Omicron Bussin Through mRNA Goo Like Hotcakes...,

 

der tagespiegel |  A group of seven Germans between the ages of 25 and 39 were infected with the Omicron variant of the coronavirus in South Africa, even though all of them have already received their booster vaccination. This is what Wolfgang Preiser, a member of the research consortium that discovered the variant, told Tagesspiegel.

“We're seeing a lot of breakthrough infections right now. What we did not know is that even a booster vaccination with Biontech / Pfizer does not prevent this, "Preiser explained to the Tagesspiegel. These infections are the first breakthrough infections reported with the Omicron variant in people who have already received their booster vaccinations.

[Also read: "Live on in your illusion" -  w wants hen's best friend Corona with globules defeat (T +)]

“Of course you shouldn't misunderstand that vaccination doesn't help. On the contrary: It only shows that even the best possible vaccination is obviously not enough to prevent infection - which we already suspected, "said Preiser.

According to a study published by Preiser and his colleagues on the case on Thursday, the tour group was infected as early as late November or early December.

All seven had received at least two of their three vaccinations with an mRNA vaccine. Six of them received the booster vaccine from Biontech, one from Moderna. Six people are under 30 years old and one person is 39 years old.

These vaccines were given to people in this order:

• People 1 to 5: Biontech, Biontech, Biontech
• Person 6: Biontech, Biontech, Moderna
• Person 7: Astrazeneca, Biontech, Biontech

The booster vaccinations were given to the subjects between five and ten months after the second vaccinations. The booster vaccinations were at least a month, but a maximum of two months ago, according to the study. Those affected were among those vaccinated very early in Germany.

According to the study, none of the seven infected people had relevant previous illnesses and none had previously tested positive. Four of them did medical internships in various local hospitals, the other three were on vacation. When they arrived in South Africa in the first half of November, they all tested negative.

 

Unvaxxed Uselessly-Eating Muggles Should Be Stripped Of Healthcare Insurance

off-guardian  |  Illinois Representative Jonathan Carroll wants to push through a change to the state’s insurance law that would mean health insurers no longer have to cover unvaccinated people who get Covid, forcing people to pay their medical bills out of pocket.

The Democrat lawmaker told the Chicago Sun-Times:

I think it’s time that we say ‘You choose not to get vaccinated, then you’re also going to assume the risk that if you do catch COVID, and you get sick, the responsibility is on you,’”

The potential corruption and abuse of such a rule should be obvious to anyone familiar with just how mendacious insurance companies can be.

In all likelihood insurance companies will simply demand a negative Covid test before paying anything, and if you test positive, no matter what you were treated for, you will be called a “covid case” and forced to pay out of pocket.

The bill could, essentially, wipe all health insurance off the books for unvaccinated people.

The vaccinated should take no comfort from this, because their vaccinated status is entirely temporary, and subject to rules that could change on a whim.

Any “double jabbed” who misses a booster, or got a brand of vaccine that was subsequently unapproved or discontinued, or wasn’t updated for the latest variant, could suddenly find themselves one of the “unvaccinated” underclass.

Of course, once it applies to vaccination status it can apply to other things. You travelled to the wrong place, or you didn’t wear a mask, you “associated with known anti-vaxxers”.

And, even more concerning, is the potentially slippery slope this starts us down. Unvaccinated don’t get health insurance. Neither do smokers who get lung cancer. Or overweight people who get diabetes. And so on and so on.

The potential good news is that putting this law on the books would require a lot of legal workarounds, including violating or changing the Affordable Care Act, which outlaws removing insurance coverage from someone based on a new medical diagnosis or test result.

Post Pandemic Stress Disorder

off-guardian  |   Doctors are warning that hundreds of thousands of people in the UK could be at increased risk of heart disease or cardiac events.

Speaking to the Evening Standard, psychological therapist Mark Rayner and vascular surgeon Tahir Hussein said that the UK could see “300,000 new patients with heart issues” in the near future.

What’s to blame? Well, that would be “Post Pandemic Stress Disorder”. A new condition “yet to be recognised”, even though “many experts believe it should be”.

It’s a totally real thing. They didn’t just completely make it up. Don’t be cynical.

You see, all the “pandemic” related anxiety and stress has taken such a toll on the public that doctors are predicting a 5% increase in heart disease, nationwide, and not just in the elderly or infirm.

According to Dr Hussein, he is already seeing…

a big increase in thrombotic-related vascular conditions in my practice. Far younger patients are being admitted and requiring surgical and medical intervention than prior to the pandemic.

Now, some of you demented anti-vaxxers out there might be asking crazy questions like “could this increase in blood clots and heart disease be linked to injecting millions of people with an untested vaccine?”

But that’s absurd. And I told you to stop being cynical.

Yes, fine, in the interests of fairness, we should mention it was recently reported that the Astra Zeneca jab can cause blood clots.

It turns out all the people saying that back in March weren’t just conspiracy theorists spreading misinformation after all. They were totally right. But the clots are only rare, so don’t worry. And they sort of know what causes it now, so future batches might be fine.

And yes, also in the interests of fairness, it’s true that both the Pfizer and Moderna shots can cause heart issues too. Both, according to the CDC, can cause pericarditis and myocarditis, the complications of which include heart attacks, heart failure and strokes.

The UK government has even produced special guidelines for dealing with myocardits, “following Covid19 vaccination”.

But, just like the blood clots, this is very rare. Obviously not so rare you don’t need a special guiding document on how to deal with it, but still very very rare.

…the point is, yes, all the major Covid vaccines are known to have cardiac-related side effects, and yes, some doctors are now predicting a major spike in heart-related health problems, but these are totally unrelated.

Dr. Matthew Memoli Pushed Back On The Jab Mandate And Got Smothered With An NIH Pillow....,

Fist tap Brother John

Does The Spike Protein Epigenetically Silence Endothelial SIRT6?

wmcresearch  |  One may view the actions of the spike protein by reversing a well-worn saying:

“If you give a man a fish, you feed him for a day. If you teach a man to fish, you feed him for a lifetime.”

The Spike prefers:

“If you stop a cell from repairing itself, it just dies. If you teach the host to stop repairing itself, you rob it of its lifetime.”

On May 31^st of this year, researchers in Israel discovered the Fountain of Youth. They observed that SIRT6 controls the rate of healthy aging. If you increase this, the mice live for an average of THIRTY PERCENT LONGER. So, imagine 130 being the new 100. SIXTY being the new THIRTY! LITERALLY!

An interesting observation was also made by the team: “If we can determine how to activate it in humans, we will be able to prolong life, and this could have enormous health and economic implications."

Enormous implications, indeed. Clearly there are those who certainly DO NOT want Seven Billion people living an extra thirty years…

So, what happens if you REMOVE SIRT6? You guessed it. Very, very bad things happen. Especially death.

Without SIRT6 your body is unable to repair the DNA damage that we experience every day, and which is ENORMOUSLY increased in states of disease, particularly so in the case of SARS-CoV-2.

THE ENDOTHELIAL SENESCENCE CONNECTION

It has been established that endothelial cells become senescent when transfected with the Spike Protein. They have not determined WHY it happens, just that it DOES HAPPEN and the effects it has. I now know why it happens. The Spike Protein is epigenetically silencing SIRT6.

What does SIRT6 do, in addition to controlling DNA repair?

DNA Repair, Gene Expression, Telomeric Maintenance, Mitosis and Meiosis, Stem Cell Pluripotency and Differentiation (how cells obtain their specific functionality), Metablic Diseases (Diabetes, for example), Cancer, Immune Regulation, Stress Response, Senescence and Aging.

Everything COVID and Long COVID.

It has already been hypothesized that Sirtuins are implicated in COVID. In a paper on COVID and related Sepsis it was determined that Metformin may improve metabolic derangements, improve mitochondrial function, and decrease cytokine production. NAD+ boosters such as resveratrol, a naturally occurring polyphenol, found in red grapes and blueberries, activate Sirtuin activity and attenuate the NF-ĸB activity, improve endothelial function, and decrease microvascular inflammation.

SIRT1 is also implicated in COVID: COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity

But, what are the possible long term implications? Organisms that are deprived of their natural SIRT6 have very, very short lifespans. Mice, for example, die within four weeks without SIRT6.

Are Vaccinated English Adults Under 60 Dying At Twice The Rate Of Same Age Unvaccinated?

alexberenson  |  This chart may seem unbelievable or impossible, but it's correct, based on weekly data from the British government. 

The brown line represents weekly deaths from all causes of vaccinated people aged 10-59, per 100,000 people.

The blue line represents weekly deaths from all causes of unvaccinated people per 100,000 in the same age range.

I have checked the underlying dataset myself and this graph is correct. Vaccinated people under 60 are twice as likely to die as unvaccinated people. And overall deaths in Britain are running well above normal.

I don’t know how to explain this other than vaccine-caused mortality.

The basic data is available here, download the Excel file and see table 4:

 

 

Neo-vaccinoid Neurotic Pediatrician Wants Mandate For Children

slate |  Why do you think there’s this disconnect that might exist between what a vaccinated parent is willing to do for themselves and what they might be willing to do for their kid?

One is that you feel a sense of responsibility to your children that sometimes feels harder than to yourself, because you’ve been taking risks with yourself your whole life. You’ve probably made some reasonably risky decisions in your 20s, both with respect to sexual activity and perhaps with substances—you’re used to understanding tradeoffs. With kids however, we’re much more restrictive. And we feel that we could be blamed. The dangers seem much bigger and the benefits sometimes pale in comparison.

Of course, weighing benefits and risks of vaccines is nothing new. That’s why families turn to their pediatricians for advice. For years, doctors have tried to increase vaccination rates and fight hesitancy. Did this same struggle occur with earlier vaccines?

When the varicella vaccine got approved in the ’90s, lots of parents were like, “Why should I vaccinate my kid against chicken pox? It’s a nothing big, minor illness. Everybody gets it.” And for a lot of people, that’s true. But when adults get chicken pox, it’s massively bad. Plus, some number of babies died every year of varicella infection. It wasn’t huge numbers, but they were real numbers.

And just a couple of years after we really started vaccinating kids, in the early 2000s, zero babies died of chicken pox. That’s a huge win, given that zero babies are immunized against chicken pox. You can’t get it until you’re 1 year of age. But by vaccinating children, we’ve protected everyone. And now today we have like 86 percent of eligible children vaccinated, and chicken pox has largely gone away.

You wrote about your experience as a young pediatrician, vaccinating kids with the varicella vaccine against chicken pox. How did you break through to skeptical parents?

I think it’s time and effort and it’s building up trust. I would talk about risk and benefits. In fact, this is part of what we do with everything. When parents are like, “I want an antibiotic for my kid’s ear infection,” I talk about these are the benefits of it and these are the risks.
It’s negotiation. It’s making sure people feel heard, making sure that you understand what they’re going through, that it’s not unreasonable and trying to find a solution that works.

In your writing about varicella, I noticed that you said in 2008, only about 34 percent of eligible adolescents were fully immunized. And by 2018, about 90 percent of kids have been vaccinated. That seems both great, and made me think: Are we talking about immunizing kids against COVID on a decade long timeframe? Is it going to take us 10 years?

Unless we have mandates, yeah, I think it is because, and, to be honest with you, we won’t get all the way there without mandates. Let’s be clear too. I can’t win 90 percent as a pediatrician. I just own that. It’s not going to happen. You need these to become so expected that the school system’s requiring it. The default has to be “vaccinated,” so that most people will do it.

 

Virus Gonna Virus - But Don't Worry - The Boosters Will Fix Everything

alexberenson |  From Singapore to the Netherlands to Iceland to Vermont. And coming soon to the entire northern half of the United States.

Alex Berenson Nov 12

875

488

This is not how it was supposed to go.

Deaths hitting new highs in Singapore (85% of the population fully vaccinated - NOT adults, the entire population):

A new lockdown in the Netherlands (70% fully vaccinated)

And in Iceland (76% fully vaccinated):

As Vermont - the most vaccinated American state (71% fully vaccinated) smashes highs for cases:

With Children Being Lined Up For mRNA Goo Jabs, Goo-Makers Now Begin Studying Myocarditis...,

wsj  |  As U.S. health authorities expand use of the leading Covid-19 vaccines, researchers investigating heart-related risks linked to the shots are exploring several emerging theories, including one centered on the spike protein made in response to vaccination.

Researchers aren’t certain why the messenger RNA vaccines, one from Pfizer Inc. PFE -2.07% and partner BioNTech SE BNTX -5.83% and the other from Moderna Inc., MRNA -3.40% are likely causing the inflammatory heart conditions myocarditis and pericarditis in a small number of cases.

Some theories center on the type of spike protein that a person makes in response to the mRNA vaccines. The mRNA itself or other components of the vaccines, researchers say, could also be setting off certain inflammatory responses in some people.

One new theory under examination: improper injections of the vaccine directly into a vein, which sends the vaccine to heart muscle.

To find answers, some doctors and scientists are running tests in lab dishes and examining heart-tissue samples from people who developed myocarditis or pericarditis after getting vaccinated.

Myocarditis describes inflammation of the heart muscle, while pericarditis refers to inflammation of the sac surrounding the muscle.

Covid-19 itself can cause both conditions. They have also been reported in a smaller number of people who got an mRNA vaccine, most commonly in men under 30 years and adolescent males.

About 877 confirmed cases of myocarditis in vaccinated people under 30 years have been reported in the U.S., out of 86 million mRNA vaccine doses administered, according to the Centers for Disease Control and Prevention.

 

Serial Mandater Gov. Gavin Newsome Laid Low By A Gob Of mRNA Goo?

childrenshealthdefense |  A source close to California Gov. Gavin Newsom today told The Defender the governor experienced an adverse reaction to the Moderna COVID vaccine he received Oct. 27.

The source, who asked not to be identified, said Newsom’s symptoms were similar to those associated with Guillain–Barré syndrome (GBS), a known side effect of many vaccines.

GBS is a neurological disorder in which the body’s immune system mistakenly attacks part of its peripheral nervous system — the network of nerves located outside of the brain and spinal cord — and can range from a very mild case with brief weakness to paralysis to leaving the person unable to breathe independently.

The governor has not been seen in public since he was photographed Oct. 27 getting his COVID booster.

On Oct. 29, Newsom’s office issued a statement referring to unspecified “family obligations” as the reason the governor canceled his scheduled appearances, including his planned meetings at the global COP 26 climate conference in Glasgow, Scotland.

A local ABC News outlet reported that when “the surprising announcement was made,” a spokesperson said Newsom planned to participate virtually in the climate conference. However, Newsom’s name was removed from the schedule and he did not participate.

The Defender reached out to Newsom’s office today by phone and email, but the office did not respond before publication.

According to Fox News, Newsom’s wife, Jennifer Siebel Newsom, on Sunday tweeted — then quickly deleted — a message urging people to “stop hating” while her husband has been out of the public eye since canceling plans, including his appearances at COP 26.

 

The "Masters" Have Redefined The Meaning Of The Word Vaccine

technofog |   The CDC caused an uproar in early September 2021, after it changed its definitions of “vaccination” and “vaccine.” For years, the CDC had set definitions for vaccination/vaccine that discussed immunity. This all changed on September 1, 2021.

The prior CDC Definitions of Vaccine and Vaccination (August 26, 2021):

Vaccine: A product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease. Vaccines are usually administered through needle injections, but can also be administered by mouth or sprayed into the nose.

Vaccination: The act of introducing a vaccine into the body to produce immunity to a specific disease.

The CDC Definitions of Vaccine and Vaccination since September 1, 2021:

Vaccine: A preparation that is used to stimulate the body’s immune response against diseases. Vaccines are usually administered through needle injections, but some can be administered by mouth or sprayed into the nose.

Vaccination: The act of introducing a vaccine into the body to produce protection from a specific disease.

People noticed. Representative Thomas Massie was among the first to discuss the change, noting the definition went from “immunity” to “protection”.

Check out @CDCgov’s evolving definition of “vaccination.” They’ve been busy at the Ministry of Truth: pic.twitter.com/4k2xf8rvsL

— Thomas Massie (@RepThomasMassie) September 8, 2021

 

To many observers, it appeared the CDC changed the definitions because of the waning effectiveness of the COVID-19 vaccines. For example, the effectiveness of the Pfizer vaccine falls over time, with an Israeli study reported in August 2021 as showing the vaccine being “only 16% effective against symptomatic infection for those individuals who had two doses of the shot back in January.”  The CDC recognizes the waning effectiveness, thus explaining their promotion of booster shots.

Of course, the usual suspects defended the CDC. The Washington Post, for example, cast doubt that the CDC changed the definition because of issues with the COVID-19 vaccines. The CDC tried to downplay the change, stating “slight changes in wording over time … haven’t impacted the overall definition.”

Internal CDC E-Mails

CDC emails we obtained via the Freedom of Information Act reveal CDC worries with how the performance of the COVID-19 vaccines didn’t match the CDC’s own definition of “vaccine”/“vaccination”. The CDC’s Ministry of Truth went hard at work in the face of legitimate public questions on this issue.

In one August 2021 e-mail, a CDC employee cited to complaints that “Right-wing covid-19 deniers are using your ‘vaccine’ definition to argue that mRNA vaccines are not vaccines…”

 

VAERS Is Supposedly Used By Public Health Officials To Detect Signals

The signals began ringing loudly in December 2020, when first covid shots were administered, and quickly became deafening. They were that loud, and the extraordinary magnitude of them has been and continues to be ignored by our government at all levels in Washington DC, all levels!

Senators this week demonstrated that they could put the heat on, witness AG Merrick Garland — when they want to take something seriously.

However, despite the Loudon rape fiascos, which senators used to slap Garland around with, Garland the Magnificent remains in office. And his order to FBI to treat parents complaining about public school corruption remain “domestic terrorists” remains in place far as I know.

Save for Wisconsin Sen. Ron Johnson, none of them have lifted a finger, while thousands and tens of thousands dead, permanently disabled, maimed, injured, blinded, cancers that were in remission came back, ditto herpes, thousands of miscarriages and who knows how many thousands of women now permanently sterilized? from these poisons sold as preventive medicine. Among many, many other injuries. And hospitals across the land fire skilled medical staff for saying anything about this grotesque bestiality. These are not hospitals; they are charnel houses!

What are these shots actually preventing, —- if 85% of those dead after covid shot got the disease anyways?

Below is data indicating how out of control the covid shot injuries are, which also indicates the moral turpitude of Congress, Biden, and his men [and Trump’s advocacy of “warp speed” vax], et al.

Note what happens in Dec. 2020.

all adverse events reported to VAERS
Dec., 2019 3,455
Jan., 2020 3,082
Feb., 2020 2,986
Mar., 2020 2,232
Apr., 2020 2,022
May, 2020 1,946
Jun., 2020 1,844
Jul., 2020 2,186
Aug., 2020 2,961
Sep., 2020 4,576
Oct., 2020 6,265
Nov., 2020 4,510
Dec., 2020 15,594
Jan., 2021 70,266
Feb., 2021 57,719
Mar., 2021 78,168
Apr., 2021 105,689
May, 2021 63,606
Jun., 2021 44,649
Jul., 2021 36,000
Aug., 2021 103,533
Sep., 2021 49,428

after covid shot-only reports to VAERS
Dec., 2020 10,891
Jan., 2021 66,581
Feb., 2021 54,550
Mar., 2021 74,461
Apr., 2021 102,189
May, 2021 61,113
Jun., 2021 42,374
Jul., 2021 33,564
Aug., 2021 100,718
Sep., 2021 47,158
Oct., 2021 29,144
Total 622,743

In the 11 months preceding covid shot rollout, Jan — Nov 2020,
34,701 adverse events reported to VAERS — for ALL vaccines combined.

In the 11 months since, Dec 2020 to Oct 2021,
622,743 adverse events for covid-only shots

Nearly 17 times more, or 1,685% more.

This is what vaccine failure looks like.

This is what government failure looks like.

Had the CDC and US Food and Drug Administration been serious about adverse events and in particular, the percentage of those either having covid or not, they would have done something to ensure that there would be data on this, for each and every VAERS report submitted.

In particular, regarding VAERS reports in which death occurs after covid shots.

While 100% data on this may seem like pie in the sky, the least we should expect is what Pfizer and Moderna claimed was 95% Vaccine Effectiveness VE. Which as we now know was base, rank, propaganda and deception, at best.

Irrespective of the fact that the actual VE of these poisons tends toward zero, one can at the very least expect that the percentage of VAERS reports on who did and did not test positive for this disease should have at a minimum been ~ 43%.

43% is the CDC estimated VE, from average of previous decade’s [through 2019/2020 flu season], of influenza shots.

Instead, only 16.42% is actually reported in VAERS data bank. That’s bad, that’s really unconscionably bad.

VAERS data shows that of all the after covid shot deaths,
2.54 % reported “SARS-COV-2 TEST NEGATIVE”
13.88% reported “SARS-COV-2 TEST POSITIVE”

Where are the other 83.58% ???

Thus, only 16.42% of this essential data is actually, as of Oct. 29 data, known via VAERS.

Assuming these proportions are at least in the ball park, this means
~85% of after covid shot deaths tested positive
~15% tested negative.
[13.88/16.42 = 84.531, or 85% rounding; 100-84.531 = ~15%]

8,086 deaths after covid shot reported to VAERS x 21X = ~165,000 actual deaths.

165,000 x 0.85 = ~144,211 died with positive test
165,000 x 0.15 = 21,631 died with negative test.

Total = ~ 165,842

Rose says that these deaths are caused by covid shots.

IM Doc And Jimmy Dore: Anti-Mandate Does Not Equal Anti-Vaxx

I have ordered tens of thousands of vaccines in my lifetime.

We have not had near the time or ability to completely assess this situation with the COVID vaccines. And certainly with what we know about the COVID vaccines now, there are really no big benefits for “public health” in general. There is enormous benefit for individual patients that are at high risk and I have spent inordinate amount of my time trying to convince these people to go for it.

In the vaccinated, it appears the contagion can be spread and caught likely just as easily as in the unvaccinated. Therefore, the risks and benefits are all on the individual side and not on the community side. This is completely different than in most of the childhood vaccines which lead us to sterilization and decreased spread to zero. Our COVID vaccines currently will be able to do no such thing. We can greatly impact high-risk individual lives with these vaccines and we should all be trying to do that – but impacting the course of spread in a vast population is much different with these COVID vaccines than say with measles. It is unfortunately simply not going to work that way until/if we get better vaccines.

If the COVID vaccines worked like the measles vaccine, we would not be having all the discussion about “protecting the vaccinated” would we? If they worked like they were early on promised, the vaccinated would not have to worry for a second about the unvaccinated. The consequences and problems would theoretically all be on the unvaccinated. We can behave that way with certainty with the measles and mumps vaccines with just microscopic levels of breakthrough. But the COVID vaccines offer no such protection. I applaud anyone who gets vaccinated – especially those in higher risk situations. I spend large amounts of my day every day doing just that. But given the way these were sold, and given what has occurred, I blame no one for being hesitant. It is my job to convince those high-risk to overcome their doubts. But demonizing anyone who has concerns and having them fired is just completely inappropriate.

I really do wish Rachel Maddow and Tucker Carlson and Chris Cuomo and even Dr. Wen and Dr. Fauci could spend just one day with me – and see what all the confusion and chaos has wrought in the minds and souls of my patients. I really do.

Public health has no business mandating these for individuals in this situation. Heart disease and strokes have killed more people than COVID this year – but you do not hear the public health authorities mandating that every adult take LIPITOR. Why not?

It is because coercion simply does not work in these situations. Coercion often severely coalesces resistance. Look around you. Much research has been done on this in the past. Just look at Dr. Fauci’s take on coercion and vaccine mandates from just last autumn before the vaccines arrived. What he said then and what he is saying now cannot both be true. (Of course when looking for that link, I was able to find 3 different contradictory things he has said about vaccines in the past year). There has been no sudden sea change in decades of public health research. And what he said last autumn had years of public health research and wisdom behind it. He appropriately exempted from his statement last year Health Care workers (and I would add the military) – which are not at all “the public” in public health.

COVID-19 ERASED The Regulatory And Trial-Related Hurdles To IMMENSE PROFIT

unlimitedhangout |  How did Moderna know that COVID-19 would create those conditions months before anyone else, and why did they later claim that their vaccine being tested in NIH trials was different than their commercial candidate? 

In late 2019, the biopharmaceutical company Moderna was facing a series of challenges that not only threatened its ability to ever take a product to market, and thus turn a profit, but its very existence as a company. There were multiple warning signs that Moderna was essentially another Theranos-style fraud, with many of these signs growing in frequency and severity as the decade drew to a close. Part I of this three-part series explored the disastrous circumstances in which Moderna found itself at that time, with the company’s salvation hinging on the hope of a divine miracle, a “Hail Mary” save of sorts, as stated by one former Moderna employee. 

While the COVID-19 crisis that emerged in the first part of 2020 can hardly be described as an act of benevolent divine intervention for most, it certainly can be seen that way from Moderna’s perspective. Key issues for the company, including seemingly insurmountable regulatory hurdles and its inability to advance beyond animal trials with its most promising—and profitable—products, were conveniently wiped away, and not a moment too soon. Since January 2020, the value of Moderna’s stock—which had embarked on a steady decline since its IPO—grew from $18.89 per share to its current value of $339.57 per share, thanks to the success of its COVID-19 vaccine.

Yet, how exactly was Moderna’s “Hail Mary” moment realized, and what were the forces and events that ensured it would make it through the FDA’s emergency use authorization (EUA) process? In examining that question, it becomes quickly apparent that Moderna’s journey of saving grace involved much more than just cutting corners in animal and human trials and federal regulations. Indeed, if we are to believe Moderna executives, it involved supplying formulations for some trial studies that were not the same as their COVID-19 vaccine commercial candidate, despite the data resulting from the former being used to sell Moderna’s vaccine to the public and federal health authorities. Such data was also selectively released at times to align with preplanned stock trades by Moderna executives, turning many of Moderna’s highest-ranking employees into millionaires, and even billionaires, while the COVID-19 crisis meant economic calamity for most Americans. 

Not only that, but—as Part II of this three-part series will show, Moderna and a handful of its collaborators at the National Institutes of Health (NIH) seemed to know that Moderna’s miracle had arrived—well before anyone else knew or could have known. Was it really a coincidental mix of “foresight” and “serendipity” that led Moderna and the NIH to plan to develop a COVID-19 vaccine days before the viral sequence was even published and months before a vaccine was even considered necessary for a still unknown disease? If so, why would Moderna—a company clearly on the brink—throw everything into and gamble the entire company on a vaccine project that had no demonstrated need at the time?

So Let Me Get This Right, You MuhFuggah's Still Working Out mRNA's Kinks?

phys.org  |  Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene. 

Because transgenes can have negative and even dangerous effects when expressed in the wrong cells, the researchers wanted to find a way to reduce off-target effects from gene therapies. One way of distinguishing different types of cells is by reading the RNA sequences inside them, which differ from tissue to tissue.

By finding a way to produce transgene only after "reading" specific RNA sequences inside cells, the researchers developed a technology that could fine-tune gene therapies in applications ranging from regenerative medicine to cancer treatment. For example, researchers could potentially create new therapies to destroy tumors by designing their system to identify cancer cells and produce a toxic protein just inside those cells, killing them in the process.

"This brings new control circuitry to the emerging field of RNA therapeutics, opening up the next generation of RNA therapeutics that could be designed to only turn on in a cell-specific or tissue-specific way," says James Collins, the Termeer Professor of Medical Engineering and Science in MIT's Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering and the senior author of the study.

This highly targeted approach, which is based on a genetic element used by viruses to control gene translation in host cells, could help to avoid some of the side effects of therapies that affect the entire body, the researchers say.

Evan Zhao, a research fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University, and Angelo Mao, an MIT postdoc and technology fellow at the Wyss Institute, are the lead authors of the study, which appears today in Nature Biotechnology.

RNA detection

Messenger RNA (mRNA) molecules are sequences of RNA that encode the instructions for building a particular protein. Several years ago, Collins and his colleagues developed a way to use RNA detection as a trigger to stimulate cells to produce a specific protein in bacterial cells. This system works by introducing an RNA molecule called a "toehold," which binds to the ribosome-binding site of an mRNA molecule that codes for a specific protein. (The ribosome is where proteins are assembled based on mRNA instructions.) This binding prevents the mRNA from being translated into protein, because it can't attach to a ribosome.

The RNA toehold also contains a sequence that can bind to a different mRNA sequence that serves as a trigger. If this target mRNA sequence is detected, the toehold releases its grip, and the mRNA that had been blocked is translated into protein. This mRNA can encode any gene, such as a fluorescent reporter molecule. That fluorescent signal gives researchers a way to visualize whether the target mRNA sequence was detected.

In the new study, the researchers set out to try to create a similar system that could be used in eukaryotic (non-bacterial) cells, including human cells.

Old Cornpop's Preposterous Covid NeoVaccinoid Mandate Encounters Some Serious Turbulence

 

denvergazette |  Republican lawmakers are pressuring President Joe Biden to drop or pause his vaccine requirements for federal defense contractors over fears they will compromise national security supply chains.

The Washington Examiner reviewed a letter Alabama Republican Sen. Tommy Tuberville sent to the White House Tuesday afternoon claiming that Biden's "federal contractor vaccine mandate will have negative effects on our national security" and called on the president "to remove — or, at a minimum, delay and clarify — vaccination requirements on private companies and academic research institutions that are actively supporting the Department of Defense."

"I share your desire to see our country through the COVID-19 pandemic as quickly as possible, and, I — like you — have elected to take the vaccine. But your administration's mandate is short-sighted, ill-conceived, and threatens our national security," Tuberville wrote in a letter sent to the White House on Tuesday. "The American warfighter is ultimately harmed when skilled workers leave the defense contractor workforce, a foreseeable consequence of your order."

Tuberville specifically noted that Alabama alone employed nearly 100,000 federal contractors in 2020, and "more than 5,000 contractors who support the Department of Defense."

"They provide capabilities to the Pentagon that are often difficult to replicate. Losing any sizable share of a small firms' workforce means a direct reduction in the ‘economy and efficiency' that your Order purports to seek to advance. When these firms are unable to perform, our country is at risk," he continued. "It is quite possible that your mandate will result in individuals leaving the workforce to avoid the vaccine, thus, resulting in increased worker absences and labor costs, and decreased efficiency. During this time of increasing worry about the technological advances of near-peer adversaries, we should focus on policies that will ensure our national security interests are protected. This order does the opposite."

"We will lose several thousand people," Raytheon CEO Greg Hayes said on CNBC Tuesday. "It's not just the prime contractors, but it's also all of our subcontractors that need to follow that mandate as well."

Tuberville's letter follows on the heels of a similar offering from nearly a dozen Republican members of the House Armed Services Committee. On Oct. 22, those lawmakers petitioned the White House and Secretary of Defense Lloyd Austin to suspend the Pentagon's vaccine mandate for contractors over fears that it could lead to military supply chain problems.

"We strongly urge you to reconsider the manner in which you are seeking to address this issue so as not to harm the livelihood of civilian contractors, industry partners, and strategic goals of our armed services," the letter reads. "Those who adamantly refuse the vaccine will accept termination. We will lose critical experience in skilled labor. We will lose opportunities for mentorship and on-the-job training from veteran craftsmen. In the long-term, we will miss quality control standards. We will face endemic cost overruns and rework as decades of lessons are not passed to the next generation."

Roughly 100 employees at United Launch Alliance, a joint venture funded by Lockheed Martin and Boeing that contracts to both the Department of Defense and NASA, walked off the job Monday over the federal government's vaccine mandates and pledged to continue protesting in the days leading up to the deadline to be vaccinated.

"The COVID-19 pandemic has affected virtually every facet of life over the past 18 months. COVID-19 also is a challenge for our business, a business that is critical to national security and civil space endeavors," a ULA representative said in a statement. "ULA decided to require vaccinations to ensure the health and safety of our employees and to align with our U.S. government customer and industry direction. This places ULA in a much better position to meet the nation's needs and our manifest commitments while protecting the health of everyone at our facilities."

 

Granny Goodness Urges Boris Johnson To Mandate mRNA Goo Jabs...,

reclaimthenet |  Former US Secretary of State and former Democrat presidential candidate Hillary Clinton has waded into UK politics and has said UK Prime Minister Boris Johnson should enforce vaccine passport mandates. She made the remarks in an appearance on BBC’s Andrew Marr Show.

During the interview, Clinton suggested the enforcement of vaccine mandates in order to contain the spike of infections ahead of the winter.

“I do think it is imperative that the Prime Minister do what he can to stop the rise in Covid in the UK. He doesn’t need to shut the society down but he does need to mandate vaccines,” Clinton said.

When Marr clarified that mandating vaccines equals the implementation of vaccine passports, Clinton said that was the right path to follow.

She referenced the situation in the New York health sector where vaccine hesitancy resulted in the implementation of a mandate. Further illustrating her point, Clinton claimed that a hospital in New York had to fire more than 1,000 employees for refusing to show a passport, suggesting that it was a good thing.

“I think you have got to make it clear that we are not going to go back into lockdown – that is not going to happen,” Clinton said.

“But if you don’t get vaccinated, if you don’t have proof of vaccination when you go into a club or a restaurant…”

Appearing to suggest people should be fired for not showing a passport, she said: “And if employers don’t enforce vaccines, we may see some problems here in the UK as the weather gets colder and people are forced back inside again.”

Clinton’s comment came after the PM publicly decided to stop vaccine certification plans, though there is some speculation they could still be used.

 

Big Pharma's RNA Therapeutics Race - Temporariness Is A Feature Not A Bug...,

c&en  | For small biotech companies hoping to strike a deal with larger drug developers, there’s no greater destination than the J.P. Morgan Healthcare Conference. In early January 2020, leaders from the start-up Shape Therapeutics made the annual pilgrimage to this mecca of biotechnology networking in San Francisco to make a pitch: What if you could edit someone’s genetic code without ever touching their DNA?

The biotech industry is awash in companies using tools like CRISPR gene editing to fix or turn off problematic DNA. If gene editing works, it could provide a one-and-done cure. But some researchers are worried that if CRISPR slips up and cuts DNA at the wrong site, the damage could also be permanent. “Targeting DNA has a lot of all-or-nothing consequences,” says David Huss, head of research at Shape.

At the conference, Huss explained to potential partners that Shape’s solution was to edit RNA instead of DNA. Our cells constantly produce short-lived RNA molecules that convert the DNA code into functional proteins. Incredibly, our bodies have already evolved an ingenious tool for editing RNA: an enzyme called ADAR—adenosine deaminase acting on RNA. The enzyme converts select adenosine (A) bases, one of four letters that compose the messenger RNA (mRNA) code, into another base that the cell interprets as guanosine (G). Shape was founded in 2018 on the basis of academic work showing that synthetic molecules called guide RNAs could recruit ADAR and direct it to make these A-to-G edits at precise sites.

Scientists estimate that A-to-G editing could fix mutations responsible for nearly 50% of genetic diseases. “We have a tool that can be applied to so many diseases that we couldn’t possibly do them all ourselves,” Huss says. When Shape executives pitched their RNA-editing technology to the Big Pharma company Roche, the two teams clicked, says Sylke Poehling, head of therapeutic modalities at Roche.

SO Much Harm To SO Many People - And Now The Harm Is Mandatory?

westernjournal |  New concerns are being raised about side effects from the Moderna vaccine against the coronavirus.

Swedish health officials have now decided that a moratorium on giving the Moderna vaccine to anyone under 31 will be extended indefinitely, the U.K. Daily Mail reported. The pause on the Moderna shots had been scheduled to end on Dec. 1.

Finland, Iceland and Denmark have taken similar steps. Norway is encouraging men under 30 not to get the Moderna shot, but is not mandating it.

For months, the Moderna vaccine has been under scrutiny because of data that shows young men who receive it are at increased risk for myocarditis, an inflammation of the heart muscle, and pericarditis, an inflammation of the sac around the heart.

The Daily Mail reported that one U.S. study that has not yet been peer-reviewed concluded that “young males under [age] 20 are up to six times more likely to develop myocarditis after contracting COVID-19 than those who have been vaccinated.”

The decision comes as the U.S. Food and Drug Administration is putting Moderna’s plans for a shot aimed at the population from age 12 to 17 on hold due to concerns over risks of the ailments, according to The Wall Street Journal.

Although a federal Centers for Disease Control and Prevention panel on Thursday approved boosters for the Moderna and Johnson & Johson vaccines, there were some cautions raised, according to CNBC.

Dr. Tom Shimabukuro said there is an increased risk of myocarditis and pericarditis with either the Moderna or Pfizer vaccine, in particular after the second dose of the vaccines.

According to the Daily Mail, the data indicated the risk was 13 times greater for those getting the Moderna vaccine than for those who got the Pfizer vaccine.

 

Physicians - Why Must 100% Of The Populace Get Jabbed?

americanthinker  |  Lately, it has been all about getting 100% of the population jabbed.  For what reason?  I am not sure, and some of the more detailed and investigated theories scare me.  I shudder to think.  But last year’s heroes are being labeled selfish and villainous for not getting the vaccine.  Hospital systems have abandoned their community’s health and ignored early successful outpatient treatment in favor of huge government subsidies for inpatient and ICU treatment.  The success of these treatments was not great, but that is another article.  Now we have the same hospital systems turning their backs on their own employees.  Basically, health providers have a choice, get shot, or get fired.  How does that help?  Both vaxxed and unvaxxed can spread the virus, so it doesn’t help anyone.  It only helps the hospital to get more government money by meeting quotas.

 I, for one, will remember that when we faced a real crisis, the hospitals and many physicians chose money and profit over their own community’s best interest.  Perhaps it is time for groups of physicians to get back to running their own healthcare clinics and hospitals.  We used to have a code of ethics.  We used to put patients first.  Not anymore.

As for physicians, those who are blindly following the government edicts are culpable in a moral atrocity.  Bullying and deriding patients who chose to refrain from this still experimental therapy is an abomination.  (You will say it isn’t experimental anymore, to which I would say that just because the government broke its own rules regarding approval, doesn’t make it legal or right).  Patients have sincere beliefs for making their choice.  Respect their thoughts.  Do you yell as much at smokers, drinkers, fornicators, drug abusers, etc?  No, I think not. I think you chose to fit in because it gives you a sense of righteousness.

And going so far as to encourage vaccination in children and pregnant women is crazy.  There is blood on the hands of any physician who does this.  With children, there is no benefit to the vaccine, only harm.  They would serve themselves and society better with natural immunity.  The vaccine hasn’t been studied on women and their babies.  It is pregnancy category X (unknown) but being pushed wholesale on these poor women without proper studies.  Shame on you, doctors who are doing this.  I certainly have lots to answer for when I meet my maker, but this is on another level.

I beg physicians to get back to basics, remember all the epidemiology and immunology that bored us to tears in school.  Investigate the real literature and take a stand.  Society needs us to do this.  Even if you have been vaccinated, help those who are fighting for their lives.  Stand up against this forced vaccine tyranny.  Support those who have legitimate reasons for declining the jab. If you don’t stand up now, who will stand up for you when you are faced with your choice of yet another booster or your job.