elites has been amplified by the pandemic. The
moral decay of the elites is as visible as their insatiable greed. The
two are of course intimately connected: once the morals of the ruling
Elites degrade, what's mine is mine and what's yours is mine, too.
I've
previously covered two other key characteristics of an empire in
terminal decline: complacency and intellectual sclerosis, what I have
termed a failure of imagination. We can see both complacency and intellectual sclerosis in the elites' response to the pandemic.
Michael Grant described these causes of decline in his excellent account The Fall of the Roman Empire, a short book I have been recommending since 2009:
There
was no room at all, in these ways of thinking, for the novel,
apocalyptic situation which had now arisen, a situation which needed
solutions as radical as itself. (The Status Quo) attitude is a
complacent acceptance of things as they are, without a single new idea.
This
acceptance was accompanied by greatly excessive optimism about the
present and future. Even when the end was only sixty years away, and the
Empire was already crumbling fast, Rutilius continued to address the
spirit of Rome with the same supreme assurance.
This blind adherence to the ideas of the past ranks high among the principal causes of the downfall of Rome. If
you were sufficiently lulled by these traditional fictions, there was
no call to take any practical first-aid measures at all.
And
so we've reached the precarious state of disunion in which the only
thing the warring elites can agree upon is that the Federal Reserve
should rescue their private wealth, regardless of cost or consequences. America
is doomed, not because its citizenry is incapable of adaptation, but
because its ruling, warring elites are incapable of surrendering any of
their wealth, power or control, or allowing anything to threaten their
precious cartels and monopolies, starting of course with the key
controlling monopoly, the Federal Reserve.
These
are Powered Air-Purifying Respirators: In our case, a white plastic
hood with a clear face shield, attached by hose to a motorized
fan/filter worn on a belt around the waist. We don these spaceman hoods
now for high-risk situations like intubations, the prologue to putting a
patient on a vent.
If
a patient is failing despite oxygen, then he might need sedated,
intubated (i.e., have a plastic breathing tube slipped into his
trachea), and put on a ventilator. We do this routinely in emergency
medicine. But it involves getting up close with a coughing, struggling
airway — perhaps between periods of vigorous bag-mask ventilation — and
it turns out this is all high-risk for aerosolizing a coronavirus, so
that it floats in the air all around us.
This
happens in a negative-pressure room — resource was already tracking the
patient in the computer to our main resuscitation bay, which has a
sliding glass door and a fan that continuously sucks air in from the
hall — so no viral particles can wander the ER. The fans draw the air
through filters and outside of the building — hopefully someplace up
high and remote, where any few scattered viral or bacterial particles
that make it so far will be killed off by sunlight. None of this,
however, protects those of us inside the room, hence the question: Should we dress like astronauts to meet the new COVID-19 patient? Or go with standard gear?
Standard
included an N 95 mask, which each of us had been wearing all shift, for
weeks now. They feel like hard cardboard, with moldable edges. When
sealed to the face, supposedly they keep out “95%” of whatever’s
floating in the air — as long as that whatever is bigger than 0.3 micrometers (300 nanometers). (This is regulated by the National Institute for Occupational Safety and Health; the N stands for “not resistant to oil,” which means it’s fine for healthcare work but not for some industrial processes.)
If
you’re wondering: “Is filtering out 95% enough?” — join the club.
Sucking in 5% of the coronavirus that comes my way sounds like a bad
deal.
Worse, the coronavirus itself is only 0.125 micrometers (125 nanometers). So … small enough to make it thru the mask?
Nevertheless, we have some clinical evidence that N 95s prevent viral or bacterial infections. And we hypothesize
that if say a coronavirus is floating in the air, it’s doing so in a
large water droplet. Suddenly, the exact size in micrometers of said
droplet is of interest, so there’s a brisk trade in math-heavy papers like this one from the Journal of Fluid Mechanics
— with its 1,000-frames-per-second images of sneeze- and cough-expelled
saliva sprays. This and other literature suggests virus-filled saliva
droplets range from 5 to 15 micrometers (5,000 to 15,000 nanometers)—
far too big to make it past the N 95.
Maybe so, but the N 95s are miserable things.
Before COVID-19 they were considered “single-use,” worn to see a patient and then discarded upon leaving the room.
Now,
in the setting of an international shortage, at every hospital I work
at or know of, they are being used in a completely new way: Worn constantly,
sometimes with a surgical mask over top to “keep the N 95 clean,” and
then turned in for some sort of deep cleaning. The CDC has offered only the most grudging of guidance
blessing this sort of reuse, but what can we do? At least we are past
the early days, when we doctors were literally studying the specs on
vacuum cleaner bags and air conditioner filters, wondering if we could
cut them up and sew them into face masks.
To
be clear: At none of the hospitals where I work did we ever run out of
protective gear. But at all of them we had reason to worry about it, and
if we haven’t run out, it’s in large part because of the ingenuity of
the physicians and nurses in suggesting workarounds.
NYTimes | The coronavirus has hit the Hasidic Jewish community in the New York
area with devastating force, killing influential religious leaders and
tearing through large, tight-knit families at a rate that community
leaders and some public health data suggest may exceed that of other
ethnic or religious groups.
The city does not track deaths by religion, but Hasidic news media report that roughly 700 members of the community in the New York area have died from Covid-19, the disease caused by the virus.
Borough
Park is a leafy neighborhood of low-rise buildings and small businesses
like the kosher bakeries and Judaica shops on Raoul Wallenberg Way that
cater to the local Hasidic population. More than 6,000 people there
have tested positive for the virus, with one of the neighborhood’s ZIP
codes being the city’s fifth most heavily affected, according to data
released by the city.
Other
neighborhoods with large Hasidic populations, like South Williamsburg
and Crown Heights, have some of the city’s highest levels of positive
Covid-19 test results, the data show.
Hasidic
groups say they prepared for the pandemic — for example, making
decisions on the closure of schools and events — by taking their cues
from the state and federal authorities, whose response to the crisis has
been at times halting and inconsistent.
But
community leaders say Hasidic enclaves in New York were also left
vulnerable to the coronavirus by a range of social factors, including
high levels of poverty, a reliance on religious leaders who were in some
cases slow to act and the insular nature of Hasidic society, which
harbors a distrust of secular authorities that is born of a troubled
history.
That
distrust has manifested itself in ways that have risked spreading the
virus and have drawn the attention of law enforcement, which in recent
weeks has been called to disperse crowds at events like weddings and
funerals in Hasidic areas of Brooklyn, upstate New York and New Jersey.
That, in turn, has led to concerns over anti-Semitism in places like Rockland County, which has one of the highest per capita infection rates in the nation and was also the site of an anti-Semitic attack in December that killed one Hasidic Jew and injured four others.
technologyreview | Starting in the fall of 2016 and continuing into 2018, researchers at
Columbia University in Manhattan began collecting nasal swabs from 191
children, teachers, and emergency workers, asking them to record when
they sneezed or had sore throats. The point was to create a map of
common respiratory viruses and their symptoms, and how long people who
recovered stayed immune to each one.
The research included four
coronaviruses, HKU1, NL63, OC42, and C229E, which circulate widely every
year but don’t get much attention because they only cause common colds.
But now that a new coronavirus in the same broad family, SARS-CoV-2,
has the world on lockdown, information about the mild viruses is among
our clues to how the pandemic might unfold.
What the Columbia researchers now describe in a preliminary report
is cause for concern. They found that people frequently got reinfected
with the same coronavirus, even in the same year, and sometimes more
than once. Over a year and a half, a dozen of the volunteers tested
positive two or three times for the same virus, in one case with just
four weeks between positive results.
That’s a stark difference
from the pattern with infections like measles or chicken pox, where
people who recover can expect to be immune for life.
For the
coronaviruses “immunity seems to wane quickly,” says Jeffrey Shaman, who
carried out the research with Marta Galanti, a postdoctoral researcher.
Whether covid-19 will follow the same pattern is unknown, but the
Columbia results suggest one way that much of the public discussion
about the pandemic could be misleading. There is talk of getting “past
the peak” and “immunity passports” for those who’ve recovered. At the
same time, some hope the infection is more widespread than generally
known, and that only a tolerable death total stands between us and high
enough levels of population immunity for the virus to stop spreading.
All that presumes immunity is long-lived, but what if it is fleeting instead?
With the coronavirus antibody tests being rolled out, the country is
about to be flooded with millions of tests to determine if individuals
have already been exposed to the virus and presumably have immunity from
it. The development is key for researchers to understand both the scope
and spread of the virus as well as how close we may be to a type of
“herd immunity.” That public health breakthrough however could trigger
some difficult legal questions. First and foremost, what if you are not
part of the herd? The country may soon have to deal with a new concept
of bias: antibody or immuno discrimination.
There is a growing and urgent need to get this economy rolling as the
virus outbreak subsides. President Donald Trump is correct that
destroying this economy will ruin the lives and dreams (and yes health)
of tens of millions of citizens. It could reduce the horizon for an
entire generation saddled with crippling debt and reduced markets.
Recovery will occur only to the degree that people feel comfortable
about getting on airplanes, trains, buses, restaurants, and other closed
spaces. With a vaccine projected as still a year away, the population
could soon be divided into the immunized and the potentially contagious.
If you are in the later group, the question is whether you can be
denied certain services.
It is not as far-fetched as you might think. Take the airlines.
Planes need to be near capacity to be profitable as a general rule.
Social distancing on an airplane is not economically viable. One
solution is to require proof of antibodies in your system with one of
these available tests. Indeed, the airlines this week floated the idea
of a required blood test. That conversely would create barriers to those
who are immuno signatures.
Various countries are already using tracking technology to identify
carriers and the same technology can be used to distinguish those who
are immune. In Moscow, the government has issued “digital permits” to
travel that bars others from public transport and even car traffic.
washingtontimes | Meanwhile, a number of suspicious actions and a paper trail suggest that the virus escaped from one of the labs, though China is clamping down on the ability to pursue those leads.
“The most logical place to investigate the virus origin has been
completely sealed off from outside inquiry by the CCP,” said the
document, referring to the Chinese Communist Party.
The party has taken draconian steps to control information about the virus since January.
“A gag order to both places was issued on Jan. 1, 2020, and a major general from the PLA who is China’s top military microbiologist essentially took over the [Wuhan Institute of Virology] since mid-January.”
Labs face scrutiny
Both of the labs under scrutiny in the report
have conducted extensive research on bat coronaviruses, including those
that have close molecular similarities to SARS-Cov-2, the full
designation of the new pathogen.
Among the most significant circumstantial
evidence identified in the report are the activities of Shi Zhengli, a
leader in bat coronavirus research with the Wuhan Institute of Virology,
China’s only high-security, level four research laboratory.
Ms. Shi has been involved in bioengineering bat
coronaviruses, and a medical doctor named Wu Xiaohua launched an online
campaign to expose Ms. Shi’s work. Dr. Wu said she believes the
coronavirus at the root of the pandemic is one of 50 viruses in a
database Ms. Shi manages.
The document also points to a 2015 academic report in Nature Medicine
by Ms. Shi and 14 other scientists who said that while researching the
potential for bat coronaviruses to infect humans, “we built a chimeric
virus encoding a novel, zoonotic [animal-origin] spike protein … that
was isolated from Chinese horseshoe bats.”
The scientists said the “hybrid virus” allowed researchers to study the ability of the virus to “cause disease.”
Dr. Wu stated in an internet posting that Ms.
Shi used laboratory animals to test the human-infecting virus, and one
of those animals may have been the origin of the pandemic.
Dr. Wu also asserted that the institute’s
virus-carrying animals had been sold as pets, dead laboratory animals
were not properly disposed of, and lab workers were known to boil and
eat laboratory-used eggs.
“Wu’s charges of WIV management negligence are specific and have not been convincingly rebutted by WIV,” the analysis said.
Ms. Shi has worked closely with several U.S.
virologists, and some American scientists have defended her and the
institute from critics who point to her work with bat viruses as a
needed focus of an investigation, the analysis says. Ms. Shi, in
response to Dr. Wu’s assertions, said in March on her social media
account: “I promise with my life that the virus has nothing to do with
the lab.”
newsweek | The NIH research consisted of two parts. The first part
began in 2014 and involved surveillance of bat coronaviruses, and had a
budget of $3.7 million. The program funded Shi Zheng-Li, a virologist
at the Wuhan lab, and other researchers to investigate and catalogue bat
coronaviruses in the wild. This part of the project was completed in
2019.
A second phase
of the project, beginning that year, included additional surveillance
work but also gain-of-function research for the purpose of understanding
how bat coronaviruses could mutate to attack humans. The project was
run by EcoHealth Alliance, a non-profit research group, under the
direction of President Peter Daszak, an expert on disease ecology. NIH
canceled the project just this past Friday, April 24th, Politico reported. Daszak did not immediately respond to Newsweek requests for comment.
The
project proposal states: "We will use S protein sequence data,
infectious clone technology, in vitro and in vivo infection experiments
and analysis of receptor binding to test the hypothesis that %
divergence thresholds in S protein sequences predict spillover
potential."
In layman's terms, "spillover potential" refers to the
ability of a virus to jump from animals to humans, which requires that
the virus be able to receptors in the cells of humans. SARS-CoV-2, for
instance, is adept at binding to the ACE2 receptor in human lungs and
other organs.
According to Richard Ebright, an infectious disease
expert at Rutgers University, the project description refers to
experiments that would enhance the ability of bat coronavirus to infect
human cells and laboratory animals using techniques of genetic
engineering. In the wake of the pandemic, that is a noteworthy detail.
Ebright,
along with many other scientists, has been a vocal opponent of
gain-of-function research because of the risk it presents of creating a
pandemic through accidental release from a lab.
Dr. Fauci is renowned for his work on the HIV/AIDS crisis in the
1990s. Born in Brooklyn, he graduated first in his class from Cornell
University Medical College in 1966. As head of NIAID since 1984, he has
served as an adviser to every U.S. president since Ronald Reagan.
A
decade ago, during a controversy over gain-of-function research on
bird-flu viruses, Dr. Fauci played an important role in promoting the
work. He argued that the research was worth the risk it entailed because
it enables scientists to make preparations, such as investigating
possible anti-viral medications, that could be useful if and when a
pandemic occurred.
The work in question was a type of
gain-of-function research that involved taking wild viruses and passing
them through live animals until they mutate into a form that could pose a
pandemic threat. Scientists used it to take a virus that was poorly
transmitted among humans and make it into one that was highly
transmissible—a hallmark of a pandemic virus. This work was done by
infecting a series of ferrets, allowing the virus to mutate until a
ferret that hadn't been deliberately infected contracted the disease.
thelastamericanvagabond |Last year, a U.S. government body
dedicated to examining how artificial intelligence can “address the
national security and defense needs of the United States” discussed in
detail the “structural” changes that the American economy and society
must undergo in order to ensure a technological advantage over China,
according to a recent document acquired through a FOIA request.
This document suggests that the U.S. follow China’s lead and even
surpass them in many aspects related to AI-driven technologies,
particularly their use of mass surveillance. This perspective clearly
clashes with the public rhetoric of prominent U.S. government officials
and politicians on China, who have labeled the Chinese government’s
technology investments and export of its surveillance systems and other
technologies as a major “threat” to Americans’ “way of life.”
In addition, many of the steps for the
implementation of such a program in the U.S., as laid out in this newly
available document, are currently being promoted and implemented as part
of the government’s response to the current coronavirus (Covid-19)
crisis. This likely due to the fact that many members of this same body
have considerable overlap with the taskforces and advisors currently
guiding the government’s plans to “re-open the economy” and efforts to
use technology to respond to the current crisis.
The FOIA document, obtained by the
Electronic Privacy Information Center (EPIC), was produced by a
little-known U.S. government organization called the National Security
Commission on Artificial Intelligence (NSCAI). It was created by
the 2018 National Defense Authorization Act (NDAA) and its official
purpose is “to consider the methods and means necessary to advance the
development of artificial intelligence (AI), machine learning, and
associated technologies to comprehensively address the national security
and defense needs of the United States.”
The NSCAI is a key part of the government’s response to what is often referred to as the coming “fourth industrial revolution,”
which has been described as “a revolution characterized by
discontinuous technological development in areas like artificial
intelligence (AI), big data, fifth-generation telecommunications
networking (5G), nanotechnology and biotechnology, robotics, the Internet of Things (IoT), and quantum computing.”
However, their main focus is ensuring that “the United States … maintain a technological advantage
in artificial intelligence, machine learning, and other associated
technologies related to national security and defense.” The vice-chair
of NSCAI, Robert Work – former Deputy Secretary of Defense and senior fellow at the hawkish Center for a New American Security (CNAS), described the commission’s purpose as determining “how the U.S. national security apparatus should approach artificial intelligence, including a focus on how the government can work with industry to compete with China’s ‘civil-military fusion’ concept.”
The recently released NSCAI document is a May 2019 presentation entitled “Chinese Tech Landscape Overview.”
Throughout the presentation, the NSCAI promotes the overhaul of the
U.S. economy and way of life as necessary for allowing the U.S. to
ensure it holds a considerable technological advantage over China, as
losing this advantage is currently deemed a major “national security”
issue by the U.S. national security apparatus. This concern about
maintaining a technological advantage can be seen in several other U.S.
military documents and think tank reports, several of whichhave warnedthat the U.S.’ technological advantage is quickly eroding.
theatlantic |COVID-19 has emboldened American tech
platforms to emerge from their defensive crouch. Before the pandemic,
they were targets of public outrage over life under their dominion.
Today, the platforms are proudly collaborating with one another, and following government guidance,
to censor harmful information related to the coronavirus. And they are
using their prodigious data-collection capacities, in coordination with
federal and state governments, to improve contact tracing, quarantine
enforcement, and other health measures. As Facebook’s Mark Zuckerberg
recently boasted, “The world has faced pandemics before, but this time we have a new superpower: the ability to gather and share data for good.”
Over the past decade,
network surveillance has grown in roughly the same proportion as speech
control. Indeed, on many platforms, ubiquitous surveillance is a
prerequisite to speech control.
The public has been told over and over
that the hundreds of computers we interact with daily—smartphones,
laptops, desktops, automobiles, cameras, audio recorders, payment
mechanisms, and more—collect, emit, and analyze data about us that are,
in turn, packaged and exploited in various ways to influence and control
our lives. We have also learned a lot—but surely not the whole
picture—about the extent to which governments exploit this gargantuan
pool of data.
Police use subpoenas to tap into huge warehouses of personal data
collected by private companies. They have used these tools to gain access to doorbell cameras that now line city blocks, microphones in the Alexa devices in millions of homes, privately owned license-plate readers that track every car, and the data in DNA databases
that people voluntarily pay to enter. They also get access to
information collected on smart-home devices and home-surveillance
cameras—a growing share of which are capable of facial recognition—to
solve crimes. And they pay to access private tow trucks equipped with cameras tracking the movements of cars throughout a city.
America’s private surveillance system goes far beyond apps, cameras, and
microphones. Behind the scenes, and unbeknownst to most Americans, data
brokers have developed algorithmic scores for each one of us—scores
that rate us on reliability, propensity to repay loans, and likelihood to commit a crime. Uber bans passengers with low ratings from drivers. Some bars and restaurants now run background checks on their patrons to see whether they’re likely to pay their tab or cause trouble. Facebook has patented a mechanism for determining a person’s creditworthiness by evaluating their social network.
Celebrating 113 years of Mama Rosa McCauley Parks
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*February 4, 1913 -- February 4, 2026*
*Some notes: The life of the courageous activist Mama Rosa McCauley Parks*
Mama Rosa's grandfather Sylvester Ed...
Monsters are people too
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Comet 3I/Atlas is on its way out on a hyberbolic course to, I don't know
where. I do know that 1I/Oumuamua is heading for the constellation Pegasus,
and ...
Remembering the Spanish Civil War
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This year marks the 90th anniversary of the launch of the Spanish Civil
War, an epoch-defining event for the international working class, whose
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Return of the Magi
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Lately, the Holy Spirit is in the air. Emotional energy is swirling out of
the earth.I can feel it bubbling up, effervescing and evaporating around
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Covid-19 Preys Upon The Elderly And The Obese
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sciencemag | This spring, after days of flulike symptoms and fever, a man
arrived at the emergency room at the University of Vermont Medical Center.
He ...
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(Damn, has it been THAT long? I don't even know which prompts to use to
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SeeNew
Can't get on your site because you've gone 'invite only'?
Man, ...
First Member of Chumph Cartel Goes to Jail
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With the profligate racism of the Chumph Cartel, I don’t imagine any of
them convicted and jailed is going to do too much better than your run of
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