Showing posts with label dopamine. Show all posts
Showing posts with label dopamine. Show all posts

Tuesday, June 03, 2014

internet addiction?


scientificamerican |  How do we size up such an addiction? One way is to look at chemistry and the brain’s wiring. Drugs and behaviors are viewed as triggers for the same chemical changes in the brain. Researchers are also testing substance-abuse treatment drugs in experimental trials for Internet addiction and gambling. And the DSM-5 has a new behavioral addictions category, of which gambling is now a part, moved from its past classification as an “impulse-control disorder.” The APA has thus hinted that behaviors can be addictive in medical-speak.

Another way to look at addictions, however, is to look at the symptoms and consequences. You could diagnose addictions differently—alcohol, Internet gaming, etc.—or you could call them patients of a single condition: an addiction syndrome. Each overdose is viewed as a manifestation of this syndrome, driven by circumstance and inherent traits. The syndrome model buckets addictions into one category with a set of symptoms and a spectrum of severity. More than a habit, it’s the consequence that defines the addiction.

A third way is to rethink an addiction like Internet gaming as the development of a new worldview. An addiction often starts off as an innocuous experience. The experience triggers a series of pleasurable feelings but it also plants a series of memories. Taken to an extreme, what an addict wants is the recreation of the memory, an alternate reality. To simply abstain from whatever it is that is addictive is to deny a worldview. The body serves as a medium for the known route (the drug or behavior) that is the ticket to the desired world (the alternate reality). Of course, there are very real chemical changes that happen in an addict’s brain. But this alternate way of looking at addiction illustrates that it is a process, not a condition, and that circumstance influences chemistry.
And thus, the final question: Who decides what matters?

Over 400 years ago to be addicted was to simply have a strong inclination toward substances or behaviors. It was a choice. But over time, addictions started to mean inclinations that were less about choice and more about lack of control. Deviance then became a problem that could be fixed through religious discourse, medicine and social pressures. Today, there’s a psychiatric manual.

The DSM wields power. It’s gone from a 130-page manual in 1952 to a 900-page bestseller that competed with J. K. Rowling and Dan Brown on Amazon’s top-selling of 2013 before settling in at #12. The book is used as a treatment guide for picking out the right mental condition, providing the basis for insurance claims.

Friday, January 24, 2014

organic negativity is not false, it's just weaker than consumerism and dopamine hegemony


itself | In a wonderful if hilarious article for the 1989 December issue of Telos, Timothy Luke, one of the primary progenitors of the artificial negativity thesis, writes a delicious article ‘Xmas Ideology: Unwrapping the New Deal and the Cold War under the Christmas Tree’1, which is replied to directly afterwards by Paul Piccone2. In it Luke claims that Christmas films such as It’s A Wonderful Life, Miracle on 34th Street, Holiday Inn and White Christmas are an almost perfect example of artificial negativity. Against the crass commercialisation of Christmas, they appear to offer an authentic core of love and human compassion that are unspoilt. In fact, Luke argues, they are merely a way of briefly compensating for the aggressive fragmentation of late capitalism, and actually perpetuating it. The films “generate ideologies of self-gratification and fulfilment as in the cult of Christmas, which rather than being cast as a Christian celebration of Christ’s birth, is instead turned into a fantasy of self-fulfilment and collective solidarity as part of a celebration of materialistic giving (and receiving)”.

Hence:
The Christian rituals of Christmas, then, have been remanufactured by capital and the state during WWII and the Cold War into “Xmas”. Without it, the rituals of life in consumer society might disintegrate even more than they have already, making Xmas an essential aspect of exchange. It mediates the forms of subjectivity in the intimate sphere of caring with corporate agendas of spending and having. Christmas as “Xmas” becomes in film the essential simulation of settled social traditions, family unity, and collective purpose for many modern American Pottersvilles that otherwise lack these qualities.

For Luke, as in It’s A Wonderful Life, such stories are a New Deal fantasy dealt out by corporations and one side, and the state seen as benevolent protector on the other through the medium of bureaucracy – Clarence the angel attempting to get his wing is after all part of a bureaucracy of angels much like the New Deal state.

Suffice to say, Piccone doesn’t like this much. He believes the films as quite capably critiquing the American they found. Indeed, rather than stressing the values of capitalism and welfarism, these classic Christmas films: “If anything, it is the concept of solidarity and, particularly in It’s A Wonderful Life, communitarian values which are idealized”. Indeed, one of the main enemies in It’s A Wonderful Life is the heartless landlord Mr Potter. The protagonist of It’s A Wonderful Life, George, is the son of the owner of a small bank Savings and Loan. When his father dies, the slum landlord Mr Potter wants to start denying loans to the working poor, because these loans are not profitable and to also take over the company. In an very famous scene in front of the board of directors, George argues that from an economic perspective the loans his father made may not have been good sense, but from a human perspective, in getting people out of the slums, they had been an obvious good “People were human beings to him, but to you, a warped, […] they’re cattle”. This convinces the board of directors to reject this, and to put him in charge of the company. Thus the older, benevolent capitalism of the small town with its concern for human values and the desire to enable people’s ambitions even if it was not profitable, the bank as service provider for people not profit, is contrasted to the centralised despotic and money orientated capitalism of Potter where profit is the only concern and people are pure objects from which to extract it. The film speaks to spiritual and moral values over money values. The same is true of Miracle on 34th Street, speculative capitalism is opposed to kindly capitalism of the small banker who knew your needs and ambitions. These films are not artificially negative, but authentically and organically negative. But this leads to a problem – they were still created by the Hollywood and, as Piccone claims, became more popular during the Reagan years because of the family values agenda he articulated. How can they be organically negative if they are put so easily to use by the Reaganite neo-conservative New Class? Piccone never accounts for this – but whatever we think of the films at hand, this small example of the major theorists of the concepts of Artificial Negativity and the New Class clashing over a particular object shows some important conceptual flaws – how do we point genuine versions of organic negativity out and be attentive to false artificial negativities? In this light, after a little anaylsis we can see that these terms have, first, no theoretical coherence and second, fulfil only one role, a purely polemic way of labelling and dismissing the distasteful.

Wednesday, December 04, 2013

god, dopamine, 3-dimensional space...,

What are God and Heaven doing up in the clouds?
neuropolitics | Space. The final frontier. And when it comes to religiosity, it just might be. Out of the clouds, Fred Previc has constructed an ingenious theory of religiosity based on the multiple mechanisms employed by the brain to map and direct its behaviors in 3-dimensional space. As we shall see, Previc's theory of religiosity has many similarities with Brack's hemisphericity theory of political orientation, both of which propose a key role to the dopaminergic system in the modulation of religiosity (and in our case, political conservatism).
 
Although our theories were derived independently, Previc's original manuscript, The role of extrapersonal brain systems in religious activity, predates the introduction of our theory (via the web) by several months. Although it does not specifically address political disposition, it is such a theory by proxy, via the strong relationship between religiosity and political conservatism. While Previc's theory makes full use of the large volume of literature implicating the dopamine system in religious behavior, it is a quantum leap in the theory of religiosity, and centered upon the various mechanisms on how the brain behaves in the four 3-dimensional spatial realms it has constructed for itself, and how time itself has become enmeshed with the brain's rendering of space.

Fred Previc knows something about space. Previc was the lead of the United States Air Force's Spatial Disorientation Countermeasures Task Group, which studied pilot spatial disorientation in flight, a major cause of aeronautic accidents. How he has subsequently woven his research and theories on the brain's rendering of space into a theory of religiosity is one the great insights in the history of neuropsychology. But what exactly is Previc's theory?

dopamine hegemony depends on the wattles...,


oulu.fi | via Northrup Grumman Information Technology - most fascinating data source research funder...., The neuropsychology of religious activity in normal and selected clinical populations is reviewed. Religious activity includes beliefs, experiences, and practice. Neuropsychological and functional imaging findings, many of which have derived from studies of experienced meditators, point to a ventral cortical axis for religious behavior, involving primarily the ventromedial temporal and frontal regions. Neuropharmacological studies generally point to dopaminergic activation as the leading neurochemical feature associated with religious activity. The ventral dopaminergic pathways involved in religious behavior most closely align with the action-extrapersonal system in the model of 3-D perceptual–motor interactions proposed by Previc (1998). These pathways are biased toward distant (especially upper) space and also mediate related extrapersonally dominated brain functions such as dreaming and hallucinations. Hyperreligiosity is a major feature of mania, obsessive-compulsive disorder, schizophrenia, temporal-lobe epilepsy and related disorders, in which the ventromedial dopaminergic systems are highly activated and exaggerated attentional or goal-directed behavior toward extrapersonal space occurs. The evolution of religion is linked to an expansion of dopaminergic systems in humans, brought about by changes in diet and other physiological influences.

Wednesday, September 25, 2013

if a path exists toward a moral economy, we're not on it...,


scientificamerican | In every financial transaction–whether you’re selling a car, paying employees, or repackaging commodity futures as financial derivatives–there are ethical calculations that influence economic activity beyond the price. Sure, you can cheat a potential buyer and not mention that your 1996 Ford Mustang GT has a cracked engine block, in the same way that your boss can stiff you on overtime. If you get away with it you will succeed in making a short-term gain or see a bump in the next quarterly earnings report. But, if you eventually develop the reputation as someone who consistently defrauds the people you do business with, there is a good chance that the value of your net worth will be as negative as the moral values you embraced. 

But why is it that businesses that are “too big to fail” don’t seem bound by the same moral economy as the rest of us? It turns out that anthropologists may have some insight, not only on this question, but also how we might integrate our economic and moral values that so often appear at odds. Researchers have found that the interconnection between economics and morality is seen most clearly in small communities where everybody knows each other, everyone has a free choice in who they deal with, and gossip can make or break reputations. This is even the case for societies that look very different from our own.

For example, in 2006 the anthropologist Joseph Henrich and colleagues published a study in the journal Science (pdf here) based on their analysis of 15 different societies ranging from American college students to urban wage workers in Ghana to semi-nomadic foragers in the Bolivian rainforest. By having each group conduct a series of economic games, the researchers found that there was a positive correlation between how much people punished cheaters and the amount of altruistic behavior in the society as a whole. What’s more, every society engaged in some form of costly punishment even though there was a great deal of variability between societies. 

The researchers’ conclusion was that altruistic punishment emerged in our species through a process of gene-culture coevolution. In other words, human psychology is biologically predisposed to enforce a system of fairness, but how much we do so depends on the culture we see reflected around us. This result was later supported by another study in 2010 that developed a model explaining how even “selfish genes” could promote altruistic traits.

Tuesday, August 27, 2013

fixing old markets with new markets the origins and practice of neoliberalism...,


nakedcapitalism | NT: Your new book, Never Let a Serious Crisis Go to Waste, is not the first work you have produced that discusses Neoliberalism. In the Postscript to the book you edited entitled “The Road from Mont Pèlerin: The Making of the Neoliberal Thought Collective” you state that:
[O]ur own guiding heuristic has been that Neoliberalism has not existed in the past as a settled or fixed state, but is better understood as a transnational movement requiring time and substantial effort in order to attain the modicum of coherence and power it has achieved today. It was not a conspiracy; rather, it was an intricately structured long-term philosophical and political project, or in our terminology, a “thought collective”.
Given this context, could you explain what the salient features of Neoliberalism are? In particular it would be helpful if you explained about why “traditional” approaches to intellectual history are inadequate for understanding Neoliberalism.

PM: Standard history of economics has been mired in the primacy of the individual author/intellectual for quite some time now. There, one tends to become attached to some particular intellectual hero, reads everything they wrote, and hence seeks to channel ‘their’ ideas to a general audience. Maybe one consults a few of their allies or opponents to add a dash of ‘context’. This, perhaps inadvertently, has resulted in deep misunderstanding of how economics has developed over the last century or more.

Ideas generally don’t incubate like that. Traditions in the history and sociology of science [my current disciplinary home] have developed a number of methods and devices in order to highlight the elaborate social character of intellectual disciplines, and display the complex trajectories of validation of knowledge. The landmarks there are many, but the one I lean upon in Never Let a Serious Crisis go to Waste is the concept of a ‘thought collective’ that dates back to the work of Ludwik Fleck.*
Whatever one thinks of the specifics, that framework has permitted me to write a history of Neoliberalism which comes to terms with some of its more slippery aspects. In the first instance, it nurtures appreciation for the fact that Neoliberalism is both a set of philosophical doctrines – and not, as some would have it, a narrow few abstract propositions in economics—and a flexible ongoing political project. The doctrines and the details of the project change through time, as do the roster of protagonists, but still maintain a coherence and stability that justifies treating the movement as an historical collective. Next, it insists that Neoliberalism cannot be reduced to the writings of the few standout neoliberals that readers of this blog may have heard of – Friedrich Hayek, Milton Friedman, James Buchanan, Gary Becker – primarily because their individual tenets conflict, some with each other, and some with some other less famous comrades. Fleck points us towards the fact that thought collectives are held together, in part, by formal social structures; in the case of the Neoliberals, it started out as the Mont Pèlerin Society [MPS] in 1947, but by the 1980s it was extended to a connected ring of think tanks around the world, from the Institute for Economic Affairs to the American Enterprise Institute to Heritage and Cato to the Atlas Foundation and beyond. As early as 1956, the Volker Fund maintained a list of 1,841 affiliated individuals; the corresponding number easily exceeds the tens of thousands today. Clearly the thought collective harbors strong impressions of who is in and who is out.

Perhaps more importantly, the ‘thought collective’ approach has helped me grapple with one of the most nettlesome aspects of Neoliberalism: How can one write an intellectual history of a bunch of anti-intellectual intellectuals? Some readers may have encountered Hayek’s sneers about those whom he dubs ‘second-hand dealers in ideas’; but that is just symptomatic of a more general stance towards knowledge which sets the Neoliberals apart from almost every other thought collective in recent history. As I explain in Chapter 2, the MPS became a society of ‘rationalists’ who ended up promoting ignorance as a virtue for the larger population. Others have also documented this straddle in their think tank perimeter, such as Tom Medvetz in his Think Tanks in America. It seems we are not in Kansas anymore (apologies to Tom Frank).

Thus, to write a history of Neoliberalism in the current crisis, Fleck counsels one must connect their various epistemic attitudes to the content of their doctrines. In the case of modern Neoliberalism, this has been made manifest in their shared conviction that The Market knows more than any human being, however wise or well-schooled. Planning is doomed; socialism is a pipe dream. The political project of Neoliberalism is not laissez-faire; rather, it is to use state power to get the populace to prostrate themselves before the only dependable source of Truth and Wisdom in human civilization—viz., something they call “The Market”. The more discombobulated the average citizen can be rendered, the quicker they will get with the program

Wednesday, April 17, 2013

nutrient-shaped, nutrient-seeking, macro-molecular machines...,

the beer of yesteryear...,
figshare | We now know that new species arise from relatively sudden changes in the supply of nutrients. The problem that remains with the concept of Darwinian Natural selection for phenotype is that statistical arguments first eliminate consideration of genes with large effects (Carter, 1969). That approach has led many evolutionary theorists and philosophers to ignore existing pleiotropy, which is especially evident in microbial species, and to also ignore the epigenetic tweaking of immense gene networks by nutrients in all species. The epigenetic effects of nutrients are clearly required for individual survival, and nutrients metabolize to species-specific pheromones. The problem with mutations theory extends to a denial of species-wide pheromone-controlled reproduction, which is required for epistasis and survival of species.

Simply put, statistical analyses are used to deny nutrient-dependent / pheromone-controlled adaptive evolution (Kohl, 2013). By default, statistical analyses also tend to 1) eliminate climate change, 2) eliminate the thermodynamic complexity of molecular bonds, and 3) eliminate the complex systems biology of thermoregulation and adaptively evolved biodiversity. Because statistical analyses of cause and effect start by eliminating biological facts from calculations and equations, some researchers have viewed adaptive evolution only in the context of a mathematical “garbage-in, garbage out” theory -- with no model of biologically based adaptive evolution.

Tuesday, March 26, 2013

review: the moral molecule, source of love and prosperity


ishe-journal | The Moral Molecule: the Source of Love and Prosperity presents, in informal language, the results of neuroeconomist Paul J. Zak’s work on the effects of the hormone oxytocin on a wide range of human behavior. It considers the hormone’s reinforcing effects on individuals, on close personal relationships, and on society as a whole. Chapters cover the evolution of trust, the pathways by which oxytocin works as a behavioral reinforcer, how other factors can interfere with oxytocin’s “good effects,” how the biology of oxytocin intersects religion, why greed isn’t good for individuals or societies, and how to create a bottom-up democracy. Zak makes a case for a link from oxytocin to empathy, to morality, to trust, to love, to economic prosperity…and to something he calls a virtuous cycle.  Testosterone effects are also described, in particular how they counteract or balance the effects oxytocin. This book review summarizes these elements and also stresses the relationship of the hormones oxytocin and testosterone to war.

Saturday, December 08, 2012

dopamine: not about pleasure anymore...,



uconn | “Often, depressed people say they don’t want to go out with their friends,” says Salamone. But it’s not that they don’t experience pleasure, he says – if their friends were around, many depressed people could have fun.

“Low levels of dopamine make people and other animals less likely to work for things, so it has more to do with motivation and cost/benefit analyses than pleasure itself,” he explains.

In essence, says Salamone, this is how amphetamines work, which increase dopamine levels and help people motivate to focus on tasks at hand.

“When you give people amphetamines, you see them putting more effort into things,” he says.
The big implications of this change in understanding come at the level of overlapping motivational symptoms of depression with those seen in other disorders such as schizophrenia, multiple sclerosis, and Parkinson’s disease. Symptoms of fatigue may be related to low levels of dopamine or changes in other parts of the same brain circuitry.

On the one hand, this lack of perceived energy is maladaptive, because it reduces the tendency to interact with the environment. But, Salamone says, it could also reflect the body’s attempt to save energy in a crisis.
He points out that new ideas in science are traditionally met with criticism. But after all the mounting evidence, he says he’s no longer regarded as “a crazy rebel,” but simply someone who thought differently.
“Science is not a collection of facts. It’s a process,” he says. “First we thought dopamine was involved only in movement. Then that faded and we thought it was pleasure. Now we’ve gone beyond that data on pleasure.”

Although he has thought about writing a popular-press book, he’s not sure he really wants to go to the public and “debunk” the dopamine hypothesis of pleasure and reward. But if he ever does, one thing is for sure.
“I can sum up all this work with one phrase, which would make a great book title,” he says. “Dopamine: it’s not about pleasure anymore.” Fist tap Arnach.

pervitin



amphetamines | In a letter dated November 9, 1939, to his "dear parents and siblings" back home in Cologne, a young soldier stationed in occupied Poland wrote: "It's tough out here, and I hope you'll understand if I'm only able to write to you once every two to four days soon. Today I'm writing you mainly to ask for some Pervitin ...; Love, Hein."

Pervitin, a stimulant commonly known as speed today, was the German army's -- the Wehrmacht's -- wonder drug.

On May 20, 1940, the 22-year-old soldier wrote to his family again: "Perhaps you could get me some more Pervitin so that I can have a backup supply?" And, in a letter sent from Bromberg on July 19, 1940, he wrote: "If at all possible, please send me some more Pervitin." The man who wrote these letters became a famous writer later in life. He was Heinrich Boell, and in 1972 he was the first German to be awarded the Nobel Prize for Literature in the post-war period.

Many of the Wehrmacht's soldiers were high on Pervitin when they went into battle, especially against Poland and France -- in a Blitzkrieg fueled by speed. The German military was supplied with millions of methamphetamine tablets during the first half of 1940. The drugs were part of a plan to help pilots, sailors and infantry troops become capable of superhuman performance. The military leadership liberally dispensed such stimulants, but also alcohol and opiates, as long as it believed drugging and intoxicating troops could help it achieve victory over the Allies. But the Nazis were less than diligent in monitoring side-effects like drug addiction and a decline in moral standards.

After it was first introduced into the market in 1938, Pervitin, a methamphetamine drug newly developed by the Berlin-based Temmler pharmaceutical company, quickly became a top seller among the German civilian population. According to a report in the Klinische Wochenschrift ("Clinical Weekly"), the supposed wonder drug was brought to the attention of Otto Ranke, a military doctor and director of the Institute for General and Defense Physiology at Berlin's Academy of Military Medicine. The effects of amphetamines are similar to those of the adrenaline produced by the body, triggering a heightened state of alert. In most people, the substance increases self-confidence, concentration and the willingness to take risks, while at the same time reducing sensitivity to pain, hunger and thirst, as well as reducing the need for sleep. In September 1939, Ranke tested the drug on 90 university students, and concluded that Pervitin could help the Wehrmacht win the war. At first Pervitin was tested on military drivers who participated in the invasion of Poland. Then, according to criminologist Wolf Kemper, it was "unscrupulously distributed to troops fighting at the front."

Saturday, October 20, 2012

seoul flaunts the come up...,



WaPo | Americans aren’t particularly accustomed to foreign music competing with their own in global markets, so when the South Korean song “Gangnam Style” popped onto U.S. music charts, it was something of a wake-up call. Korean pop music has been thriving in East Asia for years, which is remarkable in itself given the country’s small size and the wealth of successful musicians in its bigger and richer neighbor Japan.

So how do Korea’s music companies do it? Part of the industry’s success comes from being just that: industrial. Musicians are meticulously groomed, songs set to careful formulas, and all of it processed on a grand scale. The New Yorker’s John Seabrook explained the concept of “cultural technology,” a factory-like system whereby everything from composer nationality to eye shadow color to hand gestures is pre-determined by formula and protocol. Seabrook suggests that the “cultural technology” model produces music “too robotic to make it in the West” — the music’s painstaking earnestness also doesn’t quite translate for Americans — and K-pop has indeed long struggled to make it big in Western markets.

How, then, to explain the sudden U.S. success of “Gangnam Style,” written and performed by a K-popper who is of the “cultural technology” system but also an aberration within it: older, less attractive (sorry) and more satirical than his K-compatriots? How did Psy manage to utilize the successes of “cultural technology” — he’s got Americans mimicking his dance and glued to his video, in true K-pop form — while also overcoming the more “robotic” aspects of it that have hampered its Western reach?

The answer may have to do with the timing of South Korea’s “economic miracle,” in which the largely agrarian dictatorship became a wealthy and developed democracy in a few short decades. The country became rich enough to support a big domestic music industry during a time when the way people consume music was changing. Fist tap Dale.

Wednesday, June 27, 2012

unprecedented freedom to pursue dopamine hits...,



Monbiot | So now what do we do to defend life on Earth?

It is, perhaps, the greatest failure of collective leadership since the first world war. The Earth’s living systems are collapsing, and the leaders of some of the most powerful nations – the US, the UK, Germany, Russia – could not even be bothered to turn up and discuss it. Those who did attend the Earth summit last week solemnly agreed to keep stoking the destructive fires: sixteen times in their text they pledged to pursue “sustained growth”, the primary cause of the biosphere’s losses(1).

The efforts of governments are concentrated not on defending the living Earth from destruction, but on defending the machine that is destroying it. Whenever consumer capitalism becomes snarled up by its own contradictions, governments scramble to mend the machine, to ensure – though it consumes the conditions that sustain our lives – that it runs faster than ever before.

The thought that it might be the wrong machine, pursuing the wrong task, cannot even be voiced in mainstream politics. The machine greatly enriches the economic elite, while insulating the political elite from the mass movements it might otherwise confront. We have our bread; now we are wandering, in spellbound reverie, among the circuses.

We have used our unprecedented freedoms, secured at such cost by our forebears, not to agitate for justice, for redistribution, for the defence of our common interests, but to pursue the dopamine hits triggered by the purchase of products we do not need. The world’s most inventive minds are deployed not to improve the lot of humankind but to devise ever more effective means of stimulation, to counteract the diminishing satisfactions of consumption. The mutual dependencies of consumer capitalism ensure that we all unwittingly conspire in the trashing of what may be the only living planet. The failure at Rio de Janeiro belongs to us all.

Monday, June 18, 2012

like baboons, our elected leaders are literally addicted to power...,

Telegraph | Democracy, the separation of judicial powers and the free press all evolved for essentially one purpose – to reduce the chance of leaders becoming power addicts. Power changes the brain triggering increased testosterone in both men and women. Testosterone and one of its by-products called 3-androstanediol, are addictive, largely because they increase dopamine in a part of the brain’s reward system called the nucleus accumbens. Cocaine has its effects through this system also, and by hijacking our brain’s reward system, it can give short-term extreme pleasure but leads to long-term addiction, with all that that entails.

Unfettered power has almost identical effects, but in the light of yesterday’s Leveson Inquiry interchanges in London, there seems to be less chance of British government ministers becoming addicted to power. Why? Because, as it appears from the emails released by James Murdoch yesterday, they appeared to be submissive to the all-powerful Murdoch empire, hugely dependent on the support of this organization for their jobs and status, who could swing hundreds of thousands of votes for or against them.

Submissiveness and dominance have their effects on the same reward circuits of the brain as power and cocaine. Baboons low down in the dominance hierarchy have lower levels of dopamine in key brain areas, but if they get ‘promoted’ to a higher position, then dopamine rises accordingly. This makes them more aggressive and sexually active, and in humans similar changes happen when people are given power. What’s more, power also makes people smarter, because dopamine improves the functioning of the brain’s frontal lobes. Conversely, demotion in a hierarchy decreases dopamine levels, increases stress and reduces cognitive function.

But too much power - and hence too much dopamine - can disrupt normal cognition and emotion, leading to gross errors of judgment and imperviousness to risk, not to mention huge egocentricity and lack of empathy for others. The Murdoch empire and its acolytes seem to have got carried away by the power they have wielded over the British political system and the unfettered power they have had - unconstrained by any democratic constraints - has led to the quite extraordinary behaviour and arrogance that has been corporately demonstrated.

We should all be grateful that two of the three power-constraining elements of democracy - the legal system and a free press - have managed to at last reign in some of the power of the Murdoch empire. But it was a close call for both, given the threat to financial viability of the newspaper industry and to the integrity of the police system through the close links between the Murdoch empire and Scotland Yard.

Wednesday, May 09, 2012

dopamine: duality of desire

TheScientist | Why are addicts so desperate? Why is it so hard to stop? Neuroscientists seek the answer in a single molecule: dopamine—a neuromodulator long associated with reward. Dopamine focuses attention on goals, powers motor sequences designed to achieve them, and injects them with emotional urgency. A lot of this occurs in the ventral striatum, a subcortical structure densely connected to the prefrontal cortex, the cingulate cortex, and the amygdala. Yet there remains a fundamental controversy about the role of dopamine in the striatum. Is dopamine the basis of reward? Or is dopamine responsible for a desperate longing that doesn’t feel good at all?

Many neuroscientists think of the striatal dopamine circuit as a pleasure center. That could explain why addicts have a dopamine spike around the time they get high on drugs. It could also explain the action of drugs like methamphetamine and cocaine, which release and maintain high levels of dopamine and are perceived as profoundly pleasurable.

But a new approach to dopamine has surfaced, partly through the neuroscience of addiction. University of Michigan neuroscientist Kent Berridge and his colleagues view striatal circuitry as the locus of two separate functions: liking and wanting. Their research demonstrates that liking—pleasure—is mediated by opioids. But wanting is mediated by dopamine. The feeling of desire, or wanting, evolved to get us to pursue the things that make us feel good. But the pursuit itself isn’t fun.

According to Berridge, dopamine levels peak when goals are just out of reach and drop once they’ve been attained. For addicts, dopamine increases sensitivity to drug-related cues and generates a state of pursuit. This reconceptualization could explain the findings of neuroscientist Robert Risinger and colleagues who showed that dopamine peaked in the striatum just before, not after, addicts pressed a button that delivered cocaine (NeuroImage, 26: 1097-1108, 2005). And those same addicts reported “craving”—not “high”—as the experiential correlate of dopamine.

So why do meth and coke feel so good and not just like souped-up craving? Attraction to something you don’t have access to isn’t fun. When I was in the throes of intense psychological addiction, my thoughts were continuously (and unpleasantly) drawn to drug imagery. It would be so great to have some now! How can I get some tonight?! But attraction to something you are just about to get feels marvelous. Dopamine-induced engagement turns into a headlong rush of triumph when the goal is finally accessible.

This perspective on the dual nature of attraction helps make sense of addiction. Unsated attraction can be a kind of torture, and addicts may seek drugs to put an end to that torture, more than for the modicum of pleasure drugs actually bestow.

Advances in neuroscience encourage fresh insights, not only into addiction, but into the wider domains of emotion and personality development. Yet a synthesis between neuroscience and subjectivity can perhaps teach us more than either one alone.

Tuesday, May 01, 2012

prohibition costs billions, legalization would earn billions - but what about its effect on dopamine hegemony?

aclu | Over 300 economists, including three Nobel Laureates, recently signed a petition that encourages the president, Congress, governors and state legislatures to carefully consider marijuana legalization in America. The petition draws attention to an article by Harvard economist Jeffrey Miron, whose findings highlight the substantial cost-savings our government could incur if it were to tax and regulate marijuana, rather than needlessly spending billions of dollars enforcing its prohibition.

Miron predicts that legalizing marijuana would save $7.7 billion per year in government expenditure on enforcement, in addition to generating $2.4 billion annually if taxed like most consumer goods, or $6 billion per year if taxed similarly to alcohol and tobacco. The economists signing the petition note that the budgetary implications of marijuana prohibition are just one of many factors to be considered, but declare it essential that these findings become a serious part of the national decriminalization discussion.

The advantages of marijuana legalization extend far beyond an opportunity to make a dent in our federal deficit. The criminalization of marijuana is one of the many fights in the War on Drugs that has failed miserably. And while it's tempting to associate only the harder, "scarier" drugs with this botched crusade, the fact remains that marijuana prohibition is very much a part of the battle. The federal government has even classified marijuana as a Schedule 1 substance (its most serious category of substances), placing it in a more dangerous category than cocaine. More than 800,000 people are arrested for marijuana use and possession each year, and 46 percent of all drug prosecutions across the country are for marijuana possession. Yet this costly and time-consuming targeting of marijuana users by law enforcement and lawmakers has done little to quell use of the drug.

The criminalization of marijuana has not only resulted in a startlingly high number of arrests, it also reflects the devastating disparate racial impact of the War on Drugs. Despite ample evidence that marijuana is used more frequently by white people, Blacks and Latinos account for a grossly disproportionate percentage of the 800,000 people arrested annually for marijuana use and possession. These convictions hinder one's ability to find or keep employment, vote or gain access to affordable housing. The fact that these hard-to-shake consequences – bad enough as they are — are suffered more frequently by a demographic that uses marijuana less makes our current policies toward marijuana all the more unfair, unwise and unacceptable.

Sunday, April 29, 2012

with the dopamine flowing like this, you knew the booty popping couldn't be far behind...,


CNN | After focusing on "green cars" in recent years, carmakers are wowing visitors at the Auto China 2012 car show with vehicles that are big, bad and gas-guzzling.

"I would definitely be interested if the price was right," says Wang Xizhen as he ogled a deep purple Aston Martin DBS.

Aston Martin launched its Dragon 88 China-only limited edition this week. With gold dragon emblems embroidered onto its leather seats, the car also carries a hefty price tag - more than 5 million yuan (nearly $800,000).

Jeep also launched a China-inspired car -- a flashy Wrangler concept car emblazoned with a long silvery dragon across the hood.

"Jeep brand sales in China in 2011 increased 81% over the prior year and China," said Mike Manley, CEO of Jeep Brand, Chrysler group, at the unveiling on Monday. "Last year, more Jeep vehicles were sold in China than in any other country besides the U.S. and Canada."

Manley said because the brand is committed to China, it's important to design and tailor vehicles specifically to Chinese tastes. But some consumers, like Wang, disagreed.

"Just because it has a dragon on it, doesn't mean Chinese people will love it. After all, we're after going after a western brand," said Wang. "I like the subtlety of Aston Martin's dragon design, but to put a huge dragon across the entire car is going overboard."

Jeep and Aston Martin are among many foreign automakers hoping to woo hundreds of thousands of Chinese consumers visiting the show this week, especially as China has become the world's largest auto market amid a sales slump in Europe and tepid growth in the United States.

Despite the push in green cars in previous years following government subsidies for cleaner vehicles, this year's focus turned to gas-guzzling SUVs. Crowds swooned over the new Lamborghini Urus SUV concept car -- a potential competitor to the popular Porsche Cayenne.

Ford also unveiled three SUVs at the show, including the EcoSport, which is expected to be manufactured at the company's China factory in Chongqing.

"SUVs are a strength for Ford globally and here in China, the SUV segment is one of the fastest growing segments in the industry," said Joe Hinrichs, president of Ford's Asia Pacific and Africa region. "So you put the two together...it's a very exciting time."

Automakers have turned their attention to bigger cars and flashier cars to attract consumers since there are fewer government-backed incentives to pursue green technology, analysts say.


Tuesday, April 03, 2012

#revolutionwhatrevolution?

FT | When I recently discovered Twitter, I went from contemptuous to addicted in about three days. But one thing still puzzles me about the world’s 10th most popular website: the notion that it’s a revolutionary medium. The failed Moldovan rebellion of 2009 was probably the first to be dubbed the “Twitter revolution”, but since then, Twitter has been credited with launching the Iranian uprising, Arab spring and London riots. Now it has supposedly prompted the African Union to hunt for the Ugandan warlord Joseph Kony, after an anti-Kony propaganda film spread through social media and was watched more than 100 million times. I confidently predict that the next revolution anywhere on earth will be dubbed “the Twitter revolution”.

Non-tweeting readers may have formed the impression that the Twittersphere is devoted to summoning people to demonstrations in grey repressive capitals. In fact, “trending” items are usually celebrity deaths, goals in football matches or anything to do with the teenaged singer Justin Bieber. And what’s true of Twitter appears true of computers in general. They are antirevolutionary devices. The global addiction to computers is helping keep the world quiet and peaceful.

Every now and then, of course, social media do contribute to change. The Facebook page “We are all Khaled Said”, named after a young Egyptian who died in police custody, helped galvanise protesters in Cairo’s Tahrir Square last year. And bad activists use YouTube and Twitter too. “On the web one can proselytise for the jihad all day and night with friends from around the world,” writes Jytte Klausen, an expert on terrorism at Brandeis University, and colleagues.

Mostly, though, computers produce quietism. Despite Occupy Wall Street, a striking fact of the great recession in developed countries has been the passivity of young people.

Thursday, September 29, 2011

the rat race for prestige

The Atlantic | Stephen Joel Trachtenberg understands the prestige war from the inside. When he became president of George Washington University in 1988, tuition was $14,000 -- below average for a private, four-year university, as Washington Monthly reported. When he left in 2007, tuition had skyrocketed to $39,000. During that time, undergraduate applications tripled, the endowment quintupled to $1 billion, SAT scores jumped by 200 points, and the university created five new schools. This essay is adapted from an interview with The Atlantic.

You can buy a pair of jeans at Wal-Mart for $29 and one from Ralph Lauren for $98. While both cover your backside, one comes with a label of status that appeals to some and not to others. Customers -- and lets not forget that students are customers of academic services -- like choices and they usually make selections based on more than one factor, price being only one.

When my son checked into his freshman dorm, there were no lights in his room - nothing on the ceiling, walls or desk. There were two outlets: if you wanted light, Yale required you to bring your own lamp. I thought this took the parable of Plato's Cave a bit too far.

Applicants to GW look for more than overhead lights: they want living and dining choices, places to study and swim, comfortable desks and chairs, and tennis and basketball courts. Yes, they are looking for great professors but they want more than classroom life. The only way to provide more books in the library, more theaters for performances, laboratories for experiments, coffee shops for study breaks is to have the dollars to build and maintain all these things - and dollars come from tuition.

At the same time as the demand for quality services increased, so too did the cost for basic utilities: electricity, water, security, oil, insurance, personnel health and other employee benefits have all risen over the past 40 years.

PERCEPTION IS REALITY: WHY TUITION KEEPS RISING
The only way to buy more books and build more labs is more money. And the money come from tuition. The top 50 universities are not a monolithic list. They can probably be divided into two parts: the top 15 and the next 35. Within the first group, there is little difference of quality - it is all cream with nuances of flavorings. For the next group - numbers 16-50, there is cream, buttermilk, latte, and lots of special tastes. There is also jockeying for position. The top ten always get a mention by the general press. Sometimes, the next 5 or 10 are in a paragraph lower down the column. No question that number 35 wants to move up.

Tuitions rise because costs rise. As the payroll grows, tuition goes up. As the expense of goods and services used by the institution inflate, or become more extended and expanded, tuition goes up. Universities really do get better faculty by providing better compensation and benefits. Professors, it turns out, are economic men and women: Prestige tends to be indexed to quality and quality tends to be measured by the attributes of an institution: the laboratories, libraries, studios, playing fields, recreational and residential facilities; the services for counseling. When one talks about a top 50 university, one is talking about both perception and reality. These are in significant measure indexed to the size of endowment, the fundraising and the tuition income available to the school to provide what the students seek.

Tuesday, September 13, 2011

addiction is not a disease of the brain?

NPR | Addiction has been moralized, medicalized, politicized, and criminalized. And, of course, many of us are addicts, have been addicts or have been close to addicts. Addiction runs very hot as a theme.

Part of what makes addiction so compelling is that it forms a kind of conceptual/political crossroads for thinking about human nature. After all, to make sense of addiction we need to make sense of what it is to be an agent who acts, with values, in the face of consequences, under pressure, with compulsion, out of need and desire. One needs a whole philosophy to understand addiction.

Today I want to respond to readers who were outraged by my willingness even to question whether addiction is a disease of the brain.

Let us first ask: what makes something — a substance or an activity — addictive? Is there a property shared by all the things to which we can get addicted?

Unlikely. Addictive substances such as alcohol, heroin and nicotine are chemically distinct. Moreover, activities such as gambling, eating, sex — activities that are widely believed to be addictive — have no ingredients.

And yet it is remarkable — as Gene Heyman notes in his excellent book on addiction — that there are only 20 or so distinct activities and substances that produce addiction. There must be something in virtue of which these things, and these things alone, give rise to the distinctive pattern of use and abuse in the face of the medical, personal and legal perils that we know can stem from addiction.

What do gambling, sex, heroin and cocaine — and the other things that can addict us — have in common?

One strategy is to look not to the substances and activities themselves, but to the effects that they produce in addicts. And here neuroscience has delivered important insights.

If you feed an electrical wire through a rat's skull and onto to a short dopamine release circuit that connects the VTA (ventral tegmental area) and the nucleus accumbens, and if you attach that wire to a lever-press, the rat will self-stimulate — press the lever to produce the increase in dopamine — and it will do so basically foreover, forgoing food, sex, water and exercise. Addiction, it would seem, is produced by direct action on the brain!

(See here for a useful Wikipedia review of this literature.)

And indeed, there is now a substantial body of evidence supporting the claim that all drugs or activities of abuse (as we can call them), have precisely this kind of effect on this dopamine neurochemical circuit.

When the American Society of Addiction Medicine recently declared addiction to be a brain disease their conclusion was based on findings like this. Addiction is an effect brought about in a neurochemical circuit in the brain. If true, this is important, for it means that if you want to treat addiction, you need to find ways to act on this neural substrate.

Elite Donor Level Conflicts Openly Waged On The National Political Stage

thehill  |   House Ways and Means Committee Chair Jason Smith (R-Mo.) has demanded the U.S. Chamber of Commerce answer questions about th...